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1. 发明授权

US5468847A Method of isolating and purifying a biomacromolecule 失效
标题翻译：分离和纯化生物大分子的方法
公开(公告)号：US5468847A
公开(公告)日：1995-11-21
申请号：US209700
申请日：1994-03-10
申请人： Steven M. Heilmann , Gary J. Drtina , Philip D. Eitzman , Louis C. Haddad , Frederick W. Hyde , Todd W. Johnson , Jerald K. Rassmussen , Michael G. Williams
发明人： Steven M. Heilmann , Gary J. Drtina , Philip D. Eitzman , Louis C. Haddad , Frederick W. Hyde , Todd W. Johnson , Jerald K. Rassmussen , Michael G. Williams
IPC分类号： G01N33/48 , A61K38/00 , A61K47/48 , B01D15/08 , B01D39/08 , B01D39/16 , C07K1/22 , C07K1/34 , C07K17/14 , C08B37/00 , C12P21/00 , G01N1/10 , C07K1/16 , B01D61/08 , C07K1/18
CPC分类号： B01D39/083 , B01D15/08 , B01D39/086 , B01D39/1623 , B01D39/18 , B01D39/2068 , C07K1/34 , B01D15/361 , B01D15/3804 , B01D2239/0407 , B01D2239/0428 , B01D2239/1291
摘要： The invention provides a method of separating a biomacromolecule which comprises the steps of providing a separation system including a filter element which comprises a composite filtration medium, the composite filtration medium comprising a filtration layer on the upstream surface of which are located insoluble stationary phase particulates, the particulates being capable of binding to a biomacromolecule or class of biomacromolecules, a reservoir containing a solution mixture comprising at least one biomacromolecule as solute, and a pump and associated tubing to form a closed loop assembly, and recirculation pumping the solution mixture through the filter cartridge so as to bind the at least one biomacromolecule to the stationary phase particulate so as to form a biomacromolecule:stationary phase particulate product. An eluting solution can be pumped through the closed loop assembly which is capable of reversing the biomacromolecule:stationary phase particulate product binding interaction so as to liberate the biomacromolecule.
摘要翻译：本发明提供了分离生物大分子的方法，其包括提供包括复合过滤介质的过滤元件的分离系统的步骤，所述复合过滤介质在其上游表面上设置有不溶性固定相颗粒的过滤层，能够结合生物大分子或一类生物大分子的颗粒，含有至少一种作为溶质的生物大分子的溶液混合物的储存器，以及泵和相关管道以形成闭环组件，以及再循环泵送溶液混合物通过过滤器以便将至少一种生物大分子结合至固定相颗粒，以便形成生物大分子：固定相颗粒产物。洗脱溶液可以泵送通过闭环组件，其能够逆转生物大分子：固定相颗粒产物结合相互作用以释放生物大分子。

2. 发明授权

US5614105A Cartridge filters with insoluble enzyme particulates contained thereon 失效
标题翻译：其中含有不溶性酶微粒的滤芯过滤器
公开(公告)号：US5614105A
公开(公告)日：1997-03-25
申请号：US425585
申请日：1995-04-20
申请人： Steven M. Heilmann , Gary J. Drtina , Philip D. Eitzman , Louis C. Haddad , Frederick W. Hyde , Todd W. Johnson
发明人： Steven M. Heilmann , Gary J. Drtina , Philip D. Eitzman , Louis C. Haddad , Frederick W. Hyde , Todd W. Johnson
IPC分类号： B01D39/14 , C12M1/40 , C12N11/00 , C12N11/02 , C12N11/04 , C12N11/08 , B01D37/00
CPC分类号： B01D39/14 , C12N11/02 , C12N11/04 , C12N11/08
摘要： Insolubilized enzyme particulates are located on the upstream surface of a filtration layer of a filtering element which can be used in a cartridge filter. Employed in a recycling flow reaction system at relatively high flux rates, the cartridges are useful for conducting catalyzed chemical reactions of dissolved solutes, for example, esterifications, isomerizations, oxidations, reductions, and cyclizations.
摘要翻译：不溶解的酶微粒位于可用于筒式过滤器的过滤元件的过滤层的上游表面上。在相对较高的通量速率下在回收流动反应系统中使用，所述筒可用于进行溶解的溶质的催化化学反应，例如酯化，异构化，氧化，还原和环化。

3. 发明授权

US5478466A Cartridge filters with insoluble enzyme particulates contained thereon 失效
标题翻译：其中含有不溶性酶微粒的滤芯过滤器
公开(公告)号：US5478466A
公开(公告)日：1995-12-26
申请号：US427281
申请日：1995-04-21
申请人： Steven M. Heilmann , Gary J. Drtina , Philip D. Eitzman , Louis C. Haddad , Frederick W. Hyde , Todd W. Johnson
发明人： Steven M. Heilmann , Gary J. Drtina , Philip D. Eitzman , Louis C. Haddad , Frederick W. Hyde , Todd W. Johnson
IPC分类号： B01D39/14 , C12M1/40 , C12N11/00 , C12N11/02 , C12N11/04 , C12N11/08 , B01D36/00 , B01D27/00
CPC分类号： B01D39/14 , C12N11/02 , C12N11/04 , C12N11/08
摘要： Insolubilized enzyme particulates are located on the upstream surface of a filtration layer of a filtering element which can be used in a cartridge filter. Employed in a recycling flow reaction system at relatively high flux rates, the cartridges are useful for conducting catalyzed chemical reactions of dissolved solutes, for example, esterifications, isomerizations, oxidations, reductions, and cyclizations.
摘要翻译：不溶解的酶微粒位于可用于筒式过滤器的过滤元件的过滤层的上游表面上。在相对较高的通量速率下在回收流动反应系统中使用，所述筒可用于进行溶解的溶质的催化化学反应，例如酯化，异构化，氧化，还原和环化。

4. 发明授权

US06375886B1 Method and apparatus for making a nonwoven fibrous electret web from free-fiber and polar liquid 有权
标题翻译：从自由纤维和极性液体制造非织造纤维驻极体网的方法和装置
公开(公告)号：US06375886B1
公开(公告)日：2002-04-23
申请号：US09415566
申请日：1999-10-08
申请人： Seyed A. Angadjivand , Michael G. Schwartz , Philip D. Eitzman , Marvin E. Jones
发明人： Seyed A. Angadjivand , Michael G. Schwartz , Philip D. Eitzman , Marvin E. Jones
IPC分类号： H05B716
CPC分类号： D04H1/4382 , D04H1/4291
摘要： A method and apparatus for charging fibers that contain a nonconductive polymer. A polar liquid 32, 34 is sprayed onto free-fibers 24, and the free-fibers 24 are then collected to form an entangled nonwoven fibrous web 25 that may contain a portion of the polar liquid. The nonwoven web 25 is then dried 38. By applying an effective amount of polar liquid 32, 34 onto the nonconductive free-fibers 24 before forming the nonwoven web 25, followed by drying 38, the individual fibers 24 become charged. The method and apparatus enable the fibers 24 to be charged during web manufacture without subsequent processing.
摘要翻译：一种用于装入含有非导电聚合物的纤维的方法和装置。将极性液体32,34喷涂到自由纤维24上，然后收集自由纤维24以形成可包含一部分极性液体的缠结非织造纤维网25。然后将非织造纤维网25干燥38.通过在形成非织造纤维网25之前将有效量的极性液体32,34施加到非导电自由纤维24上，随后干燥38，单个纤维24变成带电。该方法和装置使纤维24能够在卷筒纸制造期间被充电而不后续处理。

5. 发明申请

US20110315144A1 RESPIRATOR THAT HAS INWARD NOSE REGION FOLD WITH HIGH LEVEL CONFORMATION 审中-公开
标题翻译：具有高水平配合的密封区域的呼吸器
公开(公告)号：US20110315144A1
公开(公告)日：2011-12-29
申请号：US12823259
申请日：2010-06-25
申请人： Philip D. Eitzman , Dean R. Duffy
发明人： Philip D. Eitzman , Dean R. Duffy
IPC分类号： A62B18/02
CPC分类号： A62B18/025 , A41D13/1123 , A62B23/025
摘要： A flat fold filtering face piece respirator 10 that includes a mask body 12 and a harness 14. The mask body 12 includes a filtering structure 16 that contains a cover web 48, 50 and a filtration layer 52 that contains electrically-charged microfibers. The filtering structure 16 is folded over upon itself in a nose region 32 of the mask body 12 to be at least 1 centimeter or more wide and to extend across the upper perimeter of the mask body in a generally straight line when the respirator is in the folded condition. The filtering structure 16 has a deflection greater than about 0.5 millimeters and has a recoverability of at least 40% in the folded condition. A mask body having this construction is beneficial in that it does not need to use a nose foam to obtain a snug fit over the nose.
摘要翻译：包括面罩主体12和线束14的平折式过滤面件呼吸器10.面罩主体12包括过滤结构16，过滤结构16包含覆盖纤维网48,50和含有带电微纤维的过滤层52。过滤结构16在面罩主体12的鼻部区域32中自身折叠成至少1厘米或更宽，并且当呼吸器处于折叠条件。过滤结构16具有大于约0.5毫米的偏转，并且在折叠状态下具有至少40％的可恢复性。具有这种结构的面罩体是有益的，因为它不需要使用鼻泡来获得鼻子上的贴合。

6. 发明授权

US06454986B1 Method of making a fibrous electret web using a nonaqueous polar liquid 失效
标题翻译：使用非水极性液体制造纤维驻极体网的方法
公开(公告)号：US06454986B1
公开(公告)日：2002-09-24
申请号：US09416216
申请日：1999-10-08
申请人： Philip D. Eitzman , Alan D. Rousseau , Marvin E. Jones , Seyed A. Angadjivand
发明人： Philip D. Eitzman , Alan D. Rousseau , Marvin E. Jones , Seyed A. Angadjivand
IPC分类号： D06M13127
CPC分类号： A41D13/1146 , B01D39/163 , B03C3/28 , D06M13/127 , D06M13/144 , D06M13/148 , D06M13/188 , D06M13/248 , D06M13/345 , D06M13/402 , D06M23/10
摘要： A method of charging fibrous webs with nonaqueous polar liquids. A web 20 that contains nonconductive fibers is wetted with a nonaqueous polar liquid 14. The web 20 is then substantially dried 22 to provide a fibrous electret web. The fibrous electret web can be used as a filter in a filtration face mask 40 that is adapted to cover the nose and mouth of the wearer. The present method has the advantage over known charging methods in that the nonaqueous liquid requires less energy for drying than is required for aqueous liquids. Additionally, many filter webs can be directly wetted with nonaqueous liquids, which cannot be easily wetted with aqueous liquids.
摘要翻译：用非极性极性液体填充纤维网的方法。含有非导电纤维的纤维网20用非极性极性液体14润湿。然后将幅材20基本上干燥22以提供纤维驻极体网。纤维驻极体网可用作过滤面罩40中的过滤器，该过滤面罩40适于覆盖穿戴者的鼻子和口部。本方法优于已知的充电方法，因为与水性液体所需的非水液体相比，非水液体需要较少的干燥能量。此外，许多过滤网可以用非水液体直接润湿，这不会容易用含水液体润湿。

7. 外观设计

USD704824S1 Respirator having folded nose region 有权
标题翻译：具有折叠鼻部区域的呼吸器
公开(公告)号：USD704824S1
公开(公告)日：2014-05-13
申请号：US29364581
申请日：2010-06-25
申请人： Dean R. Duffy , Philip D. Eitzman
设计人： Dean R. Duffy , Philip D. Eitzman

8. 发明授权

US06824718B2 Process of making a fibrous electret web 有权
标题翻译：制造纤维驻极体网的工艺
公开(公告)号：US06824718B2
公开(公告)日：2004-11-30
申请号：US10162753
申请日：2002-06-04
申请人： Philip D. Eitzman , Alan D. Rousseau
发明人： Philip D. Eitzman , Alan D. Rousseau
IPC分类号： D06M13127
CPC分类号： B03C3/28 , B01D39/163 , D01F1/10 , D01F6/06 , D04H1/4291 , D04H1/4318 , D04H1/4382 , D06M13/127 , D06M13/144 , D06M13/148 , D06M13/352 , D06M13/358 , D06M23/10 , D06M2101/20
摘要： A method for imparting an electrostatic charge to a nonwoven fibrous web 20. The fibrous web 20 is contacted with a liquid solution that includes water and a non-aqueous water soluble component, followed by drying 31. The resulting dried product is an electret article 43 that could be used as an air filter in, for example, a respirator 50.
摘要翻译：对非织造纤维网20赋予静电荷的方法。纤维网20与包含水和非水溶性组分的液体溶液接触，然后干燥31.得到的干燥产物是驻极体制品43 其可以用作例如呼吸器50中的空气过滤器。

9. 发明授权

US06406657B1 Method and apparatus for making a fibrous electret web using a wetting liquid and an aqueous polar liquid 有权
标题翻译：使用润湿液体和极性极性液体制造纤维驻极体网的方法和装置
公开(公告)号：US06406657B1
公开(公告)日：2002-06-18
申请号：US09415291
申请日：1999-10-08
申请人： Philip D. Eitzman , Alan D. Rousseau
发明人： Philip D. Eitzman , Alan D. Rousseau
IPC分类号： D06B300
CPC分类号： B03C3/28 , B01D39/163 , D01F1/10 , D01F6/06 , D04H1/4291 , D04H1/4318 , D04H1/4382 , D06M13/127 , D06M13/144 , D06M13/148 , D06M13/352 , D06M13/358 , D06M23/10 , D06M2101/20
摘要： A method for imparting an electrostatic charge to a nonwoven fibrous web 20. The fibrous web 20 is wetted with a wetting liquid 24, followed by being saturated with an aqueous polar liquid 30 and drying 31. The resulting dried product is an electret article 43 that could be used as an air filter in, for example, a respirator 50.
摘要翻译：用于将静电荷赋予非织造纤维网20的方法。纤维网20用润湿液24润湿，然后用极性极性液体30饱和并干燥31.得到的干燥产物是驻极体制品43，驻极体制品43 可以用作例如呼吸器50中的空气过滤器。

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