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1. 发明授权

US08927003B2 Extracellular matrix based gastroesophageal junction reinforcement device 有权
标题翻译：基于细胞外基质的胃食管结合加强装置
公开(公告)号：US08927003B2
公开(公告)日：2015-01-06
申请号：US13108074
申请日：2011-05-16
申请人： Stephen F. Badylak , Thomas W. Gilbert , Alejandro Nieponice
发明人： Stephen F. Badylak , Thomas W. Gilbert , Alejandro Nieponice
IPC分类号： A61L27/36 , A61K35/38 , A61L27/38
CPC分类号： A61L27/3679 , A61F2/04 , A61F2002/044 , A61K35/38 , A61L27/362 , A61L27/3629 , A61L27/3633 , A61L27/3882 , A61L2430/22
摘要： Provided are medical devices for implantation in patients having suffered the loss of or damage to at least part of their esophagus. The medical device connects the esophagus or remaining part thereof with the stomach to form a gastro-esophageal junction that promotes healing and encourages new host tissue growth while distributing the load and decreasing tension at the anastomotic site. The medical device comprises extracellular matrix shaped into a conformation that more closely approximates the geometry of the native gastro-esophageal junction than does direct attachment of the stomach to the shortened esophagus. Molds useful in manufacturing the medical device and methods of use of the device are also described herein.
摘要翻译：提供用于植入患有至少部分食管的患者的医疗装置。医疗装置将食道或其余部分与胃连接以形成胃食管连接处，其在分配负荷并减少吻合部位的张力的同时促进愈合并促进新的宿主组织生长。医疗装置包括细胞外基质成形为更接近天然胃食管结合物的几何形状的构象，而不是将胃直接附着于缩短的食道。在本文中还描述了用于制造医疗装置的模具和装置的使用方法。

2. 发明授权

US08084048B2 Vascularization enhanced graft constructs 有权
标题翻译：血管化增强移植物构建体
公开(公告)号：US08084048B2
公开(公告)日：2011-12-27
申请号：US12557176
申请日：2009-09-10
申请人： Stephen F. Badylak
发明人： Stephen F. Badylak
IPC分类号： A61K35/407 , A61K35/12
CPC分类号： A61L27/3886 , A61K35/34 , A61L27/3604 , A61L27/3804 , A61L27/3808 , A61L27/3813 , A61L27/3826 , A61L27/383
摘要： A tissue graft construct for use in repairing diseased or damaged tissues is provided. The tissue graft construct comprises a matrix composition selected from the group consisting of liver basement membrane and extracts and hydrolysates thereof, and processed collagen from vertebrate non-submucosal sources, added endothelial cells, and at least one additional preselected, exogenous population of cells which enhance the initiation of vessel-like structures in the grant. The preselected population of cells can be a population of non-keratinized or keratinized epithelial cells or a population of mesodermally derived cells selected from the group consisting of fibroblasts, smooth muscle cells, skeletal muscle cells, cardiac muscle cells, multi-potential progenitor cells, pericytes, osteogenic cells, and any other suitable cell type, preferably selected based on the tissue to be repaired. Methods for enhancing the vascularization in vivo of these tissue graft constructs and for preparing these graft constructs are also provided.
摘要翻译：提供了用于修复患病或受损组织的组织移植物构建体。组织移植物构建体包含选自肝基底膜和其提取物及其水解物的基质组合物，以及来自脊椎动物非粘膜下层源的加工胶原，加入的内皮细胞和至少一种另外预选的外源细胞群，其增强在授权中启动类似船只的结构。预选的细胞群可以是非角化角化角化细胞或角化细胞上皮细胞群或选自成纤维细胞，平滑肌细胞，骨骼肌细胞，心肌细胞，多潜能祖细胞，周细胞，成骨细胞和任何其它合适的细胞类型，优选基于待修复的组织选择。还提供了用于增强这些组织移植物构建体体内血管形成和制备这些移植物构建体的方法。

3. 发明授权

US07776596B2 Vascularization enhanced graft constructs 有权
标题翻译：血管化增强移植物构建体
公开(公告)号：US07776596B2
公开(公告)日：2010-08-17
申请号：US10428358
申请日：2003-05-02
申请人： Stephen F. Badylak
发明人： Stephen F. Badylak
IPC分类号： A01N63/00 , A61K35/22 , A61K35/37 , C12N5/00 , C12N5/08
CPC分类号： A61L27/3886 , A61K35/12 , A61L27/3604 , A61L27/3804 , A61L27/3808 , A61L27/3813 , A61L27/3826 , A61L27/383 , C12N5/0685 , C12N5/069 , C12N5/0697 , C12N2501/135 , C12N2501/15 , C12N2501/165 , C12N2502/1347 , C12N2502/253 , C12N2502/28 , C12N2509/00
摘要： A tissue graft construct for use in repairing diseased or damaged tissues is provided. The tissue graft construct comprises a matrix composition selected from the group consisting of urinary bladder submucosa and stomach submucosa, and extracts and hydrolysates thereof, added endothelial cells, and at least one additional preselected, exogenous population of cells which enhance initiation of the formation vessel-like structures in the graft construct. The preselected population of cells can be a population of non-keratinized or keratinized epithelial cells or a population of mesodermally-derived cells selected from the group consisting of fibroblasts, smooth muscle cells, skeletal muscle cells, cardiac muscle cells, multi-potential progenitor cells, pericytes, osteogenic cells, and any other suitable cell type, preferably selected based on the tissue to be repaired. Methods for enhancing the vascularization in vivo of these tissue graft constructs and for preparing these graft constructs are also provided.
摘要翻译：提供了用于修复患病或受损组织的组织移植物构建体。组织移植物构建体包含选自膀胱粘膜下层和胃粘膜下层的基质组合物，其提取物和水解物，加入的内皮细胞和至少一种额外的预选的外源细胞群，其增强了形成血管 - 类似结构在移植物构造。预选的细胞群可以是非角化角化角化细胞或角化细胞上皮细胞群或选自成纤维细胞，平滑肌细胞，骨骼肌细胞，心肌细胞，多潜能祖细胞，周细胞，成骨细胞和任何其它合适的细胞类型，优选基于待修复的组织选择。还提供了用于增强这些组织移植物构建体体内血管形成和制备这些移植物构建体的方法。

4. 发明申请

US20100041135A1 Gastric Submucosal Tissue as a Novel Diagnostic Tool 有权
标题翻译：胃粘膜下组织作为新型诊断工具
公开(公告)号：US20100041135A1
公开(公告)日：2010-02-18
申请号：US12503774
申请日：2009-07-15
申请人： Stephen F. Badylak , George B. Boder , Sherry L. Voytik-Harbin , Matthew S. Waninger , Andrew O. Brightman
发明人： Stephen F. Badylak , George B. Boder , Sherry L. Voytik-Harbin , Matthew S. Waninger , Andrew O. Brightman
IPC分类号： C12N5/07
CPC分类号： G01N33/56922 , C12N1/20 , C12N5/0068 , C12N2533/92 , G01N33/5091 , Y10S435/851
摘要： A cell culture growth substrate comprising submucosal tissue of a warm-blooded vertebrate and a method for culturing fastidious organisms is described. Submucosal tissue used in accordance with the present invention supports the proliferation of cells when said cells are contacted with submucosal tissue under conditions conducive to cell proliferation.
摘要翻译：描述了包含温血脊椎动物的粘膜下组织的细胞培养生长底物和培养有害生物的方法。当在有利于细胞增殖的条件下，当所述细胞与粘膜下组织接触时，根据本发明使用的粘膜下组织支持细胞的增殖。

5. 发明授权

US07608454B2 Vascularization enhanced graft constructs 有权
公开(公告)号：US07608454B2
公开(公告)日：2009-10-27
申请号：US10428355
申请日：2003-05-02
申请人： Stephen F. Badylak
发明人： Stephen F. Badylak
IPC分类号： A61K35/407 , A61K35/12 , C12N5/08
摘要： A tissue graft construct for use in repairing diseased or damaged tissues is provided. The tissue graft construct comprises a matrix composition selected from the group consisting of liver basement membrane and extracts and hydrolysates thereof, and processed collagen from vertebrate non-submucosal sources, added endothelial cells, and at least one additional preselected, exogenous population of cells which enhance the initiation of vessel-like structures in the grant. The preselected population of cells can be a population of non-keratinized or keratinized epithelial cells or a population of mesodermally derived cells selected from the group consisting of fibroblasts, smooth muscle cells, skeletal muscle cells, cardiac muscle cells, multi-potential progenitor cells, pericytes, osteogenic cells, and any other suitable cell type, preferably selected based on the tissue to be repaired. Methods for enhancing the vascularization in vivo of these tissue graft constructs and for preparing these graft constructs are also provided.

6. 发明授权

US06918396B1 Method for vocal cord reconstruction 有权
标题翻译：声带重建方法
公开(公告)号：US06918396B1
公开(公告)日：2005-07-19
申请号：US09857307
申请日：1999-12-01
申请人： Stephen F. Badylak , Alan R. Spievack
发明人： Stephen F. Badylak , Alan R. Spievack
IPC分类号： A61L27/36 , A61B19/00 , A61K35/12
CPC分类号： A61L27/3604 , A61L27/3633 , A61L27/3641
摘要： A method for surgical repair of damaged or diseased head and neck tissues is described. In one aspect of the invention tissue graft constructs comprising vertebrate submucosa or vertebrate basement membrane materials are used to repair and promote growth of endogenous vocal cord tissue.
摘要翻译：描述了损伤或患病的头颈部组织的手术修复方法。在本发明的一个方面，使用包含脊椎动物粘膜下层或脊椎动物基底膜材料的组织移植物构建体来修复和促进内源性声带组织的生长。

7. 发明授权

US06187039B1 Tubular submucosal graft constructs 有权
标题翻译：管状粘膜下移植物构建体
公开(公告)号：US06187039B1
公开(公告)日：2001-02-13
申请号：US09297620
申请日：1999-05-04
申请人： Michael C. Hiles , Umesh H. Patel , Leslie A. Geddes , Stephen F. Badylak
发明人： Michael C. Hiles , Umesh H. Patel , Leslie A. Geddes , Stephen F. Badylak
IPC分类号： A60F206
CPC分类号： A61L27/3604 , A61F2/06 , A61F2310/00365 , A61L27/24 , A61L27/3629 , A61L27/3687
摘要： An easy-to-produce and mechanically strong tube of an implantable submucosal tissue has been developed which is manufactured in any desired length, wall thickness, or diameter. The construct produced by the method of the invention may be used as grafts for arteries, veins, ureters, urethras, shunts, or in any application where a compliant, tissue-compatible tube is needed. The manufacture of the submucosal tissue prosthesis generally involves wrapping a first sheet of submucosal tissue (60) and a second sheet of submucosal tissue (70) around a mandrel (50), wherein the first end (74) and the second opposite end (76) of the second sheet of submucosal tissue (70) are sutured together with sutures (78). The submucosal tissue is compressed and dried on the mandrel (50) before removing the construct by pulling on a first end (54) and a second end (56) of a water permeable tape to unwind the tape and thus release the construct for eventual use.
摘要翻译：已经开发了可植入的粘膜下组织的容易制造和机械强度的管，其以任何期望的长度，壁厚或直径制造。通过本发明的方法生产的构造体可以用作动脉，静脉，输尿管，尿道，分流器的移植物，或者在需要顺应的组织相容管的任何应用中。粘膜下组织假体的制造通常包括围绕心轴（50）缠绕第一片粘膜下组织（60）和第二片粘膜下组织（70），其中第一端（74）和第二相对端（76））的第二片粘膜下组织（70）与缝合线（78）缝合在一起。在通过拉动透水性带的第一端（54）和第二端（56）去除构造物之前，在心轴（50）上压缩并干燥粘膜下组织以展开带，并因此释放结构以最终使用。

8. 发明授权

US5885619A Large area submucosal tissue graft constructs and method for making the same 失效
标题翻译：大面积粘膜下组织移植物构建及其制备方法
公开(公告)号：US5885619A
公开(公告)日：1999-03-23
申请号：US931299
申请日：1997-09-16
申请人： Umesh H. Patel , Michael C. Hiles , Bryan Whitson , Boyle Cheng , Stephen F. Badylak , Klod Kokini
发明人： Umesh H. Patel , Michael C. Hiles , Bryan Whitson , Boyle Cheng , Stephen F. Badylak , Klod Kokini
IPC分类号： A61L27/00 , A61F2/00 , A61F2/10 , A61K35/38 , A61L27/36 , A61P43/00
CPC分类号： A61L27/3691 , A61F2/0063 , A61K35/38 , A61L27/3629
摘要： A unitary heterolaminar tissue graft construct is prepared by fusing partially overlapped strips or sheets of submucosa tissue. The submucosa components are fused by compressing at least the overlapped positions of said strips between two surfaces under conditions that allow or promote dehydration of the compressed submucosa sheets. Three dimensional graft constructs can be prepared by using complementary non-planar compressive surfaces.
摘要翻译：通过融合部分重叠的粘膜下层组织片或片材来制备单一的异构层状组织移植物构建体。通过在允许或促进压缩的粘膜下层片的脱水的条件下，通过在两个表面之间至少压缩所述条的重叠位置来熔化粘膜下层组分。可以通过使用互补的非平面压缩表面来制备三维移植物构建体。

9. 发明授权

US5554389A Urinary bladder submucosa derived tissue graft 失效
标题翻译：膀胱粘膜下层组织移植
公开(公告)号：US5554389A
公开(公告)日：1996-09-10
申请号：US418763
申请日：1995-04-07
申请人： Stephen F. Badylak , Sherry L. Voytik , Andrew Brightman , Matt Waninger
发明人： Stephen F. Badylak , Sherry L. Voytik , Andrew Brightman , Matt Waninger
IPC分类号： C12N5/06 , A61K35/22 , A61L27/36 , A61P43/00 , C12N5/00
CPC分类号： A61L27/3683 , A61K35/22 , A61L27/3604 , A61L27/3645 , C12N5/0068 , C12N2533/92 , Y10S623/915
摘要： A tissue graft composition comprising bladder submucosal tissue delaminated from abluminal muscle layers and at least the luminal portion of the tunica mucosa of a segment of vertebrate urinary bladder is described. The graft composition can be implanted to replace or support damaged or diseased tissues.
摘要翻译：描述了一种组织移植组合物，其包含从腹膜肌层分层的膀胱粘膜下组织和至少脊椎动物膀胱片段的中膜粘膜的腔内部分。移植组合物可以被植入以替代或支持受损或患病的组织。

10. 发明授权

US5281422A Graft for promoting autogenous tissue growth 失效
标题翻译：用于促进自体组织生长的移植物
公开(公告)号：US5281422A
公开(公告)日：1994-01-25
申请号：US764818
申请日：1991-09-24
申请人： Stephen F. Badylak , Leslie A. Geddes , K. Donald Shelbourne , Gary C. Lantz , Arthur C. Coffey
发明人： Stephen F. Badylak , Leslie A. Geddes , K. Donald Shelbourne , Gary C. Lantz , Arthur C. Coffey
IPC分类号： A61B17/11 , A61F2/02 , A61F2/08 , A61K35/12 , A61L27/36 , A61K35/38
CPC分类号： A61L27/3645 , A61B17/1146 , A61F2/02 , A61F2/08 , A61L27/3629 , A61L27/365 , A61L27/3662 , A61L27/3695 , Y10S623/915
摘要： Surgical repair of diseased or damaged endogenous connective tissue can be accomplished using a tissue graft formed from a delaminated segment of intestinal tissue. The tissue graft comprises the intestinal tunica submucosa, muscularis mucosa and stratum compactum delaminated from the tunica muscularis and the luminal portion of the tunica mucosa. The graft can be conditioned by stretching and formed as a multilayer composition for high tensile strength and resistance to tearing at its points of attachment to existing physiological structures.
摘要翻译：可以使用由分层的肠组织段形成的组织移植来完成患病或损伤的内源性结缔组织的手术修复。组织移植物包括肠壁粘膜下层，肌层粘膜和从肌层分泌的层状结节和中膜粘膜的腔内部分。移植物可通过拉伸进行调理，并形成为具有高拉伸强度的多层组合物，并且在其附着于现有生理结构的点处具有抗撕裂性。

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