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1. 发明申请

US20070003965A1 Device for quantitative analysis of a drug or metabolite profile 有权
标题翻译：用于定量分析药物或代谢物分布的装置
公开(公告)号：US20070003965A1
公开(公告)日：2007-01-04
申请号：US11476657
申请日：2006-06-29
申请人： Steven Ramsay , Wolfgang Guggenbichler , Klaus Weinberger , Armin Graber , Wolfgang Stoeggl
发明人： Steven Ramsay , Wolfgang Guggenbichler , Klaus Weinberger , Armin Graber , Wolfgang Stoeggl
IPC分类号： C12Q1/68 , G01N33/00 , C12M1/34
CPC分类号： G01N33/5038 , G01N33/5005 , G01N33/54366 , G01N33/6848 , G01N35/00594 , G06F19/28 , H01J49/0027
摘要： A device, in particular a sample preparation device for the quantitative analysis of a drug and/or metabolite profile in a biological sample, which includes an insert for such a device being impregnated with at least one internal standard, to the internal standard itself, and to a kit comprising the device. Further, the invention also relates to an apparatus containing the device, and to a method for the quantitative analysis of a drug and/or metabolite profile in a biological sample employing the device.
摘要翻译：一种装置，特别是用于定量分析生物样品中的药物和/或代谢物分布的样品制备装置，其包括用于将至少一种内标浸渍的该装置的插入物与内标物本身，以及包括该装置的套件。此外，本发明还涉及含有该装置的装置以及用于使用该装置的生物样品中的药物和/或代谢物分布的定量分析的方法。

2. 发明申请

US20070004044A1 Apparatus and method for analyzing a metabolite profile 有权
标题翻译：用于分析代谢物分布的仪器和方法
公开(公告)号：US20070004044A1
公开(公告)日：2007-01-04
申请号：US11476637
申请日：2006-06-29
申请人： Steven Ramsay , Wolfgang Stoeggl , Klaus Weinberger , Armin Graber , Wolfgang Guggenbichler
发明人： Steven Ramsay , Wolfgang Stoeggl , Klaus Weinberger , Armin Graber , Wolfgang Guggenbichler
IPC分类号： G06F19/00 , G01N33/50
CPC分类号： G01N33/5038 , G01N33/5005 , G01N33/54366 , G01N33/6848 , G01N35/00594 , G06F19/28 , H01J49/0027
摘要： An apparatus and method analyzes a metabolic profile in a biological sample. The apparatus includes an input unit for inputting the drugs and/or metabolites to be screened; a controlling unit for determining a parameter set for metabolites preparation and for mass spectrometry analysis depending on the input of the kind of metabolites to be screened; a treatment unit for preparing the metabolites to be screened depending on the determined parameter set; a mass spectrometer for performing mass spectrometry analysis on prepared metabolites depending on the parameter set; a database for storing results of analyzing and parameter sets for metabolite preparation and for mass spectrometry analyses; and an evaluation unit for evaluating the results of mass spectrometry by use of reference results stored in the database to output an analysis of the metabolites profile.
摘要翻译：一种设备和方法分析生物样品中的代谢谱。该装置包括用于输入待筛选的药物和/或代谢物的输入单元; 用于确定用于代谢物制备的参数组和用于质谱分析的控制单元，取决于待筛选的代谢物的种类的输入; 用于根据确定的参数组制备要筛选的代谢物的处理单元; 用于根据参数集对制备的代谢物进行质谱分析的质谱仪; 用于存储分析结果的数据库和用于代谢物制备和质谱分析的参数组; 以及用于通过使用存储在数据库中的参考结果来评估质谱结果以输出代谢物分布的分析的评估单元。

3. 发明授权

US08116983B2 Device for quantitative analysis of a drug or metabolite profile 有权
标题翻译：用于定量分析药物或代谢物分布的装置
公开(公告)号：US08116983B2
公开(公告)日：2012-02-14
申请号：US11476657
申请日：2006-06-29
申请人： Steven Lewis Ramsay , Wolfgang Guggenbichler , Klaus Michael Weinberger , Armin Graber , Wolfgang Markus Stoeggl
发明人： Steven Lewis Ramsay , Wolfgang Guggenbichler , Klaus Michael Weinberger , Armin Graber , Wolfgang Markus Stoeggl
IPC分类号： G01N33/48
CPC分类号： G01N33/5038 , G01N33/5005 , G01N33/54366 , G01N33/6848 , G01N35/00594 , G06F19/28 , H01J49/0027
摘要： A device, in particular a sample preparation device for the quantitative analysis of a drug and/or metabolite profile in a biological sample, which includes an insert for such a device being impregnated with at least one internal standard, to the internal standard itself, and to a kit comprising the device. Further, the invention also relates to an apparatus containing the device, and to a method for the quantitative analysis of a drug and/or metabolite profile in a biological sample employing the device.
摘要翻译：一种装置，特别是用于定量分析生物样品中的药物和/或代谢物分布的样品制备装置，其包括用于将至少一种内标浸渍的该装置的插入物与内标物本身，以及包括该装置的套件。此外，本发明还涉及含有该装置的装置以及用于使用该装置的生物样品中的药物和/或代谢物分布的定量分析的方法。

4. 发明授权

US08265877B2 Apparatus and method for analyzing a metabolite profile 有权
标题翻译：用于分析代谢物分布的仪器和方法
公开(公告)号：US08265877B2
公开(公告)日：2012-09-11
申请号：US11476637
申请日：2006-06-29
申请人： Steven Lewis Ramsay , Wolfgang Markus Stoeggl , Klaus Michael Weinberger , Armin Graber , Wolfgang Guggenbichler
发明人： Steven Lewis Ramsay , Wolfgang Markus Stoeggl , Klaus Michael Weinberger , Armin Graber , Wolfgang Guggenbichler
IPC分类号： G01N33/48
CPC分类号： G01N33/5038 , G01N33/5005 , G01N33/54366 , G01N33/6848 , G01N35/00594 , G06F19/28 , H01J49/0027
摘要： An apparatus and method analyzes a metabolic profile in a biological sample. The apparatus includes an input unit for inputting the drugs and/or metabolites to be screened; a controlling unit for determining a parameter set for metabolites preparation and for mass spectrometry analysis depending on the input of the kind of metabolites to be screened; a treatment unit for preparing the metabolites to be screened depending on the determined parameter set; a mass spectrometer for performing mass spectrometry analysis on prepared metabolites depending on the parameter set; a database for storing results of analyzing and parameter sets for metabolite preparation and for mass spectrometry analyses; and an evaluation unit for evaluating the results of mass spectrometry by use of reference results stored in the database to output an analysis of the metabolites profile.
摘要翻译：一种设备和方法分析生物样品中的代谢谱。该装置包括用于输入待筛选的药物和/或代谢物的输入单元; 用于确定用于代谢物制备的参数组和用于质谱分析的控制单元，取决于待筛选的代谢物的种类的输入; 用于根据确定的参数组制备要筛选的代谢物的处理单元; 用于根据参数集对制备的代谢物进行质谱分析的质谱仪; 用于存储分析结果的数据库和用于代谢物制备和质谱分析的参数组; 以及用于通过使用存储在数据库中的参考结果来评估质谱结果以输出代谢物分布的分析的评估单元。

5. 发明授权

US08168141B2 Holder for holding a carrier for insertion into a cylindrical well 有权
标题翻译：用于保持用于插入圆柱形井的载体的支架
公开(公告)号：US08168141B2
公开(公告)日：2012-05-01
申请号：US12202063
申请日：2008-08-29
申请人： Steven Ramsay , Florian Bichteler , Wolfgang Guggenbichler
发明人： Steven Ramsay , Florian Bichteler , Wolfgang Guggenbichler
IPC分类号： B01L3/00 , A47F5/00 , A47G29/00
CPC分类号： B01L3/5085 , B01L2300/0609 , B01L2300/0829
摘要： The invention relates to a holder for holding a carrier, wherein the holder is inserted into a cylinder-shaped well, for example, of a multiwell plate. In addition the invention relates to a multiwell plate with such a holder. In order to provide a possibility for the reliable support of a carrier in a holder, wherein the holder ensures a secure and specified positioning of the carrier in a well and reliably prevents the carrier and the holder from falling out of the well, a holder is proposed for insertion into a cylindrical well and to support the carrier. The holder comprises a support, a holding piece and a connecting piece which connects the supporting piece with the holding piece, wherein the holder together with the lateral external surfaces of the supporting piece, the holding piece and/or connecting piece lies against at least one lateral internal surface of the well, and wherein the carrier is inserted on the support and under the holding piece.
摘要翻译：本发明涉及一种用于保持载体的保持器，其中保持器插入例如多孔板的圆筒状的孔中。此外，本发明涉及具有这种保持器的多孔板。为了提供载体在保持器中的可靠支撑的可能性，其中保持器确保承载件在井中的安全和指定的定位并可靠地防止载体和保持器从井中脱落，提出用于插入圆柱形井并支撑载体。保持器包括支撑件，保持件和将支撑件与保持件连接的连接件，其中保持器与支撑件，保持件和/或连接件的侧面外表面相对于至少一个井的侧向内表面，并且其中载体被插入支撑件上并在保持件下方。

6. 发明申请

US20090072109A1 HOLDER FOR HOLDING A CARRIER FOR INSERTION INTO A CYLINDRICAL WELL 有权
标题翻译：持有一个承运人进入一个缸体的持有人
公开(公告)号：US20090072109A1
公开(公告)日：2009-03-19
申请号：US12202063
申请日：2008-08-29
申请人： Steven Ramsay , Florian Bichteler , Wolfgang Guggenbichler
发明人： Steven Ramsay , Florian Bichteler , Wolfgang Guggenbichler
IPC分类号： A47F5/00
CPC分类号： B01L3/5085 , B01L2300/0609 , B01L2300/0829
摘要： The invention relates to a holder for holding a carrier, wherein the holder is inserted into a cylinder-shaped well, for example, of a multiwell plate. In addition the invention relates to a multiwell plate with such a holder. In order to provide a possibility for the reliable support of a carrier in a holder, wherein the holder ensures a secure and specified positioning of the carrier in a well and reliably prevents the carrier and the holder from falling out of the well, a holder is proposed for insertion into a cylindrical well and to support the carrier. The holder comprises a support, a holding piece and a connecting piece which connects the supporting piece with the holding piece, wherein the holder together with the lateral external surfaces of the supporting piece, the holding piece and/or connecting piece lies against at least one lateral internal surface of the well, and wherein the carrier is inserted on the support and under the holding piece.
摘要翻译：本发明涉及一种用于保持载体的保持器，其中保持器插入例如多孔板的圆筒状的孔中。此外，本发明涉及具有这种保持器的多孔板。为了提供载体在保持器中的可靠支撑的可能性，其中保持器确保承载件在井中的安全和指定的定位并可靠地防止载体和保持器从井中脱落，提出用于插入圆柱形井并支撑载体。保持器包括支撑件，保持件和将支撑件与保持件连接的连接件，其中保持器与支撑件，保持件和/或连接件的侧面外表面相对于至少一个井的侧向内表面，并且其中载体被插入支撑件上并在保持件下方。

7. 发明授权

US07244902B2 Method for classifying wine and coffee 有权
标题翻译：葡萄酒和咖啡分类方法
公开(公告)号：US07244902B2
公开(公告)日：2007-07-17
申请号：US10479064
申请日：2002-05-06
申请人： Michael A. Popp , Günther Bonn , Christian Huck , Wolfgang Guggenbichler
发明人： Michael A. Popp , Günther Bonn , Christian Huck , Wolfgang Guggenbichler
IPC分类号： B07C5/00
CPC分类号： G01N33/146 , G01N33/14 , G06K9/00 , Y10S250/91
摘要： A method for classifying beverages of natural origin, such as wine or coffee. Classification is carried out by means of NIR spectroscopy and corresponding numerical-mathematical conditioning of the spectral data of the individual beverage samples, wherein respective obtained spectra are then correlated with a predetermined beverage, class. By means of the method of the invention it is possible to classify wines by sort of wine, growing regions, grape, vine, vintage, kind of material or wood of the wine cask used, and varying degree of maturity of the wine, and by other chemical parameters. Coffee, for example, may be classified by coffee sort, country of origin, coffee growing region, roasting method and defined chemical parameters, e.g., caffeine content, or chlorogenic acid content.
摘要翻译：用于分类天然来源的饮料的方法，例如葡萄酒或咖啡。通过NIR光谱法和各个饮料样品的光谱数据的相应的数学 - 数学调节进行分类，其中相应的获得的光谱然后与预定饮料类相关。通过本发明的方法，可以通过葡萄酒，生长区域，葡萄，葡萄藤，葡萄酒，葡萄酒，所使用的酒桶的材料或木材，葡萄酒的成熟程度以及葡萄酒的成熟程度来分类葡萄酒。其他化学参数。例如，咖啡可以通过咖啡分类，原产地，咖啡生长区域，焙烧方法和确定的化学参数（例如咖啡因含量或绿原酸含量）进行分类。

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