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1. 发明申请

US20070032410A1 COMPOSITIONS AND METHODS FOR THE TREATMENT OF PSYCHIATRIC DISORDERS 审中-公开
标题翻译：用于治疗心理障碍的组合物和方法
公开(公告)号：US20070032410A1
公开(公告)日：2007-02-08
申请号：US11537468
申请日：2006-09-29
申请人： Steven Quay , Alexis Leonard , Henry Costantino , Anthony Sileno , Joshua Sestak
发明人： Steven Quay , Alexis Leonard , Henry Costantino , Anthony Sileno , Joshua Sestak
IPC分类号： A61K38/22
CPC分类号： A61K9/006 , A61K9/0043 , A61K38/095
摘要： Methods and compositions containing oxytocin or an oxytocin analog, specifically carbetocin, are provided for the prevention and treatment of autism spectrum disorders, related disorders and symptoms of such disorders. The methods and compositions of the invention are effective in the treatment of social withdrawal, eye contact avoidance, repetitive behaviors, anxiety, attention deficit, hyperactivity, depression, loss of speech, verbal communication difficulties, aversion to touch, visual difficulties, comprehension difficulties, and sound and light sensitivity. Additional compositions and methods are provided which employ oxytocin or an oxytocin analog in combination with a secondary or adjunctive therapeutic agent to yield more effective treatment tools against autism spectrum disorders and related disorders.
摘要翻译：提供含有催产素或催产素类似物，特别是卡贝缩略的方法和组合物，用于预防和治疗自闭症谱系障碍，相关疾病和此类病症的症状。本发明的方法和组合有效地用于治疗社会戒断，避免眼睛接触，重复行为，焦虑，注意力缺陷，多动，抑郁，言语失调，口头沟通困难，厌恶触觉，视力困难，理解困难，声光灵敏度。提供了额外的组合物和方法，其使用催产素或催产素类似物与次要或辅助治疗剂组合以产生针对孤独症谱系障碍和相关病症的更有效的治疗工具。

2. 发明申请

US20060003989A1 Compositions and methods using acetylcholinesterase (ACE) inhibitors to treat central nervous system (CNS) disorders in mammals 审中-公开
标题翻译：使用乙酰胆碱酯酶（ACE）抑制剂治疗哺乳动物中枢神经系统（CNS）疾病的组合物和方法
公开(公告)号：US20060003989A1
公开(公告)日：2006-01-05
申请号：US11112950
申请日：2005-04-22
申请人： Steven Quay , Henry Costantino , Michael Houston , Alexis Leonard
发明人： Steven Quay , Henry Costantino , Michael Houston , Alexis Leonard
IPC分类号： A61K31/55
CPC分类号： A61K31/55 , A61K9/0043 , A61K31/473 , A61K31/48 , A61K31/724 , A61K45/06
摘要： Methods and compositions of the invention employ acetylcholinesterase (ACE) inhibitors to prevent and treat diseases and other disorders of the central nervous system (CNS), including Alzheimer's disease. ACE inhibitors are administered for targeted delivery to the CNS, for example by intranasal delivery. The methods and compositions of the present invention yield therapeutic concentrations of ACE inhibitors in a CNS tissue or compartment without the attendant disadvantages, risks and side effects of oral or injection delivery. Exemplary ACE inhibitors for use within the invention include galantamine and various salts and derivatives of galantamine. Carboxylate salts of galantamine (e.g., galantamine gluconate, galantamine lactate, galantamine citrate and galantamine glucarate) described herein exhibit a significant increase in solubility compared to other forms of galantamine, such as galantamine hydrobromide.
摘要翻译：本发明的方法和组合物使用乙酰胆碱酯酶（ACE）抑制剂来预防和治疗包括阿尔茨海默病在内的中枢神经系统（CNS）的疾病和其它疾病。 ACE抑制剂用于靶向递送至CNS，例如通过鼻内递送。本发明的方法和组合物在CNS组织或隔室中产生ACE抑制剂的治疗浓度，而不伴随口服或注射递送的缺点，风险和副作用。用于本发明的示例性ACE抑制剂包括加兰他敏和加兰他敏的各种盐和衍生物。与其他形式的加兰他敏胺（如加兰他敏氢溴酸盐）相比，加兰他敏的羧酸盐（例如，葡萄糖酸加兰他敏胺，加兰他敏乳酸盐，加兰他敏柠檬酸盐和加兰他敏葡糖二酸酯）的羧酸盐显示出显着的溶解度增加。

3. 发明申请

US20060210614A1 Method of treatment of a metabolic disease using intranasal administration of exendin peptide 审中-公开
标题翻译：使用鼻内给药毒蜥外泌肽治疗代谢疾病的方法
公开(公告)号：US20060210614A1
公开(公告)日：2006-09-21
申请号：US11418982
申请日：2006-05-04
申请人： Steven Quay , Alexis Leonard , Henry Costantino
发明人： Steven Quay , Alexis Leonard , Henry Costantino
IPC分类号： A61K9/127 , A61F13/02 , A61K38/22 , A61K31/56
CPC分类号： A61K9/0043 , A61K9/0056 , A61K9/0073 , A61K9/2086 , A61K38/00 , A61K47/10 , A61K47/18 , A61K47/24
摘要： Methods for treating metabolic diseases are described for intranasal delivery of an exenatide, comprising an aqueous mixture of exendin, and a delivery enhancer selected from the group consisting of a solubilizer, a chelator, and a surfactant, and the pharmaceutical formulations used therein.
摘要翻译：描述了用于治疗代谢性疾病的方法用于鼻内递送艾塞那肽，其包含毒蜥外泌肽的水性混合物和选自增溶剂，螯合剂和表面活性剂的递送增强剂及其中使用的药物制剂。

4. 发明申请

US20070244049A1 COMPOSITIONS AND METHODS FOR ENHANCED MUCOSAL DELIVERY OF PARATHYROID HORMONE 审中-公开
公开(公告)号：US20070244049A1
公开(公告)日：2007-10-18
申请号：US11744745
申请日：2007-05-04
申请人： Steven Quay , Henry Costantino , Mary Kleppe , Ching-Yuan Li
发明人： Steven Quay , Henry Costantino , Mary Kleppe , Ching-Yuan Li
IPC分类号： A61K38/00 , A61K31/66 , C07F9/02 , C08B37/02 , C07K4/00 , A61K31/715
CPC分类号： A61K31/724 , A61K9/0043 , A61K38/29 , A61K47/183
摘要： Pharmaceutical compositions and methods are described comprising at least a parathyroid hormone peptide (PTH) preferably PTH1-34 and one or more mucosal delivery-enhancing agents for enhanced nasal mucosal delivery of PTH, for treating or preventing osteoporosis or osteopenia in a mammalian subject, preferably a human.

5. 发明申请

US20070154401A1 COMPOSITIONS AND METHODS FOR ENHANCED MUCOSAL DELIVERY OF PARATHYROID HORMONE 审中-公开
公开(公告)号：US20070154401A1
公开(公告)日：2007-07-05
申请号：US11550061
申请日：2006-10-17
申请人： Steven Quay , Henry Costantino , Mary Kleppe , Ching-Yuan Li
发明人： Steven Quay , Henry Costantino , Mary Kleppe , Ching-Yuan Li
IPC分类号： A61K9/12 , A61K38/29 , A61K31/724
CPC分类号： A61K31/724 , A61K9/0043 , A61K38/29 , A61K47/183
摘要： Pharmaceutical compositions and methods are described comprising at least a parathyroid hormone peptide (PTH) preferably PTH1-34 and one or more mucosal delivery-enhancing agents for enhanced nasal mucosal delivery of PTH, for treating or preventing osteoporosis or osteopenia in a mammalian subject, preferably a human.

6. 发明申请

US20060052305A1 Method of treating osteoporosis using intranasal parathyroid hormone 审中-公开
标题翻译：使用鼻内甲状旁腺激素治疗骨质疏松症的方法
公开(公告)号：US20060052305A1
公开(公告)日：2006-03-09
申请号：US11246406
申请日：2005-10-06
申请人： Steven Quay , Gordon Brandt , Henry Costantino
发明人： Steven Quay , Gordon Brandt , Henry Costantino
IPC分类号： A61K38/29 , A61K31/195
CPC分类号： A61K9/0043 , A61K31/724 , A61K38/29 , A61K47/14 , A61K47/26 , A61K47/36
摘要： What is described is a method for treating osteoporosis in a mammal comprising administering intranasally a therapeutically effective amount of a PTH formulation to the mammal wherein the PTH formulation is an aqueous formulation comprised of a PTH peptide and one or more excipients selected from the group consisting of a water-miscible polar organic solvent, a surface active agent, and a chelating agent for cations.
摘要翻译：描述的是一种治疗哺乳动物骨质疏松症的方法，其包括向哺乳动物鼻内施用治疗有效量的PTH制剂，其中PTH制剂是由PTH肽和一种或多种赋形剂组成的水性制剂，所述赋形剂选自水溶性极性有机溶剂，表面活性剂和阳离子螯合剂。

7. 发明申请

US20070212306A1 INTRANASAL FORMULATIONS OF INTERFERON BETA FREE OF STABILIZERS THAT ARE PROTEINS OR POLYPEPTIDES 审中-公开
标题翻译：干扰素免费使用蛋白质或多肽的稳定剂的内分泌制剂
公开(公告)号：US20070212306A1
公开(公告)日：2007-09-13
申请号：US11570068
申请日：2005-06-07
申请人： Steven Quay , Henry Costantino
发明人： Steven Quay , Henry Costantino
IPC分类号： A61K9/12 , A61K38/21
CPC分类号： A61K38/215 , A61K9/0043
摘要： Compositions and methods are provided for intranasal delivery of interferon-β yielding improved pharmacokinetic and pharmacodynamic results wherein the composition is free of a stabilizer that is a protein or a polypeptide. In certain aspects of the invention, the interferon-β is delivered to the intranasal mucosa along with one or more intranasal delivery-enhancing agent(s) to yield substantially increased absorption and/or bioavailability of the interferon-β and/or a substantially decreased time to maximal concentration of interferon-β in a tissue of a subject as compared to controls where the interferon-β is administered to the same intranasal site alone or formulated according to previously disclosed reports. The enhancement of intranasal delivery of interferon-β according to the methods and compositions of the present invention allows for the effective pharmaceutical use of these agents to treat a variety of diseases and conditions in mammalian subjects.
摘要翻译：提供组合物和方法用于鼻内递送干扰素-β，产生改善的药代动力学和药效学结果，其中组合物不含作为蛋白质或多肽的稳定剂。在本发明的某些方面，将干扰素-β与一种或多种鼻内递送增强剂一起递送至鼻内粘膜，以产生干扰素-β的显着增加的吸收和/或生物利用度和/或基本上减少与将干扰素-β单独施用于相同的鼻内部位或根据先前公开的报道配制的对照相比，在受试者组织中最大浓度的干扰素-β的时间。根据本发明的方法和组合物增加干扰素-β的鼻内递送允许这些药剂的有效药物用途来治疗哺乳动物受试者中的各种疾病和病症。

8. 发明申请

US20070167364A1 Compositions and methods for enhanced mucosal delivery of parathyroid hormone 失效
标题翻译：用于增强甲状旁腺激素粘膜递送的组合物和方法
公开(公告)号：US20070167364A1
公开(公告)日：2007-07-19
申请号：US11550051
申请日：2006-10-17
申请人： Steven Quay , Henry Costantino , Mary Kleppe , Ching -Yuan Li
发明人： Steven Quay , Henry Costantino , Mary Kleppe , Ching -Yuan Li
IPC分类号： A61K38/29 , A61M11/00 , A61K9/12
CPC分类号： A61K31/724 , A61K9/0043 , A61K38/29 , A61K47/183
摘要： Pharmaceutical compositions and methods are described comprising at least a parathyroid hormone peptide (PTH) preferably PTH1-34 and one or more mucosal delivery-enhancing agents for enhanced nasal mucosal delivery of PTH, for treating or preventing osteoporosis or osteopenia in a mammalian subject, preferably a human.
摘要翻译：描述了药物组合物和方法，其至少包含甲状旁腺激素肽（PTH），优选PTH <1-34 和一种或多种用于增强鼻粘膜递送PTH的粘膜递送增强剂，用于治疗或预防骨质疏松症或哺乳动物受试者，优选人类的骨质减少。

9. 发明申请

US20070154400A1 COMPOSITIONS AND METHODS FOR ENHANCED MUCOSAL DELIVERY OF PARATHYROID HORMONE 审中-公开
标题翻译：组合物和方法，用于增强间皮瘤的输送
公开(公告)号：US20070154400A1
公开(公告)日：2007-07-05
申请号：US11550055
申请日：2006-10-17
申请人： Steven Quay , Henry Costantino , Mary Kleppe , Ching-Yuan Li
发明人： Steven Quay , Henry Costantino , Mary Kleppe , Ching-Yuan Li
IPC分类号： A61K38/29 , A61K31/724 , A61K9/12
CPC分类号： A61K31/724 , A61K9/0043 , A61K38/29 , A61K47/183
摘要： Pharmaceutical compositions and methods are described comprising at least a parathyroid hormone peptide (PTH) preferably PTH1-34 and one or more mucosal delivery-enhancing agents for enhanced nasal mucosal delivery of PTH, for treating or preventing osteoporosis or osteopenia in a mammalian subject, preferably a human.
摘要翻译：描述了药物组合物和方法，其至少包含甲状旁腺激素肽（PTH），优选PTH <1-34 和一种或多种用于增强鼻粘膜递送PTH的粘膜递送增强剂，用于治疗或预防骨质疏松症或哺乳动物受试者，优选人类的骨质减少。

10. 发明申请

US20060189533A1 Stable pharmaceutical dosage forms of teriparatide 审中-公开
标题翻译：特立帕肽的稳定药物剂型
公开(公告)号：US20060189533A1
公开(公告)日：2006-08-24
申请号：US11390940
申请日：2006-03-27
申请人： Steven Quay , Henry Costantino , Ching-Yuan Li
发明人： Steven Quay , Henry Costantino , Ching-Yuan Li
IPC分类号： A61K38/29
CPC分类号： A61K38/29 , A61K9/0043
摘要： A parathyroid hormone (1-34) (PTH) dosage form is described that is suitable for multi-use administration. A dosage form of parathyroid hormone (1-34) (PTH) comprising an aqueous pharmaceutical formulation for aerosolized intranasal delivery of PTH having a bioavailability of about 5% or greater, wherein the formulation comprises a therapeutically effective amount of PTH and polysorbate, and wherein least 90% of the PTH can be recovered after storage for 24 weeks at 5° C.
摘要翻译：描述了适用于多用途给药的甲状旁腺激素（1-34）（PTH）剂型。甲状旁腺激素（1-34）（PTH）的剂型，其包含用于气雾化鼻内递送具有约5％或更高的生物利用度的PTH的水性药物制剂，其中所述制剂包含治疗有效量的PTH和聚山梨醇酯，并且其中在5℃下储存24周后，可以回收至少90％的PTH。

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