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1. 发明申请

US20070027483A1 Stimulating cranial nerve to treat disorders associated with the thyroid gland 有权
标题翻译：刺激颅神经治疗与甲状腺相关的疾病
公开(公告)号：US20070027483A1
公开(公告)日：2007-02-01
申请号：US11191340
申请日：2005-07-28
申请人： Steven Maschino , Steven Parnis , William Buras , Albert Guzman
发明人： Steven Maschino , Steven Parnis , William Buras , Albert Guzman
IPC分类号： A61N1/18
CPC分类号： A61N1/36053
摘要： A method, system, and an apparatus for stimulating a cranial nerve of a patient to treat a disorder, such as a metabolic or an endocrine disorder associated with the thyroid gland with an implantable medical device are provided. The method comprises coupling an electrode to the cranial nerve selected from the group consisting of a vagus nerve, a trigeminal nerve, and a glossopharyngeal nerve. The method further includes generating an electrical signal to treat a disorder associated with the thyroid gland. The electrical signal may be applied to the cranial nerve using the electrode to provide electrical nerve stimulation therapy to the patient. For treating a patient with a metabolic or an endocrine disorder associated with the thyroid gland, a neurostimulator may be adapted to apply an electrical stimulus to the vagus nerve and/or a branch of the vagus nerve associated with the thyroid gland. By balancing hormonal imbalance, the neurostimulator may provide electrical nerve stimulation therapy to the patient, thereby treating a target metabolic or an endocrine disorder associated with the thyroid gland.
摘要翻译：提供了一种用于通过可植入医疗装置刺激患者的颅神经以治疗诸如与甲状腺相关的代谢或内分泌紊乱的病症的方法，系统和装置。该方法包括将电极连接到选自迷走神经，三叉神经和咽舌神经的颅神经中。该方法还包括产生电信号以治疗与甲状腺相关的病症。可以使用电极将电信号施加到颅神经，以向患者提供电神经刺激治疗。为了治疗患有与甲状腺相关的代谢或内分泌紊乱的患者，神经刺激器可适用于向迷走神经和/或与甲状腺相关的迷走神经的分支施加电刺激。通过平衡激素不平衡，神经刺激器可以向患者提供电神经刺激疗法，从而治疗与甲状腺相关的靶代谢或内分泌紊乱。

2. 发明申请

US20070027496A1 Stimulating cranial nerve to treat pulmonary disorder 有权
标题翻译：刺激颅神经治疗肺部疾病
公开(公告)号：US20070027496A1
公开(公告)日：2007-02-01
申请号：US11191896
申请日：2005-07-28
申请人： Steven Parnis , Steven Maschino , William Buras , Albert Guzman
发明人： Steven Parnis , Steven Maschino , William Buras , Albert Guzman
IPC分类号： A61N1/00
CPC分类号： A61N1/3611 , A61N1/0551 , A61N1/3601 , A61N1/36053 , A61N1/36114 , A61N1/36139
摘要： A method for stimulating a portion of a vagus nerve of a patient to treat a pulmonary disorder is provided. At least one electrode is coupled to at least one portion of a left vagus nerve and/or a right vagus nerve of the patient. An electrical signal is applied to the portion of the vagus nerve using the electrode to treat the pulmonary disorder. The electrical signal may perform a blocking of an intrinsic neural activity on said at least one portion of the left vagus nerve and said right vagus nerve.
摘要翻译：提供了一种用于刺激患者的迷走神经的一部分以治疗肺部疾病的方法。至少一个电极耦合到患者的左迷走神经和/或右侧迷走神经的至少一部分。使用电极将电信号施加到迷走神经的部分以治疗肺部疾病。电信号可以在左迷走神经和右迷走神经的所述至少一部分上执行内在神经活动的阻断。

3. 发明申请

US20070027492A1 Autonomic nerve stimulation to treat a gastrointestinal disorder 有权
标题翻译：自主神经刺激治疗胃肠道疾病
公开(公告)号：US20070027492A1
公开(公告)日：2007-02-01
申请号：US11191846
申请日：2005-07-28
申请人： Steven Maschino , Steven Parnis , William Buras , Albert Guzman
发明人： Steven Maschino , Steven Parnis , William Buras , Albert Guzman
IPC分类号： A61N1/00
CPC分类号： A61N1/36053 , A61N1/36007
摘要： A method and apparatus for stimulating a portion of a vagus nerve of a patient to treat a gastrointestinal disorder is provided. At least one electrode is coupled to at least one portion of a vagus nerve of the patient. The portion of the a vagus nerve may include an esophageal plexus, a myenteric plexus of aurbach, a submucous plexus of the meissner, a principal nerve of the lesser curvature of the stomach, and a gastric branch of said vagus nerve. An electrical signal is applied to the portion of the vagus nerve using the electrode to treat the gastrointestinal disorder.
摘要翻译：提供了一种用于刺激患者的迷走神经的一部分以治疗胃肠道疾病的方法和装置。至少一个电极耦合到患者的迷走神经的至少一部分。迷走神经的一部分可以包括食道丛，aurbach的肌间神经丛，meissner的粘膜下神经丛，胃的较小曲率的主要神经和所述迷走神经的胃分支。使用电极将电信号施加到迷走神经的部分以治疗胃肠道疾病。

4. 发明申请

US20070027484A1 Autonomic nerve stimulation to treat a pancreatic disorder 审中-公开
标题翻译：自主神经刺激治疗胰腺疾病
公开(公告)号：US20070027484A1
公开(公告)日：2007-02-01
申请号：US11191740
申请日：2005-07-28
申请人： Albert Guzman , Steven Maschino , Steven Parnis , William Buras
发明人： Albert Guzman , Steven Maschino , Steven Parnis , William Buras
IPC分类号： A61N1/18
CPC分类号： A61N1/36007
摘要： A method for stimulating a portion of a vagus nerve of a patient to treat a pancreatic disorder is provided. At least one electrode is coupled to at least one portion of an autonomic nerve of the patient. The portion may include a celiac plexus, a superior mesenteric plexus, and a thoracic splanchnic. An electrical signal is applied to the portion of the vagus nerve using the electrode to treat the pancreatic disorder.
摘要翻译：提供了一种用于刺激患者的迷走神经的一部分以治疗胰腺疾病的方法。至少一个电极耦合到患者的自主神经的至少一部分。该部分可以包括腹膜丛，肠系膜上丛和胸内脏。使用电极将电信号施加到迷走神经的部分以治疗胰腺疾病。

5. 发明申请

US20070027504A1 Cranial nerve stimulation to treat a hearing disorder 审中-公开
标题翻译：颅神经刺激治疗听力障碍
公开(公告)号：US20070027504A1
公开(公告)日：2007-02-01
申请号：US11190796
申请日：2005-07-27
申请人： Burke Barrett , Steven Parnis , Steven Maschino , Albert Guzman
发明人： Burke Barrett , Steven Parnis , Steven Maschino , Albert Guzman
IPC分类号： A61N1/00
CPC分类号： A61N1/36053 , A61N1/0456 , A61N1/0551 , A61N1/36014 , A61N1/36036 , A61N2/006
摘要： We disclose a method of treating a patient having a hearing disorder, including coupling at least one electrode to at least one vagus nerve of the patient and applying an electrical signal to the vagus nerve using the electrode to treat the hearing disorder. We also disclose a computer readable program storage device encoded with instructions that, when executed by a computer, perform the method, and a medical device and a hearing disorder treatment system that may be used in performance of the method.
摘要翻译：我们公开了一种治疗患有听力障碍的患者的方法，包括将至少一个电极耦合到患者的至少一个迷走神经，并使用电极将电信号施加到迷走神经以治疗听力障碍。我们还公开了一种用计算机执行的指令编码的计算机可读程序存储设备，以及可用于执行该方法的医疗设备和听觉障碍治疗系统。

6. 发明申请

US20070027482A1 Cranial nerve stimulation to treat a vocal cord disorder 有权
标题翻译：颅神经刺激治疗声带紊乱
公开(公告)号：US20070027482A1
公开(公告)日：2007-02-01
申请号：US11191121
申请日：2005-07-27
申请人： Steven Parnis , Steven Maschino , Albert Guzman
发明人： Steven Parnis , Steven Maschino , Albert Guzman
IPC分类号： A61N1/18
CPC分类号： A61N1/0551 , A61N1/0456 , A61N1/36014 , A61N1/36053
摘要： Disclosed is a method of treating a patient having a vocal cord disorder, comprising coupling at least one electrode to at least one cranial nerve of the patient, wherein the cranial nerve is selected from the group consisting of a vagus nerve, a trigeminal nerve, and a glossopharyngeal nerve, and applying an electrical signal to the cranial nerve using the electrode to treat the vocal cord disorder. The electrode may be coupled to a branch of the vagus nerve selected from the group consisting of a recurrent laryngeal nerve, the external branch of a superior laryngeal nerve, the internal branch of a superior laryngeal nerve, and a pharyngeal plexus. Also disclosed is a computer readable program storage device encoded with instructions that, when executed by a computer, perform the method, and a medical device and a vocal cord disorder treatment system that may be used in performance of the method.
摘要翻译：公开了一种治疗具有声带病症的患者的方法，包括将至少一个电极耦合到患者的至少一个颅神经，其中所述颅神经选自迷走神经，三叉神经和舌咽神经，并使用电极将电信号施加到颅神经以治疗声带紊乱。电极可以耦合到迷走神经的分支，其选自复发性喉神经，上喉神经的外分支，上喉神经的内分支和咽神经丛。还公开了一种计算机可读程序存储装置，其编码有当由计算机执行时执行该方法的指令，以及可用于执行该方法的医疗装置和声带紊乱处理系统。

7. 发明申请

US20060247719A1 Weight loss method and advice 有权
标题翻译：减肥方法和建议
公开(公告)号：US20060247719A1
公开(公告)日：2006-11-02
申请号：US11118452
申请日：2005-04-29
申请人： Steven Maschino , Steven Parnis , Scott Armstrong
发明人： Steven Maschino , Steven Parnis , Scott Armstrong
IPC分类号： A61N1/18
CPC分类号： A61N1/36007 , A61F5/0003
摘要： A method and apparatus for treatment of an eating disorder includes electrically, mechanically and/or pharmaceutically/chemically stimulating a of the vagus nerve of the lower esophagus, cardia, esophageal/cardia junction, cardia/fundus junction or upper stomach so as to induce afferent action potentials on the vagus nerve. The device may be noninvasively adjusted after implantation to provide increased or decreased restriction on the patient's gastrointestinal tract. Each stimulus may be administered as a series of programmed pulses of defined amplitude, duration and period, to evoke a responsive signal to the brain by the target nerve, effective for producing a temporary feeling of satiety in the person. An implantable stimulus generator may be operatively coupled to a nerve electrode, pressure device or chemical outlet to apply a defined signal to a selected nerve branch. The implantable stimulus generator is programmable to allow clinician programming of defined signal parameters effective to treat the eating disorder of the patient. Methods are also provided to identify electrodes nearest to a branch of the vagus nerve to apply an electrical stimulation signal with improved efficiency.
摘要翻译：用于治疗进食障碍的方法和装置包括电，机械和/或药学/化学刺激下食道，贲门，食管/贲门交界处，贲门/眼底结或上胃的迷走神经，以诱导传入迷走神经的动作电位。该装置可以在植入之后进行非侵入性调节，以对患者的胃肠道提供增加或减少的限制。每个刺激可以作为一系列定义的幅度，持续时间和周期的编程脉冲施用，以引起目标神经对脑的响应信号，有效地在人体中产生暂时的饱腹感。可植入刺激发生器可以可操作地耦合到神经电极，压力装置或化学品出口以将所定义的信号施加到所选择的神经分支。可植入刺激发生器是可编程的，以允许临床医生对限定的信号参数进行编程，以有效地治疗患者的进食障碍。还提供了用于识别最靠近迷走神经分支的电极以提高效率的电刺激信号的方法。

8. 发明申请

US20060247722A1 Noninvasively adjustable gastric band 有权
标题翻译：非侵入性可调节胃带
公开(公告)号：US20060247722A1
公开(公告)日：2006-11-02
申请号：US11118980
申请日：2005-04-29
申请人： Steven Maschino , Steven Parnis , Scott Armstrong
发明人： Steven Maschino , Steven Parnis , Scott Armstrong
IPC分类号： A61N1/18
CPC分类号： A61F5/0026 , A61F5/005 , A61N1/36007
摘要： A method and apparatus for treatment of an eating disorder includes electrically, mechanically and/or pharmaceutically/chemically stimulating a of the vagus nerve of the lower esophagus, cardia, esophageal/cardia junction, cardia/fundus junction or upper stomach so as to induce afferent action potentials on the vagus nerve. The device may be noninvasively adjusted after implantation to provide increased or decreased restriction on the patient's gastrointestinal tract. Each stimulus may be administered as a series of programmed pulses of defined amplitude, duration and period, to evoke a responsive signal to the brain by the target nerve, effective for producing a temporary feeling of satiety in the person. An implantable stimulus generator may be operatively coupled to a nerve electrode, pressure device or chemical outlet to apply a defined signal to a selected nerve branch. The implantable stimulus generator is programmable to allow clinician programming of defined signal parameters effective to treat the eating disorder of the patient. Methods are also provided to identify electrodes nearest to a branch of the vagus nerve to apply an electrical stimulation signal with improved efficiency.
摘要翻译：用于治疗进食障碍的方法和装置包括电，机械和/或药学/化学刺激下食道，贲门，食管/贲门交界处，贲门/眼底结或上胃的迷走神经，以诱导传入迷走神经的动作电位。该装置可以在植入之后进行非侵入性调节，以对患者的胃肠道提供增加或减少的限制。每个刺激可以作为一系列定义的幅度，持续时间和周期的编程脉冲施用，以引起目标神经对脑的响应信号，有效地在人体中产生暂时的饱腹感。可植入刺激发生器可以可操作地耦合到神经电极，压力装置或化学品出口以将所定义的信号施加到所选择的神经分支。可植入刺激发生器是可编程的，以允许临床医生对限定的信号参数进行编程，以有效地治疗患者的进食障碍。还提供了用于识别最靠近迷走神经分支的电极以提高效率的电刺激信号的方法。

9. 发明申请

US20060247721A1 Identification of electrodes for nerve stimulation in the treatment of eating disorders 有权
标题翻译：鉴别用于治疗进食障碍的神经刺激电极
公开(公告)号：US20060247721A1
公开(公告)日：2006-11-02
申请号：US11118861
申请日：2005-04-29
申请人： Steven Maschino , Steven Parnis , Scott Armstrong
发明人： Steven Maschino , Steven Parnis , Scott Armstrong
IPC分类号： A61N1/18
CPC分类号： A61F5/0026 , A61F5/005 , A61N1/36007 , A61N1/36082 , A61N1/36185 , A61N1/3686
摘要： A method and apparatus for treatment of an eating disorder includes electrically, mechanically and/or pharmaceutically/chemically stimulating a of the vagus nerve of the lower esophagus, cardia, esophageal/cardia junction, cardia/fundus junction or upper stomach so as to induce afferent action potentials on the vagus nerve. The device may be noninvasively adjusted after implantation to provide increased or decreased restriction on the patient's gastrointestinal tract. Each stimulus may be administered as a series of programmed pulses of defined amplitude, duration and period, to evoke a responsive signal to the brain by the target nerve, effective for producing a temporary feeling of satiety in the person. An implantable stimulus generator may be operatively coupled to a nerve electrode, pressure device or chemical outlet to apply a defined signal to a selected nerve branch. The implantable stimulus generator is programmable to allow clinician programming of defined signal parameters effective to treat the eating disorder of the patient. Methods are also provided to identify electrodes nearest to a branch of the vagus nerve to apply an electrical stimulation signal with improved efficiency.
摘要翻译：用于治疗进食障碍的方法和装置包括电，机械和/或药学/化学刺激下食道，贲门，食管/贲门交界处，贲门/眼底结或上胃的迷走神经，以诱导传入迷走神经的动作电位。该装置可以在植入之后进行非侵入性调节，以对患者的胃肠道提供增加或减少的限制。每个刺激可以作为一系列定义的幅度，持续时间和周期的编程脉冲施用，以引起目标神经对脑的响应信号，有效地在人体中产生暂时的饱腹感。可植入刺激发生器可以可操作地耦合到神经电极，压力装置或化学品出口以将所定义的信号施加到所选择的神经分支。可植入刺激发生器是可编程的，以允许临床医生对限定的信号参数进行编程，以有效地治疗患者的进食障碍。还提供了用于识别最靠近迷走神经分支的电极以提高效率的电刺激信号的方法。

10. 发明申请

US20070255320A1 Method and apparatus for forming insulated implantable electrodes 审中-公开
标题翻译：用于形成绝缘可植入电极的方法和装置
公开(公告)号：US20070255320A1
公开(公告)日：2007-11-01
申请号：US11414013
申请日：2006-04-28
申请人： D. Inman , Steven Parnis , Albert Guzman
发明人： D. Inman , Steven Parnis , Albert Guzman
IPC分类号： A61N1/00
CPC分类号： A61N1/0551 , A61N1/36071 , A61N1/36114
摘要： A method, system, and an apparatus are provided for insulating an electrode implanted in a body of a patient. The method comprises surgically exposing a nerve of the patient, implanting at least one electrode in the body of the patient, wherein the implanting comprises coupling theat least one electrode to the nerve of the patient, providing a mold form, disposing the mold form around at least a portion of the at least one electrode and the nerve, introducing into the mold form a curable liquid insulant, allowing the curable liquid insulant to cure, removing the mold form from around the at least one electrode and from the patient's body, and surgically closing the exposure of the nerve.
摘要翻译：提供了一种方法，系统和装置，用于绝缘植入患者体内的电极。该方法包括手术暴露患者的神经，将至少一个电极植入患者体内，其中所述植入包括将至少一个电极耦合到患者的神经，提供模具形式，将模具周围放置在将所述至少一个电极和所述神经的至少一部分引入所述模具中形成可固化液体绝缘体，从而允许所述可固化液体绝缘剂固化，从所述至少一个电极和所述患者身体周围除去所述模具形式，以及手术关闭神经的暴露。

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