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1. 发明申请

US20070027483A1 Stimulating cranial nerve to treat disorders associated with the thyroid gland 有权
标题翻译：刺激颅神经治疗与甲状腺相关的疾病
公开(公告)号：US20070027483A1
公开(公告)日：2007-02-01
申请号：US11191340
申请日：2005-07-28
申请人： Steven Maschino , Steven Parnis , William Buras , Albert Guzman
发明人： Steven Maschino , Steven Parnis , William Buras , Albert Guzman
IPC分类号： A61N1/18
CPC分类号： A61N1/36053
摘要： A method, system, and an apparatus for stimulating a cranial nerve of a patient to treat a disorder, such as a metabolic or an endocrine disorder associated with the thyroid gland with an implantable medical device are provided. The method comprises coupling an electrode to the cranial nerve selected from the group consisting of a vagus nerve, a trigeminal nerve, and a glossopharyngeal nerve. The method further includes generating an electrical signal to treat a disorder associated with the thyroid gland. The electrical signal may be applied to the cranial nerve using the electrode to provide electrical nerve stimulation therapy to the patient. For treating a patient with a metabolic or an endocrine disorder associated with the thyroid gland, a neurostimulator may be adapted to apply an electrical stimulus to the vagus nerve and/or a branch of the vagus nerve associated with the thyroid gland. By balancing hormonal imbalance, the neurostimulator may provide electrical nerve stimulation therapy to the patient, thereby treating a target metabolic or an endocrine disorder associated with the thyroid gland.
摘要翻译：提供了一种用于通过可植入医疗装置刺激患者的颅神经以治疗诸如与甲状腺相关的代谢或内分泌紊乱的病症的方法，系统和装置。该方法包括将电极连接到选自迷走神经，三叉神经和咽舌神经的颅神经中。该方法还包括产生电信号以治疗与甲状腺相关的病症。可以使用电极将电信号施加到颅神经，以向患者提供电神经刺激治疗。为了治疗患有与甲状腺相关的代谢或内分泌紊乱的患者，神经刺激器可适用于向迷走神经和/或与甲状腺相关的迷走神经的分支施加电刺激。通过平衡激素不平衡，神经刺激器可以向患者提供电神经刺激疗法，从而治疗与甲状腺相关的靶代谢或内分泌紊乱。

2. 发明申请

US20070027496A1 Stimulating cranial nerve to treat pulmonary disorder 有权
标题翻译：刺激颅神经治疗肺部疾病
公开(公告)号：US20070027496A1
公开(公告)日：2007-02-01
申请号：US11191896
申请日：2005-07-28
申请人： Steven Parnis , Steven Maschino , William Buras , Albert Guzman
发明人： Steven Parnis , Steven Maschino , William Buras , Albert Guzman
IPC分类号： A61N1/00
CPC分类号： A61N1/3611 , A61N1/0551 , A61N1/3601 , A61N1/36053 , A61N1/36114 , A61N1/36139
摘要： A method for stimulating a portion of a vagus nerve of a patient to treat a pulmonary disorder is provided. At least one electrode is coupled to at least one portion of a left vagus nerve and/or a right vagus nerve of the patient. An electrical signal is applied to the portion of the vagus nerve using the electrode to treat the pulmonary disorder. The electrical signal may perform a blocking of an intrinsic neural activity on said at least one portion of the left vagus nerve and said right vagus nerve.
摘要翻译：提供了一种用于刺激患者的迷走神经的一部分以治疗肺部疾病的方法。至少一个电极耦合到患者的左迷走神经和/或右侧迷走神经的至少一部分。使用电极将电信号施加到迷走神经的部分以治疗肺部疾病。电信号可以在左迷走神经和右迷走神经的所述至少一部分上执行内在神经活动的阻断。

3. 发明申请

US20070027492A1 Autonomic nerve stimulation to treat a gastrointestinal disorder 有权
标题翻译：自主神经刺激治疗胃肠道疾病
公开(公告)号：US20070027492A1
公开(公告)日：2007-02-01
申请号：US11191846
申请日：2005-07-28
申请人： Steven Maschino , Steven Parnis , William Buras , Albert Guzman
发明人： Steven Maschino , Steven Parnis , William Buras , Albert Guzman
IPC分类号： A61N1/00
CPC分类号： A61N1/36053 , A61N1/36007
摘要： A method and apparatus for stimulating a portion of a vagus nerve of a patient to treat a gastrointestinal disorder is provided. At least one electrode is coupled to at least one portion of a vagus nerve of the patient. The portion of the a vagus nerve may include an esophageal plexus, a myenteric plexus of aurbach, a submucous plexus of the meissner, a principal nerve of the lesser curvature of the stomach, and a gastric branch of said vagus nerve. An electrical signal is applied to the portion of the vagus nerve using the electrode to treat the gastrointestinal disorder.
摘要翻译：提供了一种用于刺激患者的迷走神经的一部分以治疗胃肠道疾病的方法和装置。至少一个电极耦合到患者的迷走神经的至少一部分。迷走神经的一部分可以包括食道丛，aurbach的肌间神经丛，meissner的粘膜下神经丛，胃的较小曲率的主要神经和所述迷走神经的胃分支。使用电极将电信号施加到迷走神经的部分以治疗胃肠道疾病。

4. 发明申请

US20070027484A1 Autonomic nerve stimulation to treat a pancreatic disorder 审中-公开
标题翻译：自主神经刺激治疗胰腺疾病
公开(公告)号：US20070027484A1
公开(公告)日：2007-02-01
申请号：US11191740
申请日：2005-07-28
申请人： Albert Guzman , Steven Maschino , Steven Parnis , William Buras
发明人： Albert Guzman , Steven Maschino , Steven Parnis , William Buras
IPC分类号： A61N1/18
CPC分类号： A61N1/36007
摘要： A method for stimulating a portion of a vagus nerve of a patient to treat a pancreatic disorder is provided. At least one electrode is coupled to at least one portion of an autonomic nerve of the patient. The portion may include a celiac plexus, a superior mesenteric plexus, and a thoracic splanchnic. An electrical signal is applied to the portion of the vagus nerve using the electrode to treat the pancreatic disorder.
摘要翻译：提供了一种用于刺激患者的迷走神经的一部分以治疗胰腺疾病的方法。至少一个电极耦合到患者的自主神经的至少一部分。该部分可以包括腹膜丛，肠系膜上丛和胸内脏。使用电极将电信号施加到迷走神经的部分以治疗胰腺疾病。

5. 发明申请

US20070027499A1 Neurostimulation device for treating mood disorders 审中-公开
标题翻译：用于治疗情绪障碍的神经刺激装置
公开(公告)号：US20070027499A1
公开(公告)日：2007-02-01
申请号：US11192612
申请日：2005-07-29
申请人： Steven Maschino , William Buras , Stephen Brannan
发明人： Steven Maschino , William Buras , Stephen Brannan
IPC分类号： A61N1/18
CPC分类号： A61N1/36096 , A61N1/36146
摘要： A device and method for treating a mood and/or anxiety disorder are disclosed which provide for stimulation of certain areas of the brain to modulate neuronal activity of areas associated with symptoms of mood disorders. In certain embodiments, brain stimulation is combined with cranial nerve stimulation for enhancing symptomatic relief of the disorder. Certain embodiments also employ a sensing capability for optimizing the therapeutic treatment regimen.
摘要翻译：公开了用于治疗情绪和/或焦虑症的装置和方法，其提供刺激脑的某些区域以调节与情绪障碍症状相关的区域的神经元活动。在某些实施方案中，脑刺激与颅神经刺激相结合以增强病症的症状缓解。某些实施方案还采用用于优化治疗治疗方案的感测能力。

6. 发明申请

US20070173902A1 Medical imaging feedback for an implantable medical device 失效
标题翻译：可植入医疗器械的医学成像反馈
公开(公告)号：US20070173902A1
公开(公告)日：2007-07-26
申请号：US11340337
申请日：2006-01-26
申请人： Steven Maschino , William Buras
发明人： Steven Maschino , William Buras
IPC分类号： A61N1/00
CPC分类号： A61N1/08 , A61N1/36071
摘要： A method, system, and apparatus are provided for performing an adaptive stimulation process using medical imaging feedback data for affecting an operation of an implantable medical device. The first stimulation signal is applied to a neural structure for modulation of a target portion of the patient's brain associated with a disorder. Medical imaging data is acquired that is indicative of whether the target portion of the brain is modulated as a result of the first stimulation signal. The first signal characteristic is modified to generate a second stimulation signal in response to a determination that said target portion of the brain is not modulated as a result of said first stimulation signal. The first and second stimulation signals may be used to navigate an effect of the first and second stimulation signals until a targeted portion of the human body is stimulated according to a predetermined threshold.
摘要翻译：提供了一种方法，系统和装置，用于使用用于影响可植入医疗装置的操作的医学成像反馈数据来执行自适应刺激过程。将第一刺激信号应用于神经结构，用于调节与病症相关的患者脑部的目标部分。获取指示大脑的目标部分是否作为第一刺激信号的结果被调制的医学成像数据。响应于作为所述第一刺激信号的结果，大脑的所述目标部分未被调制的确定，第一信号特征被修改以产生第二刺激信号。可以使用第一和第二刺激信号来导航第一和第二刺激信号的效果，直到根据预定阈值刺激人体的目标部分。

7. 发明申请

US20070027500A1 Selective neurostimulation for treating mood disorders 有权
标题翻译：选择性神经刺激治疗情绪障碍
公开(公告)号：US20070027500A1
公开(公告)日：2007-02-01
申请号：US11193121
申请日：2005-07-29
申请人： Steven Maschino , William Buras , Stephen Brannan
发明人： Steven Maschino , William Buras , Stephen Brannan
IPC分类号： A61N1/18
CPC分类号： A61N1/36082 , A61N1/0529 , A61N1/0531 , A61N1/0534
摘要： A method and device for treating a mood and/or anxiety disorder are disclosed which comprise electrical, chemical or magnetic stimulation of certain areas of the brain to modulate neuronal activity of areas associated with symptoms of mood disorders. In certain embodiments, deep brain stimulation is combined with cranial nerve stimulation to enhance symptomatic relief of the disorder. Certain embodiments also employ a sensing capability to optimize the therapeutic treatment regimen.
摘要翻译：公开了一种用于治疗情绪和/或焦虑障碍的方法和装置，其包括对脑的某些区域的电，化学或磁刺激以调节与情绪障碍症状相关的区域的神经元活动。在某些实施方案中，深部脑刺激与颅神经刺激相结合以增强病症的症状缓解。某些实施方案还采用感测能力来优化治疗治疗方案。

8. 发明授权

US07532935B2 Selective neurostimulation for treating mood disorders 有权
标题翻译：选择性神经刺激治疗情绪障碍
公开(公告)号：US07532935B2
公开(公告)日：2009-05-12
申请号：US11193121
申请日：2005-07-29
申请人： Steven E. Maschino , William Buras , Stephen Brannan
发明人： Steven E. Maschino , William Buras , Stephen Brannan
IPC分类号： A61N1/00
CPC分类号： A61N1/36082 , A61N1/0529 , A61N1/0531 , A61N1/0534
摘要： A method and device for treating a mood and/or anxiety disorder are disclosed which comprise electrical, chemical or magnetic stimulation of certain areas of the brain to modulate neuronal activity of areas associated with symptoms of mood disorders. In certain embodiments, deep brain stimulation is combined with cranial nerve stimulation to enhance symptomatic relief of the disorder. Certain embodiments also employ a sensing capability to optimize the therapeutic treatment regimen.
摘要翻译：公开了一种用于治疗情绪和/或焦虑障碍的方法和装置，其包括对脑的某些区域的电，化学或磁刺激以调节与情绪障碍症状相关的区域的神经元活动。在某些实施方案中，深部脑刺激与颅神经刺激相结合以增强病症的症状缓解。某些实施方案还采用感测能力来优化治疗治疗方案。

9. 发明申请

US20070173891A1 Treatment of reproductive endocrine disorders by vagus nerve stimulation 有权
标题翻译：通过迷走神经刺激治疗生殖内分泌障碍
公开(公告)号：US20070173891A1
公开(公告)日：2007-07-26
申请号：US11340309
申请日：2006-01-26
申请人： William Buras
发明人： William Buras
IPC分类号： A61N1/00
CPC分类号： A61N1/36053 , A61N1/36007 , A61N1/3615 , A61N1/36167
摘要： I disclose a method of treating a reproductive endocrine disorder in a patient, including coupling at least one electrode to at least one portion of a cranial nerve of the patient; and applying an electrical signal to said cranial nerve using said electrode to treat said reproductive endocrine disorder. Among the reproductive endocrine disorders which may be treated by the method are gonadal dysgenesis, hypogonadism, hypergonadism, delayed puberty, amenorrhea, infertility, premature menopause, and polycystic ovarian disease.
摘要翻译：我公开了一种治疗患者生殖内分泌紊乱的方法，包括将至少一个电极耦合到患者的颅神经的至少一部分; 以及使用所述电极向所述颅神经施加电信号以治疗所述生殖内分泌紊乱。可以通过该方法治疗的生殖性内分泌障碍是性腺发育不良，性腺机能减退，超神经痛，青春期延迟，闭经，不孕，早产绝经和多囊卵巢疾病。

10. 发明授权

US07499752B2 Selective nerve stimulation for the treatment of eating disorders 有权
标题翻译：选择性神经刺激治疗进食障碍
公开(公告)号：US07499752B2
公开(公告)日：2009-03-03
申请号：US11192594
申请日：2005-07-29
申请人： Steven E. Maschino , William Buras , Stephen Brannan
发明人： Steven E. Maschino , William Buras , Stephen Brannan
IPC分类号： A61N1/00
CPC分类号： A61N1/36082 , A61M5/14276 , A61M2205/3523 , A61M2205/3561 , A61N1/00 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/36007
摘要： A method and apparatus for treating persons suffering from an eating disorder includes direct or indirect stimulation of selected areas of the brain associated with a symptom of the eating disorder. The stimulation regimen is programmable to enable physician optimization of stimulation signal parameters to ameliorate at least one symptom of bulimia or another eating disorder. Certain embodiments employ deep brain stimulation and/or sensing together with cranial nerve stimulation and/or sensing.
摘要翻译：用于治疗患有进食障碍的人的方法和装置包括与进食障碍症状相关的脑的选定区域的直接或间接刺激。刺激方案是可编程的，以使医师优化刺激信号参数以改善至少一种贪食症或另一种进食障碍症状。某些实施例采用深脑刺激和/或感测以及颅神经刺激和/或感测。

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