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1. 发明授权

US06255095B1 Human diacylglycerol kinase iota 有权
标题翻译：人二酰甘油激酶
公开(公告)号：US06255095B1
公开(公告)日：2001-07-03
申请号：US09412545
申请日：1999-10-05
申请人： Stephen M. Prescott , Li Ding , Elie Traer
发明人： Stephen M. Prescott , Li Ding , Elie Traer
IPC分类号： C12N912
CPC分类号： C12N9/1205
摘要： Diacylglycerol (DAG) plays a central role in both the synthesis of complex lipids and in intracellular signaling; diacylglycerol kinase (DGK) catalyzes the phosphorylation of DAG, which yields phosphatidic acid. A family of DGKs has been identified in multicellular organisms over the past few years, but the physiological function(s) of this diversity is not clear. One clue has come from the Drosophila DGK2, rdgA, since mutations in this gene cause retinal degeneration. The present invention relates to a novel DGK, designated DGK&igr;, which was isolated from human retina and brain libraries. DGK&igr; contains two cysteine-rich repeats, a region similar to the phosphorylation site domain of MARCKS, a conserved catalytic domain, and four ankyrin repeats at its C-terminus. By primary structure, DGK&igr; is most similar to human DGK&zgr; and Drosophila rdgA. A>12 kb mRNA for DGK&igr; was detected only in brain and retina among the tissues examined. In cells transfected with the DGK&igr; cDNA, an approximately 130 kDa protein was detected by immunoassay, and activity assays demonstrated that it encodes a functional DAG kinase. The protein was found to be in both the cytoplasm and nucleus, with this localization controlled by PKC isoforms &agr; and &ggr;. The gene encoding DGK&igr; was localized to human chromosome 7q32.3-33, which is known to be a locus for an inherited form of retinitis pigmentosa. These results have defined a novel isoform of DAG kinase, which may have important cellular functions in the retina and brain.
摘要翻译：二酰基甘油（DAG）在复合脂质的合成和细胞内信号传导中起重要作用; 二酰基甘油激酶（DGK）催化DAG的磷酸化，其产生磷脂酸。过去几年，DGKs家族已被鉴定为多细胞生物，但这种多样性的生理功能尚不清楚。一个线索来自果蝇DGK2，rdgA，因为该基因的突变导致视网膜变性。本发明涉及一种从人视网膜和脑文库中分离得到的一种称为DGK和igr的新型DGK。 DGK＆igr 含有两个富含半胱氨酸的重复序列，一个与MARCKS的磷酸化位点结构域相似的区域，一个保守的催化结构域，在其C-末端有四个锚蛋白重复序列。通过主要结构，DGK＆igr; 最类似于人类DGK＆zgr; 和果蝇rdgA。 A> 12 kb的mRNA用于DGK和igr; 在所检查的组织中仅在脑和视网膜中检测到。在用DGK和igr转染的细胞中 cDNA通过免疫测定检测到约130kDa的蛋白质，活性测定证明它编码功能性DAG激酶。发现蛋白质在细胞质和细胞核两者中，其定位受PKC同种型α和γ的控制。编码DGK和igr的基因被定位于人染色体7q32.3-33，其被认为是色素性视网膜炎的遗传形式的基因座。这些结果定义了DAG激酶的新型同工型，其可能在视网膜和脑中具有重要的细胞功能。

2. 发明授权

US09633143B2 Process and apparatus for generating a three-dimensional swept envelope of a vehicle 有权
公开(公告)号：US09633143B2
公开(公告)日：2017-04-25
申请号：US14110703
申请日：2012-04-05
申请人： Milton Santano Elias Carrasco , Daniel Akwera Shihundu , Billy Siu Fai Chan , Steven Kin-Shing Cheng , Christian Grant Milne , Guanggui Pei , Darren Earl Brown , Li Ding
发明人： Milton Santano Elias Carrasco , Daniel Akwera Shihundu , Billy Siu Fai Chan , Steven Kin-Shing Cheng , Christian Grant Milne , Guanggui Pei , Darren Earl Brown , Li Ding
IPC分类号： G06G7/48 , G06F17/50
CPC分类号： G06F17/5009 , G06F17/5095
摘要： A method, apparatus, media and signals for generating a computer representation of a three-dimensional swept envelope of a vehicle having a wheeled chassis operable to support a vehicle body for movement along a terrain is disclosed. The method involves receiving terrain data representing a 3D terrain, receiving data defining parameters of the vehicle, and receiving data defining a path for movement of the vehicle from an initial position on the terrain to a displaced position on the terrain. The method also involves disposing a computer representation of the vehicle on the 3D representation of the terrain at successive locations along the path using the parameters. Disposing involves determining points of engagement between wheels of the wheeled chassis and the 3D representation of the terrain to dispose the chassis with respect to the terrain, and determining a corresponding 3D location of the vehicle body with respect to the terrain. The method further involves generating a plurality of spatial extents of the vehicle at the successive locations, the spatial extents defining the 3D swept envelope of the vehicle when moving between the initial position and the displaced position. In another aspect a method for generating a computer representation of a three-dimensional swept envelope of an object moving along a guideway disposed with respect to a 3D representation of a terrain is disclosed.

3. 发明申请

US20130138093A1 OPTICAL MATERIAL AND METHOD FOR MODIFYING THE REFRACTIVE INDEX 有权
标题翻译：光学材料和修正折射指数的方法
公开(公告)号：US20130138093A1
公开(公告)日：2013-05-30
申请号：US13686952
申请日：2012-11-28
申请人： Wayne H. Knox , Li Ding , Jay F. Kunzler , Dharmendra Jani , Candido D. Pinto
发明人： Wayne H. Knox , Li Ding , Jay F. Kunzler , Dharmendra Jani , Candido D. Pinto
IPC分类号： A61B18/20 , A61F2/14
CPC分类号： A61F2/14 , A61B18/20 , A61F2/142 , A61F2/1451 , A61F2/147 , A61F2/16 , A61F9/008 , A61L27/16 , A61L27/18 , A61L27/52 , B29D11/00355 , B29D11/00461 , B29D11/023 , B29K2083/00 , B29K2105/0061 , C08J7/12 , C08J7/123 , C08J2333/14 , C08J2339/06 , C08J2383/04 , G02B1/041 , G02C7/022 , G02C2202/12 , G02C2202/14
摘要： An optical device comprising an optical hydrogel with select regions that have been irradiated with laser light having a pulse energy from 0.01 nJ to 50 nJ and a wavelength from 600 nm to 900 nm. The irradiated regions are characterized by a positive change in refractive index of from 0.01 to 0.06, and exhibit little or no scattering loss. The optical hydrogel is prepared with a hydrophilic monomer.
摘要翻译：一种光学装置，包括具有已经用激光照射的选择区域的光学水凝胶，所述激光具有0.01nJ至50nJ的脉冲能量和600nm至900nm的波长。照射区域的特征在于折射率的正变化为0.01至0.06，并且表现出很小的或没有散射损失。用亲水性单体制备光学水凝胶。

4. 发明申请

US20130026359A1 METHOD AND APPARATUS FOR GENERATING AND ANALYZING IONS 有权
标题翻译：用于产生和分析离子的方法和装置
公开(公告)号：US20130026359A1
公开(公告)日：2013-01-31
申请号：US13634190
申请日：2011-04-22
申请人： Sumio Kumashiro , Wenjian Sun , Li Ding
发明人： Sumio Kumashiro , Wenjian Sun , Li Ding
IPC分类号： H01J49/26 , H01J49/04 , H01J49/16
CPC分类号： H01J49/10 , G01N27/622 , H01J49/066 , H01J49/161 , H01J49/164 , H01J49/165 , H01J49/24
摘要： The current invention involves a method and a device for generating and analyzing ions in order to analyze samples directly without sample preparation. The gaseous neutral molecules are desorbed under atmospheric pressure by a desorption method. The desorbed neutral molecules are then transferred into a low pressure region where they are post-ionized by a mist from an electrospray probe tip or by photons from a vacuum UV source. The generated ions are then focused in a time varying electric field in the low pressure chamber before they are transferred into a mass spectrometer or ion mobility spectrometer for further analysis.
摘要翻译：本发明涉及用于生成和分析离子的方法和装置，以便在不进行样品制备的情况下直接分析样品。气态中性分子通过解吸法在大气压下解吸。然后将解吸的中性分子转移到低压区域，在那里它们被来自电喷雾探针尖端的雾或者来自真空UV源的光子后离子化。然后将所产生的离子聚焦在低压室中的时变电场中，然后将其转移到用于进一步分析的质谱仪或离子迁移谱仪中。

5. 发明授权

US08025892B2 Cosmetic particulate gel carriers for topically applied active agents 有权
标题翻译：用于局部施用的活性剂的化妆品颗粒状凝胶载体
公开(公告)号：US08025892B2
公开(公告)日：2011-09-27
申请号：US10017259
申请日：2001-11-12
申请人： Pascal E. Delrieu , Li Ding
发明人： Pascal E. Delrieu , Li Ding
IPC分类号： A61K31/14 , A61K8/02 , A61K9/14 , A61K9/50 , C11D1/62
CPC分类号： A61K8/042 , A61K8/025 , A61K8/11 , A61K8/365 , A61K8/645 , A61K8/676 , A61K8/73 , A61K8/731 , A61K8/735 , A61K2800/56 , A61Q19/00 , Y10S514/937 , Y10S514/944
摘要： Gel particles or beads can be prepared by forming a hot aqueous solution of a gelling agent, and discharging the hot gelling agent solution through a discharge orifice into a cold moving stream of hydrophobic liquid so that the gelling agent solution cools rapidly and good quality gel particles coalesce in the cold hydrophobic liquid stream. The cold hydrophobic liquid stream can be contained in a conduit so that the cold hydrophobic liquid stream moves past the discharge orifice and exerts a force on hot solution in the discharge orifice, the force acting to withdraw the hot solution from the discharge orifice. Optionally, the gel particles can be crushable gel beads 10 formed of an agar complex providing cosmetic, pharmaceutical, etc. delivery vehicles for topical delivery of biologically or cosmetically active agents. Preferred agar beads 10 are complexes of a continuous phase of agar gel 12 in a self-supporting solid or semi-solid form with a restraining polymer 14. Various active agents 16 may be bound to restraining polymer 14, for, example ascorbic acid, lactic acid or papain.
摘要翻译：可以通过形成热胶凝剂的水溶液，并将热胶凝剂溶液通过排出孔排出到冷流动的疏水液体中，使得胶凝剂溶液快速冷却，并且优质的凝胶颗粒在冷疏水性液体流中聚结。冷疏水性液体流可以包含在导管中，使得冷的疏水性液体流移动通过排出孔，并且在排出孔中的热溶液上施加力，该力用于从排出孔抽出热溶液。任选地，凝胶颗粒可以是由琼脂复合物形成的可压碎凝胶珠10，其提供用于局部递送生物或化妆活性剂的化妆品，药物等递送载体。优选的琼脂珠10是具有抑制聚合物14的自支撑固体或半固体形式的琼脂凝胶12的连续相的复合物。各种活性剂16可以与约束聚合物14结合，例如抗坏血酸，乳酸酸或木瓜蛋白酶。

6. 发明申请

US20110049352A1 ION SOURCE 有权
标题翻译：离子源
公开(公告)号：US20110049352A1
公开(公告)日：2011-03-03
申请号：US12552476
申请日：2009-09-02
申请人： Li Ding , Wenjian Sun
发明人： Li Ding , Wenjian Sun
IPC分类号： H01J49/16 , H01J49/26
CPC分类号： H01J49/162 , H01J49/0463 , H01J49/165
摘要： This invention relates to a desorpton/ionization source operated under ambient conditions for direct analysis of solid or liquid samples on a surface. The source comprises of a laser desorption system and a UV/electrospray combined ionization system. The source is suitable for simultaneously ionizing samples with different polarity in a complex mixture. At the same time, the compact design of the source with multiple channels can maintain the level of local concentration of the analyte ions inside the source for higher efficiency of sample ionization and introduction.
摘要翻译：本发明涉及在环境条件下操作的用于在表面上直接分析固体或液体样品的解吸/离子源。该源包括激光解吸系统和UV /电喷雾组合电离系统。该源适用于在复杂混合物中同时电离不同极性的样品。同时，具有多个通道的源的紧凑设计可以保持源内的分析物离子的局部浓度水平，以提高样品电离和引入的效率。

7. 发明授权

US07897916B2 Tandem ion-trap time-of-flight mass spectrometer 有权
标题翻译：串联离子阱飞行时间质谱仪
公开(公告)号：US07897916B2
公开(公告)日：2011-03-01
申请号：US10598194
申请日：2005-02-23
申请人： Michael Sudakov , Li Ding
发明人： Michael Sudakov , Li Ding
IPC分类号： H01J49/42
CPC分类号： H01J49/40 , H01J49/004 , H01J49/423
摘要： A tandem linear ion trap and time-of-flight mass spectrometer, where the ion trap has a straight central axis orthogonal to the flight path of the mass spectrometer. The ion trap comprises a set of electrodes, (401, 403, 402, 404) at least one of the electrodes has a slit for ejecting ions towards the mass spectrometer; a set of DC voltage supplies (+V, −V, V1, V2) to provide discrete DC levels and a number of fast electronic switches (409) for connecting/disconnecting the DC supplies to at least two of the electrodes; a neutral gas filling the ion trap and a digital controller to provide a switching procedure of ion trapping, manipulation with ions, cooling and including a state at which all ions are ejected from the ion trap towards the mass spectrometer.
摘要翻译：串联线性离子阱和飞行时间质谱仪，其中离子阱具有与质谱仪的飞行路径正交的直的中心轴。离子阱包括一组电极（401,403,402,404），至少一个电极具有用于向质谱仪喷射离子的狭缝; 一组直流电压源（+ V，-V，V1，V2）以提供离散DC电平以及用于将DC电源连接/断开至少两个电极的多个快速电子开关（409）填充离子阱的中性气体和数字控制器，以提供离子捕获，用离子的操作，冷却和包括从离子阱向质谱仪喷射所有离子的状态的切换过程。

8. 发明授权

US07893401B2 Mass spectrometer using a dynamic pressure ion source 有权
标题翻译：质谱仪使用动态离子源
公开(公告)号：US07893401B2
公开(公告)日：2011-02-22
申请号：US12158458
申请日：2006-12-20
申请人： Li Ding
发明人： Li Ding
IPC分类号： H01J49/04
CPC分类号： H01J49/062 , H01J49/0481 , H01J49/164
摘要： A mass spectrometer has a pulsed ion source, a first ion trap (10) for trapping ions generated by the pulsed ion source and for locating trapped ions for subsequent ejection from the first ion trap. A pulse of cooling gas is introduced into the first ion trap (10) at a peak pressure suitable for enabling the first ion trap (10) to trap ions. A turbomolecular pump (17) reduces the pressure of cooling gas before the trapped ions are ejected from the first ion trap (1) towards a second ion trap (20) for analysis. The pulsed ion source has a sample plate (14) which forms an end wall of the first ion trap (10).
摘要翻译：质谱仪具有脉冲离子源，第一离子阱（10），用于捕获由脉冲离子源产生的离子，并用于定位捕获的离子用于随后从第一离子阱排出。将冷却气体的脉冲以适于使第一离子阱（10）捕获离子的峰值压力引入到第一离子阱（10）中。涡轮分子泵（17）在被捕获的离子从第一离子阱（1）向第二离子阱（20）排出之前降低冷却气体的压力，用于分析。脉冲离子源具有形成第一离子阱（10）的端壁的样品板（14）。

9. 发明授权

US07789910B2 Optical material and method for modifying the refractive index 有权
$Optical material and method for modifying the refractive index$
标题翻译：用于改变折射率的光学材料和方法
公开(公告)号：US07789910B2
公开(公告)日：2010-09-07
申请号：US11948298
申请日：2007-11-30
申请人： Wayne H. Knox , Li Ding , Jay F. Kunzler , Dharmendra Jani , Candido D. Pinto
发明人： Wayne H. Knox , Li Ding , Jay F. Kunzler , Dharmendra Jani , Candido D. Pinto
IPC分类号： A61F2/16
CPC分类号： A61F2/1613 , A61B18/20 , A61F2/14 , A61F2/16 , A61F2/1627 , A61F2/1635 , B29D11/00461 , B29D11/023 , C08J7/12 , C08J7/123 , G02C2202/14
摘要： A method for modifying the refractive index of an optical, polymeric material. The method comprises irradiating select regions of the optical, polymeric material with a focused, visible or near-IR laser having a pulse energy from 0.05 nJ to 1000 nJ. The irradiation results in the formation of refractive optical structures, characterized by a change in refractive index, exhibit little or no scattering loss, and exhibit no significant differences in the Raman spectrum with respect to the non-irradiated optical, polymeric material. The method can be used to modify the refractive index of an intraocular lens following the surgical implantation of the intraocular lens in a human eye. The invention is also directed to an optical device comprising refractive optical structures, wherein the refractive structures are characterized by a change in refractive index, exhibit little or no scattering loss, and exhibit no significant differences in the Raman spectrum with respect to the non-irradiated optical, polymeric material.
摘要翻译：用于改变光学聚合物材料的折射率的方法。该方法包括用具有0.05nJ至1000nJ的脉冲能量的聚焦，可见或近红外激光照射光学聚合物材料的选择区域。照射导致折射光学结构的形成，其特征在于折射率的变化，显示很少或没有散射损失，并且在拉曼光谱方面相对于未照射的光学聚合物材料没有显着差异。该方法可以用于在人眼中手术植入人工晶状体后修改眼内透镜的折射率。本发明还涉及一种包括折射光学结构的光学器件，其中折射结构的特征在于折射率的变化，表现出很少的或没有散射损耗，并且在拉曼光谱方面相对于未辐照的表现没有显着的差异光学，聚合材料。

10. 发明申请

US20100005429A1 INTEGRATED SINGLE SPICE DECK SENSITIZATION FOR GATE LEVEL TOOLS 有权
标题翻译：针对门级水平工具的集成单个单位敏感度
公开(公告)号：US20100005429A1
公开(公告)日：2010-01-07
申请号：US12166630
申请日：2008-07-02
申请人： Jindrich Zejda , Narender Hanchate , Rupesh Nayak , Li Ding
发明人： Jindrich Zejda , Narender Hanchate , Rupesh Nayak , Li Ding
IPC分类号： G06F17/50
CPC分类号： G06F17/5036 , G06F17/505
摘要： One embodiment of the present invention provides systems and techniques for generating a transistor-level description of a subcircuit. A user may want to simulate a subcircuit in a circuit using a transistor-level simulator, and one or more cells in the subcircuit may need to be sensitized so that the cells are in a desired state when the subcircuit is simulated. An embodiment modifies the subcircuit by inserting analog switches in front of the cells that need to be sensitized, so that the analog switches can be used to apply a sensitization sequence to the cells during the transistor-level simulation. The embodiment can then generate a transistor-level description of the modified subcircuit. Next, the transistor-level description of the subcircuit can be stored, thereby enabling the transistor-level simulator to simulate the subcircuit.
摘要翻译：本发明的一个实施例提供了用于产生子电路的晶体管级描述的系统和技术。用户可能需要使用晶体管级模拟器来模拟电路中的分支电路，并且子电路中的一个或多个单元可能需要被敏化，使得当模拟子电路时，单元格处于期望状态。实施例通过将模拟开关插入需要敏化的单元前面来修改子电路，使得模拟开关可用于在晶体管级仿真期间向单元施加致敏序列。然后，该实施例可以生成修改后的子电路的晶体管级描述。接下来，可以存储子电路的晶体管级描述，从而使晶体管级模拟器能够模拟子电路。

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