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1. 发明申请

US20050181503A1 Purines are self-renewal signals for neural stem cells, and purine receptor antagonists promote neuronal and glial differentiation therefrom 有权
标题翻译：嘌呤是神经干细胞的自我更新信号，嘌呤受体拮抗剂促进神经元和胶质细胞分化
公开(公告)号：US20050181503A1
公开(公告)日：2005-08-18
申请号：US11054919
申请日：2005-02-10
申请人： Steven Goldman , Maiken Nedergaard , Jane Lin
发明人： Steven Goldman , Maiken Nedergaard , Jane Lin
IPC分类号： C12N5/0797 , C12N5/08
CPC分类号： C12N5/0623 , C12N2500/40 , C12N2501/999
摘要： The present invention relates to a method of inhibiting differentiation of a population of neural stem cells by contacting a purinergic receptor agonist and a population of neural stem cells under conditions effective to inhibit differentiation of the population of neural stem cells. Another aspect of the present invention relates to a method of producing neurons and/or glial cells from a population of neural stem cells by culturing a population of neural stem cells with a purinergic receptor antagonist under conditions effective to cause the neural stem cells to differentiate into neurons and/or glial cells. The purinergic receptor agonist can also be used in a method of inducing proliferation and self-renewal of neural stem cells in a subject and a method of treating a neurological disease or neurodegenerative condition in a subject. The purinergic receptor antagonist can also be used in treating a neoplastic disease of the brain or spinal cord in a subject.
摘要翻译：本发明涉及通过在有效抑制神经干细胞群分化的条件下使嘌呤能受体激动剂和神经干细胞群接触来抑制神经干细胞群体的分化的方法。本发明的另一方面涉及通过在有效地使神经干细胞分化成为的神经干细胞的条件下用嘌呤能受体拮抗剂培养一群神经干细胞来从神经干细胞群体产生神经元和/或神经胶质细胞的方法神经元和/或神经胶质细胞。嘌呤能受体激动剂也可用于诱导受试者中神经干细胞的增殖和自我更新的方法以及治疗受试者神经疾病或神经变性病症的方法。嘌呤能受体拮抗剂也可用于治疗受试者中脑或脊髓的肿瘤性疾病。

2. 发明申请

US20050112109A1 Discovery, localization, harvest, and propagation of an FGF2 and BDNF-responsive population of neural and neuronal progenitor cells in the adult human forebrain 审中-公开
标题翻译： FGF2和BDNF反应群体的神经和神经元祖细胞在成年人前脑中的发现，定位，收获和繁殖
公开(公告)号：US20050112109A1
公开(公告)日：2005-05-26
申请号：US10969896
申请日：2004-10-21
申请人： Steven Goldman , Maiken Nedergaard
发明人： Steven Goldman , Maiken Nedergaard
IPC分类号： A61K35/12 , A61K48/00 , C12N5/02 , C12N5/0797 , C12Q1/00 , C12N5/08 , C12N15/86 , C12N15/88
CPC分类号： C12N5/0623 , A61K35/12 , A61K48/00 , C12N2501/105 , C12N2501/115 , C12N2501/13 , C12N2510/00
摘要： The present invention provides neuronal progenitor cells which have been identified in histological sections of the adult human brain. The present invention also provides methods to localize, characterize, harvest, and propagate neuronal progenitor cells derived from human brain tissue. Additional methods are provided for introducing and expressing genes in the brain.
摘要翻译：本发明提供已经在成人人脑的组织切片中鉴定的神经元祖细胞。本发明还提供了定位，表征，收获和繁殖衍生自人脑组织的神经元祖细胞的方法。提供用于在脑中引入和表达基因的其它方法。

3. 发明申请

US20050164975A1 Purine receptor inhibition as a therapeutic strategy in spinal cord and brain 有权
标题翻译：嘌呤受体抑制作为脊髓和脑中的治疗策略
公开(公告)号：US20050164975A1
公开(公告)日：2005-07-28
申请号：US10979526
申请日：2004-11-02
申请人： Maiken Nedergaard , Steven Goldman
发明人： Maiken Nedergaard , Steven Goldman
IPC分类号： A61K20060101 , A61K31/33 , A61K31/47 , A61K31/496 , A61K31/4965 , A61K31/655 , A61K31/7076
CPC分类号： A61K31/33 , A61K31/47
摘要： The present invention is directed to a method of treating a subject with acute spinal cord injury by administering a purine receptor antagonist to the subject under conditions effective to treat spinal cord injury. The purine receptor antagonist inhibits P2X purine receptor activation. The inhibition of P2X purine receptor activation can also be used in conjunction with methods of treating a subject with spinal cord ischemia resulting from stroke or vascular insult, interruption, or mechanical injury, treating a subject with ischemic or traumatic insults of brain tissue in regions expressing P2X receptors, and for inhibiting ATP-triggered brain or spinal cord cell death.
摘要翻译：本发明涉及通过在有效治疗脊髓损伤的条件下向受试者施用嘌呤受体拮抗剂来治疗患有急性脊髓损伤的受试者的方法。嘌呤受体拮抗剂抑制P2X嘌呤受体活化。 P2X嘌呤受体活化的抑制也可以与由中风或血管损伤，中断或机械损伤引起的脊髓缺血治疗受试者的方法一起使用，在表达的区域中治疗脑组织的缺血性或创伤性损伤的受试者 P2X受体，并用于抑制ATP触发的脑或脊髓细胞死亡。

4. 发明申请

US20130005676A1 ENHANCING THE THERAPEUTIC EFFECT OF ACUPUNCTURE WITH ADENOSINE 审中-公开
标题翻译：提高针刺治疗腺苷的疗效
公开(公告)号：US20130005676A1
公开(公告)日：2013-01-03
申请号：US13511801
申请日：2010-11-24
申请人： Maiken Nedergaard
发明人： Maiken Nedergaard
IPC分类号： A61K31/7076 , A61K31/7056 , A61P19/02 , A61P25/00 , A61P29/00
CPC分类号： A61K31/52 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a method of improving the therapeutic effect of acupuncture in a subject. The method involves administering adenosine, an adenosine mimetric, an adenosine modulator, an adenosine transport inhibitor, enzymes involved in adenosine metabolism, and/or an adenosine receptor agonist to the subject under conditions effective to improve the therapeutic effect of the acupuncture.
摘要翻译：本发明涉及一种改善针灸对象的治疗效果的方法。该方法包括在有效改善针灸治疗效果的条件下，对受试者施用腺苷，腺苷比计，腺苷调节剂，腺苷转运抑制剂，参与腺苷代谢的酶和/或腺苷受体激动剂。

5. 发明申请

US20150202215A1 METHOD OF TREATING AND PREVENTING BRAIN IMPAIRMENT USING Na+-K+-2Cl- COTRANSPORTER ISOFORM 1 INHIBITORS 有权
标题翻译：使用Na + -K + -2Cl- COTRANSPORTER ISOFORM 1抑制剂治疗和预防脑损伤的方法
公开(公告)号：US20150202215A1
公开(公告)日：2015-07-23
申请号：US14415968
申请日：2013-03-15
申请人： Maiken Nedergaard , Alexander Stanley Thrane , Vinita Rangroo Thrane
发明人： Maiken Nedergaard , Alexander Stanley Thrane , Vinita Rangroo Thrane
IPC分类号： A61K31/635 , A61K31/402 , A61K31/454 , A61K31/44 , A61K31/4152 , A61K31/18 , A61K31/196 , A61K31/192
CPC分类号： A61K31/635 , A61K31/18 , A61K31/192 , A61K31/196 , A61K31/341 , A61K31/402 , A61K31/4035 , A61K31/41 , A61K31/4152 , A61K31/44 , A61K31/454
摘要： The disclosure relates to a method of treating and/or preventing brain impairment in a subject that has or is susceptible to ammonia neurotoxicity (increased plasma ammonia), by administering a Na-; —K+-2CI- cotransporter isoform 1 (“NKCC1”) inhibitor to the selected subject under conditions effective to treat and/or prevent brain impairment. The disclosure further relates to methods of maintaining the fundamental function of astrocytic potassium buffering and inhibiting accumulation of potassium star rounding astrocytes, both of which involve contacting astrocytes with a NKCC 1 inhibitor.
摘要翻译：本公开涉及通过施用Na-，治疗和/或预防患有氨神经毒性或增加血浆氨的受试者的脑损伤的方法。 -K + -2CI-转运蛋白同种型1（“NKCC1”）抑制剂在有效治疗和/或预防脑损伤的条件下与所选受试者接触。本公开还涉及维持星形细胞钾缓冲的基本功能并抑制钾星形星形胶质细胞的积累的方法，这两者都涉及使星形胶质细胞与NKCC1抑制剂接触。

6. 发明授权

US07923448B2 Purine receptor inhibition as a therapeutic strategy in spinal cord and brain 有权
标题翻译：嘌呤受体抑制作为脊髓和脑中的治疗策略
公开(公告)号：US07923448B2
公开(公告)日：2011-04-12
申请号：US10979526
申请日：2004-11-02
申请人： Maiken Nedergaard , Steven A. Goldman
发明人： Maiken Nedergaard , Steven A. Goldman
IPC分类号： A61K31/497 , A61K31/4965 , A61K31/70 , A01N43/04
CPC分类号： A61K31/33 , A61K31/47
摘要： The present invention is directed to a method of treating a subject with acute spinal cord injury by administering a purine receptor antagonist to the subject under conditions effective to treat spinal cord injury. The purine receptor antagonist inhibits P2X purine receptor activation. The inhibition of P2X purine receptor activation can also be used in conjunction with methods of treating a subject with spinal cord ischemia resulting from stroke or vascular insult, interruption, or mechanical injury, treating a subject with ischemic or traumatic insults of brain tissue in regions expressing P2X receptors, and for inhibiting ATP-triggered brain or spinal cord cell death.
摘要翻译：本发明涉及通过在有效治疗脊髓损伤的条件下向受试者施用嘌呤受体拮抗剂来治疗患有急性脊髓损伤的受试者的方法。嘌呤受体拮抗剂抑制P2X嘌呤受体活化。 P2X嘌呤受体活化的抑制也可以与由中风或血管损伤，中断或机械损伤引起的脊髓缺血治疗受试者的方法一起使用，在表达的区域中治疗脑组织的缺血性或创伤性损伤的受试者 P2X受体，并用于抑制ATP触发的脑或脊髓细胞死亡。

7. 发明授权

US09616075B2 Method of treating and preventing brain impairment using Na+-K+-2Cl-cotransporter isoform 1 inhibitors 有权
公开(公告)号：US09616075B2
公开(公告)日：2017-04-11
申请号：US14415968
申请日：2013-03-15
申请人： Maiken Nedergaard , Alexander Stanley Thrane , Vinita Rangroo Thrane
发明人： Maiken Nedergaard , Alexander Stanley Thrane , Vinita Rangroo Thrane
IPC分类号： A61K31/18 , A61K31/4152 , A61K31/454 , A61K31/635 , A61K31/192 , A61K31/44 , A61K31/196 , A61K31/4035 , A61K31/341 , A61K31/402 , A61K31/41
CPC分类号： A61K31/635 , A61K31/18 , A61K31/192 , A61K31/196 , A61K31/341 , A61K31/402 , A61K31/4035 , A61K31/41 , A61K31/4152 , A61K31/44 , A61K31/454
摘要： The disclosure relates to a method of treating and/or preventing brain impairment in a subject that has or is susceptible to ammonia neurotoxicity (increased plasma ammonia), by administering a Na-; —K+-2CI- cotransporter isoform 1 (“NKCC1”) inhibitor to the selected subject under conditions effective to treat and/or prevent brain impairment. The disclosure further relates to methods of maintaining the fundamental function of astrocytic potassium buffering and inhibiting accumulation of potassium star rounding astrocytes, both of which involve contacting astrocytes with a NKCC 1 inhibitor.

8. 发明申请

US20100284984A1 ADENOSINE AND ITS MIMETICS. MODULATORS, TRANSPORT INHIBITORS, AND RECEPTOR AGONISTS AS A THERAPEUTIC TOOL TO REPLACE OR IMPROVE THE EFFICACY OF DEEP BRAIN STIMULATION 审中-公开
标题翻译：腺苷及其物质。调节剂，运输抑制剂和受体激动剂作为治疗剂替代或改善深层脑刺激的效果
公开(公告)号：US20100284984A1
公开(公告)日：2010-11-11
申请号：US12671437
申请日：2008-07-29
申请人： Maiken Nedergaard
发明人： Maiken Nedergaard
IPC分类号： A61K38/43 , A61K31/7076 , A61K38/02 , A61K31/7088 , A61P25/16 , A61P25/28 , A61P25/08
CPC分类号： A61K31/7076 , A61N1/36082
摘要： The present invention relates to a method of enhancing brain stimulation of a subject. This method involves selecting a subject in need of brain stimulation and electrically stimulating the brain of the subject. Adenosine, an adenosine mimetic, an adenosine modulator, an adenosine transport inhibitor, or an adenosine receptor agonist are administered to the subject under conditions effective to enhance electrical stimulation of the brain of the subject. The administration of adenosine, an adenosine mimetic, an adenosine modulator, an adenosine transport inhibitor, or an adenosine receptor agonist to the subject can alternatively be carried out with electrically stimulating the brain of the subject.
摘要翻译：本发明涉及增强受试者脑刺激的方法。该方法涉及选择需要脑刺激并电刺激受试者脑部的受试者。腺苷，腺苷模拟物，腺苷调节剂，腺苷转运抑制剂或腺苷受体激动剂在有效增强受试者脑的电刺激的条件下给予受试者。对受试者的腺苷，腺苷模拟物，腺苷调节剂，腺苷转运抑制剂或腺苷受体激动剂的给药也可以用电刺激受试者的脑来进行。

9. 发明申请

US20070135413A1 TREATMENT OF GLIAL TUMORS WITH GLUTAMATE ANTAGONISTS 审中-公开
标题翻译：用谷氨酸拮抗剂治疗眼部肿瘤
公开(公告)号：US20070135413A1
公开(公告)日：2007-06-14
申请号：US11625674
申请日：2007-01-22
申请人： Maiken Nedergaard
发明人： Maiken Nedergaard
IPC分类号： A61K31/55 , A61K31/498 , A61K31/495 , A61K31/5513
CPC分类号： A61K31/4747 , A61K31/00 , A61K31/136
摘要： The present invention relates to a method of treating glial tumors in a subject, which includes providing a glutamate antagonist or a NMDA receptor antagonist and administering the glutamate antagonist or NMDA receptor antagonist to a subject with a glial tumor of the brain or spinal cord under conditions effective to treat the glial tumor.
摘要翻译：本发明涉及一种治疗受试者的神经胶质瘤的方法，其包括提供谷氨酸拮抗剂或NMDA受体拮抗剂，并且在条件下给予具有脑或脊髓胶质瘤的受试者的谷氨酸拮抗剂或NMDA受体拮抗剂有效治疗胶质瘤。

10. 发明授权

US07829332B2 Purines are self-renewal signals for neural stem cells, and purine receptor antagonists promote neuronal and glial differentiation therefrom 有权
标题翻译：嘌呤是神经干细胞的自我更新信号，嘌呤受体拮抗剂促进神经元和胶质细胞分化
公开(公告)号：US07829332B2
公开(公告)日：2010-11-09
申请号：US11054919
申请日：2005-02-10
申请人： Steven A. Goldman , Maiken Nedergaard , Jane Lin
发明人： Steven A. Goldman , Maiken Nedergaard , Jane Lin
IPC分类号： C12N5/06
CPC分类号： C12N5/0623 , C12N2500/40 , C12N2501/999
摘要： The present invention relates to a method of inhibiting differentiation of a population of neural stem cells by contacting a purinergic receptor agonist and a population of neural stem cells under conditions effective to inhibit differentiation of the population of neural stem cells. Another aspect of the present invention relates to a method of producing neurons and/or glial cells from a population of neural stem cells by culturing a population of neural stem cells with a purinergic receptor antagonist under conditions effective to cause the neural stem cells to differentiate into neurons and/or glial cells. The purinergic receptor agonist can also be used in a method of inducing proliferation and self-renewal of neural stem cells in a subject and a method of treating a neurological disease or neurodegenerative condition in a subject. The purinergic receptor antagonist can also be used in treating a neoplastic disease of the brain or spinal cord in a subject.
摘要翻译：本发明涉及通过在有效抑制神经干细胞群分化的条件下使嘌呤能受体激动剂和神经干细胞群接触来抑制神经干细胞群体的分化的方法。本发明的另一方面涉及通过在有效地使神经干细胞分化成为的神经干细胞的条件下用嘌呤能受体拮抗剂培养一群神经干细胞来从神经干细胞群体产生神经元和/或神经胶质细胞的方法神经元和/或神经胶质细胞。嘌呤能受体激动剂也可用于诱导受试者中神经干细胞的增殖和自我更新的方法以及治疗受试者神经疾病或神经变性病症的方法。嘌呤能受体拮抗剂也可用于治疗受试者中脑或脊髓的肿瘤性疾病。

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