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1. 发明申请

US20080097540A1 ECG INPUT TO IMPLANTABLE PULSE GENERATOR USING CAROTID SINUS LEADS 审中-公开
标题翻译：心电图输入到使用卡路里电针的可植入脉冲发生器
公开(公告)号：US20080097540A1
公开(公告)日：2008-04-24
申请号：US11956685
申请日：2007-12-14
申请人： Stephen Bolea , Robert Kieval , Bruce Persson , David Serdar , Peter Keith , Eric Irwin , Martin Rossing
发明人： Stephen Bolea , Robert Kieval , Bruce Persson , David Serdar , Peter Keith , Eric Irwin , Martin Rossing
IPC分类号： A61N1/365
CPC分类号： A61N1/36117 , A61B5/02028 , A61N1/05 , A61N1/0551 , A61N1/056 , A61N1/08 , A61N1/36053 , A61N1/3611 , A61N1/36114 , A61N1/36125 , A61N1/36135 , A61N1/36185 , A61N1/3702
摘要： A monitoring device is provided to monitor a patient. The monitoring device includes at least one lead having an electrode. The lead is positioned proximate a location within the patient's body, and the lead is adapted to sense cardiac electrical activity. The monitoring device also includes a control system coupled to the at least one lead to receive a signal representative of the cardiac electrical activity.
摘要翻译：提供监测装置以监测患者。监测装置包括至少一个具有电极的引线。导线位于患者体内的位置附近，并且引线适于感测心脏电活动。监测装置还包括耦合到至少一个引线以接收代表心脏电活动的信号的控制系统。

2. 发明申请

US20070185542A1 BAROREFLEX THERAPY FOR DISORDERED BREATHING 审中-公开
标题翻译： BAROREFLEX治疗异常呼吸
公开(公告)号：US20070185542A1
公开(公告)日：2007-08-09
申请号：US11617089
申请日：2006-12-28
申请人： Stephen Bolea , Robert Kieval , Bruce Persson , David Serdar , Peter Keith , Eric Irwin , Martin Rossing
发明人： Stephen Bolea , Robert Kieval , Bruce Persson , David Serdar , Peter Keith , Eric Irwin , Martin Rossing
IPC分类号： A61N1/00
CPC分类号： A61N1/0556 , A61N1/36114 , A61N1/36117
摘要： Devices, systems and methods are described by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.
摘要翻译：描述的装置，系统和方法通过其可以通过激活压力感受器来选择性地和可控地降低血压，神经系统活性和神经激素活性。压力感受器激活装置位于压力感受器附近，优选位于颈动脉窦中的压力感受器。控制系统可用于调节压力感受器激活装置。控制系统可以利用定义刺激方案的算法，其促进长期功效并降低功率需求/消耗。压力感受器激活装置可以利用电极来激活压力感受器。电极可以适于连接到颈动脉窦处或附近的颈动脉，并且可以设计成使外来组织刺激最小化。

3. 发明申请

US20070106340A1 ELECTRODE STRUCTURES AND METHODS FOR THEIR USE IN CARDIOVASCULAR REFLEX CONTROL 审中-公开
标题翻译：用于心脏反射控制的电极结构和方法
公开(公告)号：US20070106340A1
公开(公告)日：2007-05-10
申请号：US11535666
申请日：2006-09-27
申请人： Stephen Bolea , Robert Kieval , Bruce Persson , David Serdar , Peter Keith , Eric Irwin , Martin Rossing
发明人： Stephen Bolea , Robert Kieval , Bruce Persson , David Serdar , Peter Keith , Eric Irwin , Martin Rossing
IPC分类号： A61N1/00
CPC分类号： A61N1/36117 , A61B5/02028 , A61N1/05 , A61N1/0551 , A61N1/056 , A61N1/08 , A61N1/36053 , A61N1/3611 , A61N1/36114 , A61N1/36125 , A61N1/36135 , A61N1/36185 , A61N1/3702
摘要： Devices, systems and methods are described by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, preferably a baroreceptor located in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption. The baroreceptor activation device may utilize electrodes to activate the baroreceptors. The electrodes may be adapted for connection to the carotid arteries at or near the carotid sinus, and may be designed to minimize extraneous tissue stimulation.
摘要翻译：描述的装置，系统和方法通过其可以通过激活压力感受器来选择性地和可控地降低血压，神经系统活性和神经激素活性。压力感受器激活装置位于压力感受器附近，优选位于颈动脉窦中的压力感受器。控制系统可用于调节压力感受器激活装置。控制系统可以利用定义刺激方案的算法，其促进长期功效并降低功率需求/消耗。压力感受器激活装置可以利用电极来激活压力感受器。电极可以适于连接到颈动脉窦处或附近的颈动脉，并且可以设计成使外来组织刺激最小化。

4. 发明申请

US20070049989A1 STIMULUS REGIMENS FOR CARDIOVASCULAR REFLEX CONTROL 有权
标题翻译：用于心脏反射控制的刺激方案
公开(公告)号：US20070049989A1
公开(公告)日：2007-03-01
申请号：US11552005
申请日：2006-10-23
申请人： Martin Rossing , Robert Kieval , David Serdar , Bruce Persson
发明人： Martin Rossing , Robert Kieval , David Serdar , Bruce Persson
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/0551 , A61N1/0558 , A61N1/36007 , A61N1/36117 , A61N1/3627 , A61N1/36514
摘要： Baroreflex activation is achieved by providing suitable control signals to a baroreflex activation device. A method comprises establishing a therapy interval (possibly on the order of minutes to hours, or possibly of indefinite duration), within the therapy interval, establishing a plurality of dose intervals, and generating an electrical output signal. The electrical output signal has a time dependence such that the average electrical power applied to the baroreflex activation device differs between first and second portions of at least some dose intervals. Another method comprises establishing a series of therapy interval portions, during at least some therapy intervals, establishing a plurality of burst intervals (perhaps having durations commensurate with an interval between heartbeats), and generating an electrical output signal. The electrical output signal has a time dependence such that the average electrical power applied to the baroreflex activation device differs between first and second portions of the therapy intervals and also differs between first and second portions of at least some burst intervals.
摘要翻译：通过向压力反射激活装置提供合适的控制信号来实现巴罗反射激活。一种方法包括在治疗间隔内建立治疗间隔（可能在数分钟到数小时，或者可能是不确定的持续时间），建立多个剂量间隔，以及产生电输出信号。电输出信号具有时间依赖性，使得施加到压力反射激活装置的平均电功率在至少一些剂量间隔的第一和第二部分之间不同。另一种方法包括在至少一些治疗间隔期间建立一系列治疗间隔部分，建立多个突发间隔（可能具有与心跳之间的间隔相当的持续时间），以及产生电输出信号。电输出信号具有时间依赖性，使得施加到压力反射激活装置的平均电功率在治疗间隔的第一和第二部分之间不同，并且在至少一些突发间隔的第一和第二部分之间也不同。

5. 发明申请

US20070185543A1 SYSTEM AND METHOD FOR SUSTAINED BAROREFLEX STIMULATION 有权
标题翻译：系统和方法用于持续的BAROREFLEX激发
公开(公告)号：US20070185543A1
公开(公告)日：2007-08-09
申请号：US11735303
申请日：2007-04-13
申请人： Martin Rossing , Robert Kieval , David Serdar , Bruce Persson
发明人： Martin Rossing , Robert Kieval , David Serdar , Bruce Persson
IPC分类号： A61N1/36
CPC分类号： A61N1/36114 , A61N1/0551 , A61N1/0558 , A61N1/36007 , A61N1/36117 , A61N1/3627 , A61N1/36514
摘要： The present invention comprises a medical device having a baroreflex stimulator to generate a stimulation signal, the stimulation signal being adapted to stimulate a baroreflex, and a controller to communicate with the baroreflex stimulator and implement a baroreflex stimulus regimen to vary an intensity of the baroreflex stimulation provided by the stimulation signal to maintain stimulation efficacy.
摘要翻译：本发明包括具有压力反射刺激器以产生刺激信号的医疗装置，所述刺激信号适于刺激压力反射，以及控制器与压力反射刺激器通信并实施压力反射刺激方案以改变压力反射刺激的强度由刺激信号提供，以维持刺激功效。

6. 发明申请

US20050251212A1 Stimulus regimens for cardiovascular reflex control 有权
标题翻译：用于心血管反射控制的刺激方案
公开(公告)号：US20050251212A1
公开(公告)日：2005-11-10
申请号：US11186140
申请日：2005-07-20
申请人： Robert Kieval , Bruce Persson , David Serdar , Peter Keith
发明人： Robert Kieval , Bruce Persson , David Serdar , Peter Keith
IPC分类号： A61N1/00 , A61N1/08 , A61N1/36 , H03C3/09
CPC分类号： A61N1/36117 , A61N1/08
摘要： Devices, systems and methods by which the blood pressure, nervous system activity, and neurohormonal activity may be selectively and controllably reduced by activating baroreceptors. A baroreceptor activation device is positioned near a baroreceptor, for example a baroreceptor in the carotid sinus. A control system may be used to modulate the baroreceptor activation device. The control system may utilize an algorithm defining a stimulus regimen which promotes long term efficacy and reduces power requirements/consumption.
摘要翻译：通过激活压力感受器可以选择性地和可控地降低血压，神经系统活性和神经激素活性的装置，系统和方法。压力感受器激活装置位于压力感受器附近，例如颈动脉窦中的压力感受器。控制系统可用于调节压力感受器激活装置。控制系统可以利用定义刺激方案的算法，其促进长期功效并降低功率需求/消耗。

7. 发明申请

US20080103545A1 Obstructive sleep apnea treatment devices, systems and methods 有权
标题翻译：阻塞性睡眠呼吸暂停治疗装置，系统和方法
公开(公告)号：US20080103545A1
公开(公告)日：2008-05-01
申请号：US11907533
申请日：2007-10-12
申请人： Stephen Bolea , Thomas Hoegh , Bruce Persson , Robert Atkinson , Sidney Hauschild , Paula Kaplan , Brian Kuhnley , Keith Jasperson , Wondimeneh Tesfayesus , Christopher Thorp
发明人： Stephen Bolea , Thomas Hoegh , Bruce Persson , Robert Atkinson , Sidney Hauschild , Paula Kaplan , Brian Kuhnley , Keith Jasperson , Wondimeneh Tesfayesus , Christopher Thorp
IPC分类号： A61N1/36
CPC分类号： A61N1/3606 , A61B5/0809 , A61B5/4818 , A61B5/7239 , A61N1/0556 , A61N1/0558 , A61N1/3601 , A61N1/37229
摘要： Devices, systems and methods for nerve stimulation for OSA therapy.
摘要翻译：用于OSA治疗的神经刺激的装置，系统和方法。

8. 发明申请

US20080103407A1 Obstructive sleep apnea treatment devices, systems and methods 有权
公开(公告)号：US20080103407A1
公开(公告)日：2008-05-01
申请号：US11907532
申请日：2007-10-12
申请人： Stephen Bolea , Thomas Hoegh , Bruce Persson , Robert Atkinson , Scott Mazar
发明人： Stephen Bolea , Thomas Hoegh , Bruce Persson , Robert Atkinson , Scott Mazar
IPC分类号： A61N1/05 , A61B5/08
CPC分类号： A61N1/3606 , A61B5/0809 , A61B5/4818 , A61B5/7239 , A61N1/0556 , A61N1/0558 , A61N1/3601 , A61N1/37229
摘要： Devices, systems and methods for nerve stimulation for OSA therapy.

9. 发明授权

US06251061B1 Cardiac assist device using field controlled fluid 失效
标题翻译：使用现场控制流体的心脏辅助装置
公开(公告)号：US06251061B1
公开(公告)日：2001-06-26
申请号：US09149941
申请日：1998-09-09
申请人： Roger N. Hastings , Bruce Persson , Dnyanesh Talpade , Daniel M. LaFontaine
发明人： Roger N. Hastings , Bruce Persson , Dnyanesh Talpade , Daniel M. LaFontaine
IPC分类号： A61F202
CPC分类号： A61M1/1055 , A61M1/1068 , A61M1/1086 , A61M1/12 , A61M2205/33 , A61M2205/3303
摘要： A cardiac assist device and method of use for assisting the function of a heart. The assist device includes a compressor positioned against the epicardial wall of the heart and a field generator for driving a fluid coupled to the compressor to exert pressure on the heart. The field generator may be a magnetic field generator and the fluid coupled to the compressor may be a ferrofluid. The compressor may include two containment regions containing ferrofluid on opposite sides of the heart, and a pair of compression portions coupled to the containment regions. The filled generator may be electromagnetic which includes two electromagnets having corresponding core portions and corresponding coils. The electromagnets may be disposed with their north and south poles in alignment and separated by a gap to allow relative movement. The electromagnets may be external or internal to the body.
摘要翻译：一种用于辅助心脏功能的心脏辅助装置和方法。所述辅助装置包括抵靠心脏心外壁的压缩机和用于驱动与压缩机相连的流体以对心脏施加压力的场发生器。场发生器可以是磁场发生器，并且耦合到压缩机的流体可以是铁磁流体。压缩机可以包括在心脏的相对侧上包含铁磁流体的两个容纳区域和耦合到容纳区域的一对压缩部分。填充发电机可以是电磁的，其包括具有对应的芯部分和相应线圈的两个电磁体。电磁铁可以配置成使它们的北极和南极对齐并且被间隙分开以允许相对运动。电磁铁可以是外部的或内部的。

10. 发明授权

US08290595B2 Method and apparatus for stimulation of baroreceptors in pulmonary artery 有权
标题翻译：用于刺激肺动脉压力感受器的方法和装置
公开(公告)号：US08290595B2
公开(公告)日：2012-10-16
申请号：US11482264
申请日：2006-07-07
申请人： Robert S. Kieval , Peter T. Keith , David J. Serdar , Bruce Persson
发明人： Robert S. Kieval , Peter T. Keith , David J. Serdar , Bruce Persson
IPC分类号： A61N1/05
CPC分类号： A61N1/36114 , A61N1/08 , A61N1/36117
摘要： Devices and methods for controlling the low-pressure baroreflex system for the treatment and/or management of cardiovascular, renal, and neurological disorders.
摘要翻译：用于控制用于治疗和/或治疗心血管，肾脏和神经障碍的低压压力反射系统的装置和方法。

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