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1. 发明申请

US20060127881A1 Automated segmentation, classification, and tracking of cell nuclei in time-lapse microscopy 审中-公开
标题翻译：延时显微术中细胞核的自动分割，分类和跟踪
公开(公告)号：US20060127881A1
公开(公告)日：2006-06-15
申请号：US11257523
申请日：2005-10-25
申请人： Stephen Wong , Xiaowei Chen
发明人： Stephen Wong , Xiaowei Chen
IPC分类号： C12Q1/00 , C12Q1/68 , G06F19/00 , G06K9/00
CPC分类号： G06K9/00127 , G06T7/246 , G06T2207/10056 , G06T2207/30024
摘要： Methods and apparatus are provided for the automated analysis of images of living cells acquired by time-lapse microscopy. The new methods and apparatus can be used for the segmentation, classification and tracking of individual cells in a cell population, and for the extraction of biologically significant features from the cell images. Based upon certain extracted features, the inventive image analysis methods can characterize a cell as mitotic or interphase and/or can classify a cell into one of the following mitotic phases: prophase, metaphase, arrested metaphase, and anaphase with high accuracy.
摘要翻译：提供了用于通过延时显微镜获得的活细胞的图像的自动分析的方法和装置。新的方法和装置可用于细胞群体中各细胞的分割，分类和追踪，以及从细胞图像中提取生物学显着特征。基于某些提取的特征，本发明的图像分析方法可以将细胞表征为有丝分裂或间期，和/或可以将细胞分类为以下有丝分裂期之一：前期，中期，停止的中期和后期高精度。

2. 发明申请

US20080097815A1 Methods for employing temporary time zones and predictive locations and systems thereof 审中-公开
标题翻译：采用临时时区及其预测位置及其系统的方法
公开(公告)号：US20080097815A1
公开(公告)日：2008-04-24
申请号：US11584490
申请日：2006-10-23
申请人： David Koretz , Robert Chamberlin , James Simpson , Stephen Wong
发明人： David Koretz , Robert Chamberlin , James Simpson , Stephen Wong
IPC分类号： G06F15/02
CPC分类号： G06Q10/109 , G06Q10/1095
摘要： A method, system, and computer readable medium for enabling a user within an application to select a time zone for a temporary period of time include selecting a temporary time zone having a start time and an end time, and changing a time of events that fall within the temporary time zone.
摘要翻译：用于使应用程序内的用户能够选择临时时段的时区的方法，系统和计算机可读介质包括选择具有开始时间和结束时间的临时时区，以及改变下降的事件的时间在临时时区内。

3. 发明授权

US5432479A D.C. current compensation circuit for a nonlinear amplifier 失效
标题翻译：用于非线性放大器的直流电流补偿电路
公开(公告)号：US5432479A
公开(公告)日：1995-07-11
申请号：US221122
申请日：1994-03-31
申请人： Stephen Wong
发明人： Stephen Wong
IPC分类号： H03F1/30
CPC分类号： H03F1/301
摘要： A D.C. current compensation circuit for a nonlinear amplifier includes a compensating amplifier of substantially the same circuit configuration as that of the nonlinear amplifier, and a current mirror for coupling the compensation amplifier to the nonlinear amplifier to be compensated. The compensating amplifier is provided with feedback from its output to its input, so that a D.C. current provided to the output of the compensating amplifier can be used to compensate the D.C. input current of the nonlinear amplifier. In this manner, the nonlinear amplifier can be compensated for changes in gain due to temperature or manufacturing process variations.
摘要翻译：用于非线性放大器的直流电流补偿电路包括与非线性放大器基本相同的电路配置的补偿放大器和用于将补偿放大器耦合到要补偿的非线性放大器的电流镜。补偿放大器提供从其输出到其输入的反馈，使得提供给补偿放大器的输出的直流电流可以用于补偿非线性放大器的直流输入电流。以这种方式，由于温度或制造工艺变化，可以补偿非线性放大器的增益变化。

4. 发明授权

US08606740B2 Classification of subcortical structures 有权
标题翻译：皮质下结构分类
公开(公告)号：US08606740B2
公开(公告)日：2013-12-10
申请号：US12441973
申请日：2007-09-18
申请人： Shabbar F. Danish , Stephen Wong , Gordon H. Baltuch , Jurg L. Jaggi
发明人： Shabbar F. Danish , Stephen Wong , Gordon H. Baltuch , Jurg L. Jaggi
IPC分类号： G06F9/44
CPC分类号： A61B5/0476 , A61B5/4064 , A61B5/7203 , A61B5/7264
摘要： Subcortical neural structures are classified during a microelectrode recording (MER) procedure. As the electrode traverses subcortical structures toward a target neural structure, neural activity is analyzed. The neural activity is converted to electrical signals. Features pertaining to characteristics of the neural activity are extracted from the electrical signals. The features are synergistically combined using fuzzy clustering logic, for example. In an example embodiment, the combined results are provided in a form of a color coded map indicating the different structural regions traversed. Observation of the map provides an objective indication of the demarcations of the various structural regions traversed and an objective technique for classifying the structural regions.
摘要翻译：皮质神经结构在微电极记录（MER）过程中被分类。当电极穿过皮质下结构朝向目标神经结构时，分析神经活动。将神经活动转化为电信号。从电信号中提取与神经活动特征有关的特征。使用模糊聚类逻辑协同组合特征。在一个示例性实施例中，组合结果以指示穿过的不同结构区域的颜色编码图形的形式提供。地图的观察提供了各种结构区域划界的客观指标，以及对结构区域进行分类的客观技术。

5. 发明申请

US20080098000A1 System and method for storing user data in a centralized database and intelligently reducing data entry 审中-公开
标题翻译：用于将用户数据存储在集中式数据库中并智能地减少数据输入的系统和方法
公开(公告)号：US20080098000A1
公开(公告)日：2008-04-24
申请号：US11584640
申请日：2006-10-23
申请人： David A. Koretz , Rob Chamberlin , James Simpson , Stephen Wong
发明人： David A. Koretz , Rob Chamberlin , James Simpson , Stephen Wong
IPC分类号： G06F17/30
CPC分类号： G06Q30/06
摘要： A method and system for storing user-specific information in a centralized database and reducing data entry by intelligently determining what data is already stored in the centralized database and what data needs to be collected from the user. The method includes receiving a request from a user of a user computing system to initiate a transaction, wherein the transaction requires user-specific information in at least one associated field to complete the transaction, and receiving a request from a service provider system for the user-specific information. The method further includes providing the service provider system with the user-specific information when the user-specific information is stored in the centralized database, and, when the user-specific information is not stored in the centralized database, requesting the user-specific information from the user computing system, receiving the user-specific information from the user computing system, and storing the user-specific information received from user computing system in the centralized database.
摘要翻译：一种在中央数据库中存储用户特定信息并通过智能地确定已经存储在集中式数据库中的数据以及需要从用户收集什么数据来减少数据输入的方法和系统。该方法包括接收来自用户计算系统的用户以发起事务的请求，其中事务在至少一个关联字段中需要用户特定信息以完成交易，并且从用户的服务提供商系统接收用户请求 -具体信息。该方法还包括当用户特定信息存储在集中式数据库中时向服务供应商系统提供用户特定信息，并且当用户特定信息未被存储在集中式数据库中时，请求用户特定信息从用户计算系统接收来自用户计算系统的用户特定信息，并将从用户计算系统接收的用户特定信息存储在集中式数据库中。

6. 发明申请

US20060235016A1 Morpholine Dopamine Agonists 失效
标题翻译：吗啉多巴胺激动剂
公开(公告)号：US20060235016A1
公开(公告)日：2006-10-19
申请号：US11425030
申请日：2006-06-19
申请人： Charlotte Allerton , Andrew Baxter , Andrew Cook , David Hepworth , Stephen Wong
发明人： Charlotte Allerton , Andrew Baxter , Andrew Cook , David Hepworth , Stephen Wong
IPC分类号： A61K31/5377 , C07D413/04
CPC分类号： C07D265/30 , C07D413/04
摘要： The present invention provides for compounds of formula (I), (Ia) and (Ib) Wherein: A is selected from C—X and N, B is selected from C—Y and N, R1 is selected from H and (C1-C6)alkyl, R2 is selected from H and (C1-C6)alkyl, X is selected from H, HO, C(O)NH2, NH2 Y is selected from H, HO, NH2, Br, Cl and F Z is selected from H, HO F, CONH2 and CN; And pharmaceutically acceptable salts, solvates and prodrugs thereof; With the provisos that: for a compound of formula (I), (Ia) or (Ib), when A is C—X, B is C—Y, R1 is H or (C1-C6)alkyl and R2 is H or (C1-C6)alkyl at least one of X, Y and Z must be OH; for a compound of formula (I), when A is C—X and B is C—Y, Y is H, Z is H, R1 is H and R2 is H, then X cannot be OH; these compounds are useful as a medicament.
摘要翻译：本发明提供式（I），（Ia）和（Ib）的化合物，其中A选自CX和N，B选自CY和N，R 1选自H 和（C 1 -C 6 -C 6）烷基，R 2选自H和（C 1 -C 6烷基） C 1 -C 6烷基，X选自H，HO，C（O）NH 2，NH 2 Y选自H，HO， NH 2，Br，Cl和FZ选自H，HOF，CONH 2和CN; 其药学上可接受的盐，溶剂合物和前药; 条件是：对于式（I），（Ia）或（Ib）的化合物，当A为CX时，B为CY，R 1为H或（C 1 < C 1 -C 6烷基，R 2是H或（C 1 -C 6 -C 6）烷基， X，Y和Z中的至少一个必须是OH; 对于式（I）化合物，当A为CX且B为CY时，Y为H，Z为H，R 1为H且R 2为H，那么X不能是OH; 这些化合物可用作药物。

7. 发明申请

US20060052435A1 Selective dopamin d3 receptor agonists for the treatment of sexual dysfunction 审中-公开
标题翻译：选择性多巴胺d3受体激动剂治疗性功能障碍
公开(公告)号：US20060052435A1
公开(公告)日：2006-03-09
申请号：US10499210
申请日：2002-12-10
申请人： Pieter Van der Graaf , Christopher Peter Wayman , Andrew Baxter , Andrew Cook , Stephen Wong
发明人： Pieter Van der Graaf , Christopher Peter Wayman , Andrew Baxter , Andrew Cook , Stephen Wong
IPC分类号： A61K31/405
CPC分类号： A61K31/5375 , A61K31/00 , A61K45/06
摘要： The use of a composition comprising a selective dopamine D3 receptor agonist, wherein said dopamine D3 receptor agonist is at least about 15-times more functionally selective for a dopamine D3 receptor as compared with a dopamine D2 receptor when measured using the same functional assay, in the preparation of a medicament for the treatment and/or prevention of sexual dysfunction.
摘要翻译：使用包含选择性多巴胺D3受体激动剂的组合物，其中所述多巴胺D3受体激动剂对于多巴胺D3受体的功能选择性与多巴胺D2受体相比，当使用相同的功能测定法测定时，其功能选择性为至少约15倍，制备用于治疗和/或预防性功能障碍的药物。

8. 发明授权

US5930804A Web-based biometric authentication system and method 失效
标题翻译：基于Web的生物识别系统和方法
公开(公告)号：US5930804A
公开(公告)日：1999-07-27
申请号：US871035
申请日：1997-06-09
申请人： Yuan-Pin Yu , Stephen Wong , Mark B. Hoffberg
发明人： Yuan-Pin Yu , Stephen Wong , Mark B. Hoffberg
IPC分类号： G06F1/00 , G06F21/00 , G06F21/20 , G07C9/00 , H04L29/06 , G06F9/00
CPC分类号： H04L63/0861 , G06F21/32 , G06F21/33 , G06Q20/4014 , G07C9/00158 , G06F2211/007 , Y10S707/99931 , Y10S707/99933 , Y10S707/99945 , Y10S707/99948
摘要： A Web-based authentication system and method, the system comprising at least one Web client station, at least one Web server station and an authentication center. The Web client station is linked to a Web cloud, and provides selected biometric data of an individual who is using the Web client station. The Web server station is also linked to the Web cloud. The authentication center is linked to at least one of the Web client and Web server stations so as to receive the biometric data. The authentication center, having records of one or more enrolled individuals, provides for comparison of the provided data with selected records. The method comprises the steps of (i) establishing parameters associated with selected biometric characteristics to be used in authentication; (ii) acquiring, at the Web client station, biometric data in accordance with the parameters; (iii) receiving, at an authentication center, a message that includes biometric data; (iv) selecting, at the authentication center, one or more records from among records associated with one or more enrolled individuals; and (v) comparing the received data with selected records. The comparisons of the system and method are to determine whether the so-compared live data sufficiently matches the selected records so as to authenticate the individual seeking access of the Web server station, which access is typically to information, services and other resources provided by one or more application servers associated with the Web server station.
摘要翻译：一种基于Web的认证系统和方法，所述系统包括至少一个Web客户站，至少一个Web服务器站和认证中心。 Web客户端站链接到Web云，并提供使用Web客户端的个人所选择的生物特征数据。 Web服务器站也链接到Web云。认证中心被链接到至少一个Web客户端和Web服务器站，以便接收生物特征数据。具有一个或多个注册个人的记录的认证中心提供所提供的数据与所选记录的比较。该方法包括以下步骤：（i）建立与在认证中使用的所选生物特征相关的参数; （ii）根据参数在Web客户端获取生物特征数据; （iii）在认证中心处接收包括生物测定数据的消息; （iv）在认证中心从与一个或多个登记个人相关联的记录中选择一个或多个记录; 和（v）将接收到的数据与所选记录进行比较。系统和方法的比较是确定如此比较的实时数据是否足够地匹配所选择的记录，以便对Web服务器站的个人寻求访问进行认证，该访问通常是信息，服务和由一个或更多与Web服务器站相关联的应用服务器。

9. 发明授权

US5510972A Bridge rectifier circuit having active switches and an active control circuit 失效
标题翻译：桥式整流电路具有有源开关和有源控制电路
公开(公告)号：US5510972A
公开(公告)日：1996-04-23
申请号：US268705
申请日：1994-06-29
申请人： Stephen Wong
发明人： Stephen Wong
IPC分类号： H02M7/219 , H02M7/217
CPC分类号： H02M7/219 , H02M2007/2195 , Y02B70/1408
摘要： A bridge rectifier circuit uses active switches for at least two of its four rectifying elements, and employs an active control circuit to control the state of the active switches. The active control circuit receives its input from the AC input to the bridge rectifier circuit, is powered by the DC output of the bridge rectifier circuit, and provides control outputs to the active switches. In this manner, a bridge rectifier circuit having improved performance and decreased power dissipation is achieved.
摘要翻译：桥式整流电路使用有源开关用于其四个整流元件中的至少两个，并采用有源控制电路来控制有源开关的状态。有源控制电路从AC输入到桥式整流电路接收输入，由桥式整流电路的直流输出供电，并向主动开关提供控制输出。以这种方式，实现了具有改进的性能和降低的功率耗散的桥式整流电路。

10. 发明授权

US5485292A High voltage differential sensor having a capacitive attenuator 失效
标题翻译：具有电容衰减器的高压差动传感器
公开(公告)号：US5485292A
公开(公告)日：1996-01-16
申请号：US439617
申请日：1995-05-12
申请人： Stephen Wong , Satyendranath Mukherjee , Naveed Majid
发明人： Stephen Wong , Satyendranath Mukherjee , Naveed Majid
IPC分类号： G01R15/06 , G01R19/00 , H03K5/12 , H03K5/153
CPC分类号： G01R15/06
摘要： A high-voltage differential sensor includes an attenuator formed of two matched monolithic capacitance divider networks. Each divider network is formed of a series connection of monolithically integrated capacitors, which together generate an attenuated differential signal from a high-voltage differential input signal. The attenuated differential signal from the capacitance divider networks is then amplified and fed to a comparator, which generates a first output level when the high-voltage differential input signal is above a selected level, and generates a second output level when the high-voltage differential input signal is below the selected level. By using monolithically integrated capacitors in the divider networks of the attenuator, a simple, compact, low power, high performance high-voltage differential sensor is obtained.
摘要翻译：高压差分传感器包括由两个匹配的单片电容分压器网络形成的衰减器。每个分压网络由单片集成电容器的串联连接形成，它们一起从高电压差分输入信号产生衰减的差分信号。来自电容分压器网络的衰减的差分信号然后被放大并馈送到比较器，当比较器高电压差分输入信号高于选定电平时，该比较器产生第一输出电平，并且当高压差分输入信号低于所选电平。通过在衰减器的分压网络中使用单片集成电容器，可以获得简单，紧凑，低功耗，高性能的高压差分传感器。

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