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1. 发明授权

US08962023B2 UV cured gel and method of making 有权
标题翻译：紫外线固化凝胶及其制备方法
公开(公告)号：US08962023B2
公开(公告)日：2015-02-24
申请号：US11236943
申请日：2005-09-28
申请人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Thomas M. Swanick
发明人： Roger Labrecque , Philip McNamara , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Thomas M. Swanick
IPC分类号： A61K9/00 , A61L27/54 , A61F13/02 , A61K9/06 , A61K31/225 , A61K31/355 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/08 , A61L2/20 , A61L27/36 , A61L27/52 , A61L31/00 , A61L31/10 , A61L31/14 , A61F2/06 , B05D3/06
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A method of UV curing and corresponding resulting non-polymeric cross-linked gel are provided. The cross-linked gel can be combined with a medical device structure. The cross-linked gel can provide anti-adhesion characteristics, in addition to improved healing and anti-inflammatory response. The cross-linked gel is generally formed of a naturally occurring oil, or an oil composition formed in part of a naturally occurring oil, that is at least partially cured forming a cross-linked gel derived from at least one fatty acid compound. In addition, the oil composition can include a therapeutic agent component, such as a drug or other bioactive agent. The curing method can vary the application of UV light in both intensity and duration to achieve a desired amount of cross-linking forming the gel.
摘要翻译：提供UV固化方法和相应的所得非聚合交联凝胶。交联凝胶可以与医疗装置结构组合。除了改善愈合和抗炎反应之外，交联凝胶还可提供抗粘附特性。交联凝胶通常由天然存在的油或部分天然存在的油形成的油组合物形成，其至少部分固化形成由至少一种脂肪酸化合物衍生的交联凝胶。此外，油组合物可以包括治疗剂组分，例如药物或其它生物活性剂。固化方法可以改变UV光在强度和持续时间上的应用，以实现形成凝胶的所需量的交联。

2. 发明授权

US08795703B2 Stand-alone film and methods for making the same 有权
标题翻译：独立电影和制作相同的方法
公开(公告)号：US08795703B2
公开(公告)日：2014-08-05
申请号：US11237264
申请日：2005-09-28
申请人： Thomas M. Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Philip McNamara
发明人： Thomas M. Swanick , Joseph Ferraro , Paul Martakos , Lisa Rogers , Theodore Karwoski , Steve A. Herweck , Keith Faucher , Philip McNamara
IPC分类号： A61F2/00 , A61K9/14 , A61K35/60
CPC分类号： A61K35/60 , A61F2/06 , A61F13/02 , A61F13/023 , A61F2250/0067 , A61K9/0024 , A61K9/06 , A61K31/225 , A61K31/355 , A61K38/13 , A61K47/12 , A61K47/14 , A61L2/07 , A61L2/081 , A61L2/087 , A61L2/206 , A61L2/208 , A61L27/36 , A61L27/3604 , A61L27/52 , A61L27/54 , A61L31/005 , A61L31/10 , A61L31/145 , A61L2202/24 , A61L2300/22 , A61L2300/252 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/42 , A61L2300/602 , B05D3/067
摘要： A stand-alone film is derived at least in part from fatty acids. The stand-alone film can have anti-adhesive, anti-inflammatory, non-inflammatory, and wound healing properties, and can additionally include one or more therapeutic agents incorporated therein. Corresponding methods of making the stand-alone film include molding, casting, or otherwise applying a liquid or gel to a substrate, and curing or otherwise treating to form the stand-alone film. The resulting stand-alone film is bioabsorbable.
摘要翻译：至少部分地从脂肪酸衍生独立的膜。独立膜可以具有抗粘连，抗炎，非炎性和伤口愈合性质，并且还可以包括一种或多种掺入其中的治疗剂。制造独立膜的相应方法包括将液体或凝胶成型，铸造或以其它方式施加到基底，以及固化或以其他方式处理以形成独立的膜。所得到的独立膜是生物可吸收的。

3. 发明授权

US08722077B2 Drug delivery coating for use with a stent 有权
标题翻译：用于支架的药物输送涂层
公开(公告)号：US08722077B2
公开(公告)日：2014-05-13
申请号：US13593656
申请日：2012-08-24
申请人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck
发明人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck
IPC分类号： A61F2/00 , A61K9/00
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： A coated medical device and a method of providing a coating on an implantable medical device result in a medical device having a bio-absorbable coating. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The coated medical device is implantable in a patient to effect controlled delivery of the coating, including the therapeutic agent, to the patient.
摘要翻译：涂覆的医疗装置和在可植入医疗装置上提供涂层的方法导致具有生物可吸收涂层的医疗装置。涂层包括生物吸收载体组分。除了生物可吸收载体组分之外，还可以提供治疗剂成分。涂覆的医疗装置可植入患者体内以实现对包括治疗剂在内的涂层的可控输送。

4. 发明授权

US08263102B2 Drug delivery coating for use with a stent 有权
标题翻译：用于支架的药物输送涂层
公开(公告)号：US08263102B2
公开(公告)日：2012-09-11
申请号：US11236908
申请日：2005-09-28
申请人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck
发明人： Roger Labrecque , Geoffrey Moodie , Joseph Ferraro , Lisa Rogers , Paul Martakos , Theodore Karwoski , Steve A. Herweck
IPC分类号： A61F2/00 , A61K9/00
CPC分类号： A61L31/08 , A61F2/82 , A61F2/86 , A61F2250/0067 , A61K47/10 , A61K47/22 , A61K47/44 , A61L31/10 , A61L31/148 , A61L31/16 , A61L2300/22 , A61L2300/416 , A61L2300/428 , A61L2300/45 , A61L2300/606 , A61L2300/802 , A61L2420/02 , A61M25/0009 , A61M25/0045
摘要： A coated medical device an a method of providing a coating on an implantable medical device result in a medical device having a bio-absorbable coating. The coating includes a bio-absorbable carrier component. In addition to the bio-absorbable carrier component, a therapeutic agent component can also be provided. The coated medical device is implantable in a patient to effect controlled delivery of the coating, including the therapeutic agent, to the patient.
摘要翻译：涂覆的医疗装置是在可植入医疗装置上提供涂层的方法，导致具有生物吸收性涂层的医疗装置。涂层包括生物吸收载体组分。除了生物可吸收载体组分之外，还可以提供治疗剂成分。涂覆的医疗装置可植入患者体内以实现对包括治疗剂在内的涂层的可控输送。

5. 发明授权

US06955661B1 Expandable fluoropolymer device for delivery of therapeutic agents and method of making 有权
标题翻译：用于递送治疗剂的可扩展含氟聚合物装置和制备方法
公开(公告)号：US06955661B1
公开(公告)日：2005-10-18
申请号：US09411797
申请日：1999-10-01
申请人： Steve A. Herweck , Peter H. Gingras , Paul Martakos , Theodore Karwoski
发明人： Steve A. Herweck , Peter H. Gingras , Paul Martakos , Theodore Karwoski
IPC分类号： A61F2/958 , A61L29/04 , B29C47/00 , B29C55/24 , A61M5/00
CPC分类号： A61M25/1029 , A61L29/041 , A61M25/10 , A61M2025/0057 , A61M2025/105 , A61M2025/1075 , B29C47/00 , B29C47/0023 , B29C55/24 , B29C2049/465 , B29K2027/18 , B29L2022/022 , B29L2031/753 , B32B2305/026 , C08L27/18
摘要： A radially expandable fluid delivery device for delivering a fluid to a treatment site within the body is disclosed. The fluid delivery device is constructed of a microporous, biocompatible fluoropolymer material having a microstructure that can provide a controlled, uniform, low-velocity fluid distribution through the walls of the fluid delivery device to effectively deliver fluid to the treatment site without damaging tissue proximate the walls of the device. The fluid delivery device includes a tubular member defined by a wall having a thickness transverse to the longitudinal axis of the tubular member and extending between an inner and an outer surface. The wall is characterized by a microstructure of nodes interconnected by fibrils. The tubular member is deployable from a first, reduced diameter configuration to a second, increased diameter configuration upon the introduction of a pressurized fluid to the lumen. The tubular member includes at least one microporous portion having a porosity sufficient for the pressurized fluid to permeate through the wall. Substantially all of the nodes within the microporous portion are oriented such that spaces between the nodes form micro-channels extending from the inner surface-to the outer surface of the wall.
摘要翻译：公开了一种用于将流体输送到体内的治疗部位的可径向扩张的流体输送装置。流体输送装置由具有微结构的微孔生物相容性含氟聚合物材料构成，微结构可以通过流体输送装置的壁提供受控的，均匀的低速流体分配，以有效地将流体输送到治疗部位，而不会损伤邻近的设备的墙壁。流体输送装置包括由壁限定的管状构件，其具有横向于管状构件的纵向轴线并在内表面和外表面之间延伸的厚度。壁的特征在于通过纤维互连的节点的微结构。当将加压流体引入内腔时，管状构件可从第一缩径直径构型展开至第二增大直径构型。管状构件包括具有足以使加压流体渗透通过壁的孔隙的至少一个微孔部分。基本上微孔部分内的所有节点被定向成使得节点之间的空间形成从壁的内表面延伸到外表面的微通道。

6. 发明授权

US06783554B2 Pile mesh prosthesis 有权
标题翻译：桩网假体
公开(公告)号：US06783554B2
公开(公告)日：2004-08-31
申请号：US09789333
申请日：2001-02-20
申请人： Ryan A. Amara , Peter H. Gingras , Theodore Karwoski , Steve A. Herweck
发明人： Ryan A. Amara , Peter H. Gingras , Theodore Karwoski , Steve A. Herweck
IPC分类号： A61F202
CPC分类号： D04B1/22 , A61B17/12022 , A61B17/12099 , A61B17/12168 , A61B17/12177 , A61F2/0063 , A61F2250/0023 , D04B1/02 , D04B21/02 , D04B21/10 , D10B2509/08
摘要： A method and apparatus relating to a biocompatible soft tissue implant is disclosed. The implant, in the form of a prosthesis, is constructed of a knitted pile mesh material arranged into either a 3-dimensional structure or a planar shape or structure. The material or fabric includes a plurality of filament extensions projecting outwardly therefrom. The filament extensions can be radially projecting looping filaments from one or more rows of the knitted pile mesh material. The combination of the filament extensions with the 3-dimensional structure results in the biocompatible implant having a structural resistance to hinder anticipated crushing forces applied to the implant, and also provide a suitable 3-dimensional structure for promoting rapid tissue in-growth to anchor such implant without migration and strengthen the repaired tissue area.
摘要翻译：公开了一种与生物相容性软组织植入相关的方法和装置。以假体形式的植入物由布置成3维结构或平面形状或结构的针织绒头网状材料构成。材料或织物包括从其向外突出的多个细丝延伸部。丝线延伸部可以是一排或多排针织绒网材料的径向突出的细丝。长丝延伸与三维结构的组合导致生物相容性植入物具有阻碍施加到植入物的预期破碎力的结构阻力，并且还提供合适的三维结构，用于促进快速组织生长以锚定植入物没有迁移，并加强了修复的组织区域。

7. 发明授权

US06423089B1 Vascular endoprosthesis and method 有权
标题翻译：血管内假体和方法
公开(公告)号：US06423089B1
公开(公告)日：2002-07-23
申请号：US09296349
申请日：1999-04-22
申请人： Peter Gingras , Paul Martakos , Theodore Karwoski , Steve A. Herweck
发明人： Peter Gingras , Paul Martakos , Theodore Karwoski , Steve A. Herweck
IPC分类号： A61F206
CPC分类号： A61F2/82 , A61F2/07 , A61F2/90 , A61F2/958 , A61L31/048 , C08L27/18
摘要： A vascular endoprosthesis is formed of a tubular liner preform with a continuous surface and having a diameter smaller than that of an intended vessel. The liner is inserted to a treatment site, and its sheet material undergoes a radially-directed expansion to a final size that fits the vessel. Insertion and in situ expansion are achieved using a catheter assembly in which either an internal stent, such as a stiff-filament helically woven tube, or an inflatable balloon urge the liner preform outwardly against the inner wall of the vessel. The stent, or one or more simple internal snap-rings anchor the expanded liner in place. The expanded liner is porous, or becomes more porous during expansion, and one or more aspects of its porosity are tailored to the intended treatment goal of immobilizing treatment material, isolating cells, or permitting controlled permeation of selected materials.
摘要翻译：血管内假体由具有连续表面并且直径小于预期血管的直径的管状衬垫预制件形成。将衬垫插入到处理部位，并且其片材经历径向膨胀至适合容器的最终尺寸。使用导管组件实现插入和原位扩张，其中内部支架例如刚性丝状螺旋编织管或可膨胀气囊将衬垫预制件向外压靠在容器的内壁上。支架或一个或多个简单的内部卡环将扩张的衬垫固定就位。膨胀的衬垫是多孔的，或在膨胀期间变得更多孔，并且其孔隙率的一个或多个方面是针对固定化处理材料，分离细胞或允许所选材料的受控渗透的预期治疗目标。

8. 发明授权

US06287337B1 Multi-stage prosthesis 有权
标题翻译：多期假体
公开(公告)号：US06287337B1
公开(公告)日：2001-09-11
申请号：US09246312
申请日：1999-02-08
申请人： Paul Martakos , Peter Gingras , Theodore Karwoski , Steve A. Herweck
发明人： Paul Martakos , Peter Gingras , Theodore Karwoski , Steve A. Herweck
IPC分类号： A61F206
CPC分类号： A61F2/07 , A61F2/06 , A61F2/105 , A61F2/2412 , A61F2/88 , A61F2002/072 , A61F2240/001 , A61L27/16 , A61L27/34 , A61L27/507 , C08L27/18
摘要： A porous tube suitable for use as a vascular graft prosthesis and a method of making it is disclosed. It has a structure of porous polytetrafluoroethylene having a fibrous structure of nodes and fibers connecting the nodes together and an integrated intrawall circumferential support adjacent to areas of variable porosity. This invention provides a polytetrafluoroethylene polymer in a porous form useful as artificial internal organs for, for example vascular bypass, vascular access, and endovascular prosthesis. PTFE walls are found with radial zones of differing porosity are described.
摘要翻译：公开了适合用作血管移植假体的多孔管及其制造方法。它具有多孔聚四氟乙烯的结构，其具有连接节点的节点和纤维的纤维结构，以及与可变孔隙度区域相邻的整体的内部周向支撑。本发明提供一种多孔形式的聚四氟乙烯聚合物，其用作例如血管旁路，血管通路和血管内假体的人造内脏。发现PTFE壁具有不同孔隙率的径向区域。

9. 发明授权

US5807358A Dry suction regulator blood collection device 失效
标题翻译：干式吸力调节器采血装置
公开(公告)号：US5807358A
公开(公告)日：1998-09-15
申请号：US472144
申请日：1995-06-07
申请人： Steve A. Herweck , Theodore Karwoski , David Cross
发明人： Steve A. Herweck , Theodore Karwoski , David Cross
IPC分类号： A61M1/00 , A61M1/36
CPC分类号： A61M1/3627 , A61M1/0013 , A61M1/0031 , A61M1/0033
摘要： A blood collection device has a modular suction regulator assembly in the form of an adjustable negative pressure relief valve which controls the level of suction in a collection chamber by admitting air to a short bleed-in passage proximate to a suction connection. The modular assembly is a canister which drops into a receptacle oriented transversely in the collection vessel, and defines a laterally-directed intake manifold which resists blockage. The intake passes centrally through the canister along a path spanned by a filter, past a hat-shaped poppet supported on a compression spring. Fluted and threaded members control the scale and range of poppet response so that the assembly may be calibrated before installation. A face plate covers the installed canister, and radial vanes in the intake manifold double as gripping elements for manual adjustment of the assembly. A bellows meter provides refined suction resolution by linearly advancing across an oblique or curved reference line. Other improvements include a compact and balanced layout of suction canister, seal chamber and collection chamber, and a rigid handle assembly having five faces integral with the device.
摘要翻译：血液采集装置具有可调式负压释放阀形式的模块式抽吸调节器组件，其通过将空气接近靠近抽吸连接处的短的通入通道来控制收集室中的抽吸水平。模块化组件是一种罐，该罐可以放入收集容器中横向定向的容器中，并限定一个防止阻塞的横向定向的进气歧管。进气口沿着由过滤器跨过的路径中心穿过罐体，经过支撑在压缩弹簧上的帽形提升阀。槽形和螺纹构件控制提升阀响应的尺寸和范围，以便在安装之前校准组件。面板覆盖安装的罐，并且进气歧管中的径向叶片作为用于手动调节组件的夹紧元件加倍。波纹管表通过线性前进穿过斜线或弯曲参考线提供精确的吸力分辨率。其他改进包括吸盘，密封腔和收集室的紧凑平衡的布局，以及具有与该装置一体的五个面的刚性手柄组件。

10. 发明授权

US5722964A Filtered blood collection device 失效
标题翻译：过滤采血装置
公开(公告)号：US5722964A
公开(公告)日：1998-03-03
申请号：US487468
申请日：1995-06-07
申请人： Steve A. Herweck , Theodore Karwoski , Nicholas Want
发明人： Steve A. Herweck , Theodore Karwoski , Nicholas Want
IPC分类号： A61M1/00 , A61M1/36
CPC分类号： A61M1/0013 , A61M1/0031 , A61M1/0033 , A61M1/3627
摘要： A blood collection vessel includes a blood inlet, a pooling region in which blood from the inlet collects, and an outlet in the pooling region for reinfusion of the collected blood. A filter located in the blood path between inlet and outlet extends at least in part into the pooling region and impounds clots so they remain away from the outlet but suspended in the collected blood. Preferably, the filter is located to provide venting between both sides of the filter. In one embodiment the filter is a vertical wall, which defines a shielded outlet column or chimney extending above the outlet. Blood permeates to the outlet region over a broad area, and the column forms an open suction path that prevents suction differentials from arising across the filter, so clots cannot be sucked through the large-pore material. With the clots residing in the collected fluid, the total fluid loss is directly displayed in a single window at all times, and maximal use is made of the limited volume in the vessel. In another embodiment, the filter constitutes a false floor or basket in the pooling region. A preferred construction employs filter material on a support grid, to form a flexible and self-supporting filter sheet, which inserts like a plate to compartmentalize the collection vessel and form an impounding surface in the pooling region.
摘要翻译：血液采集容器包括血液入口，来自入口的血液收集的汇集区域以及汇集区域中用于回收血液回输的出口。位于入口和出口之间的血液路径中的过滤器至少部分地延伸到汇集区域中并扣留凝块，使得它们保持远离出口但悬浮在收集的血液中。优选地，过滤器被定位成在过滤器的两侧之间提供排气。在一个实施例中，过滤器是垂直壁，其限定在出口上方延伸的屏蔽出口塔或烟囱。血液在大面积上渗透到出口区域，柱形成一个开放的吸入路径，防止吸入差异跨越过滤器，因此凝块不能通过大孔材料吸入。在收集的液体中存在凝块的情况下，总的流体损失始终直接显示在单个窗口中，并且最大限度地利用了容器中有限的体积。在另一个实施例中，过滤器构成汇集区域中的假地板或篮子。优选的结构是在支撑格栅上使用过滤材料，以形成柔性和自支撑的过滤片，其将类似板的插入物分隔成收集容器并在汇集区域中形成蓄水表面。

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