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1. 发明授权

US06423089B1 Vascular endoprosthesis and method 有权
标题翻译：血管内假体和方法
公开(公告)号：US06423089B1
公开(公告)日：2002-07-23
申请号：US09296349
申请日：1999-04-22
申请人： Peter Gingras , Paul Martakos , Theodore Karwoski , Steve A. Herweck
发明人： Peter Gingras , Paul Martakos , Theodore Karwoski , Steve A. Herweck
IPC分类号： A61F206
CPC分类号： A61F2/82 , A61F2/07 , A61F2/90 , A61F2/958 , A61L31/048 , C08L27/18
摘要： A vascular endoprosthesis is formed of a tubular liner preform with a continuous surface and having a diameter smaller than that of an intended vessel. The liner is inserted to a treatment site, and its sheet material undergoes a radially-directed expansion to a final size that fits the vessel. Insertion and in situ expansion are achieved using a catheter assembly in which either an internal stent, such as a stiff-filament helically woven tube, or an inflatable balloon urge the liner preform outwardly against the inner wall of the vessel. The stent, or one or more simple internal snap-rings anchor the expanded liner in place. The expanded liner is porous, or becomes more porous during expansion, and one or more aspects of its porosity are tailored to the intended treatment goal of immobilizing treatment material, isolating cells, or permitting controlled permeation of selected materials.
摘要翻译：血管内假体由具有连续表面并且直径小于预期血管的直径的管状衬垫预制件形成。将衬垫插入到处理部位，并且其片材经历径向膨胀至适合容器的最终尺寸。使用导管组件实现插入和原位扩张，其中内部支架例如刚性丝状螺旋编织管或可膨胀气囊将衬垫预制件向外压靠在容器的内壁上。支架或一个或多个简单的内部卡环将扩张的衬垫固定就位。膨胀的衬垫是多孔的，或在膨胀期间变得更多孔，并且其孔隙率的一个或多个方面是针对固定化处理材料，分离细胞或允许所选材料的受控渗透的预期治疗目标。

2. 发明授权

US06287337B1 Multi-stage prosthesis 有权
标题翻译：多期假体
公开(公告)号：US06287337B1
公开(公告)日：2001-09-11
申请号：US09246312
申请日：1999-02-08
申请人： Paul Martakos , Peter Gingras , Theodore Karwoski , Steve A. Herweck
发明人： Paul Martakos , Peter Gingras , Theodore Karwoski , Steve A. Herweck
IPC分类号： A61F206
CPC分类号： A61F2/07 , A61F2/06 , A61F2/105 , A61F2/2412 , A61F2/88 , A61F2002/072 , A61F2240/001 , A61L27/16 , A61L27/34 , A61L27/507 , C08L27/18
摘要： A porous tube suitable for use as a vascular graft prosthesis and a method of making it is disclosed. It has a structure of porous polytetrafluoroethylene having a fibrous structure of nodes and fibers connecting the nodes together and an integrated intrawall circumferential support adjacent to areas of variable porosity. This invention provides a polytetrafluoroethylene polymer in a porous form useful as artificial internal organs for, for example vascular bypass, vascular access, and endovascular prosthesis. PTFE walls are found with radial zones of differing porosity are described.
摘要翻译：公开了适合用作血管移植假体的多孔管及其制造方法。它具有多孔聚四氟乙烯的结构，其具有连接节点的节点和纤维的纤维结构，以及与可变孔隙度区域相邻的整体的内部周向支撑。本发明提供一种多孔形式的聚四氟乙烯聚合物，其用作例如血管旁路，血管通路和血管内假体的人造内脏。发现PTFE壁具有不同孔隙率的径向区域。

3. 发明授权

US6042666A Prosthesis with in-wall modulation 失效
标题翻译：具有壁内调制的假体
公开(公告)号：US6042666A
公开(公告)日：2000-03-28
申请号：US105736
申请日：1998-06-26
申请人： Theodore Karwoski , Paul Martakos , Peter Gingras , Steve A. Herweck , Tom Swanick
发明人： Theodore Karwoski , Paul Martakos , Peter Gingras , Steve A. Herweck , Tom Swanick
IPC分类号： A61F2/00 , A61F2/06 , A61F2/10 , A61F2/24 , A61F2/88 , A61L27/16 , A61L27/34 , A61L27/40 , B32B31/00
CPC分类号： A61F2/07 , A61F2/06 , A61L27/16 , A61L27/34 , A61L27/40 , A61F2/105 , A61F2/2412 , A61F2/88 , A61F2002/072 , A61F2240/001
摘要： The wall of a prosthesis has a region which modulates communication through the porosity of the wall. The prosthesis is unitary, but may be assembled in successive bodies which are coalesced, so that the porous microstructure changes distinctly at stages through the thickness dimension of the wall. One embodiment is formed entirely of fluoropolymer, and has at least one surface adapted to support tissue regeneration and ingrowth. The modulation region is a stratum of high water entry pressure that reduces pulsatile hydraulic pressure transmission, or locally alters fluid-born-distribution of biological material through the wall and allows more natural gradients for tissue regeneration and growth in the outer region of the wall.
摘要翻译：假体的壁具有通过壁的孔隙调节连通的区域。假体是单一的，但是可以组合成连续的体，其被聚结，使得多孔微结构在阶段通过壁的厚度尺寸明显变化。一个实施方案完全由氟聚合物形成，并且具有适于支持组织再生和向内生长的至少一个表面。调制区域是高水入口压力的层次，可降低脉动式液压传递，或局部改变生物材料通过壁的流体出生分布，并允许更多的自然梯度用于组织再生和壁的外部区域的生长。

4. 发明授权

US6010529A Expandable shielded vessel support 失效
标题翻译：可扩展屏蔽容器支架
公开(公告)号：US6010529A
公开(公告)日：2000-01-04
申请号：US759877
申请日：1996-12-03
申请人： Steve A. Herweck , Peter Gingras , Paul Martakos , Theodore Karwoski
发明人： Steve A. Herweck , Peter Gingras , Paul Martakos , Theodore Karwoski
IPC分类号： A61F2/00 , A61F2/06 , A61F2/10 , A61F2/24 , A61F2/88 , A61L31/04 , A61L31/10 , A61F2/04
CPC分类号： A61F2/07 , A61F2/06 , A61F2/88 , A61L31/04 , A61L31/10 , A61F2/105 , A61F2002/072 , A61F2240/001 , Y10S623/901
摘要： A radially expandable support body is enveloped within a cocoon. In a preferred construction, the support is a stent, and a tube of polymeric material, e.g. polytetrafluoroethylene (PTFE), passes through the interior of the stent body and is turned back upon itself over the stent to form a cuff. The assembly is then heated and the outer layer contacts and coalesces with the inner layer, closely surrounding the stent body within a folded envelope having a continuous and seamless end. In one embodiment, an end portion of the tube is expanded before folding back over the stent. The end portion, which becomes an exterior surface of the finished product, thus acquires a greater degree of porosity. Each end of the central tube may be so expanded, and folded back to seal all surfaces and both ends. The stent body itself may be a ring, or a short series of spaced-apart rings, or a wire or web, or a sheet possessing a number of apertures extending entirely through the sheet. The spaces or apertures are covered over or bridged by both the inner and outer polymer layers. The apertures, which may comprise under five to over eighty percent of the surface area of the stent, constitute regions or a grid of points through which the material is coalesced and continuously bonded, and around which strain is distributed by the support. These points or regions remain tacked together so expansion of the assembly does not delaminate the polymer or create flaps and pockets. In another embodiment, a two tube construction is cuffed and assembled into a similarly unitized and seamless stent. One tube is cuffed back, and the other tube covers the cuffed stent. In this embodiment both the tube thicknesses and porosities may differ substantially. For example the inner porosity may be selected to enhance blood flow or intimal regeneration, and the outer surface may have a porosity to encourage anchoring to external muscle tissue.
摘要翻译：径向可扩展的支撑体被包围在茧内。在优选的结构中，支撑件是支架，以及聚合物材料管，例如。聚四氟乙烯（PTFE）穿过支架主体的内部并在支架上自身转回以形成袖带。然后将组件加热并且外层与内层接触并聚结，在具有连续和无缝端部的折叠外壳内紧密地围绕支架主体。在一个实施例中，管的端部在折回到支架之前膨胀。成为成品的外表面的端部因此获得更大程度的孔隙率。中心管的每个端部可以如此膨胀，并且被折回以密封所有表面和两端。支架主体本身可以是一个环，或一系列间隔开的环，或者线或腹板，或者具有完全贯穿片材的多个孔的片。空间或孔被内聚合物层和外聚合物层覆盖或桥接。可以包括支架表面积的五到八十成以上的孔构成区域或网格，通过该点或网格将材料聚结并连续地结合，并且通过支撑分布在哪个应变附近。这些点或区域保持粘合在一起，因此组件的膨胀不会分解聚合物或产生襟翼和口袋。在另一个实施例中，将双管结构压合并组装成相似的单元化且无缝的支架。一根管子被套在后面，另一根管子覆盖着袖口支架。在该实施例中，管的厚度和孔隙度可能基本上不同。例如，可以选择内部孔隙率以增强血流或内膜再生，并且外表面可以具有孔隙度以促进锚定到外部肌肉组织。

5. 发明授权

US06416537B1 Multi-stage prosthesis 有权
标题翻译：多期假体
公开(公告)号：US06416537B1
公开(公告)日：2002-07-09
申请号：US09604382
申请日：2000-06-27
申请人： Paul Martakos , Peter Gingras , Theodore Karwoski , Steve A. Herweck
发明人： Paul Martakos , Peter Gingras , Theodore Karwoski , Steve A. Herweck
IPC分类号： A61F206
CPC分类号： A61F2/07 , A61F2/06 , A61F2/105 , A61F2/2412 , A61F2/88 , A61F2002/072 , A61F2240/001 , A61L27/16 , A61L27/34 , A61L27/507 , C08L27/18
摘要： A porous tube suitable for use as a vascular graft prosthesis and a method of making it is disclosed. It has a structure of porous polytetrafluoroethylene having a fibrous structure of nodes and fibers connecting the nodes together and an integrated intrawall circumferential support adjacent to areas of variable porosity. This invention provides a polytetrafluoroethylene polymer in a porous form useful as artificial internal organs for, for example vascular bypass, vascular access, and endovascular prosthesis. PTFE walls are found with radial zones of differing porosity are described.
摘要翻译：公开了适合用作血管移植假体的多孔管及其制造方法。它具有多孔聚四氟乙烯的结构，其具有连接节点的节点和纤维的纤维结构，以及与可变孔隙度区域相邻的整体的内部周向支撑。本发明提供一种多孔形式的聚四氟乙烯聚合物，其用作例如血管旁路，血管通路和血管内假体的人造内脏。发现PTFE壁具有不同孔隙率的径向区域。

6. 发明授权

US06270523B1 Expandable shielded vessel support 有权
标题翻译：可扩展屏蔽容器支架
公开(公告)号：US06270523B1
公开(公告)日：2001-08-07
申请号：US09419467
申请日：1999-10-15
申请人： Steve A. Herweck , Peter Gingras , Paul Martakos , Theodore Karwoski
发明人： Steve A. Herweck , Peter Gingras , Paul Martakos , Theodore Karwoski
IPC分类号： A61F206
CPC分类号： A61F2/07 , A61F2/06 , A61F2/105 , A61F2/88 , A61F2002/072 , A61F2240/001 , A61L31/04 , A61L31/10 , C08L27/18 , Y10S623/901
摘要： A radially expandable support body is enveloped within a cocoon. In a preferred construction, the support is a stent, and a tube of polymeric material, e.g., polytetraeluoroethylene (PTFE), passes through the interior of the stent body and is turned back upon itself over the stent to form a cuff. The assembly is then heated and the outer layer contacts and coalesces with the inner layer, closely surrounding the stent body within a folded envelope having a continuous and seamless end. In one embodiment, an end portion of the tube is expanded before folding back over the-stent. The end portion, which becomes an exterior surface of the finished product, thus acquires a greater degree of porosity. Each end of the central tube may be so expanded, and folded back to seal all surfaces and both ends. The stent body itself may be a ring, or a short series of spaced-apart rings, or a wire or web, or a sheet possessing a number of apertures extending entirely through the sheet. The spaces or apertures are covered over or bridged by both the inner and outer polymer layers. The apertures, which may comprise under five to over eighty percent of the surface area of the stent, constitute regions or a grid of points through which the material is coalesced and continuously bonded, and around which strain is distributed by the support. These points or regions remain tacked together so expansion of the assembly does not delaminate the polymer or create flaps and pockets. In another embodiment, a two tube construction is cuffed and assembled into a similarly unitized and seamless stent. One tube is cuffed back, and the other tube covers the cuffed stent. In this embodiment both the tube thicknesses and porosities may differ substantially. For example the inner porosity may be selected to enhance blood flow or intimal regeneration, and the outer surface may have a porosity to encourage anchoring to external muscle tissue.
摘要翻译：径向可扩展的支撑体被包围在茧内。在优选的结构中，支撑件是支架，并且聚合物材料管例如聚多异氰酸乙烯（PTFE）穿过支架主体的内部并且在其上自我转过支架以形成袖带。然后将组件加热并且外层与内层接触并聚结，在具有连续和无缝端部的折叠外壳内紧密地围绕支架主体。在一个实施例中，管的端部在折叠回支架之前膨胀。成为成品的外表面的端部因此获得更大程度的孔隙率。中心管的每个端部可以如此膨胀，并且被折回以密封所有表面和两端。支架主体本身可以是一个环，或一系列间隔开的环，或者线或腹板，或者具有完全贯穿片材的多个孔的片。空间或孔被内聚合物层和外聚合物层覆盖或桥接。可以包括支架表面积的五到八十成以上的孔构成区域或网格，通过该点或网格将材料聚结并连续地结合，并且通过支撑分布在哪个应变附近。这些点或区域保持粘合在一起，因此组件的膨胀不会分解聚合物或产生襟翼和口袋。在另一个实施例中，将双管结构压合并组装成相似的单元化且无缝的支架。一根管子被套在后面，另一根管子覆盖着袖口支架。在该实施例中，管的厚度和孔隙度可能基本上不同。例如，可以选择内部孔隙率以增强血流或内膜再生，并且外表面可以具有孔隙度以促进锚定到外部肌肉组织。

7. 发明授权

US5897587A Multi-stage prosthesis 失效
标题翻译：多期假体
公开(公告)号：US5897587A
公开(公告)日：1999-04-27
申请号：US760113
申请日：1996-12-03
申请人： Paul Martakos , Peter Gingras , Theodore Karwoski , Steve A. Herweck
发明人： Paul Martakos , Peter Gingras , Theodore Karwoski , Steve A. Herweck
IPC分类号： A61F2/00 , A61F2/06 , A61F2/10 , A61F2/24 , A61F2/88 , A61L27/16 , A61L27/34 , A61L27/50
CPC分类号： A61F2/07 , A61F2/06 , A61L27/16 , A61L27/34 , A61L27/507 , A61F2/105 , A61F2/2412 , A61F2/88 , A61F2002/072 , A61F2240/001
摘要： A porous tube suitable for use as a vascular graft prosthesis and a method of making it is disclosed. It has a structure of porous polytetrafluoroethylene having a fibrous structure of nodes and fibers connecting the nodes together and an integrated intrawall circumferential support adjacent to areas of variable porosity. This invention provides a polytetrafluoroethylene polymer in a porous form useful as artificial internal organs for, for example vascular bypass, vascular access, and endovascular prosthesis. PTFE walls with radial zones of differing porosity are described.
摘要翻译：公开了适合用作血管移植假体的多孔管及其制造方法。它具有多孔聚四氟乙烯的结构，其具有连接节点的节点和纤维的纤维结构，以及与可变孔隙度区域相邻的整体的内部周向支撑。本发明提供一种多孔形式的聚四氟乙烯聚合物，其用作例如血管旁路，血管通路和血管内假体的人造内脏。描述具有不同孔隙率的径向区域的PTFE壁。

8. 发明授权

US07740793B2 Expandable fluoropolymer device for delivery of therapeutic agents and method of making 有权
标题翻译：用于递送治疗剂的可扩展含氟聚合物装置和制备方法
公开(公告)号：US07740793B2
公开(公告)日：2010-06-22
申请号：US11068680
申请日：2005-02-28
申请人： Steve A. Herweck , Peter Gingras , Paul Martakos , Theodore Karwoski
发明人： Steve A. Herweck , Peter Gingras , Paul Martakos , Theodore Karwoski
IPC分类号： A61M29/00
CPC分类号： A61M25/1029 , A61L29/041 , A61M25/10 , A61M2025/0057 , A61M2025/105 , A61M2025/1075 , B29C47/00 , B29C47/0023 , B29C55/24 , B29C2049/465 , B29K2027/18 , B29L2022/022 , B29L2031/753 , B32B2305/026 , C08L27/18
摘要： A method of making a radially expandable fluid delivery device includes providing a tube of biocompatible fluoropolymer material with a predetermined porosity based on an extrusion and expansion forming process, applying a radial expansion force to the tube expanding the tube to a predetermined diameter dimension, and removing the radial expansion force. The tube is radially inelastic while sufficiently pliable to be collapsible and inflatable from a collapsed configuration to an expanded configuration upon introduction of an inflation force, such that the expanded configuration occurs upon inflation to the predetermined diameter dimension. The fluid delivery device is constructed of a microporous, biocompatible fluoropolymer material having a microstructure that can provide a controlled, uniform, low-velocity fluid distribution through the walls of the fluid delivery device to effectively deliver fluid to the treatment site without damaging tissue proximate the walls of the device.
摘要翻译：一种制造可径向膨胀的流体递送装置的方法包括：基于挤出和膨胀成形方法提供具有预定孔隙率的生物相容性氟聚合物材料管，向扩管管的管施加径向膨胀力至预定直径尺寸，径向膨胀力。该管是径向无弹性的，同时在引入膨胀力时足够柔软地可从折叠构型膨胀到膨胀构型，使得膨胀构型在膨胀到预定直径尺寸时发生。流体输送装置由具有微结构的微孔生物相容性含氟聚合物材料构成，微结构可以通过流体输送装置的壁提供受控的，均匀的低速流体分配，以有效地将流体输送到治疗部位，而不会损伤邻近的设备的墙壁。

9. 发明授权

US5824050A Prosthesis with in-wall modulation 失效
公开(公告)号：US5824050A
公开(公告)日：1998-10-20
申请号：US760115
申请日：1996-12-03
申请人： Theodore Karwoski , Paul Martakos , Peter Gingras , Steve A. Herweck , Tom Swanick
发明人： Theodore Karwoski , Paul Martakos , Peter Gingras , Steve A. Herweck , Tom Swanick
IPC分类号： A61F2/00 , A61F2/06 , A61F2/10 , A61F2/24 , A61F2/88 , A61L27/16 , A61L27/34 , A61L27/40 , A61F2/04
CPC分类号： A61F2/07 , A61F2/06 , A61L27/16 , A61L27/34 , A61L27/40 , A61F2/105 , A61F2/2412 , A61F2/88 , A61F2002/072 , A61F2240/001
摘要： The wall of a prosthesis has a region which modulates communication through the porosity of the wall. The prosthesis is unitary, but may be assembled in successive bodies which are coalesced, so that the porous microstructure changes distinctly at stages through the thickness dimension of the wall. One embodiment is formed entirely of fluoropolymer, and has at least one surface adapted to support tissue regeneration and ingrowth. The modulation region is a stratum of high water entry pressure that reduces pulsatile hydraulic pressure transmission, or locally alters fluid-born-distribution of biological material through the wall and allows more natural gradients for tissue regeneration and growth in the outer region of the wall.

10. 发明授权

US5925074A Vascular endoprosthesis and method 失效
公开(公告)号：US5925074A
公开(公告)日：1999-07-20
申请号：US759861
申请日：1996-12-03
申请人： Peter Gingras , Paul Martakos , Theodore Karwoski , Steve A. Herweck
发明人： Peter Gingras , Paul Martakos , Theodore Karwoski , Steve A. Herweck
IPC分类号： A61F2/82 , A61L31/04 , A61F2/06
CPC分类号： A61F2/82 , A61F2/07 , A61L31/048 , A61F2/90 , A61F2/958
摘要： A vascular endoprosthesis is formed of a tubular liner preform with a continuous surface and having a diameter smaller than that of an intended vessel. The liner is inserted to a treatment site, and its sheet material undergoes a radially-directed expansion to a final size that fits the vessel. Insertion and in situ expansion are achieved using a catheter assembly in which either an internal stent, such as a stiff-filament helically woven tube, or an inflatable balloon urge the liner preform outwardly against the inner wall of the vessel. The stent, or one or more simple internal snap-rings anchor the expanded liner in place. The expanded liner is porous, or becomes more porous during expansion, and one or more aspects of its porosity are tailored to the intended treatment goal of immobilizing treatment material, isolating cells, or permitting controlled permeation of selected materials.

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