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1. 发明申请

US20050159743A1 Method for treating a sphincter 有权
标题翻译：治疗括约肌的方法
公开(公告)号：US20050159743A1
公开(公告)日：2005-07-21
申请号：US11079697
申请日：2005-03-14
申请人： Stuart Edwards , David Utley , Ronald Lax , John Gaiser
发明人： Stuart Edwards , David Utley , Ronald Lax , John Gaiser
IPC分类号： A61B18/00 , A61B18/12 , A61B18/14 , A61B18/18 , A61F7/00 , A61F7/12
CPC分类号： A61B18/1492 , A61B18/1206 , A61B18/1477 , A61B18/18 , A61B2018/00011 , A61B2018/00029 , A61B2018/00047 , A61B2018/00214 , A61B2018/0022 , A61B2018/00494 , A61B2018/00553 , A61B2018/00666 , A61B2018/00678 , A61B2018/00684 , A61B2018/00702 , A61B2018/00708 , A61B2018/00726 , A61B2018/00744 , A61B2018/00791 , A61B2018/00875 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2218/002
摘要： A method for treating a sphincter provides a polymer material having a liquid state. The method also provides a catheter having a distal end, a tissue piercing device carried by the distal end, and an energy delivery device coupled to the tissue piercing device. The tissue piercing device has a lumen. The method introduces the catheter into an esophagus and pierces an exterior sphincter tissue surface within with the tissue piercing device. The method advances the tissue piercing device into an interior sphincter tissue site and conveys the polymer material while in a liquid state through the lumen into the interior sphincter tissue site. The method delivers energy to the tissue piercing device to transform the polymer material into a less liquid state within the interior sphincter tissue site, to thereby remodel the sphincter.
摘要翻译：用于治疗括约肌的方法提供具有液体状态的聚合物材料。该方法还提供了具有远端的导管，由远端承载的组织刺穿装置，以及耦合到组织刺穿装置的能量输送装置。组织穿刺装置具有内腔。该方法将导管引入食道并刺穿组织穿刺装置内的外括约肌组织表面。该方法使组织穿刺装置进入内部括约肌组织部位，并将液体状态下的聚合物材料通过内腔输送到内括约肌组织部位。该方法将能量传递到组织刺穿装置，以将聚合物材料转变成内部括约肌组织部位内的较少液体状态，从而改变括约肌。

2. 发明授权

US06325798B1 Vacuum-assisted systems and methods for treating sphincters and adjoining tissue regions 有权
标题翻译：真空辅助系统和治疗括约肌和邻近组织区域的方法
公开(公告)号：US06325798B1
公开(公告)日：2001-12-04
申请号：US09304743
申请日：1999-05-04
申请人： Stuart Edwards , John Gaiser , David Utley , Scott West , Jay Chin , Ronald Lax
发明人： Stuart Edwards , John Gaiser , David Utley , Scott West , Jay Chin , Ronald Lax
IPC分类号： A61B1818
CPC分类号： A61B18/1206 , A61B18/12 , A61B18/1477 , A61B18/1485 , A61B18/1492 , A61B2017/22067 , A61B2017/308 , A61B2017/3488 , A61B2018/00011 , A61B2018/00029 , A61B2018/00077 , A61B2018/00148 , A61B2018/00214 , A61B2018/00232 , A61B2018/00261 , A61B2018/00267 , A61B2018/00273 , A61B2018/00285 , A61B2018/00291 , A61B2018/00553 , A61B2018/00654 , A61B2018/0066 , A61B2018/00702 , A61B2018/00755 , A61B2018/00791 , A61B2018/00797 , A61B2018/00815 , A61B2018/00875 , A61B2018/00898 , A61B2018/046 , A61B2018/1425 , A61B2018/1475 , A61B2090/036 , A61B2090/3782 , A61B2218/002 , A61B2218/007
摘要： Systems and methods treat a tissue region at or near a sphincter by deploying a carrier, which carries an electrode that can be advanced to penetrate tissue. Negative pressure is applied through a suction port on the carrier near the electrode, to draw tissue in the tissue region inward against the carrier. The systems and methods advance the electrode to penetrate tissue drawn against the carrier. The vacuum anchors the surrounding tissue and mediates against the “tenting” of tissue during electrode penetration. Without tenting, the electrode penetrates mucosal tissue fully, to obtain a desired depth of penetration.
摘要翻译：系统和方法通过展开携带可以被推进穿透组织的电极的载体来处理括约肌处或附近的组织区域。通过电极附近的载体上的吸入口施加负压，将组织区域中的组织向内抵靠载体。这些系统和方法使电极移动以穿透抵靠载体的组织。真空锚定周围的组织，并在电极穿透期间抵抗组织的“隆起”进行介导。没有隆起，电极完全渗透粘膜组织，以获得所需的穿透深度。

3. 发明申请

US20070112341A1 Apparatus to detect and treat aberrant myoelectric activity 失效
标题翻译：检测和治疗异常肌电活动的装置
公开(公告)号：US20070112341A1
公开(公告)日：2007-05-17
申请号：US11651750
申请日：2007-01-10
申请人： Stuart Edwards , David Utley , Ronald Lax
发明人： Stuart Edwards , David Utley , Ronald Lax
IPC分类号： A61B18/18
CPC分类号： A61B5/04884 , A61B18/1477 , A61B18/1485 , A61B90/39 , A61B2018/00553 , A61B2018/00738 , A61B2018/046 , A61B2090/3925 , A61B2560/0242
摘要： An apparatus to treat a sphincter has a support member. A sphincter electropotential mapping device includes a mapping electrode. The sphincter electropotential mapping device is coupled to the support member and configured to detect aberrant myoelectric activity of the sphincter.
摘要翻译：治疗括约肌的装置具有支撑构件。括约肌电位映射装置包括映射电极。括约肌电位映射设备耦合到支撑构件并且被配置为检测括约肌的异常肌电活动。

4. 发明申请

US20050245926A1 Sphincter treatment apparatus 失效
标题翻译：括约肌治疗仪
公开(公告)号：US20050245926A1
公开(公告)日：2005-11-03
申请号：US11175471
申请日：2005-07-06
申请人： Stuart Edwards , David Utley , Ronald Lax , Theodore Kucklick , Peter Muller
发明人： Stuart Edwards , David Utley , Ronald Lax , Theodore Kucklick , Peter Muller
IPC分类号： A61B18/00 , A61B18/14
CPC分类号： A61B18/14 , A61B17/32 , A61B18/1477 , A61B18/1492 , A61B18/1815 , A61B2018/00011 , A61B2018/00029 , A61B2018/00148 , A61B2018/00214 , A61B2018/0022 , A61B2018/00267 , A61B2018/00494 , A61B2018/00553 , A61B2018/00577 , A61B2018/00702 , A61B2018/00726 , A61B2018/00744 , A61B2018/00791 , A61B2018/00875 , A61B2018/00916 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1472 , A61B2018/183 , A61B2090/3614 , A61B2090/3782
摘要： A sphincter treatment apparatus includes an energy delivery device introduction member including a proximal end with a first radius of curvature and a distal end with a second radius of curvature. The introduction member is configured to be introduced into the sphincter in a non-deployed state and to be expanded to a deployed state to at least partially expand the sphincter or an adjoining structure. An energy delivery device is coupled to the introduction member. A retainer member is coupled to the energy delivery device introduction member and configured to controllably position the introduction member in an orifice of the sphincter.
摘要翻译：括约肌治疗装置包括能量输送装置导入构件，其包括具有第一曲率半径的近端和具有第二曲率半径的远端。引入构件被配置为以非展开状态引入括约肌并且被扩展到展开状态以至少部分地扩展括约肌或相邻结构。能量输送装置联接到引入构件。保持器构件联接到能量输送装置引入构件并构造成将引导构件可控地定位在括约肌的孔中。

5. 发明申请

US20060247616A1 Ablation treatment apparatus 审中-公开
标题翻译：消融治疗仪
公开(公告)号：US20060247616A1
公开(公告)日：2006-11-02
申请号：US11397069
申请日：2006-04-03
申请人： Stuart Edwards , James Baker , Bruno Strul , Ronald Lax
发明人： Stuart Edwards , James Baker , Bruno Strul , Ronald Lax
IPC分类号： A61B18/14
CPC分类号： A61B18/18 , A61B18/1206 , A61B18/14 , A61B18/1402 , A61B18/1477 , A61B18/1482 , A61B18/1492 , A61B18/1815 , A61B2017/00026 , A61B2017/00084 , A61B2018/00011 , A61B2018/00196 , A61B2018/00452 , A61B2018/00476 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00726 , A61B2018/00761 , A61B2018/00779 , A61B2018/00791 , A61B2018/00821 , A61B2018/00827 , A61B2018/00875 , A61B2018/00892 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2018/1435 , A61B2018/162 , A61B2018/1861 , A61B2218/002 , A61M3/0279 , A61M25/007 , A61N5/02 , A61N5/04 , A61N5/045
摘要： An RF treatment apparatus includes a catheter with a catheter lumen. A removable needle electrode is positioned in the catheter lumen in a fixed relationship to the catheter. The needle electrode includes a needle lumen and a needle electrode distal end. A removable introducer is slidably positioned in the needle lumen. The introducer includes an introducer distal end. A first sensor is positioned on a surface of the needle electrode or the insulator. An RF power source is coupled to the needle electrode and a return electrode. An insulator sleeve is slidably positioned around the electrode and includes a second sensor. Resources are associated with the electrodes, sensors as well as the RF power source for maintaining a selected power at the electrode independent of changes in current or voltage.
摘要翻译： RF治疗装置包括具有导管内腔的导管。可拆卸针电极以与导管固定的关系定位在导管内腔中。针状电极包括针内腔和针电极末端。可移除的导引器可滑动地定位在针腔内。导引器包括导引器远端。第一传感器位于针状电极或绝缘体的表面上。 RF电源耦合到针电极和返回电极。绝缘体套筒可滑动地定位在电极周围并且包括第二传感器。资源与电极，传感器以及RF电源相关联，用于在电流或电压的变化下保持电极处的选定功率。

6. 发明申请

US20050033279A1 RF treatment apparatus 审中-公开
标题翻译：射频治疗仪
公开(公告)号：US20050033279A1
公开(公告)日：2005-02-10
申请号：US10737694
申请日：2003-12-15
申请人： Stuart Edwards , James Baker , Bruno Strul , Ronald Lax
发明人： Stuart Edwards , James Baker , Bruno Strul , Ronald Lax
IPC分类号： A61B17/00 , A61B18/00 , A61B18/12 , A61B18/14 , A61B18/18 , A61B18/22 , A61M1/00 , A61M3/02 , A61M25/00 , A61N5/02 , A61N5/04
CPC分类号： A61B18/1482 , A61B18/1206 , A61B18/14 , A61B18/1402 , A61B18/1477 , A61B18/1492 , A61B18/18 , A61B18/1815 , A61B2017/00026 , A61B2017/00084 , A61B2018/00011 , A61B2018/00196 , A61B2018/00452 , A61B2018/00476 , A61B2018/00577 , A61B2018/00642 , A61B2018/00666 , A61B2018/00678 , A61B2018/00702 , A61B2018/00708 , A61B2018/00726 , A61B2018/00761 , A61B2018/00779 , A61B2018/00791 , A61B2018/00821 , A61B2018/00827 , A61B2018/00875 , A61B2018/00892 , A61B2018/124 , A61B2018/1253 , A61B2018/126 , A61B2018/1425 , A61B2018/1435 , A61B2018/162 , A61B2018/1861 , A61B2218/002 , A61M25/007 , A61N5/02 , A61N5/04 , A61N5/045
摘要： An RF treatment apparatus includes a catheter with a catheter lumen. A removable needle electrode is positioned in the catheter lumen in a fixed relationship to the catheter. The needle electrode includes a needle lumen and a needle electrode distal end. A removable introducer is slidably positioned in the needle lumen. The introducer includes an introducer distal end. A first sensor is positioned on a surface of the needle electrode or the insulator. An RF power source is coupled to the needle electrode and a return electrode. An insulator sleeve is slidably positioned around the electrode and includes a second sensor. Resources are associated with the electrodes, sensors as well as the RF power source for maintaining a selected power at the electrode independent of changes in current or voltage.
摘要翻译： RF治疗装置包括具有导管内腔的导管。可拆卸针电极以与导管固定的关系定位在导管内腔中。针状电极包括针内腔和针电极末端。可移除的导引器可滑动地定位在针腔内。导引器包括导引器远端。第一传感器位于针状电极或绝缘体的表面上。 RF电源耦合到针电极和返回电极。绝缘体套筒可滑动地定位在电极周围并且包括第二传感器。资源与电极，传感器以及RF电源相关联，用于在电流或电压的变化下保持电极处的选定功率。

7. 发明申请

US20050203503A1 Infusion array ablation apparatus 审中-公开
标题翻译：输液阵列消融装置
公开(公告)号：US20050203503A1
公开(公告)日：2005-09-15
申请号：US11034503
申请日：2005-01-12
申请人： Stuart Edwards , James Baker , Hugh Sharkey , Ronald Lax
发明人： Stuart Edwards , James Baker , Hugh Sharkey , Ronald Lax
IPC分类号： A61B17/00 , A61B18/00 , A61B18/12 , A61B18/14 , A61B18/18 , A61B18/22 , A61M3/02 , A61M25/00 , A61N1/40 , A61N5/04 , C22C1/04 , C22C14/00 , C22F1/18
摘要： An infusion array ablation apparatus includes an elongated delivery device having a lumen and an infusion array positionable in the lumen. The infusion array includes an RF electrode and at least a first and a second infusion member. Each infusion member has a tissue piercing distal portion and an infusion lumen. At least one of the first or second infusion members is positionable in the elongated delivery device in a compacted state and deployable from the elongated delivery device with curvature in a deployed state. Also, at least one of the first or second infusion members exhibits a changing direction of travel when advanced from the elongated delivery device to a selected tissue site. At least one infusion port is coupled to one of the elongated delivery device, the infusion array, the first infusion member or the second infusion member.
摘要翻译：输液阵列消融装置包括细长递送装置，其具有可定位在内腔中的内腔和输液排列。输注阵列包括RF电极和至少第一和第二输注构件。每个输注构件具有组织穿刺远端部分和输注腔。第一或第二输注构件中的至少一个可以处于压实状态的细长输送装置中定位并且可以从伸长的输送装置以部署状态的曲率展开。此外，第一或第二输注构件中的至少一个表现出当从细长递送装置前进到选定的组织部位时改变的行进方向。至少一个输注端口连接到细长递送装置，输注阵列，第一输注构件或第二输注构件中的一个。

8. 发明申请

US20060047331A1 Method and apparatus for controlled contraction of soft tissue 审中-公开
公开(公告)号：US20060047331A1
公开(公告)日：2006-03-02
申请号：US11058845
申请日：2005-02-15
申请人： Ronald Lax , Gary Fanton , Stuart Edwards
发明人： Ronald Lax , Gary Fanton , Stuart Edwards
IPC分类号： A61F7/00 , A61F7/12
CPC分类号： A61B18/148 , A61B2018/00023 , A61B2018/00083 , A61B2018/00452 , A61B2018/00702 , A61B2018/00791 , A61B2018/143 , A61B2018/1472 , A61B2018/1497 , A61B2018/1861 , A61N1/40
摘要： An apparatus and method are provided for control contraction of tissue that includes collagen fibers. The apparatus includes a handpiece, and an electrode with an electrode proximal end associated with the handpiece. A distal end of the electrode has a geometry that delivers a controlled amount of energy to the tissue for a desired contraction of the collagen fibers. This is achieved while dissociation and breakdown of the collagen fibers is minimized. The handpiece, with electrode, is adapted to be introduced through an operating cannula in percutaneous applications. Additionally, an operating cannula may be included in the apparatus and be attached to the handpiece. The apparatus and method provides for a desired level of contraction of collagen soft tissue without dissociation or breakdown of collagen fibers.

9. 发明申请

US20050010203A1 Medical probe device and method 有权
公开(公告)号：US20050010203A1
公开(公告)日：2005-01-13
申请号：US10910333
申请日：2004-08-03
申请人： Stuart Edwards , Ronald Lax , Ingemar Lundquist , Hugh Sharkey
发明人： Stuart Edwards , Ronald Lax , Ingemar Lundquist , Hugh Sharkey
IPC分类号： A61B5/01 , A61B10/00 , A61B10/02 , A61B10/06 , A61B17/00 , A61B17/22 , A61B17/24 , A61B17/28 , A61B17/34 , A61B18/00 , A61B18/08 , A61B18/14 , A61B18/18 , A61B18/22 , A61B18/24 , A61B19/00 , A61F7/00 , A61M1/00 , A61M3/02 , A61M25/00 , A61M25/092 , A61M25/14 , A61N1/06 , A61N1/40 , A61N5/02 , A61N5/04 , A61N5/06 , A61B18/04
CPC分类号： A61N5/02 , A61B10/02 , A61B10/0241 , A61B18/00 , A61B18/082 , A61B18/1206 , A61B18/1477 , A61B18/148 , A61B18/1485 , A61B18/18 , A61B18/1815 , A61B18/24 , A61B2017/00084 , A61B2017/00092 , A61B2017/00106 , A61B2017/00274 , A61B2017/00292 , A61B2017/003 , A61B2017/00867 , A61B2017/22072 , A61B2017/22077 , A61B2017/22082 , A61B2017/248 , A61B2017/2939 , A61B2017/3488 , A61B2018/00005 , A61B2018/00011 , A61B2018/00083 , A61B2018/00095 , A61B2018/00196 , A61B2018/0022 , A61B2018/00547 , A61B2018/00577 , A61B2018/00678 , A61B2018/00702 , A61B2018/00726 , A61B2018/00744 , A61B2018/0075 , A61B2018/00761 , A61B2018/00791 , A61B2018/00797 , A61B2018/00821 , A61B2018/00869 , A61B2018/00886 , A61B2018/0091 , A61B2018/00916 , A61B2018/00946 , A61B2018/00982 , A61B2018/1253 , A61B2018/126 , A61B2018/1273 , A61B2018/128 , A61B2018/1412 , A61B2018/1425 , A61B2018/1861 , A61B2018/2238 , A61B2090/0814 , A61B2090/3614 , A61B2090/3782 , A61B2090/3925 , A61F2007/0054 , A61M3/0279 , A61M25/0068 , A61M25/0069 , A61M25/008 , A61M25/0082 , A61M2025/0086 , A61M2025/0087 , A61M2025/0089 , A61M2025/009 , A61M2025/0096 , A61M2025/018 , A61N1/06 , A61N1/40 , A61N1/403 , A61N5/04 , A61N5/045
摘要： A medical probe device comprises a catheter having a stylet guide housing with one or more stylet ports in a side wall thereof and a stylet guide for directing a flexible stylet outward through the stylet port and through intervening tissue at a preselected, adjustable angle to a target tissue. The total catheter assembly includes a stylet guide lumen communicating with the stylet port and a stylet positioned in said stylet guide lumen for longitudinal movement from the port through intervening tissue to a target tissue. The stylet can be an electrical conductor enclosed within a non-conductive layer, the electrical conductor being a radiofrequency electrode. Preferably, the non-conductive layer is a sleeve which is axially moveable on the electrical conductor to expose a selected portion of the electrical conductor surface in the target tissue. The stylet can also be a microwave antenna. The stylet can also be a hollow tube for delivering treatment fluid to the target tissue. It can also include a fiber optic cable for laser treatment. The catheter can include one or more inflatable balloons located adjacent to the stylet port for anchoring the catheter or dilation. Ultrasound transponders and temperature sensors can be attached to the probe end and/or stylet. The stylet guide can define a stylet path from an axial orientation in the catheter through a curved portion to a lateral orientation at the stylet port.

10. 发明申请

US20060254603A1 Universal introducer 审中-公开
标题翻译：通用导引器
公开(公告)号：US20060254603A1
公开(公告)日：2006-11-16
申请号：US11491763
申请日：2006-07-24
申请人： Stuart Edwards , Ronald Lax , Theodore Parker , Thomas Wehman , Theodore Kucklick
发明人： Stuart Edwards , Ronald Lax , Theodore Parker , Thomas Wehman , Theodore Kucklick
IPC分类号： A61B18/18
CPC分类号： A61B17/00491 , A61B17/0057 , A61B17/3415 , A61B18/14 , A61B18/1482 , A61B18/1487 , A61B2017/00084 , A61B2017/00495 , A61B2017/005 , A61B2017/00637 , A61B2017/0065 , A61B2017/00672 , A61B2017/3441 , A61B2017/3492 , A61B2018/0063 , A61B2090/064 , A61M25/0662
摘要： A device for introducing a catheter into a vessel through a puncture in a vessel and for sealing the puncture. The device includes an elongated body having a proximal end and a distal end sized to be positioned within a tissue site which includes the puncture. The elongated body includes a utility lumen sized to allow a catheter to be delivered through the utility lumen. The utility lumen is positioned within the elongated body so positioning the elongated body within the tissue site allows a catheter delivered through the utility lumen to enter the vessel. The elongated body also includes a closure lumen having an entrance port. A closure composition can be delivered through the entrance port into the closure lumen. The closure lumen also includes an exit port adjacent the distal end of the elongated body. The closure composition delivered into the closure lumen can be delivered through the exit port to the tissue site adjacent the puncture.
摘要翻译：一种用于通过穿孔在容器中将导管引入容器并用于密封穿刺的装置。该装置包括细长体，其具有近端和远端，其尺寸设置成包括穿刺的组织部位内。细长主体包括大小适于允许导管通过效用管腔输送的应用腔。实用管腔定位在细长体内，从而将细长体定位在组织部位内，允许通过效用腔输送的导管进入血管。细长体还包括具有入口的封闭腔。封闭组合物可通过入口端口输送到封闭腔。闭合腔还包括邻近细长体的远端的出口。输送到闭合腔内的封闭组合物可以通过出口传送到穿刺附近的组织部位。

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