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1. 发明申请

US20050271702A1 Polymer-based sustained release device 有权
标题翻译：基于聚合物的持续释放装置
公开(公告)号：US20050271702A1
公开(公告)日：2005-12-08
申请号：US11104877
申请日：2005-04-13
申请人： Steven Wright , Troy Christensen , Thean Yeoh , Michael Rickey , Joyce Hotz , Rajesh Kumar , Henry Costantino
发明人： Steven Wright , Troy Christensen , Thean Yeoh , Michael Rickey , Joyce Hotz , Rajesh Kumar , Henry Costantino
IPC分类号： A61K9/00 , A61K9/16 , A61K9/50 , A61K38/09 , A61K38/17 , A61K38/18 , A61K38/19 , A61K38/20 , A61K38/21 , A61K38/22 , A61K38/24 , A61K38/26 , A61K38/27 , A61K38/28 , A61K38/33 , A61K38/35 , A61K47/26 , A61K47/38
CPC分类号： A61K47/34 , A61K9/0024 , A61K9/1623 , A61K9/1647 , A61K9/1694 , A61K38/2278 , A61K38/26 , A61K47/26 , A61K47/38
摘要： This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.
摘要翻译：本发明涉及用于持续释放生物活性多肽的组合物，以及形成和使用所述组合物用于持续释放生物活性多肽的方法。本发明的缓释组合物包含分散在其中的生物相容性聚合物，生物活性多肽和糖。

2. 发明申请

US20070166352A1 Polymer-based sustained release device 有权
标题翻译：基于聚合物的持续释放装置
公开(公告)号：US20070166352A1
公开(公告)日：2007-07-19
申请号：US11521091
申请日：2006-09-14
申请人： Steven Wright , Troy Christenson , Thean Yeoh , Michael Rickey , Joyce Hotz , Rajesh Kumar , Mark Fineman , Christine Smith , John Ong , David Lokensgard , Henry Costantino
发明人： Steven Wright , Troy Christenson , Thean Yeoh , Michael Rickey , Joyce Hotz , Rajesh Kumar , Mark Fineman , Christine Smith , John Ong , David Lokensgard , Henry Costantino
IPC分类号： A61K39/395 , A61K38/28 , A61K38/27 , A61K38/26 , A61K38/43
CPC分类号： A61K47/34 , A61K9/0002 , A61K9/1647 , A61K9/1694 , A61K9/5089 , A61K31/573 , A61K38/2278 , A61K38/26
摘要： This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.
摘要翻译：本发明涉及用于持续释放生物活性多肽的组合物，以及形成和使用所述组合物用于持续释放生物活性多肽的方法。本发明的缓释组合物包含分散在其中的生物相容性聚合物，生物活性多肽和糖。

3. 发明申请

US20060110423A1 Polymer-based sustained release device 审中-公开
公开(公告)号：US20060110423A1
公开(公告)日：2006-05-25
申请号：US11107550
申请日：2005-04-15
申请人： Steven Wright , Troy Christenson , Thean Yeoh , Michael Rickey , Joyce Hotz , Rajesh Kumar , Henry Costantino , David Lokensgard , Christine Smith
发明人： Steven Wright , Troy Christenson , Thean Yeoh , Michael Rickey , Joyce Hotz , Rajesh Kumar , Henry Costantino , David Lokensgard , Christine Smith
IPC分类号： A61K38/22 , A61F13/00
CPC分类号： A61K9/1647 , A61K9/0024 , A61K9/1623 , A61K9/1694 , A61K38/2278 , A61K38/26
摘要： This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide and a sugar.

4. 发明申请

US20070027085A1 Microencapsulation and sustained release of biologically active polypeptides 审中-公开
公开(公告)号：US20070027085A1
公开(公告)日：2007-02-01
申请号：US11541323
申请日：2006-09-29
申请人： Henry Costantino , Joyce Hotz
发明人： Henry Costantino , Joyce Hotz
IPC分类号： A61K38/22 , A61K31/70
CPC分类号： A61K9/5031 , A61K9/1611 , A61K9/1623 , A61K9/1647 , A61K38/2278
摘要： This invention relates to compositions for the sustained release of biologically active polypeptides, and methods of forming and using said compositions, for the sustained release of biologically active polypeptides. The sustained release compositions of this invention comprise a biocompatible polymer having dispersed therein, a biologically active polypeptide, a sugar and a salting-out salt.

5. 发明申请

US20070293657A1 COMPLEXES AND METHODS OF FORMING COMPLEXES OF RIBONUCLEIC ACIDS AND PEPTIDES 审中-公开
标题翻译：形成抗坏血酸和肽的复合物的复合物和方法
公开(公告)号：US20070293657A1
公开(公告)日：2007-12-20
申请号：US11670905
申请日：2007-02-02
申请人： Roger Adami , Daniel Morris , Henry Costantino
发明人： Roger Adami , Daniel Morris , Henry Costantino
IPC分类号： C07K2/00 , C07K14/00 , C07K7/08
CPC分类号： C07K14/003 , A61K47/6455 , A61K47/6901 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2310/321 , C12N2310/3513 , C12N2320/32 , C12N2310/3521
摘要： A complex of a double stranded (ds) ribonucleic acid and a peptide produced by a method comprising dissolving the nucleic acid in an aqueous solution, dissolving the peptide in an aqueous solution, mixing the solubilized ds nucleic acid and the solubilized peptide, and treating the mixture by freezing and thawing, heating and cooling, or salting and desalting.
摘要翻译：通过将核酸溶解在水溶液中，将该肽溶解在水溶液中，混合溶解的ds核酸和溶解肽，并且将所述多核苷酸混合物通过冷冻和解冻，加热和冷却，或盐析和脱盐。

6. 发明申请

US20070213270A1 PEPTIDE YY FORMULATIONS HAVING INCREASED STABILITY AND RESISTANCE TO MICROBIAL AGENTS 审中-公开
标题翻译：具有增加稳定性和抵抗微生物代谢的肽类药物
公开(公告)号：US20070213270A1
公开(公告)日：2007-09-13
申请号：US11570223
申请日：2005-06-16
申请人： Henry Costantino , Mary Kleppe , Annemarie Cohen
发明人： Henry Costantino , Mary Kleppe , Annemarie Cohen
IPC分类号： A61K38/22 , A61K31/724
CPC分类号： B82Y5/00 , A61K9/0043 , A61K9/08 , A61K31/724 , A61K38/22 , A61K47/14 , A61K47/40 , A61K47/6951 , A61K2300/00
摘要： Pharmaceutical compositions and methods are described comprising at least one Y2 receptor-binding peptide, such as peptide YY (PYY), Neuropeptide Y (NPY) or Pancreatic Peptide (PP) wherein the formulations have increased resistance to microbial contamination and is comprised of a Y2 receptor-binding peptide, water, a cyclodextrin and sodium benzoate.
摘要翻译：描述了药物组合物和方法，其包含至少一种Y2受体结合肽，例如肽YY（PYY），神经肽Y（NPY）或胰腺肽（PP），其中制剂具有增加的抗微生物污染的抗性，并由Y2组成受体结合肽，水，环糊精和苯甲酸钠。

7. 发明申请

US20060210614A1 Method of treatment of a metabolic disease using intranasal administration of exendin peptide 审中-公开
标题翻译：使用鼻内给药毒蜥外泌肽治疗代谢疾病的方法
公开(公告)号：US20060210614A1
公开(公告)日：2006-09-21
申请号：US11418982
申请日：2006-05-04
申请人： Steven Quay , Alexis Leonard , Henry Costantino
发明人： Steven Quay , Alexis Leonard , Henry Costantino
IPC分类号： A61K9/127 , A61F13/02 , A61K38/22 , A61K31/56
CPC分类号： A61K9/0043 , A61K9/0056 , A61K9/0073 , A61K9/2086 , A61K38/00 , A61K47/10 , A61K47/18 , A61K47/24
摘要： Methods for treating metabolic diseases are described for intranasal delivery of an exenatide, comprising an aqueous mixture of exendin, and a delivery enhancer selected from the group consisting of a solubilizer, a chelator, and a surfactant, and the pharmaceutical formulations used therein.
摘要翻译：描述了用于治疗代谢性疾病的方法用于鼻内递送艾塞那肽，其包含毒蜥外泌肽的水性混合物和选自增溶剂，螯合剂和表面活性剂的递送增强剂及其中使用的药物制剂。

8. 发明申请

US20070154401A1 COMPOSITIONS AND METHODS FOR ENHANCED MUCOSAL DELIVERY OF PARATHYROID HORMONE 审中-公开
公开(公告)号：US20070154401A1
公开(公告)日：2007-07-05
申请号：US11550061
申请日：2006-10-17
申请人： Steven Quay , Henry Costantino , Mary Kleppe , Ching-Yuan Li
发明人： Steven Quay , Henry Costantino , Mary Kleppe , Ching-Yuan Li
IPC分类号： A61K9/12 , A61K38/29 , A61K31/724
CPC分类号： A61K31/724 , A61K9/0043 , A61K38/29 , A61K47/183
摘要： Pharmaceutical compositions and methods are described comprising at least a parathyroid hormone peptide (PTH) preferably PTH1-34 and one or more mucosal delivery-enhancing agents for enhanced nasal mucosal delivery of PTH, for treating or preventing osteoporosis or osteopenia in a mammalian subject, preferably a human.

9. 发明申请

US20060127320A1 Method of delivering parathyroid hormone to a human 审中-公开
标题翻译：甲状旁腺激素给人的方法
公开(公告)号：US20060127320A1
公开(公告)日：2006-06-15
申请号：US11347551
申请日：2006-02-03
申请人： Henry Costantino , Connie Kwok
发明人： Henry Costantino , Connie Kwok
IPC分类号： A61L9/04 , A61M11/00 , A61K38/29
CPC分类号： A61K9/0043 , A61K31/724 , A61K38/29 , A61K47/40 , A61M15/08
摘要： What is described is a method of delivering PTH to a human, comprising exposing a layer of mucosal cells to a mixture of PTH and an enhancer, wherein the enhancer is capable of modulating the barrier function of a cellular tight junction. Specifically, the method of delivering PTH to a human by intranasal administration comprises use of an aqueous solution of growth and excipients in a bottle and a droplet-generating actuator attached to the bottle and fluidly connected to the PTH solution in the container, wherein the actuator produces a spray of the PTH solution through a tip of the actuator when the actuator is engaged, wherein the spray of PTH solution has a spray pattern ellipticity ratio of from about 1.0 to about 1.4 when measured at a height of 3.0 cm from the actuator tip.
摘要翻译：所描述的是将PTH递送到人的方法，包括将粘膜细胞层暴露于PTH和增强子的混合物，其中增强剂能够调节细胞紧密连接的屏障功能。具体地说，通过鼻内给药将PTH递送给人的方法包括使用瓶中的生长和赋形剂的水溶液和附着在瓶子上的液滴产生致动器并且流体连接到容器中的PTH溶液，其中致动器当致动器接合时，通过致动器的尖端产生PTH溶液的喷雾，其中在距离致动器尖端3.0cm的高度处测量时，PTH溶液的喷雾具有约1.0至约1.4的喷雾图案椭圆率。

10. 发明申请

US20060052305A1 Method of treating osteoporosis using intranasal parathyroid hormone 审中-公开
标题翻译：使用鼻内甲状旁腺激素治疗骨质疏松症的方法
公开(公告)号：US20060052305A1
公开(公告)日：2006-03-09
申请号：US11246406
申请日：2005-10-06
申请人： Steven Quay , Gordon Brandt , Henry Costantino
发明人： Steven Quay , Gordon Brandt , Henry Costantino
IPC分类号： A61K38/29 , A61K31/195
CPC分类号： A61K9/0043 , A61K31/724 , A61K38/29 , A61K47/14 , A61K47/26 , A61K47/36
摘要： What is described is a method for treating osteoporosis in a mammal comprising administering intranasally a therapeutically effective amount of a PTH formulation to the mammal wherein the PTH formulation is an aqueous formulation comprised of a PTH peptide and one or more excipients selected from the group consisting of a water-miscible polar organic solvent, a surface active agent, and a chelating agent for cations.
摘要翻译：描述的是一种治疗哺乳动物骨质疏松症的方法，其包括向哺乳动物鼻内施用治疗有效量的PTH制剂，其中PTH制剂是由PTH肽和一种或多种赋形剂组成的水性制剂，所述赋形剂选自水溶性极性有机溶剂，表面活性剂和阳离子螯合剂。

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