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1. 发明授权

US06773670B2 Blood filter having a sensor for active gas removal and methods of use 失效
标题翻译：血液过滤器具有用于活性气体去除的传感器和使用方法
公开(公告)号：US06773670B2
公开(公告)日：2004-08-10
申请号：US10067434
申请日：2002-02-05
申请人： Steven K. Stringer , Kevin L. Hultquist , Mehrdad Farhangnia , Fred I. Linker , Ben F. Brian, III
发明人： Steven K. Stringer , Kevin L. Hultquist , Mehrdad Farhangnia , Fred I. Linker , Ben F. Brian, III
IPC分类号： A61M136
CPC分类号： A61M1/3626 , A61M1/1006 , A61M1/101 , A61M1/262 , A61M1/267 , A61M1/3606 , A61M1/3627 , A61M1/3643 , A61M1/3644 , A61M1/3666 , Y10S128/03 , Y10S261/28 , Y10S417/902
摘要： Apparatus and methods for removing gas from a blood handling system. A filter apparatus for monitoring and removing gas is provided comprising of a gas removal/blood filter, a sensor to sense the presence of gas, and a valve operably coupled to the sensor to evacuate gas from the apparatus when the sensor detects an accumulation of gas. When used with a previously known blood handling system, the present filter apparatus facilitates priming and the addition of additional blood handling elements during operation of the blood handling system.
摘要翻译：从血液处理系统中除去气体的装置和方法。提供了一种用于监测和去除气体的过滤装置，其包括气体去除/血液过滤器，用于感测气体存在的传感器，以及可操作地耦合到传感器的阀，当传感器检测到气体的积聚时，从装置排出气体。当与先前已知的血液处理系统一起使用时，本过滤装置有利于在血液处理系统的操作期间起动和添加额外的血液处理元件。

2. 发明授权

US06960322B2 Integrated blood handling system having active gas removal system and methods of use 失效
标题翻译：具有活性气体去除系统和使用方法的综合血液处理系统
公开(公告)号：US06960322B2
公开(公告)日：2005-11-01
申请号：US10616116
申请日：2003-07-08
申请人： Steven K. Stringer , Kevin L. Hultquist , Mehrdad Farhangnia , Ben F. Brian, III , Fred I. Linker , James M. Culp , Jean-Pierre Dueri , Thomas A. Afzal
发明人： Steven K. Stringer , Kevin L. Hultquist , Mehrdad Farhangnia , Ben F. Brian, III , Fred I. Linker , James M. Culp , Jean-Pierre Dueri , Thomas A. Afzal
IPC分类号： A61M1/14 , A61M1/10 , A61M1/36 , A61M37/00 , B01D47/08 , B01D53/22 , C02F1/44
CPC分类号： A61M1/3626 , A61M1/1006 , A61M1/101 , A61M1/1013 , A61M1/1025 , A61M1/262 , A61M1/267 , A61M1/3606 , A61M1/3627 , A61M1/3666 , Y10S261/28
摘要： Apparatus and methods for pumping and oxygenating blood are provided that include a gas removal system. An integrated blood processing unit is provided in which a gas removal/blood filter, pump and blood oxygenation element are mounted within a common housing. The gas removal system includes a sensor mounted on the housing to sense the presence of gas, and a valve is operably coupled to the sensor to evacuate gas from the system when the sensor detects an accumulation of gas.
摘要翻译：提供了用于泵送和充氧血液的装置和方法，其包括气体去除系统。提供了一种集成血液处理单元，其中气体去除/血液过滤器，泵和血氧元件安装在公共壳体内。气体去除系统包括安装在壳体上以感测气体存在的传感器，并且当传感器检测到气体积聚时，阀可操作地耦合到传感器以从系统排出气体。

3. 发明授权

US07541000B2 Micro-processor controlled active gas removal apparatus 失效
标题翻译：微处理器控制的活性气体去除装置
公开(公告)号：US07541000B2
公开(公告)日：2009-06-02
申请号：US11236269
申请日：2005-09-26
申请人： Steven K. Stringer , Kevin L. Hultquist , Mehrdad Farhangnia , Ben F. Brian, III , Fred I. Linker , James M. Culp , Jean-Pierre Dueri , Thomas A. Afzal
发明人： Steven K. Stringer , Kevin L. Hultquist , Mehrdad Farhangnia , Ben F. Brian, III , Fred I. Linker , James M. Culp , Jean-Pierre Dueri , Thomas A. Afzal
IPC分类号： A61M1/14 , A61M37/00 , C02F1/44 , B01D53/22 , B01D47/08
CPC分类号： A61M1/3626 , A61M1/1006 , A61M1/101 , A61M1/1013 , A61M1/1025 , A61M1/262 , A61M1/267 , A61M1/3606 , A61M1/3627 , A61M1/3666 , Y10S261/28
摘要： Apparatus and methods for pumping and oxygenating blood are provided that include a gas removal system. An integrated blood processing unit is provided in which a gas removal/blood filter, pump and blood oxygenation element are mounted within a common housing. The gas removal system includes a sensor mounted on the housing to sense the presence of gas, and a valve is operably coupled to the sensor to evacuate gas from the system when the sensor detects an accumulation of gas.
摘要翻译：提供了用于泵送和充氧血液的装置和方法，其包括气体去除系统。提供了一种集成血液处理单元，其中气体去除/血液过滤器，泵和血氧元件安装在公共壳体内。气体去除系统包括安装在壳体上以感测气体存在的传感器，并且当传感器检测到气体积聚时，阀可操作地耦合到传感器以从系统排出气体。

4. 发明授权

US06730267B2 Integrated blood handling system having active gas removal system and methods of use 失效
公开(公告)号：US06730267B2
公开(公告)日：2004-05-04
申请号：US09780923
申请日：2001-02-09
申请人： Steven K. Stringer , Kevin L. Hultquist , Mehrdad Farhangnia , Ben F. Brian, III , Fred I. Linker , James M. Culp , Jean-Pierre Dueri , Thomas A. Afzal
发明人： Steven K. Stringer , Kevin L. Hultquist , Mehrdad Farhangnia , Ben F. Brian, III , Fred I. Linker , James M. Culp , Jean-Pierre Dueri , Thomas A. Afzal
IPC分类号： A61M114
CPC分类号： A61M1/3626 , A61M1/1006 , A61M1/101 , A61M1/1013 , A61M1/1025 , A61M1/262 , A61M1/267 , A61M1/3606 , A61M1/3627 , A61M1/3666 , Y10S261/28
摘要： Apparatus and methods for pumping and oxygenating blood are provided that include a gas removal system. An integrated blood processing unit is provided in which a gas removal/blood filter, pump and blood oxygenation element are mounted within a common housing. The gas removal system includes a sensor mounted on the housing to sense the presence of gas, and a valve is operably coupled to the sensor to evacuate gas from the system when the sensor detects an accumulation of gas.

5. 发明授权

US06689315B2 Integrated blood handling system having improved pump 失效
标题翻译：具有改进泵的综合血液处理系统
公开(公告)号：US06689315B2
公开(公告)日：2004-02-10
申请号：US10117964
申请日：2002-04-05
申请人： Fred I. Linker , Jean-Pierre Dueri , Paul LaRoy Edwards , Ronald Cambron , Ben F. Brian, III
发明人： Fred I. Linker , Jean-Pierre Dueri , Paul LaRoy Edwards , Ronald Cambron , Ben F. Brian, III
IPC分类号： A61M136
CPC分类号： A61M1/3626 , A61M1/1006 , A61M1/101 , A61M1/262 , A61M1/267 , A61M1/3606 , A61M1/3627 , A61M1/3643 , A61M1/3644 , A61M1/3666 , Y10S128/03 , Y10S261/28 , Y10S417/902
摘要： Apparatus and methods for pumping and oxygenating blood are provided that include a gas removal system and a pump impeller with a single piece metal insert. An integrated blood processing unit is provided in which a gas removal/blood filter, pump and blood oxygenation element are mounted within a common housing. The gas removal system includes a sensor mounted on the housing to sense the presence of gas, and a valve is operably coupled to the sensor to evacuate gas from the system when the sensor detects an accumulation of gas.
摘要翻译：提供了用于泵送和充氧血液的装置和方法，其包括气体去除系统和具有单件金属插入件的泵叶轮。提供了一种集成血液处理单元，其中气体去除/血液过滤器，泵和血氧元件安装在公共壳体内。气体去除系统包括安装在壳体上以感测气体存在的传感器，并且当传感器检测到气体积聚时，阀可操作地耦合到传感器以从系统排出气体。

6. 发明申请

US20080183257A1 SUTURELESS LEAD RETENTION FEATURES 有权
标题翻译：无懈可击的铅保持功能
公开(公告)号：US20080183257A1
公开(公告)日：2008-07-31
申请号：US12022135
申请日：2008-01-29
申请人： Mir A. Imran , Albert G. Burdulis , Kamran Behzadian , Fred I. Linker , Nicholas C. Debeer , Arturo Rosqueta
发明人： Mir A. Imran , Albert G. Burdulis , Kamran Behzadian , Fred I. Linker , Nicholas C. Debeer , Arturo Rosqueta
IPC分类号： A61N1/05
CPC分类号： A61N1/0558 , A61N1/057 , A61N2001/0585
摘要： A system includes a lead having a lead body and at least one electrode; and a retention feature disposed along the lead body proximal to the at least one electrode and configured to assist in atraumatically anchoring the lead to nearby tissue when the lead is positioned in the body. A system includes a lead having a lead body and at least one electrode; and a coiled retention feature disposed along the lead body proximal to the at least one electrode and configured to assist in anchoring the lead to nearby tissue when the lead is positioned in a body. A lead for stimulating a target neural tissue includes an elongate body; at least one electrode disposed along the elongate body; and a passive retention feature disposed along the lead body proximal to the at least one electrode and configured to assist in anchoring the elongate body to tissue near the target neural tissue.
摘要翻译：一种系统包括具有引线体和至少一个电极的引线; 以及保持特征，沿着所述引线体设置在所述至少一个电极的近侧，并且被配置为当所述引线位于所述主体中时辅助将所述引线无损伤地固定到附近的组织。一种系统包括具有引线体和至少一个电极的引线; 以及螺旋保持特征，沿着所述引线体设置在所述至少一个电极的近侧，并且被配置为当所述引线位于身体中时辅助将引线固定到附近的组织。用于刺激靶神经组织的引线包括细长体; 沿着所述细长体设置的至少一个电极; 以及被动保持特征，沿着所述引线体设置在所述至少一个电极的近侧，并且被配置成有助于将所述细长体锚固到所述靶神经组织附近的组织。

7. 发明授权

US09044592B2 Sutureless lead retention features 有权
标题翻译：无缝导线保留功能
公开(公告)号：US09044592B2
公开(公告)日：2015-06-02
申请号：US12022135
申请日：2008-01-29
申请人： Mir A. Imran , Albert G. Burdulis , Kamran Behzadian , Fred I. Linker , Nicholas C. Debeer , Arturo Rosqueta
发明人： Mir A. Imran , Albert G. Burdulis , Kamran Behzadian , Fred I. Linker , Nicholas C. Debeer , Arturo Rosqueta
IPC分类号： A61N1/05
CPC分类号： A61N1/0558 , A61N1/057 , A61N2001/0585
摘要： A system includes a lead having a lead body and at least one electrode; and a retention feature disposed along the lead body proximal to the at least one electrode and configured to assist in atraumatically anchoring the lead to nearby tissue when the lead is positioned in the body. A system includes a lead having a lead body and at least one electrode; and a coiled retention feature disposed along the lead body proximal to the at least one electrode and configured to assist in anchoring the lead to nearby tissue when the lead is positioned in a body. A lead for stimulating a target neural tissue includes an elongate body; at least one electrode disposed along the elongate body; and a passive retention feature disposed along the lead body proximal to the at least one electrode and configured to assist in anchoring the elongate body to tissue near the target neural tissue.
摘要翻译：一种系统包括具有引线体和至少一个电极的引线; 以及保持特征，沿着所述引线体设置在所述至少一个电极的近侧，并且被配置为当所述引线位于所述主体中时辅助将所述引线无损伤地固定到附近的组织。一种系统包括具有引线体和至少一个电极的引线; 以及螺旋保持特征，沿着所述引线体设置在所述至少一个电极的近侧，并且被配置为当所述引线位于身体中时辅助将引线固定到附近的组织。用于刺激靶神经组织的引线包括细长体; 沿着所述细长体设置的至少一个电极; 以及被动保持特征，沿着所述引线体设置在所述至少一个电极的近侧，并且被配置成有助于将所述细长体锚固到所述靶神经组织附近的组织。

8. 发明申请

US20110276056A1 METHODS, SYSTEMS AND DEVICES FOR REDUCING MIGRATION 审中-公开
标题翻译：用于减少移动的方法，系统和设备
公开(公告)号：US20110276056A1
公开(公告)日：2011-11-10
申请号：US13104787
申请日：2011-05-10
申请人： Eric J. Grigsby , Daniel M. Brounstein , Fred I. Linker
发明人： Eric J. Grigsby , Daniel M. Brounstein , Fred I. Linker
IPC分类号： A61N1/05 , A61B19/00
CPC分类号： A61N1/0558 , A61N1/05 , A61N1/0551 , A61N1/057
摘要： Devices, systems and methods for reducing migration of leads, catheters and similar devices are provided. In particular, devices, systems and methods are provided for creating a slack anchor which assists in maintaining the lead or catheter in a desired position. In some embodiments, the slack anchor is created within the epidural space. When targeting nerve anatomy within the spinal column or in the vicinity of the epidural space, anchoring within the epidural space allows the associated lead or catheter to be anchored as close to the target therapy site as desired or possible. By anchoring close to the target therapy site, the risk of movement or migration is significantly reduced or eliminated.
摘要翻译：提供了用于减少引线，导管和类似装置迁移的装置，系统和方法。特别地，提供了用于创建松弛锚的装置，系统和方法，其帮助将导线或导管保持在期望的位置。在一些实施例中，松弛锚固体在硬膜外腔内产生。当瞄准脊柱内或硬膜外腔附近的神经解剖结构时，在硬膜外腔内的锚定允许相关联的导联或导管根据需要或可能靠近目标治疗部位而被锚定。通过靠近目标治疗部位进行锚定，大大减少或消除了移动或迁移的风险。

9. 发明申请

US20200016398A1 METHODS, SYSTEMS AND DEVICES FOR REDUCING MIGRATION 审中-公开
公开(公告)号：US20200016398A1
公开(公告)日：2020-01-16
申请号：US16579389
申请日：2019-09-23
申请人： Eric J. Grigsby , Daniel M. Brounstein , Fred I. Linker
发明人： Eric J. Grigsby , Daniel M. Brounstein , Fred I. Linker
IPC分类号： A61N1/05
摘要： Devices, systems and methods for reducing migration of leads, catheters and similar devices are provided. In particular, devices, systems and methods are provided for creating a slack anchor which assists in maintaining the lead or catheter in a desired position. In some embodiments, the slack anchor is created within the epidural space. When targeting nerve anatomy within the spinal column or in the vicinity of the epidural space, anchoring within the epidural space allows the associated lead or catheter to be anchored as close to the target therapy site as desired or possible. By anchoring close to the target therapy site, the risk of movement or migration is significantly reduced or eliminated.

10. 发明申请

US20100179562A1 STIMULATION LEADS, DELIVERY SYSTEMS AND METHODS OF USE 审中-公开
标题翻译：刺激引线，输送系统和使用方法
公开(公告)号：US20100179562A1
公开(公告)日：2010-07-15
申请号：US12687737
申请日：2010-01-14
申请人： Fred I. Linker , Daniel M. Brounstein , Albert G. Burdulis , Eric T. Johnson , Phillip C. Burke , Evan S. VandenBrink , Eric J. Grigsby , Henry L.S. Tan
发明人： Fred I. Linker , Daniel M. Brounstein , Albert G. Burdulis , Eric T. Johnson , Phillip C. Burke , Evan S. VandenBrink , Eric J. Grigsby , Henry L.S. Tan
IPC分类号： A61B17/00 , A61N1/05
CPC分类号： A61N1/0551 , A61B17/3401 , A61B17/3468 , A61M25/0662
摘要： Devices, systems and methods are provided for accessing and treating anatomies associated with a variety of conditions while minimizing possible complications and side effects. This is achieved by directly neuromodulating a target anatomy associated with the condition while minimizing or excluding undesired neuromodulation of other anatomies. Typically, this involves stimulating portions of neural tissue of the central nervous system, wherein the central nervous system includes the spinal cord and the pairs of nerves along the spinal cord which are known as spinal nerves. In particular, some embodiments of the present invention are used to selectively stimulate portions of the spinal nerves, particularly one or more dorsal root ganglions (DRGs), to treat chronic pain while causing minimal deleterious side effects such as undesired motor responses.
摘要翻译：设备，系统和方法被提供用于访问和处理与各种条件相关联的解剖学，同时最小化可能的并发症和副作用。这是通过直接神经调节与病症相关的目标解剖结构来实现的，同时最小化或排除其他解剖结构的不希望的神经调节。通常，这涉及刺激中枢神经系统神经组织的部分，其中中枢神经系统包括脊髓和沿着脊髓的神经对，这些神经被称为脊神经。特别地，本发明的一些实施例用于选择性地刺激脊髓神经的部分，特别是一个或多个背根神经节（DRG），以治疗慢性疼痛，同时引起最小的有害的副作用，例如不期望的运动反应。

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