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1. 发明授权

US06759008B1 Apparatus and method for blood oxygenation 有权
标题翻译：用于血氧的设备和方法
公开(公告)号：US06759008B1
公开(公告)日：2004-07-06
申请号：US09410179
申请日：1999-09-30
申请人： William R. Patterson , Jeffrey L. Creech
发明人： William R. Patterson , Jeffrey L. Creech
IPC分类号： A61M136
CPC分类号： A61M1/1698 , A61M1/3613 , A61M2202/0476 , B01F3/04758 , Y10S261/27
摘要： An apparatus for blood oxygenation and delivery is provided. The apparatus advantageously comprises a liquid-to-liquid oxygenation assembly with a pressurizable chamber having inlets for a first gas-supersaturated fluid and a second fluid, such as blood. The inlets are advantageously positioned on the mixing chamber in such a way that the first fluid and the second fluid enter the mixing chamber normally to each other to promote mixing and liquid-to-liquid gas transfer. The apparatus also includes a delivery system coupled to the blood oxygenation assembly. The delivery system includes a generally tubular elongated member having a proximal end portion, a distal end portion, and a transition portion located between the proximal end portion and the distal end portion. The transitional portion is relatively flexible compared to the proximal end portion and is relatively stiff compared to the distal end portion. In another embodiment, the delivery system includes a generally tubular elongated member having a proximal end portion and a distal end portion with a plurality of holes.
摘要翻译：提供了用于血氧和输送的装置。该装置有利地包括液体至液体氧合组件，其具有用于第一气体过饱和流体和第二流体（例如血液）的入口的可加压室。入口有利地位于混合室中，使得第一流体和第二流体通常彼此进入混合室，以促进混合和液体 - 液体气体的转移。该装置还包括耦合到血液氧合组件的递送系统。输送系统包括具有近端部分，远端部分和位于近端部分和远端部分之间的过渡部分的大致管状细长部件。过渡部分与近端部分相比是相对柔性的，并且与远端部分相比是相对较硬的。在另一个实施例中，输送系统包括大致管状的细长构件，其具有近端部分和具有多个孔的远端部分。

2. 发明授权

US06620382B1 Method and compositions for treatment of cancers 失效
标题翻译：用于治疗癌症的方法和组合物
公开(公告)号：US06620382B1
公开(公告)日：2003-09-16
申请号：US09083307
申请日：1998-05-22
申请人： M. Rigdon Lentz
发明人： M. Rigdon Lentz
IPC分类号： A61M136
CPC分类号： A61K35/14 , A61K31/00 , A61K31/337 , A61K31/454 , A61K31/555 , A61K31/704 , A61K35/16 , A61K38/18 , A61K38/1816 , A61K38/193 , A61K38/196 , A61K41/00 , A61K41/0019 , A61M1/34 , A61M1/342 , A61M1/3441 , A61M1/3472 , A61M1/3482 , A61M1/3681 , A61M2202/0417 , A61M2205/50 , A61M2205/75 , A61N5/1028 , B01D15/00 , B01D29/50 , B01D37/00 , B01D61/02 , A61K2300/00
摘要： A method to treat cancer uses ultrapheresis, refined to remove compounds of less than 120,000 daltons molecular weight, followed by administration of replacement fluid, to stimulate the patient's immune system to attack solid tumors. In the preferred embodiment, the patient is ultrapheresed using a capillary tube ultrafilter having a pore size of 0.02 to 0.05 microns, with a molecular weight cutoff of 120,000 daltons, sufficient to filter one blood volume. The preferred replacement fluid is ultrapheresed normal plasma. The patient is preferably treated daily for three weeks, diagnostic tests conducted to verify that there has been shrinkage of the tumors, then the treatment regime is repeated. The treatment is preferably combined with an alternative therapy, for example, treatment with an anti-angiogenic compound, one or more cytokines such as TNF, gamma interferon, or IL-2, or a procoagulant compound. The treatment increases endogenous, local levels of cytokines, such as TNF. This provides a basis for an improved effect when combined with any treatment that enhances cytokine activity against the tumors, for example, treatments using alkylating agents, doxyrubicin, carboplatinum, cisplatinum, and taxol. Alternatively, the ultrapheresis treatment can be combined with local chemotherapy, systemic chemotherapy, and/or radiation.
摘要翻译：一种治疗癌症的方法是使用超级血液分离法，精制以除去小于120,000道尔顿分子量的化合物，然后施用替代液，以刺激患者的免疫系统攻击实体瘤。在优选实施例中，使用孔径为0.02至0.05微米，分子量截留值为120,000道尔顿的毛细管超滤器将患者超薄，足以过滤一个血液体积。优选的替代液体是超分离的正常血浆。患者优选每天治疗三周，进行诊断测试以证实肿瘤已经收缩，然后重复治疗方案。治疗优选与替代疗法组合，例如用抗血管生成化合物，一种或多种细胞因子如TNF，γ干扰素或IL-2或促凝血剂化合物的治疗。治疗增加内源性，局部水平的细胞因子，如TNF。当提供增强细胞因子对肿瘤活性的治疗，例如使用烷化剂，多柔比星，卡铂，顺铂和紫杉醇的治疗时，这提供了改善效果的基础。或者，超单位治疗可以与局部化疗，全身化学疗法和/或辐射结合。

3. 发明授权

US06565807B1 Method of blood oxygenation 失效
标题翻译：血氧合法
公开(公告)号：US06565807B1
公开(公告)日：2003-05-20
申请号：US09467670
申请日：1999-12-21
申请人： William R. Patterson , Stephen E. Myrick , Vincent Divino, Jr. , Jeffrey L. Creech , Mark S. Buhr
发明人： William R. Patterson , Stephen E. Myrick , Vincent Divino, Jr. , Jeffrey L. Creech , Mark S. Buhr
IPC分类号： A61M136
CPC分类号： A61M1/1698 , A61M1/3613 , A61M2202/0476 , B01F3/04758 , Y10S128/03 , Y10S261/28
摘要： An apparatus and method for blood oxygenation are provided. The apparatus includes a chamber having a first inlet to receive a gas-supersaturating fluid, e.g., physiologic saline; a second inlet to receive a gas, e.g., oxygen, from a gas supply; and an outlet coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet creates within the chamber fine droplets of fluid into which the gas diffuses to create the gas-supersaturated fluid, which is removed via the outlet. The removed gas-supersaturated fluid mixes with blood within a liquid-to-liquid oxygenation assembly to form oxygenated blood for delivery to a patient. Alternately, the blood may be provided by the pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen diffuses across the membrane(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site.
摘要翻译：提供了一种用于血氧的装置和方法。该装置包括具有第一入口以容纳气体过饱和流体例如生理盐水的室; 用于接收来自气体供应源的气体例如氧的第二入口; 和连接到毛细管组件的出口。联接到第一入口的雾化喷嘴在室内形成细小的液体，气体扩散到其中，以产生气体过饱和流体，其通过出口被去除。去除的气体过饱和流体与液体至液体氧合装置内的血液混合以形成用于输送给患者的含氧血液。或者，血液可以由泵提供给高压中空纤维或其它类型的膜氧合器，其中氧气扩散通过膜并进入血液以形成氧合血液，再次用于输送到患者或其他部位。

4. 发明授权

US06506340B1 Antifoaming device and method for extracorporeal blood processing 失效
标题翻译：消泡装置及体外血液处理方法
公开(公告)号：US06506340B1
公开(公告)日：2003-01-14
申请号：US08069867
申请日：1993-06-01
申请人： Chi-Chun Tsai , Robert E Haynes
发明人： Chi-Chun Tsai , Robert E Haynes
IPC分类号： A61M136
CPC分类号： A61M1/3627 , A61M1/32 , A61M1/325 , Y10S128/03 , Y10S261/28
摘要： A medical instrument and method is provided for defoaming or preventing formation of foam in blood during extracorporeal blood circulation. The method comprises durably coating hydrophobic blood-contact surfaces with a nontoxic, biocompatible surface-active defoaming agent.
摘要翻译：提供了用于在体外血液循环期间消泡或防止血液中泡沫形成的医疗仪器和方法。该方法包括用无毒的，生物相容的表面活性消泡剂将疏水性血液接触表面持久地涂覆。

5. 发明授权

US06811750B2 Apparatus for blood oxygenation 有权
标题翻译：血氧合仪
公开(公告)号：US06811750B2
公开(公告)日：2004-11-02
申请号：US10071702
申请日：2002-02-08
申请人： William R. Patterson , Stephen E. Myrick , Vincent Divino, Jr. , Jeffrey L. Creech , Mark S. Buhr
发明人： William R. Patterson , Stephen E. Myrick , Vincent Divino, Jr. , Jeffrey L. Creech , Mark S. Buhr
IPC分类号： A61M136
CPC分类号： A61M1/1698 , A61M1/3613 , A61M2202/0476 , B01F3/04758 , Y10S128/03 , Y10S261/28
摘要： Apparatus and method for blood oxygenation are provided. The apparatus includes a chamber having a first inlet to receive a fluid, e.g., physiologic saline; a second inlet to receive a gas, e.g., oxygen, from a gas supply; and an outlet coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet creates within the chamber fine droplets of fluid into which the gas diffuses to create a gas-supersaturated fluid, which is removed via the outlet. The removed gas-supersaturated fluid mixes with blood within a liquid-to-liquid oxygenation assembly to form oxygenated blood for delivery to a patient. Alternately, the blood may be provided by a pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen diffuses across the membrane(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site.
摘要翻译：提供了用于血氧合的装置和方法。该装置包括具有用于接收流体例如生理盐水的第一入口的室; 用于接收来自气体供应源的气体例如氧的第二入口; 和连接到毛细管组件的出口。耦合到第一入口的雾化喷嘴在室内形成细小的液体，气体扩散到该液体中，以产生气体过饱和流体，其通过出口被去除。去除的气体过饱和流体与液体至液体氧合装置内的血液混合以形成用于输送给患者的含氧血液。或者，血液可以由泵提供给高压中空纤维或其它类型的膜氧合器，其中氧气扩散通过膜并进入血液以形成氧合血液，再次输送到患者或其他部位。

6. 发明授权

US06676900B1 Method for the preparation and delivery of gas-enriched fluids 失效
标题翻译：用于制备和输送富含气体的流体的方法
公开(公告)号：US06676900B1
公开(公告)日：2004-01-13
申请号：US09699751
申请日：2000-10-30
申请人： Vincent Divino, Jr. , Seth A. Foerster , James M. Gessert , Robert A. Mest , Paul J. Zalesky , James Richard Spears
发明人： Vincent Divino, Jr. , Seth A. Foerster , James M. Gessert , Robert A. Mest , Paul J. Zalesky , James Richard Spears
IPC分类号： A61M136
CPC分类号： C01B13/02 , A61M1/1678 , A61M1/1698 , A61M1/32 , A61M1/3603 , A61M1/361 , A61M1/3612 , A61M1/3613 , A61M1/3621 , A61M1/3626 , A61M25/007 , A61M25/09 , A61M2025/0036 , A61M2025/0037 , A61M2025/004 , A61M2202/0476 , Y10S261/28 , A61M2202/0007
摘要： A gas-enriched fluid is provided by the combination of a first fluid, such as a patient's blood, with a second gas-supersaturated fluid, such as an oxygen supersaturated fluid. In this example, a catheter assembly includes a portion that receives the patient's blood from a pump and that receives the oxygen supersaturated fluid from an appropriate fluid source. The oxygen supersaturated fluid is advantageously combined with the blood in an area of laminar flow, and then this gas-enriched fluid is delivered to the patient through an appropriate lumen coupled to the portion of the catheter assembly.
摘要翻译：通过第一流体（例如患者血液）与第二气体过饱和流体（例如氧过饱和流体）的组合来提供富气体流体。在该示例中，导管组件包括从泵接收患者血液并从适当的流体源接收氧过饱和流体的部分。氧过饱和流体有利地在层流区域中与血液组合，然后将该富含气体的流体通过耦合到导管组件的该部分的适当内腔递送至患者。

7. 发明授权

US06630107B1 Blood pumping equipment for extracorporeal circulation and ventricular assistance 失效
标题翻译：抽血设备用于体外循环和心室辅助
公开(公告)号：US06630107B1
公开(公告)日：2003-10-07
申请号：US09428906
申请日：1999-10-28
申请人： Salvador Merce Vives
发明人： Salvador Merce Vives
IPC分类号： A61M136
CPC分类号： A61M1/302 , A61M1/1006 , A61M1/1049 , A61M1/1081 , A61M1/1087 , A61M1/1096 , A61M1/32
摘要： The equipment comprises an impulsion pump (5-5′) with a displaceable piston (7), that adopts a bellows shape, located in the inside of the same, the chamber of the pump receiving the patient's venous blood from a reservoir (4). In the communication (16) between the reservoir and the chamber a float valve (17) has been provided for, a valve that closes the passage when the piston (7) impels the blood through a nozzle (15), passing through a valve (22), then through a heat exchanger (28) and then through an oxygenator (29) from which the oxygenated blood is sent once again to the patient. The shaft (9) of the nozzle (7) is operated by a mechanism (14) that transforms the rotating and alternate movements of a servomotor (12) into linear movements, the operation of this servomotor (12) being controllable by means of a computerized console, permitting a pulsatile blood flow to be provided with adjustable flow and frequency. The equipment forms a disposable fungible unit, used to substitute the pumping action of the heart of a patient, when he is subjected to heart surgery or ventricular assistance.
摘要翻译：该设备包括具有位移活塞（7）的冲击泵（5-5'），其采用位于其内部的波纹管形状，泵的腔室从储存器（4）接收患者的静脉血，。在储存器和腔室之间的连通（16）中，已经设置有浮阀（17），用于当活塞（7）通过喷嘴（15）推动血液通过阀（ 22），然后通过热交换器（28），然后通过氧合器（29），再次将氧合血液再次发送给患者。喷嘴（7）的轴（9）由将伺服电动机（12）的旋转和交替运动转换为线性运动的机构（14）操作，该伺服电机（12）的操作可通过计算机控制台，允许脉动血流被提供可调的流量和频率。该设备形成一次性可替换单元，用于替代患者心脏的泵送动作，当他进行心脏手术或心室辅助时。

8. 发明授权

US06596235B2 Method for blood oxygenation 失效
公开(公告)号：US06596235B2
公开(公告)日：2003-07-22
申请号：US09778433
申请日：2001-02-07
申请人： Vincent Divino, Jr. , Paul J. Zalesky , William R. Patterson
发明人： Vincent Divino, Jr. , Paul J. Zalesky , William R. Patterson
IPC分类号： A61M136
CPC分类号： A61M1/1698 , A61M1/3613 , A61M2202/0476 , B01F3/04758
摘要： An apparatus and method for blood oxygenation is provided, advantageously comprising an extracorporeal circuit for the preparation and delivery of hyperoxic or hyperbaric blood. In one embodiment, an apparatus for gas-supersaturating fluids, e.g., physiologic saline, includes a chamber having a first inlet to receive the fluid; a second inlet to receive a gas, e.g., oxygen, from a gas supply that maintains pressure within the chamber at a predetermined level, advantageously about 600 p.s.i.; and an outlet advantageously coupled to a capillary assembly. An atomizer nozzle coupled to the first inlet advantageously creates within the chamber fine droplets of fluid into which gas diffuses to create the gas-supersaturated fluid, which collects within the chamber below the atomizer nozzle for removal via the outlet. The removed gas-supersaturated fluid mixes with blood provided by a blood pump, the mixing occurring within a liquid-to-liquid oxygenation assembly including a pressurizable chamber having inlets for the gas-supersaturated fluid and blood, the inlets advantageously arranged to create a vortical or cyclonic fluid flow within the chamber to promote mixing. The mixed fluid exits the chamber via an outlet for delivery to a patient (e.g., sub-selective delivery) or other site via a catheter, infusion guidewire, or other interventional fluid delivery device, the mixed fluid advantageously comprising blood having increased oxygen levels, i.e., oxygenated blood. Alternately, the blood may be provided by the pump to a high pressure hollow fiber or other type membrane oxygenator within which oxygen, advantageously provided at a pressure greater than atmospheric, diffuses across the membrane(s) and into the blood to form oxygenated blood, again for delivery to a patient or other site. Advantageously, the oxygenated blood is delivered at a target pO2 greater than about 760 mm Hg and is delivered from the liquid-to-liquid oxygenation assembly or membrane oxygenator via a fluid conduit having an approximate pressure drop greater than the target pO2.

9. 发明授权

US06730266B2 Hemofiltration systems, methods and devices used to treat inflammatory mediator related disease 有权
标题翻译：用于治疗炎症介质相关疾病的血液滤过系统，方法和装置
公开(公告)号：US06730266B2
公开(公告)日：2004-05-04
申请号：US09912904
申请日：2001-07-25
申请人： James R. Matson , Patrice A. Lee
发明人： James R. Matson , Patrice A. Lee
IPC分类号： A61M136
CPC分类号： A61M1/3472 , A61M1/3437 , A61M1/3475 , A61M1/3486
摘要： A hemofiltration system for a mammal is provided with a hemofilter and an adsorbent device. The hemofilter removes ultrafiltrate from a blood stream extracted from the mammal to create a filtered blood stream and an ultrafiltrate stream. The adsorbent device has one or more adsorbent materials and is used to adsorb inflammatory mediators from the ultrafiltrate stream received from the hemofilter removing inflammatory mediators that cause inflammatory mediator related disease, sepsis, and SIRS/MODS/MOSF to create a post adsorption ultrafiltrate stream. The post adsorption ultrafiltrate stream is selectively combined with the filtered blood stream and together with the filtered blood stream is returned to the mammal.
摘要翻译：用于哺乳动物的血液滤过系统设置有血液滤器和吸附装置。血液滤器从从哺乳动物提取的血流中除去超滤，以产生经过滤的血流和超滤液。吸附剂装置具有一种或多种吸附剂材料，并且用于从引起炎症介质相关疾病，败血症和SIRS / MODS / MOSF的血液滤过器除去炎症介质的超滤液物流中吸附炎症介质以产生吸附后的超滤液流。选择性将后吸附超滤液物流与经过滤的血液流合并，并将经过滤的血流返回哺乳动物。

10. 发明授权

US06673314B1 Interactive systems and methods for supporting hemofiltration therapies 有权
标题翻译：用于支持血液滤过疗法的交互式系统和方法
公开(公告)号：US06673314B1
公开(公告)日：2004-01-06
申请号：US09513771
申请日：2000-02-25
申请人： Jeffrey H. Burbank , Dennis M. Treu , Barry N. Fulkerson , Steven A. White
发明人： Jeffrey H. Burbank , Dennis M. Treu , Barry N. Fulkerson , Steven A. White
IPC分类号： A61M136
CPC分类号： A61M1/342 , A61M1/1639 , A61M1/34 , A61M1/3403 , A61M1/341 , A61M1/3441 , A61M1/3444 , A61M1/3448 , A61M1/3458 , A61M1/36 , A61M1/361 , A61M1/3612 , A61M1/3626 , A61M1/3639 , A61M1/3646 , A61M1/367 , A61M39/0208 , A61M2205/126 , A61M2205/128 , A61M2205/15 , A61M2205/3331 , A61M2205/3334 , A61M2205/35 , A61M2205/3553 , A61M2205/3569 , A61M2205/502 , A61M2205/505 , A61M2205/60 , A61M2205/6018 , A61M2205/6072 , Y10S128/92 , Y10S210/929
摘要： A hemofiltration machine at a local treatment site is linked to a remote main data base server by a local transmitting/receiving device. The machine acts as a satellite of the main data base server. The machine performs specified therapy tasks while monitoring basic safety functions and providing the person at the treatment location notice of safety alarm conditions for resolution. Otherwise, the machine transmits procedure data to the main data base server. The main data base server relieves the machine from major data processing tasks and related complexity. The main data base server, remote from the machine, controls the processing and distribution of the data, including the flow of information and data to the person undergoing therapy.
摘要翻译：本地治疗部位的血液滤过机通过本地发送/接收装置连接到远程主数据库服务器。该机器作为主数据库服务器的卫星。机器执行指定的治疗任务，同时监视基本的安全功能，并在治疗位置的人员通知安全警报条件以进行解决。否则，机器将过程数据发送到主数据库服务器。主要数据库服务器可以减轻主机数据处理任务和相关复杂性。远离机器的主要数据库服务器控制数据的处理和分发，包括向正在接受治疗的人员提供的信息和数据流。

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