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1. 发明授权

US5595987A Method of slowing ventricular arrhythmias using zatebradine 失效
标题翻译：使用zatebradine减慢室性心律失常的方法
公开(公告)号：US5595987A
公开(公告)日：1997-01-21
申请号：US231480
申请日：1994-07-22
申请人： Steven Lasker , Richard Klein
发明人： Steven Lasker , Richard Klein
IPC分类号： A61K31/55
CPC分类号： A61K31/55 , Y10S514/821
摘要： The present invention relates to a method of using zatebradine by intravenous (IV) injection to retard or eliminate arrhythmias due to abnormal spontaneous activity in subendocardial Purkinje fibers. More specifically, the present invention relates to the use of zatebradine to reduce intracellular Na.sup.+ activity in Purkinje fibers and block I.sub.f current. Arrhythmias due to abnormal spontaneous activity in subendocardial Purkinje fibers occur 24 hours after occlusion of the left anterior descending (LAD) coronary artery in canine heart. These Purkinje fibers in the infarcted hearts are depolarized and have elevated intracellular Na.sup.+ activity. The major current underlying normal automaticity in these fibers is the I.sub.f current. Zatebradine reduces intracellular Na.sup.+ activity in Purkinje fibers by 4 mM. In vivo, 0.25-1.0 mg/kg intravenous injections of zatebradine slow ventricular rhythms by 24%. Although zatebradine also slows sinus nodal rate, it precipitates a more severe arrhythmia. However, during right atrial pacing, capture of ventricular rhythms occurs at lower rates (i.e. 28% reduction) in the presence of zatebradine. Thus, zatebradine eliminates the arrhythmia when the right atria is paced at the original sinus rate.
摘要翻译：本发明涉及通过静脉内（IV）注射使用茨巴布丁以延迟或消除由于心内浦肯野纤维中的异常自发活动引起的心律失常的方法。更具体地，本发明涉及使用茨巴布丁来减少浦肯野纤维中的细胞内Na +活性并阻断如果电流。心内膜下Purkinje纤维异常自发活动的心律失常发生在犬心脏左前降支（LAD）冠状动脉阻塞后24小时。梗塞心脏中的这些浦肯野纤维被去极化并具有升高的细胞内Na +活性。这些光纤中当前主要的基本正常自动度是If电流。 Zatebradine将Purkinje纤维中的细胞内Na +活性降低4mM。在体内，0.25-1.0mg / kg静滴注射左旋舒巴坦慢心室节律24％。尽管zatebradine也减慢了鼻窦结节率，但却导致更严重的心律失常。然而，在右心房起搏期间，在zatebradine存在下，以较低的速率（即28％的减少）发生心室节律的捕获。因此，当右心房以原始窦速度起搏时，zatebradine消除了心律失常。

2. 发明申请

US20060085342A1 Binding to business objects and web services 有权
标题翻译：绑定到业务对象和Web服务
公开(公告)号：US20060085342A1
公开(公告)日：2006-04-20
申请号：US10968693
申请日：2004-10-19
申请人： John Chen , Joseph Stegman , Karol Zadora-Przylecki , Steven Lasker
发明人： John Chen , Joseph Stegman , Karol Zadora-Przylecki , Steven Lasker
IPC分类号： G06Q99/00
CPC分类号： G06Q10/10
摘要： A system and method for method facilitating design-time data binding of business object(s) and/or web service(s) is provided. Developer(s) can specify their own class(es) that do not require specific inheritance, interface implementation or default public constructors. The system includes a binding component that generates control information associated with control(s) based, at least in part, upon binding information associated with an entity (e.g., object, business object and/or web service). The system further includes a control generator that generates control(s) of a form associated with the entity based upon the generated by the binding component. The binding component can utilize public property(ies) of the entity (e.g., object, business object and/or web service). The entity can represent a hierarchy of objects that drill down (e.g., endlessly), including circular relationships. At design-time, a user (e.g., developer) can drag the root of an object (e.g., a business object and/or a web service) onto a form. Control(s) associated with the form are created by the system based on a schema of the object.
摘要翻译：提供了一种促进业务对象和/或Web服务的设计时数据绑定的方法的系统和方法。开发人员可以指定不需要特定继承，接口实现或默认公共构造函数的自己的类。该系统至少部分地基于绑定与实体（例如，对象，业务对象和/或web服务）相关联的信息来生成与控制相关联的控制信息的绑定组件。该系统还包括控制生成器，其基于由绑定组件产生的生成与该实体相关联的形式的控件。绑定组件可以利用实体的公共属性（例如，对象，业务对象和/或web服务）。该实体可以表示向下钻取（例如，无休止地）的对象的层次结构，包括循环关系。在设计时，用户（例如，开发者）可以将对象的根（例如，业务对象和/或web服务）拖动到表单上。与表单关联的控件由系统基于对象的模式创建。

3. 发明申请

US20060150172A1 Binding to types 有权
标题翻译：绑定到类型
公开(公告)号：US20060150172A1
公开(公告)日：2006-07-06
申请号：US10968207
申请日：2004-10-19
申请人： Iain Heath , Joseph Stegman , Mark Boulter , Steven Lasker
发明人： Iain Heath , Joseph Stegman , Mark Boulter , Steven Lasker
IPC分类号： G06F9/44
CPC分类号： G06F8/20
摘要： A system and method for system and method data binding to type(s) of object(s) is provided. The system can be employed in a software application development environment to facilitate data binding to types of entity(ies) (e.g., object(s), web service(s) and/or a hierarchy of objects) rather than instance(s) of the entity(ies). With the ability to bind to types, the system provides the ability to abstract schema by which the control(s) are bound from the source of data. The system allows developer(s) and/or architect(s) to specify their own base classes for their own object(s). The system includes a binding source component that supports the ability to set its data source to a type, rather then a specific instance. For example, when the data source is changed, the binding source component can evaluate whether the data source (e.g., object) can be instanced and whether the data source (e.g., object) supports necessary designer interface(s). If the type isn't supported by the designer, using reflection, the binding source component can interrogate the public properties of the type. Additionally, the binding source component can analyze complex object(s).
摘要翻译：提供了一种系统和方法，用于绑定到对象类型的系统和方法数据。该系统可以用于软件应用程序开发环境中，以促进数据绑定到实体（例如，对象，Web服务和/或对象的层次结构）的类型，而不是实例实体。具有绑定到类型的能力，系统提供抽象模式的能力，通过该模式控制从数据源绑定。系统允许开发人员和/或架构师为自己的对象指定自己的基类。该系统包括绑定源组件，该组件支持将其数据源设置为类型而不是特定实例的能力。例如，当数据源被改变时，绑定源组件可以评估数据源（例如，对象）是否可被实例化，以及数据源（例如，对象）是否支持必要的设计器接口。如果设计器不支持类型，则使用反射，绑定源组件可以询问类型的公共属性。另外，绑定源组件可以分析复杂的对象。

4. 发明申请

US20060085400A1 Data access layer design and code generation 有权
标题翻译：数据访问层设计和代码生成
公开(公告)号：US20060085400A1
公开(公告)日：2006-04-20
申请号：US10968734
申请日：2004-10-19
申请人： Lorenzo Minore , Paul Yuknewicz , Steven Lasker , Antoine Cote
发明人： Lorenzo Minore , Paul Yuknewicz , Steven Lasker , Antoine Cote
IPC分类号： G06F17/30
CPC分类号： G06F8/20
摘要： A system and method that facilitate data access in a software development environment is provided. The system generates strongly typed objects (e.g., TableAdapter(s)) that encapsulate raw, untyped data access logic, for example, via generated wrapped method(s). The system can group together like database commands in a common data access component. For example, the TableAdapter can encapsulate a configured DataAdapter and expose public method(s) for the “Fill” and “Update” methods normally found on the DataAdapter. The system provides a mapping between database types and common language runtime data types including the impedance mismatch of null representations. The system includes a data access configuration component (e.g., configuration wizard) that configures data access component(s) (e.g., TableAdapter(s)). The configured data access component(s) can be employed at design-time to facilitate access to data object(s) (e.g., database(s)) by application(s). The user of data access component(s) configured by the data access configuration component can, for example, dramatically improve developer productivity and/or reduce the quantity of runtime errors that are introduced into code. In one example, the data access component is a generated class/type. The data access component can be instanced on multiple forms components and/or with the developer's own class(es). Thus, change(s) to a query and/or interface can be accomplished within the data access component and be available to the forms components and/or object(s) that utilize the data access component.
摘要翻译：提供了一种在软件开发环境中促进数据访问的系统和方法。系统生成例如通过生成的包装方法封装原始，未类型化数据访问逻辑的强类型对象（例如，TableAdapter）。系统可以将公共数据访问组件中的数据库命令组合在一起。例如，TableAdapter可以封装一个配置的DataAdapter，并公开DataAdapter中通常发现的“Fill”和“Update”方法的公共方法。该系统提供数据库类型和公共语言运行时数据类型之间的映射，包括零表示的阻抗失配。该系统包括配置数据访问组件（例如，TableAdapter）的数据访问配置组件（例如，配置向导）。可以在设计时使用配置的数据访问组件，以方便通过应用访问数据对象（例如，数据库）。例如，由数据访问配置组件配置的数据访问组件的用户可以显着地提高开发人员的生产力和/或减少引入到代码中的运行时错误的数量。在一个示例中，数据访问组件是生成的类/类型。数据访问组件可以在多个表单组件和/或开发人员自己的类上实例化。因此，可以在数据访问组件内完成对查询和/或接口的更改，并且对于使用数据访问组件的表单组件和/或对象可用。

5. 发明申请

US20060101390A1 Lookup control configuration 有权
标题翻译：查找控制配置
公开(公告)号：US20060101390A1
公开(公告)日：2006-05-11
申请号：US10968668
申请日：2004-10-19
申请人： Steven Lasker
发明人： Steven Lasker
IPC分类号： G06F9/44
CPC分类号： G06F8/20 , Y10S715/961
摘要： A system and method for facilitating lookup control configuration is provided. The system incorporates the persistence of the metadata required to associate a field and a display value of a lookup list, and facilitates creation of a lookup type user interface control. Thus, a user (e.g., developer) can drag a lookup control to a design surface and set the relevant property(ies) on the control. The user can then drag lists of information onto the control to automatically set the properties of the lookup control to display the values of the list. The user can then run their application to see immediate results. Optionally, the user can leverage Smart tags to change the default values set to different values.
摘要翻译：提供了一种便于查找控制配置的系统和方法。系统结合了将字段关联和查找列表的显示值所需的元数据的持久性，并且便于创建查找类型用户界面控件。因此，用户（例如，开发者）可以将查找控件拖动到设计表面并且将相关属性设置在控件上。然后，用户可以将信息列表拖放到控件上，以自动设置查找控件的属性以显示列表的值。然后，用户可以运行其应用程序来查看即时结果。可选地，用户可以利用智能标签来将默认值设置为不同的值。

6. 发明申请

US20060085380A1 Reentrant database object wizard 有权
标题翻译：可重入数据库对象向导
公开(公告)号：US20060085380A1
公开(公告)日：2006-04-20
申请号：US10968437
申请日：2004-10-19
申请人： Antoine Cote , Paul Yuknewicz , Steven Lasker
发明人： Antoine Cote , Paul Yuknewicz , Steven Lasker
IPC分类号： G06F17/30
CPC分类号： G06F8/20 , G06F9/453 , Y10S707/99942 , Y10S707/99943 , Y10S707/99952
摘要： A system and method for a reentrant database object wizard is provided. The system provides the ability to compare a currently generated dataset to the objects of the underlying database. Columns and tables that are not common between both the dataset and the database are visually displayed for the user to make a decision on inclusion or exclusion. In addition, columns and tables that were previously within the dataset that are no longer available on the database connection are displayed, for example, with warning icons so that the user can either resolve the missing column or table within the database, or remove the column/table from their typed dataset. The system includes a comparison component and a display component. The comparison component provides comparison information based upon a comparison of a dataset to an associated database. The display component displays the comparison information. The system can further, optionally, include an input component which can be employed by a user to provide information associated with the user's decision on inclusion and/or exclusion of column(s) and/or table(s) to the system. Thereafter, based upon the user's input, the system can provide can provide based upon a comparison of the modified dataset to the associated database.
摘要翻译：提供了可重入数据库对象向导的系统和方法。该系统提供了将当前生成的数据集与底层数据库的对象进行比较的能力。在数据集和数据库之间不常见的列和表可以直观地显示给用户作出包含或排除的决定。此外，还将显示以前在数据集中不再可用于数据库连接的列和表，例如，带有警告图标，以便用户可以解析数据库中缺少的列或表，或删除列 /表从他们的类型数据集。该系统包括比较部件和显示部件。比较组件基于数据集与相关数据库的比较来提供比较信息。显示组件显示比较信息。该系统还可以进一步包括输入组件，其可以由用户使用来提供与用户关于将列和/或表的包含和/或排除到系统的决定相关联的信息。此后，基于用户的输入，系统可以提供可以基于修改的数据集与相关联的数据库的比较来提供。

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