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1. 发明申请

US20050227252A1 Diffraction grating-based encoded articles for multiplexed experiments 审中-公开
$Diffraction grating-based encoded articles for multiplexed experiments$
标题翻译：用于多重实验的基于衍射光栅的编码文章
公开(公告)号：US20050227252A1
公开(公告)日：2005-10-13
申请号：US10990057
申请日：2004-11-15
申请人： John Moon , Martin Putnam , Michel Perbost , John Quinn , Mary Trounstine
发明人： John Moon , Martin Putnam , Michel Perbost , John Quinn , Mary Trounstine
IPC分类号： B01L3/00 , C12M1/34 , C12Q1/68 , G01N33/53 , G01N33/543 , G01N33/68
CPC分类号： G01N33/6845 , B01L3/508 , G01N33/54313 , G01N33/54353
摘要： The present invention provides methods and compositions directed toward assays of a broad range of analytes using specific targeting chemicals that bind to the analytes. The assays are founded on the use of coded assay articles to which the targeting chemicals are attached. Additionally the codes are such that they are interrogated and determined in real time. The target is analyzed as to identity, presence and quantity in real time. The methods and compositions of the invention are highly suitable for use in high-complexity multiplexed assay systems. All the methods and compositions are based on assay article that includes an optical substrate to which the chemical is bound, and in which is disposed at least one diffraction grating. The grating provides an output optical signal when illuminated by an incident light signal which is indicative of the code in the substrate. In general, coded assay article or sets thereof are employed in assay methods, including multiplexed assay methods, according to which a sample is contacted with an article or a set, and any analytes that bind to the attached chemical are identified according to the code, detected and/or quantitated.
摘要翻译：本发明提供了使用与分析物结合的特定靶向化学物质来测定广泛范围的分析物的方法和组合物。测定建立在使用靶向化学品所连接的编码测定制品的基础上。此外，这些代码使得它们被实时询问并确定。对目标进行身份，存在和数量的实时分析。本发明的方法和组合物非常适用于高复杂度复合测定系统。所有方法和组合物都基于包含化学结合的光学基底的测定制品，并且其中设置有至少一个衍射光栅。当由入射光信号照亮时，光栅提供输出光信号，该入射光信号指示衬底中的代码。通常，编码的测定法或其组合用于测定方法，包括多重测定方法，根据该测定方法，将样品与制品或组合物接触，并且根据代码鉴定与附着的化学物质结合的任何分析物，检测和/或定量。

2. 发明申请

US20060057729A1 Diffraction grating-based encoded element having a substance disposed thereon 审中-公开
$Diffraction grating-based encoded element having a substance disposed thereon$
标题翻译：衍射光栅编码元件，其上设置有物质
公开(公告)号：US20060057729A1
公开(公告)日：2006-03-16
申请号：US11206987
申请日：2005-08-18
申请人： John Moon , Martin Putnam , Michel Perbost
发明人： John Moon , Martin Putnam , Michel Perbost
IPC分类号： G03H1/00 , G01N21/64
CPC分类号： G01N21/6428 , G01N21/4788 , G03H1/26 , G03H2001/0033
摘要： The present invention generally provides multicomponent articles of manufacture and methods of making them. In its broadest aspect, the invention provides a multicomponent article that includes a diffraction grating-based encoded element, wherein the encoded element includes an optical substrate having at least one surface, and an optical coding element; and a substance disposed on at least a portion of the surface of the substrate. The optical substrate may be made from a wide variety of materials. Importantly the multicomponent article may be a reagent particle wherein the substance includes a reagent. The reagent may be chosen from a wide range of biological macromolecules and oligomeric molecules, from any organic chemical or inorganic chemical compound including pharmaceutical agents and candidate pharmaceutical agents, modifications of any of them, and from any microbiological entity, a cell, and similar entities. In another aspect the invention provides a coded reagent library including a plurality of reagent particles described herein the preceding paragraphs. In another aspect the invention provides a method of preparing a multicomponent article including the steps of providing a diffraction grating-based encoded element, and binding a substance to a surface of said optical substrate. The invention also provides a method of preparing a coded reagent library. Additionally the invention provides a method of synthesizing a polynucleotide reagent on a multicomponent article.
摘要翻译：本发明通常提供多组分制品及其制备方法。在其最广泛的方面，本发明提供了一种包括基于衍射光栅的编码元件的多组分制品，其中编码元件包括具有至少一个表面的光学基底和光学编码元件; 以及设置在所述基板的表面的至少一部分上的物质。光学基底可以由各种各样的材料制成。重要的是，多组分制品可以是试剂颗粒，其中物质包括试剂。试剂可以选自广泛范围的生物大分子和低聚分子，包括任何有机化学或无机化合物，包括药剂和候选药剂，其任何一种的修饰，以及任何微生物实体，细胞和类似实体。在另一方面，本发明提供了一种编码的试剂库，其包括前述各段所述的多种试剂颗粒。在另一方面，本发明提供了一种制备多组分制品的方法，包括以下步骤：提供基于衍射光栅的编码元件，并将物质结合到所述光学基底的表面。本发明还提供了编码试剂库的方法。另外，本发明提供了在多组分制品上合成多核苷酸试剂的方法。

3. 发明申请

US20060134324A1 Filament with easily removed protective coating and methods for stripping the same 审中-公开
标题翻译：长丝易剥离保护涂层及剥离方法
公开(公告)号：US20060134324A1
公开(公告)日：2006-06-22
申请号：US11283517
申请日：2005-11-17
申请人： Martin Putnam , Michel Perbost , Robert Brucato
发明人： Martin Putnam , Michel Perbost , Robert Brucato
IPC分类号： B05D5/06 , B05D1/18
CPC分类号： D01D11/06
摘要： The present invention provides a filament with an easily removable protective coating as well as a method and apparatus for applying the protective coating to the filament during a draw process that can be easily removed with a reasonably benign solvent such as water, or if necessary, acetone or ethanol. The protective coating is water-soluble and can be easily dissolved in-line with a spooling process. The coating material may include a water-soluble “wax-like” material called Aquabond 65, distributed by Aquabond Technologies, as well as other grades of Aquabond such Aquabond 55 and Aquabond 85, which behave essentially the same but are dissolved at different temperatures.
摘要翻译：本发明提供了一种具有容易移除的保护涂层的长丝以及用于在拉伸过程中将保护涂层施加到长丝上的方法和装置，该方法和装置可以用相当良好的溶剂（如水）或如果需要丙酮容易地除去或乙醇。保护涂层是水溶性的，并且可以容易地与卷绕过程一起溶解。涂层材料可以包括由Aquabond Technologies分发的水溶性“蜡状”材料Aquabond 65，以及其它等级的Aquabond，如Aquabond 55和Aquabond 85，其性能基本相同但在不同温度下溶解。

4. 发明申请

US20050023246A1 Methods and devices for modifying a substrate surface 失效
标题翻译：用于修饰基材表面的方法和装置
公开(公告)号：US20050023246A1
公开(公告)日：2005-02-03
申请号：US10632600
申请日：2003-08-01
申请人： John McEntee , Michel Perbost , Joseph Vandenburg
发明人： John McEntee , Michel Perbost , Joseph Vandenburg
IPC分类号： B08B3/12 , B24B1/04 , B24B31/10 , C03C19/00 , C09K3/14 , B08B7/00 , C23F1/00
CPC分类号： B24B1/04 , B01J2219/00527 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B08B3/12 , B24B31/10 , C03C19/00 , C09K3/1472
摘要： Methods and compositions for modifying a substrate surface are provided. In accordance with the subject methods, a substrate surface is contacted with a particulate-containing fluid. The fluid is then ultrasonically or sonically agitated to modify the substrate surface. In certain embodiments, the particulate-containing fluid has a pH above the isoelectric point of the substrate. Also provided are devices capable of providing ultrasonic and/or sonic energy and which include a non-acidic, particulate-containing fluid. The subject invention also provides systems and kits for use in practicing the subject methods.
摘要翻译：提供了修饰基材表面的方法和组合物。根据本发明的方法，将基底表面与含颗粒的流体接触。然后将液体超声波或超声波搅拌以改变基底表面。在某些实施方案中，含颗粒的流体具有高于基底的等电点的pH。还提供能够提供超声波和/或声能的装置，并且其包括非酸性的含颗粒的流体。本发明还提供用于实践本发明方法的系统和试剂盒。

5. 发明授权

US09073033B2 Methods and compositions for processing chemical reactions 有权
标题翻译：用于处理化学反应的方法和组合物
公开(公告)号：US09073033B2
公开(公告)日：2015-07-07
申请号：US13008317
申请日：2011-01-18
申请人： Michal Lebl , Michel Perbost , Chad F. DeRosier , Mark J. Nibbe , Steve R. Burgett , David L. Heiner
发明人： Michal Lebl , Michel Perbost , Chad F. DeRosier , Mark J. Nibbe , Steve R. Burgett , David L. Heiner
IPC分类号： B01L3/00 , B01J19/22 , B01J14/00 , B01J19/00 , B01L7/00
CPC分类号： B01J19/22 , B01J14/005 , B01J19/0046 , B01J2219/00306 , B01J2219/00324 , B01J2219/00351 , B01J2219/0036 , B01J2219/00378 , B01J2219/0038 , B01J2219/00495 , B01J2219/00518 , B01J2219/00533 , B01J2219/00585 , B01J2219/00596 , B01J2219/00644 , B01J2219/00686 , B01J2219/00693 , B01J2219/00722 , B01L3/50851 , B01L7/5255 , B01L2300/069 , B01L2300/0812 , B01L2300/0829 , B01L2300/123
摘要： Disclosed herein are compositions, methods and systems for the processing of chemical reactions, such as the synthesis of polymers.
摘要翻译：本文公开了用于处理化学反应的组合物，方法和系统，例如聚合物的合成。

6. 发明申请

US20050106685A1 Method of synthesizing polynucleotides using ionic liquids 失效
标题翻译：使用离子液体合成多核苷酸的方法
公开(公告)号：US20050106685A1
公开(公告)日：2005-05-19
申请号：US11020408
申请日：2004-12-22
申请人： Joel Myerson , Michel Perbost , Douglas Dellinger , Geraldine Dellinger
发明人： Joel Myerson , Michel Perbost , Douglas Dellinger , Geraldine Dellinger
IPC分类号： C07D213/20 , C07D233/54 , C07D521/00 , C07H21/00 , C07H21/04 , C12P19/34
CPC分类号： C07D233/56 , C07D213/20 , C07D231/12 , C07D233/54 , C07D249/08 , C07H21/00
摘要： A method of synthesizing polynucleotides is disclosed. The method involves contacting a first nucleotide with a selected reactive group in the presence of an ionic liquid. The selected reactive group may be on a second nucleotide, a polynucleotide, or on a moiety on an insoluble substrate, for example in an oligonucleotide synthesizer.
摘要翻译：公开了一种合成多核苷酸的方法。该方法包括在离子液体存在下使第一核苷酸与选定的反应性基团接触。选择的反应性基团可以在第二核苷酸，多核苷酸上，或在不溶性底物上的部分上，例如在寡核苷酸合成仪中。

7. 发明授权

US08524450B2 Microvessels, microparticles, and methods of manufacturing and using the same 有权
标题翻译：微血管，微粒及其制造方法和使用方法
公开(公告)号：US08524450B2
公开(公告)日：2013-09-03
申请号：US12916242
申请日：2010-10-29
申请人： John A. Moon , M. Shane Bowen , Ryan C. Smith , Michel Perbost , Michal Lebl , Steven H. Modiano
发明人： John A. Moon , M. Shane Bowen , Ryan C. Smith , Michel Perbost , Michal Lebl , Steven H. Modiano
IPC分类号： C07H21/04 , C12M1/00 , G01N15/06 , C40B30/10
CPC分类号： G01N33/50 , B01J19/0046 , B01J2219/00306 , B01J2219/00511 , B01J2219/0052 , B01J2219/00524 , B01J2219/00545 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00673 , B01J2219/00702 , B01J2219/0072 , B01L3/502761 , B01L3/5082 , B01L3/50857 , B01L3/5088 , B01L3/545 , C40B20/04 , G01N21/01 , G01N21/253 , G01N21/6452 , G01N35/00732
摘要： A method of reading a plurality of encoded microvessels used in an assay for biological or chemical analysis. The method can include providing a plurality of encoded microvessels. The microvessels can include a respective microbody and a reservoir core configured to hold a substance in the reservoir core. The microbody can include a material that surrounds the reservoir core and facilitates detection of a characteristic of the substance within the reservoir core. Optionally, the material can be transparent so as to facilitate detection of an optical characteristic of a substance within the reservoir core. The microbody can include an identifiable code associated with the substance. The method can also include determining the corresponding codes of the microvessels.
摘要翻译：读取用于生物或化学分析的测定中使用的多个编码微血管的方法。该方法可以包括提供多个编码微血管。微血管可以包括相应的微体和被配置为将物质保持在储存器芯中的储存器芯。微体可以包括围绕储存器芯的材料，并且有助于检测储存器芯内物质的特性。任选地，材料可以是透明的，以便于检测储存器芯内物质的光学特性。微体可以包括与物质相关联的可识别代码。该方法还可以包括确定微血管的相应代码。

8. 发明申请

US20110178285A1 METHODS AND COMPOSITIONS FOR PROCESSING CHEMICAL REACTIONS 有权
标题翻译：用于加工化学反应的方法和组合物
公开(公告)号：US20110178285A1
公开(公告)日：2011-07-21
申请号：US13008317
申请日：2011-01-18
申请人： Michal Lebl , Michel Perbost , Chad F. DeRosier , Mark J. Nibbe , Steve R. Burgett , David L. Heiner
发明人： Michal Lebl , Michel Perbost , Chad F. DeRosier , Mark J. Nibbe , Steve R. Burgett , David L. Heiner
IPC分类号： C07H21/00 , B01J7/02 , B05D5/00
CPC分类号： B01J19/22 , B01J14/005 , B01J19/0046 , B01J2219/00306 , B01J2219/00324 , B01J2219/00351 , B01J2219/0036 , B01J2219/00378 , B01J2219/0038 , B01J2219/00495 , B01J2219/00518 , B01J2219/00533 , B01J2219/00585 , B01J2219/00596 , B01J2219/00644 , B01J2219/00686 , B01J2219/00693 , B01J2219/00722 , B01L3/50851 , B01L7/5255 , B01L2300/069 , B01L2300/0812 , B01L2300/0829 , B01L2300/123
摘要： Disclosed herein are compositions, methods and systems for the processing of chemical reactions, such as the synthesis of polymers.
摘要翻译：本文公开了用于处理化学反应的组合物，方法和系统，例如聚合物的合成。

9. 发明申请

US20050208541A1 Chemical arrays 失效
公开(公告)号：US20050208541A1
公开(公告)日：2005-09-22
申请号：US11030562
申请日：2005-01-05
申请人： Steven Lefkowitz , Michel Perbost , Roy Kanemoto , Carol Schembri
发明人： Steven Lefkowitz , Michel Perbost , Roy Kanemoto , Carol Schembri
IPC分类号： B01J19/00 , C40B50/14 , C40B60/14 , C40B70/00 , G01N35/00 , C12Q1/68 , G01N33/48 , G01N33/50 , G06F19/00
CPC分类号： B82Y30/00 , B01J19/0046 , B01J2219/00274 , B01J2219/00378 , B01J2219/00497 , B01J2219/00518 , B01J2219/00527 , B01J2219/00547 , B01J2219/00585 , B01J2219/0059 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00675 , B01J2219/00677 , B01J2219/00689 , B01J2219/00695 , C40B50/14 , C40B60/14 , C40B70/00 , G01N35/00009 , G01N2035/00158
摘要： Methods, apparatus, and computer program products to form arrays of polymers each having a pattern of features on a surface of a flexible elongated web, comprising. In a method polymers or their precursor units are applied at an application station to the surface. Multiple features are covered at a reagent station with a continuous volume of reagent which chemically reacts with precursors or the web. The flexible elongated web is driven in a lengthwise direction through the application station. This sequence may be repeated as needed to form the arrays along the web. Also provided is a method preparing a surface of a flexible elongated web to receive a biopolymer array.

10. 发明申请

US20050112679A1 Use of ionic liquids for fabrication of polynucleotide arrays 失效
公开(公告)号：US20050112679A1
公开(公告)日：2005-05-26
申请号：US11020428
申请日：2004-12-22
申请人： Joel Myerson , Michel Perbost , Douglas Delinger , Geraldine Dellinger
发明人： Joel Myerson , Michel Perbost , Douglas Delinger , Geraldine Dellinger
IPC分类号： C07B61/00 , C07H21/00 , C40B50/14 , C40B60/14 , C12Q1/68 , B05D3/00
CPC分类号： B82Y30/00 , B01J2219/00378 , B01J2219/00608 , B01J2219/00612 , B01J2219/00626 , B01J2219/00675 , B01J2219/00677 , C07B2200/11 , C07H21/00 , C40B50/14 , C40B60/14 , Y02P20/542
摘要： A method of fabricating polynucleotide arrays includes dissolving a nucleotide monomer, oligonucleotide, or polynucleotide in a solvent containing ionic liquid and depositing the resulting solution on an array substrate. The method has particular application to fabrication of an addressable array of polynucleotides on a substrate that carries substrate bound moieties each with a hydroxyl group. The process may be repeated at specific locations on the array to elongate the polynucleotide deposited on the array.

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