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1. 发明申请

US20160060224A1 N-MYRISTOYL TRANSFERASE INHIBITORS 有权
标题翻译： N-肉豆蔻酰转移酶抑制剂
公开(公告)号：US20160060224A1
公开(公告)日：2016-03-03
申请号：US14840660
申请日：2015-08-31
申请人： Stephen Brand , Paul Wyatt , Stephen Thompson , Victoria Smith , Tracy Bayliss , Justin Harrison , Neil Norcross , Laura Cleghorn , Ian Gilbert , Ruth Brenk
发明人： Stephen Brand , Paul Wyatt , Stephen Thompson , Victoria Smith , Tracy Bayliss , Justin Harrison , Neil Norcross , Laura Cleghorn , Ian Gilbert , Ruth Brenk
IPC分类号： C07D231/42 , C07D401/12 , C07D403/12 , C07D401/14
CPC分类号： C07D231/42 , A61K31/415 , C07D213/75 , C07D239/69 , C07D263/50 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to N-heterocyclic sulphonamide compounds, in particular pyrazole sulphonamide compounds, and their use as N-myristoyl transferase inhibitors.
摘要翻译：本发明涉及N-杂环磺酰胺化合物，特别是吡唑磺酰胺化合物及其作为N-肉豆蔻酰转移酶抑制剂的用途。

2. 发明授权

US09156811B2 N-myristoyl transferase inhibitors 有权
标题翻译： N-肉豆蔻酰转移酶抑制剂
公开(公告)号：US09156811B2
公开(公告)日：2015-10-13
申请号：US13061811
申请日：2009-08-29
申请人： Stephen Brand , Paul Wyatt , Stephen Thompson , Victoria Smith , Tracy Bayliss , Justin Harrison , Neil Norcross , Laura Cleghorn , Ian Gilbert , Ruth Brenk
发明人： Stephen Brand , Paul Wyatt , Stephen Thompson , Victoria Smith , Tracy Bayliss , Justin Harrison , Neil Norcross , Laura Cleghorn , Ian Gilbert , Ruth Brenk
IPC分类号： A61K31/415 , C07D231/42 , C07D401/04 , C07D213/75 , C07D239/69 , C07D263/50 , C07D403/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04
CPC分类号： C07D231/42 , A61K31/415 , C07D213/75 , C07D239/69 , C07D263/50 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to N-heterocyclic sulphonamide compounds, in particular pyrazole sulphonamide compounds, and their use as N-myristoyl transferase inhibitors.
摘要翻译：本发明涉及N-杂环磺酰胺化合物，特别是吡唑磺酰胺化合物及其作为N-肉豆蔻酰转移酶抑制剂的用途。

3. 发明申请

US20110312921A1 N-Myristoyl Transferase Inhibitors 有权
标题翻译： N-肉豆蔻酰转移酶抑制剂
公开(公告)号：US20110312921A1
公开(公告)日：2011-12-22
申请号：US13061811
申请日：2009-08-29
申请人： Stephen Brand , Paul Wyatt , Stephen Thompson , Victoria Smith , Tracy Bayliss , Justin Harrison , Neil Norcross , Laura Cleghorn , Ian Gilbert , Ruth Brenk
发明人： Stephen Brand , Paul Wyatt , Stephen Thompson , Victoria Smith , Tracy Bayliss , Justin Harrison , Neil Norcross , Laura Cleghorn , Ian Gilbert , Ruth Brenk
IPC分类号： A61K31/635 , A61K31/415 , A61K31/4709 , A61K31/5377 , A61K31/437 , A61K31/427 , A61K31/538 , A61P35/00 , A61P31/00 , A61P3/10 , A61P25/00 , A61P33/00 , A61P31/10 , A61P31/12 , A61K31/4155
CPC分类号： C07D231/42 , A61K31/415 , C07D213/75 , C07D239/69 , C07D263/50 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/04
摘要： The present invention relates to N-heterocyclic sulphonamide compounds, in particular pyrazole sulphonamide compounds, and their use as N-myristoyl transferase inhibitors.
摘要翻译：本发明涉及N-杂环磺酰胺化合物，特别是吡唑磺酰胺化合物及其作为N-肉豆蔻酰转移酶抑制剂的用途。

4. 发明申请

US20110220080A1 SPLIT-CYCLE AIR-HYBRID ENGINE WITH AIR TANK VALVE 审中-公开
标题翻译：带空气罐阀的分体式循环空气混合发动机
公开(公告)号：US20110220080A1
公开(公告)日：2011-09-15
申请号：US13046827
申请日：2011-03-14
申请人： Riccardo Meldolesi , Nicholas Badain , Ian Gilbert
发明人： Riccardo Meldolesi , Nicholas Badain , Ian Gilbert
IPC分类号： F02B33/22
CPC分类号： F02B33/22 , F02B41/06 , F02B2075/025
摘要： A split-cycle air-hybrid engine includes a rotatable crankshaft. A compression piston is slidably received within a compression cylinder. An expansion piston is slidably received within an expansion cylinder. A crossover passage interconnects the compression and expansion cylinders. The crossover passage includes a crossover compression (XovrC) valve and a crossover expansion (XovrE) valve. An air reservoir is operatively connected to the crossover passage. An air reservoir valve selectively controls air flow into and out of the air reservoir. In an Engine Firing (EF) mode, the air reservoir valve is kept closed. In an Air Expander (AE) and an Air Expander and Firing (AEF) mode, the air reservoir valve is kept open for a duration that is at least as long as a duration of the XovrE valve opening event. In an Air Compressor (AC) mode and a Firing and Charging (FC) mode, the air reservoir valve is selectively opened and closed.
摘要翻译：分体式空气混合动力发动机包括可旋转的曲轴。压缩活塞可滑动地容纳在压缩气缸内。膨胀活塞可滑动地容纳在膨胀缸内。交叉通道将压缩和膨胀气瓶相互连接。交叉通道包括交叉压缩（XovrC）阀和交叉膨胀（XovrE）阀。空气储存器可操作地连接到交叉通道。空气储存阀选择性地控制空气流入和流出空气储存器。在发动机起火（EF）模式下，储气阀保持关闭。在空气膨胀器（AE）和空气扩展器和燃烧（AEF）模式中，储气阀保持打开持续时间至少等于XovrE阀打开事件的持续时间。在空气压缩机（AC）模式和点火和充电（FC）模式中，储气阀选择性地打开和关闭。

5. 发明申请

US20050244710A1 SEALING RING ASSEMBLY AND MOUNTING METHOD 失效
标题翻译：密封环组件和安装方法
公开(公告)号：US20050244710A1
公开(公告)日：2005-11-03
申请号：US10905717
申请日：2005-01-18
申请人： Ian Mayes , James Gough , Ian Gilbert , Harvey Podgorney
发明人： Ian Mayes , James Gough , Ian Gilbert , Harvey Podgorney
IPC分类号： H01L21/66 , H01M2/08 , F16J15/02
CPC分类号： H01L22/00
摘要： A sealing ring assembly and an improved method for mounting a sealing ring into an electrochemical cell used for Electrochemical Capacitance Voltage (ECV) profiling measurements. The ring is located in a holder having at least one secondary bore providing fluid communication between a forward face of the holder and the central bore of the ring, directed parallel to but tangentially offset relative to the inner wall of the central bore so as to impart a degree of rotational flow to electrolyte entering the sealing ring through the or each secondary bore which effectively removes gas bubbles and refreshes the electrolyte. The holder facilitates ring removal with a much reduced risk of damage to the delicate sealing surface.
摘要翻译：密封环组件和用于将密封环安装到用于电化学电容电压（ECV）分析测量的电化学电池中的改进方法。所述环位于具有至少一个次级孔的保持器中，所述至少一个次级孔在保持器的前表面和环的中心孔之间提供流体连通，其平行于中心孔的内壁平行但相切地偏移，以便赋予通过该孔或每个次级孔进入密封环的电解质的旋转流程，其有效地去除气泡并刷新电解质。保持架有助于清除环，从而减少对精密密封面的损坏风险。

6. 发明申请

US20140158102A1 SPLIT-CYCLE AIR-HYBRID ENGINE WITH AIR EXPANDER AND FIRING MODE 审中-公开
标题翻译：具有空气膨胀机和燃烧模式的分体循环空气混合发动机
公开(公告)号：US20140158102A1
公开(公告)日：2014-06-12
申请号：US14179644
申请日：2014-02-13
申请人： Riccardo Meldolesi , Nicholas Badain , Ian Gilbert
发明人： Riccardo Meldolesi , Nicholas Badain , Ian Gilbert
IPC分类号： F02B33/22
CPC分类号： F02B33/22 , F02B41/06 , F02B2075/025
摘要： A split-cycle air hybrid engine includes a rotatable crankshaft. A compression piston is slidably received within a compression cylinder and operatively connected to the crankshaft. An expansion piston is slidably received within an expansion cylinder and operatively connected to the crankshaft. A crossover passage interconnects the compression and expansion cylinders. The crossover passage includes a crossover compression (XovrC) valve and a crossover expansion (XovrE) valve defining a pressure chamber therebetween. An air reservoir is operatively connected to the crossover passage. An air reservoir valve selectively controls air flow into and out of the air reservoir. In an Air Expander and Firing (AEF) mode of the engine, the engine has a residual expansion ratio at XovrE valve closing of 15.7 to 1 or greater, and more preferably in the range of 15.7 to 1 and 40.8 to 1.
摘要翻译：分体式空气混合动力发动机包括可旋转的曲轴。压缩活塞可滑动地容纳在压缩气缸内并且可操作地连接到曲轴。膨胀活塞可滑动地容纳在膨胀缸内并且可操作地连接到曲轴。交叉通道将压缩和膨胀气瓶相互连接。交叉通道包括交叉压缩（XovrC）阀和在其间限定压力室的交叉膨胀（XovrE）阀。空气储存器可操作地连接到交叉通道。空气储存阀选择性地控制空气流入和流出空气储存器。在发动机的空气膨胀机和燃烧（AEF）模式中，发动机在XovrE阀关闭时的残余膨胀比为15.7-1或更大，更优选在15.7至1和40.8至1的范围内。

7. 发明授权

US08539920B2 Valve lash adjustment system for a split-cycle engine 失效
标题翻译：用于分相发动机的阀门间隙调节系统
公开(公告)号：US08539920B2
公开(公告)日：2013-09-24
申请号：US12690514
申请日：2010-01-20
申请人： Riccardo Meldolesi , Clive Lacy , Anthony Perkins , Ian Gilbert
发明人： Riccardo Meldolesi , Clive Lacy , Anthony Perkins , Ian Gilbert
IPC分类号： F01L1/18
CPC分类号： F01L1/2405 , F01L1/08 , F01L1/185 , F01L1/22 , F01L2003/258 , F01L2101/00 , F02B33/22
摘要： The present invention provides a valve actuation system comprising a valve train for actuating a valve, the valve train including actuating elements and a valve lash, and a valve lash adjustment system for adjusting the valve lash, wherein the valve train and the valve lash adjustment system do not share any common actuating elements.
摘要翻译：本发明提供一种阀致动系统，其包括用于致动阀的气门机构，所述气门机构包括致动元件和阀间隙，以及用于调节阀间隙的阀间隙调节系统，其中所述气门机构和所述阀间隙调节系统不要共享任何常见的执行元件。

8. 发明申请

US20100180848A1 VALVE LASH ADJUSTMENT SYSTEM FOR A SPLIT-CYCLE ENGINE 失效
公开(公告)号：US20100180848A1
公开(公告)日：2010-07-22
申请号：US12711546
申请日：2010-02-24
申请人： Riccardo Meldolesi , Clive Lacy , Anthony Perkins , Ian Gilbert
发明人： Riccardo Meldolesi , Clive Lacy , Anthony Perkins , Ian Gilbert
IPC分类号： F01L1/18
CPC分类号： F01L1/2405 , F01L1/08 , F01L1/185 , F01L1/22 , F01L2003/258 , F01L2101/00 , F02B33/22
摘要： The present invention provides a valve actuation system comprising a valve train for actuating a valve, the valve train including actuating elements and a valve lash, and a valve lash adjustment system for adjusting the valve lash, wherein the valve train and the valve lash adjustment system do not share any common actuating elements.

9. 发明申请

US20100180847A1 VALVE LASH ADJUSTMENT SYSTEM FOR A SPLIT-CYCLE ENGINE 失效
标题翻译：用于分段循环发动机的阀门调节系统
公开(公告)号：US20100180847A1
公开(公告)日：2010-07-22
申请号：US12690514
申请日：2010-01-20
申请人： Riccardo Meldolesi , Clive Lacy , Anthony Perkins , Ian Gilbert
发明人： Riccardo Meldolesi , Clive Lacy , Anthony Perkins , Ian Gilbert
IPC分类号： F01L1/18
CPC分类号： F01L1/2405 , F01L1/08 , F01L1/185 , F01L1/22 , F01L2003/258 , F01L2101/00 , F02B33/22
摘要： The present invention provides a valve actuation system comprising a valve train for actuating a valve, the valve train including actuating elements and a valve lash, and a valve lash adjustment system for adjusting the valve lash, wherein the valve train and the valve lash adjustment system do not share any common actuating elements.
摘要翻译：本发明提供一种阀致动系统，其包括用于致动阀的气门机构，所述气门机构包括致动元件和阀间隙，以及用于调节阀间隙的阀间隙调节系统，其中所述气门机构和所述阀间隙调节系统不要共享任何常见的执行元件。

10. 发明申请

US20080312183A1 Dutpase Inhibitors 失效
标题翻译： Dutpase抑制剂
公开(公告)号：US20080312183A1
公开(公告)日：2008-12-18
申请号：US10585283
申请日：2005-01-06
申请人： Ian Gilbert , Corinne Nguyen , Gian Filippo Ruda , Alessandro Schipani , Ganasan Kasinathan , Nils-Gunnar Johansson , Dolores Gonzalez Pacanowska
发明人： Ian Gilbert , Corinne Nguyen , Gian Filippo Ruda , Alessandro Schipani , Ganasan Kasinathan , Nils-Gunnar Johansson , Dolores Gonzalez Pacanowska
IPC分类号： A61K31/513 , C07D239/54 , C07F7/18 , A61P33/00 , A61K31/695
CPC分类号： A61K31/505 , A61K31/506 , A61K31/7072 , C07D239/54 , C07D405/06 , C07F7/1804 , Y02A50/409 , Y02A50/411
摘要： Deoxyuridine derivatives of the formula (I) where R1 is H or various substituents; D is —NHCO—, —CONH—, -0-, —C(═O)—, —CH═CH, —C≡C—, —NR5—; R4 is hydrogen or various substituents; R5 is H, C1-C4 alkyl, C1-C4 alkanoyl; E is Si or C; R6, R7 and R8 are independently selected from C1-C8 alkyl, C2-C8 alkenyl, C2-C8 alkynyl or a stable monocyclic, bicyclic or tricyclic ring system; G is —O—, —S—, —CHR10—, —C(═O)—; J is —CH2—, or when G is CHR10 may also be —O— or —NH—; R10 is H, F, —CH3, —CH2NH2, —CH2OH; —OHR11 is H, F, —CH3, —CH2NH2, —CH2OH, —CH(OH)CH3, CH(NH3)CH3; or R10 and R11 together define an olefinic bond, or together form a —CH2-group, thereby defining a cis or trans cyclopropyl group; have utility in the prophylaxis or treatment of protozoal diseases such as malaria.
摘要翻译：式（I）的脱氧尿苷衍生物，其中R 1为H或各种取代基; D是-NHCO-，-CONH - ， - O - ， - C（-O） - ， - CH-CH，-C≡C-，-NR5-; R4是氢或各种取代基; R5是H，C1-C4烷基，C1-C4烷酰基; E为Si或C; R 6，R 7和R 8独立地选自C 1 -C 8烷基，C 2 -C 8烯基，C 2 -C 8炔基或稳定的单环，双环或三环系; G是-O - ， - S - ， - CHR 10 - ， - C（-O） - ; J是-CH 2 - ，或者当G是CHR 10时也可以是-O-或-NH-; R 10是H，F，-CH 3，-CH 2 NH 2，-CH 2 OH; -OH R 11是H，F，-CH 3，-CH 2 NH 2，-CH 2 OH，-CH（OH）CH 3，CH（NH 3）CH 3; 或R 10和R 11一起界定烯键，或一起形成-CH 2 - 基团，由此限定顺式或反式环丙基; 可用于预防或治疗诸如疟疾的原生动物疾病。

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