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1. 发明授权

US06955661B1 Expandable fluoropolymer device for delivery of therapeutic agents and method of making 有权
标题翻译：用于递送治疗剂的可扩展含氟聚合物装置和制备方法
公开(公告)号：US06955661B1
公开(公告)日：2005-10-18
申请号：US09411797
申请日：1999-10-01
申请人： Steve A. Herweck , Peter H. Gingras , Paul Martakos , Theodore Karwoski
发明人： Steve A. Herweck , Peter H. Gingras , Paul Martakos , Theodore Karwoski
IPC分类号： A61F2/958 , A61L29/04 , B29C47/00 , B29C55/24 , A61M5/00
CPC分类号： A61M25/1029 , A61L29/041 , A61M25/10 , A61M2025/0057 , A61M2025/105 , A61M2025/1075 , B29C47/00 , B29C47/0023 , B29C55/24 , B29C2049/465 , B29K2027/18 , B29L2022/022 , B29L2031/753 , B32B2305/026 , C08L27/18
摘要： A radially expandable fluid delivery device for delivering a fluid to a treatment site within the body is disclosed. The fluid delivery device is constructed of a microporous, biocompatible fluoropolymer material having a microstructure that can provide a controlled, uniform, low-velocity fluid distribution through the walls of the fluid delivery device to effectively deliver fluid to the treatment site without damaging tissue proximate the walls of the device. The fluid delivery device includes a tubular member defined by a wall having a thickness transverse to the longitudinal axis of the tubular member and extending between an inner and an outer surface. The wall is characterized by a microstructure of nodes interconnected by fibrils. The tubular member is deployable from a first, reduced diameter configuration to a second, increased diameter configuration upon the introduction of a pressurized fluid to the lumen. The tubular member includes at least one microporous portion having a porosity sufficient for the pressurized fluid to permeate through the wall. Substantially all of the nodes within the microporous portion are oriented such that spaces between the nodes form micro-channels extending from the inner surface-to the outer surface of the wall.
摘要翻译：公开了一种用于将流体输送到体内的治疗部位的可径向扩张的流体输送装置。流体输送装置由具有微结构的微孔生物相容性含氟聚合物材料构成，微结构可以通过流体输送装置的壁提供受控的，均匀的低速流体分配，以有效地将流体输送到治疗部位，而不会损伤邻近的设备的墙壁。流体输送装置包括由壁限定的管状构件，其具有横向于管状构件的纵向轴线并在内表面和外表面之间延伸的厚度。壁的特征在于通过纤维互连的节点的微结构。当将加压流体引入内腔时，管状构件可从第一缩径直径构型展开至第二增大直径构型。管状构件包括具有足以使加压流体渗透通过壁的孔隙的至少一个微孔部分。基本上微孔部分内的所有节点被定向成使得节点之间的空间形成从壁的内表面延伸到外表面的微通道。

2. 发明授权

US06395208B1 Method of making an expandable fluoropolymer device 有权
标题翻译：制造可膨胀氟聚合物装置的方法
公开(公告)号：US06395208B1
公开(公告)日：2002-05-28
申请号：US09410329
申请日：1999-10-01
申请人： Steve A. Herweck , Peter H. Gingras , Paul Martakos , Theodore Karwoski
发明人： Steve A. Herweck , Peter H. Gingras , Paul Martakos , Theodore Karwoski
IPC分类号： B29C4904
CPC分类号： B29C55/24 , A61L29/041 , A61M25/10 , B29C47/00 , B29C47/0023 , B29C47/0026 , B29C2049/465 , B29K2027/18 , B29L2022/022 , B29L2031/753 , B32B2305/026 , C08L27/18
摘要： A method of making a radially expandable device having a body constructed of a generally inelastic, expanded fluoropolymer material. The body is deployable upon application of a radial expansion force from a reduced diameter, collapsed configuration to an expanded configuration having a pre-defined and fixed increased diameter. The body has a singular, unitary construction of generally homogenous material that is characterized by a seamless construction of expanded fluoropolymer material, such as expanded polytetrafluoroethylene (ePTFE), and is preferably constructed through an extrusion and expansion process. The body is further characterized by a microstructure of nodes interconnected by fibrils in which substantially all the nodes of the body are oriented generally perpendicularly to the longitudinal axis of the body. The monolithic construction of the body and the orientation of the nodes, perpendicular to the longitudinal axis of the body, yields a radially expandable device that predictably and dependably expands to a predefined, fixed maximum diameter that is generally independent of the expansion force used to radially expand the device.
摘要翻译：一种制造径向可膨胀装置的方法，该装置具有由通常无弹性的膨胀的含氟聚合物材料构成的主体。当径向膨胀力从减小的直径，收缩构型施加到具有预定义和固定的增大直径的膨胀构型时，主体可展开。本体具有通常均匀材料的单一，单一结构，其特征在于扩展的氟聚合物材料如膨胀聚四氟乙烯（ePTFE）的无缝构造，并且优选通过挤出和膨胀方法构造。身体的特征还在于通过原纤维相互连接的节点的微结构，其中主体的基本上所有的节点大致垂直于身体的纵向轴线定向。身体的整体结构和垂直于身体的纵向轴线的节点的取向产生可预测和可靠地扩展到预定的，固定的最大直径的径向可扩张装置，其通常与用于径向的膨胀力无关展开设备。

3. 发明授权

US09050442B2 Expandable fluoropolymer device for delivery of therapeutic agents and method of making 有权
标题翻译：用于递送治疗剂的可扩展含氟聚合物装置和制备方法
公开(公告)号：US09050442B2
公开(公告)日：2015-06-09
申请号：US12820938
申请日：2010-06-22
申请人： Steve A. Herweck , Peter H. Gingras , Paul Martakos , Theodore Karwoski
发明人： Steve A. Herweck , Peter H. Gingras , Paul Martakos , Theodore Karwoski
IPC分类号： A61M31/00 , A61M25/10 , A61L29/04 , B29C55/24 , A61M25/00 , B29C47/00 , B29C49/46 , B29K27/18 , B29L22/02 , B29L31/00
CPC分类号： A61M25/1029 , A61L29/041 , A61M25/10 , A61M2025/0057 , A61M2025/105 , A61M2025/1075 , B29C47/00 , B29C47/0023 , B29C55/24 , B29C2049/465 , B29K2027/18 , B29L2022/022 , B29L2031/753 , B32B2305/026 , C08L27/18
摘要： A method of making a radially expandable fluid delivery device includes providing a tube of biocompatible fluoropolymer material with a predetermined porosity based on an extrusion and expansion forming process, applying a radial expansion force to the tube expanding the tube to a predetermined diameter dimension, and removing the radial expansion force. The tube is radially inelastic while sufficiently pliable to be collapsible and inflatable from a collapsed configuration to an expanded configuration upon introduction of an inflation force, such that the expanded configuration occurs upon inflation to the predetermined diameter dimension. The fluid delivery device is constructed of a microporous, biocompatible fluoropolymer material having a microstructure that can provide a controlled, uniform, low-velocity fluid distribution through the walls of the fluid delivery device to effectively deliver fluid to the treatment site without damaging tissue proximate the walls of the device.
摘要翻译：一种制造可径向膨胀的流体递送装置的方法包括：基于挤出和膨胀成形方法提供具有预定孔隙率的生物相容性氟聚合物材料管，向扩管管的管施加径向膨胀力至预定直径尺寸，径向膨胀力。该管是径向无弹性的，同时在引入膨胀力时足够柔软地可从折叠构型膨胀到膨胀构型，使得膨胀构型在膨胀到预定直径尺寸时发生。流体输送装置由具有微结构的微孔生物相容性含氟聚合物材料构成，微结构可以通过流体输送装置的壁提供受控的，均匀的低速流体分配，以有效地将流体输送到治疗部位，而不会损伤邻近的设备的墙壁。

4. 发明授权

US07637886B2 Expandable fluoropolymer device and method of making 有权
公开(公告)号：US07637886B2
公开(公告)日：2009-12-29
申请号：US10131396
申请日：2002-04-22
申请人： Steve A. Herweck , Peter H. Gingras , Paul Martakos , Theodore Karwoski
发明人： Steve A. Herweck , Peter H. Gingras , Paul Martakos , Theodore Karwoski
IPC分类号： A61M29/00
CPC分类号： A61L29/041 , A61M25/10 , B29C47/00 , B29C47/0023 , B29C55/24 , B29C2049/465 , B29K2027/18 , B29L2022/022 , B29L2031/753 , B32B2305/026 , Y10T428/1376 , C08L27/18
摘要： A radially expandable device having a body constructed of a generally inelastic, expanded fluoropolymer material is described. The body is deployable upon application of a radial expansion force from a reduced diameter, collapsed configuration to an expanded configuration having a pre-defined and fixed increased diameter. The body has a singular, unitary construction of generally homogenous material that is characterized by a seamless construction of expanded fluoropolymer material, such as expanded polytetrafluoroethylene (ePTFE), and is preferably constructed through an extrusion and expansion process. The body is further characterized by a microstructure of nodes interconnected by fibrils in which substantially all the nodes of the body are oriented generally perpendicularly to the longitudinal axis of the body. The monolithic construction of the body and the orientation of the nodes, perpendicular to the longitudinal axis of the body, yields a radially expandable device that predictably and dependably expands to a predefined, fixed maximum diameter that is generally independent of the expansion force used to radially expand the device. In addition, the microstructure of nodes interconnected by fibrils provides at least one predetermined flow rate of fluid therethrough over a range of fluid pressures.

5. 发明授权

US06783554B2 Pile mesh prosthesis 有权
标题翻译：桩网假体
公开(公告)号：US06783554B2
公开(公告)日：2004-08-31
申请号：US09789333
申请日：2001-02-20
申请人： Ryan A. Amara , Peter H. Gingras , Theodore Karwoski , Steve A. Herweck
发明人： Ryan A. Amara , Peter H. Gingras , Theodore Karwoski , Steve A. Herweck
IPC分类号： A61F202
CPC分类号： D04B1/22 , A61B17/12022 , A61B17/12099 , A61B17/12168 , A61B17/12177 , A61F2/0063 , A61F2250/0023 , D04B1/02 , D04B21/02 , D04B21/10 , D10B2509/08
摘要： A method and apparatus relating to a biocompatible soft tissue implant is disclosed. The implant, in the form of a prosthesis, is constructed of a knitted pile mesh material arranged into either a 3-dimensional structure or a planar shape or structure. The material or fabric includes a plurality of filament extensions projecting outwardly therefrom. The filament extensions can be radially projecting looping filaments from one or more rows of the knitted pile mesh material. The combination of the filament extensions with the 3-dimensional structure results in the biocompatible implant having a structural resistance to hinder anticipated crushing forces applied to the implant, and also provide a suitable 3-dimensional structure for promoting rapid tissue in-growth to anchor such implant without migration and strengthen the repaired tissue area.
摘要翻译：公开了一种与生物相容性软组织植入相关的方法和装置。以假体形式的植入物由布置成3维结构或平面形状或结构的针织绒头网状材料构成。材料或织物包括从其向外突出的多个细丝延伸部。丝线延伸部可以是一排或多排针织绒网材料的径向突出的细丝。长丝延伸与三维结构的组合导致生物相容性植入物具有阻碍施加到植入物的预期破碎力的结构阻力，并且还提供合适的三维结构，用于促进快速组织生长以锚定植入物没有迁移，并加强了修复的组织区域。

6. 发明申请

US20110118703A1 EXPANDABLE FLUOROPOLYMER DEVICE FOR DELIVERY OF THERAPEUTIC AGENTS AND METHOD OF MAKING 有权
标题翻译：用于输送治疗药物的可扩展的氟聚合物装置和制备方法
公开(公告)号：US20110118703A1
公开(公告)日：2011-05-19
申请号：US12820938
申请日：2010-06-22
申请人： Steve A. Herweck , Peter H. Gingras , Paul Martakos , Theodore Karworski
发明人： Steve A. Herweck , Peter H. Gingras , Paul Martakos , Theodore Karworski
IPC分类号： A61M25/10
CPC分类号： A61M25/1029 , A61L29/041 , A61M25/10 , A61M2025/0057 , A61M2025/105 , A61M2025/1075 , B29C47/00 , B29C47/0023 , B29C55/24 , B29C2049/465 , B29K2027/18 , B29L2022/022 , B29L2031/753 , B32B2305/026 , C08L27/18
摘要： A method of making a radially expandable fluid delivery device includes providing a tube of biocompatible fluoropolymer material with a predetermined porosity based on an extrusion and expansion forming process, applying a radial expansion force to the tube expanding the tube to a predetermined diameter dimension, and removing the radial expansion force. The tube is radially inelastic while sufficiently pliable to be collapsible and inflatable from a collapsed configuration to an expanded configuration upon introduction of an inflation force, such that the expanded configuration occurs upon inflation to the predetermined diameter dimension. The fluid delivery device is constructed of a microporous, biocompatible fluoropolymer material having a microstructure that can provide a controlled, uniform, low-velocity fluid distribution through the walls of the fluid delivery device to effectively deliver fluid to the treatment site without damaging tissue proximate the walls of the device.
摘要翻译：一种制造可径向膨胀的流体递送装置的方法包括：基于挤出和膨胀成形方法提供具有预定孔隙率的生物相容性氟聚合物材料管，向扩管管的管施加径向膨胀力至预定直径尺寸，径向膨胀力。该管是径向无弹性的，同时在引入膨胀力时足够柔软地可从折叠构型膨胀到膨胀构型，使得膨胀构型在膨胀到预定直径尺寸时发生。流体输送装置由具有微结构的微孔生物相容性含氟聚合物材料构成，微结构可以通过流体输送装置的壁提供受控的，均匀的低速流体分配，以有效地将流体输送到治疗部位，而不会损伤邻近的设备的墙壁。

7. 发明授权

US6066776A Self-forming prosthesis for repair of soft tissue defects 失效
标题翻译：用于修复软组织缺损的自体成形假体
公开(公告)号：US6066776A
公开(公告)日：2000-05-23
申请号：US895050
申请日：1997-07-16
申请人： Jonathan L. Goodwin , Peter H. Gingras , Steve A. Herweck
发明人： Jonathan L. Goodwin , Peter H. Gingras , Steve A. Herweck
IPC分类号： A61F2/00 , A61F2/02
CPC分类号： A61F2/0063 , Y10S623/901
摘要： A prosthesis is provided that is advantageously used to fill a soft tissue or muscle defect, such as an inquinal or femoral hernia. In a first aspect of the invention, multiple layers of a flexible, mesh material are attach together at a finite number of joins. A tab is placed at the geometric center of one of the mesh layers to facilitate insertion of the mesh into the defect. The tab also creates a blunt tip that reduces irritation and discomfort to the patient. In a second aspect of the invention, a prosthesis is provided that includes a barrier layer between two or more layers of flexible, mesh material to prevent adhesion of the device to the tissue. All layers are attached together by a finite number of joins. A tab is placed at the geometric center of one of the mesh layers to facilitate insertion of the mesh into the defect. The prostheses of the invention are self-forming in that they change from a two dimensional configuration to a three dimensional configuration upon insertion of the device into the defect.
摘要翻译：提供了一种假体，其有利地用于填充软组织或肌肉缺损，例如询问或股骨疝。在本发明的第一方面中，柔性网状材料的多层以有限数量的连接连接在一起。在一个网格层的几何中心处放置一个突片，以便于将网格插入到缺陷中。该标签还创建一个钝头，减少患者的刺激和不适。在本发明的第二方面中，提供一种假体，其包括两层或多层柔性网状材料之间的阻挡层，以防止该装置粘附到组织上。所有层通过有限数量的连接连接在一起。在一个网格层的几何中心处放置一个突片，以便于将网格插入到缺陷中。本发明的假体是自形成的，因为它们在将装置插入缺陷时从二维构型变为三维构型。

8. 发明授权

US06315791B1 Self-expanding prothesis 有权
标题翻译：自我扩张的假象
公开(公告)号：US06315791B1
公开(公告)日：2001-11-13
申请号：US09220878
申请日：1998-12-23
申请人： Peter H. Gingras , Theodore Karwoski , Susan Hamelin , Jonathan Goodwin
发明人： Peter H. Gingras , Theodore Karwoski , Susan Hamelin , Jonathan Goodwin
IPC分类号： A61F206
CPC分类号： A61F2/82 , A61F2/06 , A61F2/07 , A61F2/105 , A61F2/88 , A61F2/90 , A61F2002/072 , A61F2240/001 , A61L31/04 , A61L31/10 , C08L27/18
摘要： An expandable prosthesis includes a self-expanding stent deployable between a substantially radially compressed configuration and a substantially radially expanded configuration. A biocompatible coating is attached to at least a portion of the outer surface of the self-expanding stent in the radially compressed configuration to inhibit radially expansion of the self-expanding stent to the radially expanded configuration. The biocompatible material is preferably integrally mounted to the self-expanding stent thus eliminating the need for a separate, independent delivery tube or sheath for maintaining the self-expanding stent in the radially compressed configuration during delivery of the self-expanding stent into a body vessel.
摘要翻译：可扩张假体包括可在基本上径向压缩的构型和基本上径向扩张的构型之间展开的自扩张支架。生物相容性涂层以径向压缩构型连接到自扩张支架的外表面的至少一部分上，以阻止自膨胀支架径向膨胀到径向扩张构型。生物相容性材料优选地一体地安装到自扩张支架上，从而消除了将自扩张支架输送到体内容器中的独立的独立输送管或护套用于将自扩张支架保持在径向压缩构型中。

9. 发明授权

US06808533B1 Covered stent and method of covering a stent 有权
标题翻译：覆盖支架和覆盖支架的方法
公开(公告)号：US06808533B1
公开(公告)日：2004-10-26
申请号：US09627566
申请日：2000-07-28
申请人： Jonathan L. Goodwin , Gary A. Jordan , Peter H. Gingras
发明人： Jonathan L. Goodwin , Gary A. Jordan , Peter H. Gingras
IPC分类号： A61F206
CPC分类号： A61F2/86 , A61F2/91 , A61F2002/072 , A61F2210/0076 , A61F2220/005 , A61L31/10 , A61L31/146 , C08L27/18
摘要： A radially deployable covered stent that predictably and dependably expands to an increased diameter state at relatively low deployment pressures while concomitantly minimizing the risk of tearing of the stent covering during expansion. The stent covering includes an inner cover and an outer cover that are bonded together through and around the stent structure to cover the stent. The stent cover is constructed from expanded polytetrafluoroethylene (ePTFE) having a structure of nodes interconnected by fibrils. The stent covering has a radial thickness of at least about 0.008″ and an average internodal distance (IND) of at least about 100 microns when the stent is in the reduced diameter, unexpanded state. The covered stent deploys at an average deployment pressure of less than or equal to about 10 atm. A method for covering a stent structure according to the present invention includes placing a compression member in the form of a tubular sleeve over the outer cover and heating the compressed covered stent to bond the inner cover to the outer cover. An adhesive in the form of an aqueous dispersion of PTFE can be applied to either the inner cover or the outer cover to facilitate bonding of the inner cover to the outer cover.
摘要翻译：可径向展开的覆盖支架可预测地且可靠地在相对较低的部署压力下扩张到增加的直径状态，同时最小化扩张期间支架覆盖物撕裂的风险。支架覆盖物包括通过支架结构并且围绕支架结构粘合在一起以覆盖支架的内盖和外盖。支架盖由膨胀的聚四氟乙烯（ePTFE）构成，其具有通过纤维互连的节点结构。当支架处于减小直径，未膨胀状态时，支架覆盖物具有至少约0.008“的径向厚度和至少约100微米的平均间隔距离（IND）。覆盖的支架以小于或等于约10atm的平均部署压力部署。根据本发明的覆盖支架结构的方法包括将管状套筒形式的压缩构件放置在外盖上并加热压缩的被覆盖的支架以将内盖结合到外盖。可以将PTFE的水性分散体形式的粘合剂施加到内盖或外盖上，以便于内盖与外盖接合。

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