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1. 发明申请

US20050176626A1 Genes differentially expressed by acutely isolated resident progenitor cells of the human white matter 审中-公开
标题翻译：由人类白质的急性分离的宿主祖细胞差异表达的基因
公开(公告)号：US20050176626A1
公开(公告)日：2005-08-11
申请号：US10985306
申请日：2004-11-10
申请人： Steven Goldman , Fraser Sim
发明人： Steven Goldman , Fraser Sim
IPC分类号： A61K20060101 , A61K31/737 , A61K38/17 , G01N33/68
CPC分类号： A61K31/555 , A61K31/737 , G01N33/6896 , G01N2500/00 , G01N2800/28
摘要： The present invention relates to a method of modulating production of neurons and/or oligodendrocytes from neural progenitor cells of human white matter and to a method of treating a subject for a condition modulated by underproduction of oligodendrocytes from human white matter. Both of these methods involve administering an agonist or antagonist of one or more molecules set forth in Tables 1 and/or 2 to the neural progenitor cells. Also disclosed is a method of using an inhibitor of sterol synthesis to differentiate oligodendrocyte progenitor cells to oligodendrocytes.
摘要翻译：本发明涉及一种从人类白质神经祖细胞调节神经元和/或少突胶质细胞的产生的方法，以及一种治疗受试者由人类白质不足生成少突胶质细胞调节的病症的方法。这两种方法都涉及向神经祖细胞施用表1和/或2所示的一种或多种分子的激动剂或拮抗剂。还公开了使用甾醇合成抑制剂将少突胶质细胞祖细胞分化为少突胶质细胞的方法。

2. 发明申请

US20060166887A1 Method of inducing neuronal production in the brain and spinal cord 有权
公开(公告)号：US20060166887A1
公开(公告)日：2006-07-27
申请号：US11392020
申请日：2006-03-29
申请人： Steven Goldman , Abdellatif Benraiss
发明人： Steven Goldman , Abdellatif Benraiss
IPC分类号： A61K38/18
CPC分类号： A61K48/00 , A61K38/185 , C12N2799/021
摘要： The present invention relates to methods of inducing neuronal production in the brain, recruiting neurons to the brain, and treating a neurodegenerative condition by providing a nucleic acid construct encoding a neurotrophic factor, and injecting the nucleic acid construct intraventricularly into a subject's brain.

3. 发明授权

US08399518B2 Administration of 3,5-diiodothyropropionic acid for stimulating weight loss, and/or lowering triglyceride levels, and/or treatment of metabolic syndrome 失效
标题翻译：施用3,5-二碘丙酸以刺激体重减轻和/或降低甘油三酯水平和/或治疗代谢综合征
公开(公告)号：US08399518B2
公开(公告)日：2013-03-19
申请号：US12596818
申请日：2008-02-27
申请人： Eugene Morkin , Louis R. Bucalo , Steven Goldman
发明人： Eugene Morkin , Louis R. Bucalo , Steven Goldman
IPC分类号： A61K31/19 , C07C65/00 , C07C229/00
CPC分类号： A61K31/42
摘要： Methods and compositions are disclosed for stimulating weight loss and/or lowering triglyceride levels in an individual mammal in need thereof. In an exemplary method, a pharmaceutical composition comprising a therapeutically effective amount of DITPA, and optionally one or more lipid-reducing agents, is administered to an individual mammal to stimulate weight loss, and/or reduce levels of triglyceride and/or lipoprotein in the mammal.
摘要翻译：公开了用于刺激有需要的个体哺乳动物体重减轻和/或降低甘油三酯水平的方法和组合物。在一个示例性方法中，将包含治疗有效量的DITPA和任选的一种或多种降脂剂的药物组合物施用于个体哺乳动物以刺激体重减轻和/或降低甘油三酯和/或脂蛋白的水平哺乳动物。

4. 发明申请

US20110059055A1 TREATING MYELIN DISEASES WITH OPTIMIZED CELL PREPARATIONS 有权
标题翻译：用优化的细胞制备治疗甲状腺疾病
公开(公告)号：US20110059055A1
公开(公告)日：2011-03-10
申请号：US12990874
申请日：2009-05-07
申请人： Steven Goldman , Fraser J. Sim
发明人： Steven Goldman , Fraser J. Sim
IPC分类号： A61K35/30 , A61P25/00 , A61P27/02 , C12Q1/02 , C12N5/00 , G01N33/567 , C12N15/63
CPC分类号： A61K35/30 , A61K35/12 , C07K14/70596 , C12N5/0622 , C12N5/0623 , C12N9/1276 , G01N33/5058
摘要： The disclosure relates to oligodendrocyte-biased glial progenitor cells and methods of making, isolating, and using such cells.
摘要翻译：本公开涉及少突胶质细胞偏向胶质祖细胞及其制备，分离和使用方法。

5. 发明申请

US20100249235A1 ADMINISTRATION OF 3,5-DIIODOTHYROPROPIONIC ACID FOR STIMULATING WEIGHT LOSS, AND/OR LOWERING TRIGLYCERIDE LEVELS, AND/OR TREATMENT OF METABOLIC SYNDROME 失效
标题翻译：用于刺激重量损失和/或降低TRIGLYCERIDE水平和/或治疗代谢综合征的3,5-二碘丙酸的施用
公开(公告)号：US20100249235A1
公开(公告)日：2010-09-30
申请号：US12596818
申请日：2008-02-27
申请人： Eugene Morkin , Louis R. Bucalo , Steven Goldman
发明人： Eugene Morkin , Louis R. Bucalo , Steven Goldman
IPC分类号： A61K31/192 , A61P3/04
CPC分类号： A61K31/42
摘要： The invention provides methods and compositions for stimulating weight loss or lowering triglyceride levels in an individual in need thereof. In methods of the invention, a pharmaceutical composition comprising a therapeutically effective amount of DITPA, and optionally one or a plurality of lipid lowering agents, is administered to an individual to stimulate weight loss, lower triglyceride and/or lipoprotein levels, and/or to treat one or more symptoms of metabolic syndrome.
摘要翻译：本发明提供用于在有需要的个体中刺激体重减轻或降低甘油三酯水平的方法和组合物。在本发明的方法中，向个体施用包含治疗有效量的DITPA和任选的一种或多种降脂剂的药物组合物，以刺激体重减轻，降低甘油三酯和/或脂蛋白水平，和/或治疗代谢综合征的一种或多种症状。

6. 发明申请

US20060171927A1 Method of inducing neuronal production in the brain and spinal cord 有权
公开(公告)号：US20060171927A1
公开(公告)日：2006-08-03
申请号：US11397036
申请日：2006-04-03
申请人： Steven Goldman , Abdellatif Benraiss
发明人： Steven Goldman , Abdellatif Benraiss
IPC分类号： A61K48/00
CPC分类号： A61K48/00 , A61K38/185 , C12N2799/021
摘要： The present invention relates to methods of inducing neuronal production in the brain, recruiting neurons to the brain, and treating a neurodegenerative condition by providing a nucleic acid construct encoding a neurotrophic factor, and injecting the nucleic acid construct intraventricularly into a subject's brain.

7. 发明申请

US20050164975A1 Purine receptor inhibition as a therapeutic strategy in spinal cord and brain 有权
标题翻译：嘌呤受体抑制作为脊髓和脑中的治疗策略
公开(公告)号：US20050164975A1
公开(公告)日：2005-07-28
申请号：US10979526
申请日：2004-11-02
申请人： Maiken Nedergaard , Steven Goldman
发明人： Maiken Nedergaard , Steven Goldman
IPC分类号： A61K20060101 , A61K31/33 , A61K31/47 , A61K31/496 , A61K31/4965 , A61K31/655 , A61K31/7076
CPC分类号： A61K31/33 , A61K31/47
摘要： The present invention is directed to a method of treating a subject with acute spinal cord injury by administering a purine receptor antagonist to the subject under conditions effective to treat spinal cord injury. The purine receptor antagonist inhibits P2X purine receptor activation. The inhibition of P2X purine receptor activation can also be used in conjunction with methods of treating a subject with spinal cord ischemia resulting from stroke or vascular insult, interruption, or mechanical injury, treating a subject with ischemic or traumatic insults of brain tissue in regions expressing P2X receptors, and for inhibiting ATP-triggered brain or spinal cord cell death.
摘要翻译：本发明涉及通过在有效治疗脊髓损伤的条件下向受试者施用嘌呤受体拮抗剂来治疗患有急性脊髓损伤的受试者的方法。嘌呤受体拮抗剂抑制P2X嘌呤受体活化。 P2X嘌呤受体活化的抑制也可以与由中风或血管损伤，中断或机械损伤引起的脊髓缺血治疗受试者的方法一起使用，在表达的区域中治疗脑组织的缺血性或创伤性损伤的受试者 P2X受体，并用于抑制ATP触发的脑或脊髓细胞死亡。

8. 发明申请

US20050129672A1 Regulatory sequences that direct gene expression to spinal motor neurons and uses thereof 有权
标题翻译：将基因表达引导到脊髓运动神经元的调节序列及其用途
公开(公告)号：US20050129672A1
公开(公告)日：2005-06-16
申请号：US10984406
申请日：2004-11-09
申请人： Steven Goldman , Takahiro Nakano
发明人： Steven Goldman , Takahiro Nakano
IPC分类号： A01K67/027 , A61K48/00 , C07H21/04 , C12N5/08 , C12N15/85 , C12N15/86
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2217/05 , A01K2227/105 , C12N2830/008
摘要： The present invention relates to an enhancer which functions only in human brain and/or spinal cord motor neurons, where the enhancer comprises a nucleotide sequence of SEQ ID NO: 5, SEQ ID NO: 10, or SEQ ID NO: 16. The enhancer can be utilized as part of a nucleic acid construct which also has a nucleic acid encoding a marker protein or a therapeutic protein, a 3′ control region, and, optionally, a basal promoter, where these components are positioned with respect to one another to permit expression of the marker protein or the therapeutic protein. The enhancer of the present invention is useful in a method of isolating an enriched or purified population of motor neurons from a mixed population of human brain and/or spinal cells. In addition, the enhancer of the present invention can be used in a method of therapeutically targeting motor neurons.
摘要翻译：本发明涉及仅在人脑和/或脊髓运动神经元中起作用的增强子，其中增强子包含SEQ ID NO：5，SEQ ID NO：10或SEQ ID NO：16的核苷酸序列。增强子可以用作核酸构建体的一部分，其还具有编码标记蛋白或治疗性蛋白质的核酸，3'对照区域和任选的基础启动子，其中这些组分相对于彼此定位至允许标记蛋白或治疗性蛋白质的表达。本发明的增强剂可用于从人脑和/或脊髓细胞的混合群体中分离富集或纯化的运动神经元群体的方法。此外，本发明的增强剂可以用于治疗靶向运动神经元的方法。

9. 发明申请

US20090076151A1 METHOD FOR STIMULATING WEIGHT LOSS AND/OR FOR LOWERING TRIGLYCERIDES IN PATIENTS 审中-公开
标题翻译：刺激重量损失和/或用于降低患者中TRIGLYCERID的方法
公开(公告)号：US20090076151A1
公开(公告)日：2009-03-19
申请号：US12323405
申请日：2008-11-25
申请人： Eugene MORKIN , Cynthia Ruth Adamson , Steven Goldman
发明人： Eugene MORKIN , Cynthia Ruth Adamson , Steven Goldman
IPC分类号： A61K31/197 , A61P3/04
CPC分类号： A61K31/192 , A61K9/4866 , A61K9/7023 , A61K31/195 , A61K31/198
摘要： Administration of a therapeutically effective amount of 3,5-diiodothyropropionic acid stimulates weight loss in patients, lowers triglyceride levels and reduces risk of death or progression of coronary heart disease in patients with metabolic syndrome.
摘要翻译：施用治疗有效量的3,5-二碘丙酸可刺激患者的体重减轻，降低甘油三酯水平，降低代谢综合征患者冠心病死亡或进展的风险。

10. 发明申请

US20050003544A1 Enriched or purified population of motor neurons and its preparation from a population of embryonic stem cells 有权
标题翻译：丰富或纯化的运动神经元群体及其从胚胎干细胞群体的制备
公开(公告)号：US20050003544A1
公开(公告)日：2005-01-06
申请号：US10865637
申请日：2004-06-10
申请人： Steven Goldman , Neeta Roy , Takahiro Nakano
发明人： Steven Goldman , Neeta Roy , Takahiro Nakano
IPC分类号： C12N5/0793 , C12N15/87 , C12N5/08 , C12N15/88
CPC分类号： C12N5/0619 , C12N2501/13 , C12N2501/385 , C12N2501/41 , C12N2502/1335 , C12N2506/02
摘要： The present invention is directed to a method of isolating an enriched or purified population of motor neurons from a population of embryonic stem cells. This method involves providing a population of embryonic stem cells and selecting a promoter or enhancer which functions only in the motor neurons selected. A nucleic acid molecule encoding a marker protein under control of the promoter or enhancer is introduced into the induced population of embryonic stem cells. The motor neurons are allowed to express the marker protein and, the cells expressed in the marker protein are separated from the population of embryonic stem cells. The population of embryonic stem cells can be induced to produce a mixed population of cells comprising motor neurons before or after a nucleic acid molecule encoding the marker protein under control of the promoter enhancer is introduced into the population of embryonic stem cells. As a result, an enriched or purified population of motor neurons is isolated.
摘要翻译：本发明涉及从胚胎干细胞群中分离富集或纯化的运动神经元群体的方法。该方法涉及提供胚胎干细胞群并选择仅在选择的运动神经元中起作用的启动子或增强子。将编码在启动子或增强子控制下的标记蛋白的核酸分子引入诱导的胚胎干细胞群中。允许运动神经元表达标记蛋白，并将标记蛋白中表达的细胞与胚胎干细胞群体分离。在将启动子增强子控制的编码标记蛋白的核酸分子引入胚胎干细胞群体之前或之后，可以诱导胚胎干细胞的群体产生包含运动神经元的混合细胞群。结果，分离富集或纯化的运动神经元群体。

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