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1. 发明申请

US20080009917A1 APPLICATIONS OF HEART RATE VARIABILITY ANALYSIS IN ELECTROTHERAPY AFFECTING AUTONOMIC NERVOUS SYSTEM RESPONSE 审中-公开
标题翻译：影响自主神经系统反应的电疗中心率变异性分析的应用
公开(公告)号：US20080009917A1
公开(公告)日：2008-01-10
申请号：US11751574
申请日：2007-05-21
申请人： Martin Rossing , Robert Kieval , Eric Erwin , Brad Pedersen , Vadim Braginisky
发明人： Martin Rossing , Robert Kieval , Eric Erwin , Brad Pedersen , Vadim Braginisky
IPC分类号： A61N1/36
CPC分类号： A61N1/36114 , A61B5/02405 , A61B5/4035 , A61B5/4052 , A61N1/36117 , G06F19/3481
摘要： A method of operating a baroreflex therapy system includes providing an implantable baroreflex activation device, providing a sensing arrangement, and providing a controller in operable communication with the baroreflex activation device and the sensing arrangement. The sensing arrangement is used to measure a physical parameter of a patient to generate physical parameter data. The physical parameter data is communicated to the controller, wherein the controller performs heart rate variability analysis based on the physical parameter data. An indication of results of the heart rate variability analysis are provided, upon which a determination may be made to adjust a baroreflex therapy to be delivered by the implantable baroreflex activation device.
摘要翻译：操作压力反射治疗系统的方法包括提供可植入的压力反射激活装置，提供感测装置，以及提供与压力反射激活装置和感测装置可操作地通信的控制器。感测装置用于测量患者的物理参数以产生物理参数数据。将物理参数数据传送到控制器，其中控制器基于物理参数数据执行心率变异性分析。提供了心率变异性分析结果的指示，可以进行可调节的压力反射疗法以由可植入的压力反射激活装置输送。

2. 发明申请

US20070276442A1 IMPLANTABLE ELECTRODE ASSEMBLY HAVING REVERSE ELECTRODE CONFIGURATION 审中-公开
标题翻译：具有反向电极配置的可植入电极组件
公开(公告)号：US20070276442A1
公开(公告)日：2007-11-29
申请号：US11836035
申请日：2007-08-08
申请人： Jeffrey Hagen , Mary Cole , Martin Rossing
发明人： Jeffrey Hagen , Mary Cole , Martin Rossing
IPC分类号： A61N1/05
CPC分类号： A61N1/05 , A61N1/0556 , A61N1/3956
摘要： Methods and apparatus for generating an electric field inside a patient include at least a first electrode and a second electrode on a common implantable substrate. Each of the electrodes has a respective proximal end and a respective distal end. Electrical energy can be applied that causes electrical current to flow simultaneously through the first and second electrodes preferentially from the proximal end of one electrode to the distal end of the other electrode.
摘要翻译：用于在患者体内产生电场的方法和装置包括在可共同植入的基底上的至少第一电极和第二电极。每个电极具有相应的近端和相应的远端。可以施加电能，其导致电流同时通过第一和第二电极从一个电极的近端到另一个电极的远端。

3. 发明申请

US20070167984A1 Method and apparatus for stimulation of baroreceptors 审中-公开
标题翻译：用于刺激压力感受器的方法和装置
公开(公告)号：US20070167984A1
公开(公告)日：2007-07-19
申请号：US11482505
申请日：2006-07-07
申请人： Robert Kieval , Matthew Burns , Peter Keith , David Serdar , Martin Rossing
发明人： Robert Kieval , Matthew Burns , Peter Keith , David Serdar , Martin Rossing
IPC分类号： A61N1/32
CPC分类号： A61N1/36114 , A61N1/08 , A61N1/36117
摘要： Devices and methods for controlling the baroreflex system for the treatment and/or management of cardiovascular, renal, and neurological disorders.
摘要翻译：用于控制压力反射系统用于治疗和/或治疗心血管，肾脏和神经障碍的装置和方法。

4. 发明申请

US20070049989A1 STIMULUS REGIMENS FOR CARDIOVASCULAR REFLEX CONTROL 有权
标题翻译：用于心脏反射控制的刺激方案
公开(公告)号：US20070049989A1
公开(公告)日：2007-03-01
申请号：US11552005
申请日：2006-10-23
申请人： Martin Rossing , Robert Kieval , David Serdar , Bruce Persson
发明人： Martin Rossing , Robert Kieval , David Serdar , Bruce Persson
IPC分类号： A61N1/00
CPC分类号： A61N1/36114 , A61N1/0551 , A61N1/0558 , A61N1/36007 , A61N1/36117 , A61N1/3627 , A61N1/36514
摘要： Baroreflex activation is achieved by providing suitable control signals to a baroreflex activation device. A method comprises establishing a therapy interval (possibly on the order of minutes to hours, or possibly of indefinite duration), within the therapy interval, establishing a plurality of dose intervals, and generating an electrical output signal. The electrical output signal has a time dependence such that the average electrical power applied to the baroreflex activation device differs between first and second portions of at least some dose intervals. Another method comprises establishing a series of therapy interval portions, during at least some therapy intervals, establishing a plurality of burst intervals (perhaps having durations commensurate with an interval between heartbeats), and generating an electrical output signal. The electrical output signal has a time dependence such that the average electrical power applied to the baroreflex activation device differs between first and second portions of the therapy intervals and also differs between first and second portions of at least some burst intervals.
摘要翻译：通过向压力反射激活装置提供合适的控制信号来实现巴罗反射激活。一种方法包括在治疗间隔内建立治疗间隔（可能在数分钟到数小时，或者可能是不确定的持续时间），建立多个剂量间隔，以及产生电输出信号。电输出信号具有时间依赖性，使得施加到压力反射激活装置的平均电功率在至少一些剂量间隔的第一和第二部分之间不同。另一种方法包括在至少一些治疗间隔期间建立一系列治疗间隔部分，建立多个突发间隔（可能具有与心跳之间的间隔相当的持续时间），以及产生电输出信号。电输出信号具有时间依赖性，使得施加到压力反射激活装置的平均电功率在治疗间隔的第一和第二部分之间不同，并且在至少一些突发间隔的第一和第二部分之间也不同。

5. 发明申请

US20070021792A1 Baroreflex Modulation Based On Monitored Cardiovascular Parameter 审中-公开
标题翻译：基于监测心血管参数的Baroreflex调制
公开(公告)号：US20070021792A1
公开(公告)日：2007-01-25
申请号：US11428131
申请日：2006-06-30
申请人： Robert Kieval , Martin Rossing , David Serdar
发明人： Robert Kieval , Martin Rossing , David Serdar
IPC分类号： A61N1/00
CPC分类号： A61N1/36117 , A61B5/02028 , A61N1/05 , A61N1/0551 , A61N1/056 , A61N1/08 , A61N1/36053 , A61N1/3611 , A61N1/36114 , A61N1/36125 , A61N1/36135 , A61N1/36185 , A61N1/3702
摘要： The present invention is a system for providing baroreceptor stimulation comprising, a sensor to sense a physiologic parameter and provide a signal indicative of the physiologic parameter, a baroreceptor activation device, which includes, a pulse generator to intermittently generate a stimulation signal to provide baroreceptor stimulation for a baroreflex therapy, and a control system to adjust the stimulation signal based on the signal indicative of the physiologic parameter such that the stimulation signal provides a desired baroreceptor stimulation corresponding to a desired physiologic parameter.
摘要翻译：本发明是一种用于提供压力感受器刺激的系统，其包括感测生理参数并提供指示生理参数的信号的传感器，压力感受器激活装置，其包括脉冲发生器以间歇地产生刺激信号以提供压力感受器刺激用于压力反射治疗，以及控制系统，用于基于指示生理参数的信号来调节刺激信号，使得刺激信号提供对应于期望生理参数的期望的压力感受器刺激。

6. 发明申请

US20120289844A1 DEVICES, SYSTEMS, AND METHODS FOR IMPROVING LEFT VENTRICULAR STRUCTURE AND FUNCTION USING BAROREFLEX ACTIVATION THERAPY 审中-公开
标题翻译：使用BAROREFLEX激活治疗改善左心室结构和功能的装置，系统和方法
公开(公告)号：US20120289844A1
公开(公告)日：2012-11-15
申请号：US13556830
申请日：2012-07-24
申请人： Robert S. KIEVAL , Martin Rossing
发明人： Robert S. KIEVAL , Martin Rossing
IPC分类号： A61N1/365 , A61B5/02 , A61N1/362
CPC分类号： A61N1/36114 , A61N1/36117
摘要： Described here are devices, systems, and methods for improving left ventricular function in a patient with systolic heart failure with left ventricular dysfunction using baroreflex activation therapy. In general the systems have at least one electrode and a control system in communication with the electrode, the control system including a processor and memory, wherein the memory includes software defining a stimulus regime configured to effect improvement in left ventricular function. The methods for improving left ventricular function in a subject typically include identifying a patient in need of left ventricular function improvement and stimulating a baroreceptor with a baroreceptor activation device to improve left ventricular function.
摘要翻译：这里描述的是用于使用压力反射激活治疗来改善具有左心室功能障碍的收缩期心力衰竭患者的左心室功能的装置，系统和方法。通常，系统具有至少一个与电极连通的电极和控制系统，所述控制系统包括处理器和存储器，其中所述存储器包括限定被配置为实现左心室功能改善的刺激方案的软件。用于改善受试者左心室功能的方法通常包括识别需要左心室功能改善的患者，并用压力感受器激活装置刺激压力感受器以改善左心室功能。

7. 发明申请

US20110137374A1 DEVICES AND METHODS FOR ELECTRODE IMPLANTATION 有权
标题翻译：用于电极植入的装置和方法
公开(公告)号：US20110137374A1
公开(公告)日：2011-06-09
申请号：US12940798
申请日：2010-11-05
申请人： Robert S. Kieval , Martin Rossing
发明人： Robert S. Kieval , Martin Rossing
IPC分类号： A61N1/36
CPC分类号： A61N1/08 , A61N1/0556 , A61N1/36071 , A61N1/36114
摘要： Systems and methods provide baroreflex activation to treat or reduce pain and/or to cause or enhance sedation or sleep. Methods involve activating the baroreflex system to provide pain reduction, sedation, improved sleep or some combination thereof. Systems include at least one baroreflex activation device, at least one sensor for sensing physiological activity of the patient, and a processor coupled with the baroreflex activation device(s) and the sensor(s) for processing sensed data received from the sensor and for activating the baroreflex activation device. In some embodiments, the system is fully implantable within a patient, such as in an intravascular, extravascular or intramural location.
摘要翻译：系统和方法提供压力反射激活以治疗或减少疼痛和/或引起或增强镇静或睡眠。方法包括激活压力反射系统以提供疼痛减轻，镇静，改善的睡眠或其某些组合。系统包括至少一个压力反射激活装置，用于感测患者的生理活动的至少一个传感器，以及与压力反射激活装置和传感器耦合的处理器，用于处理从传感器接收的感测数据并激活压力反射激活装置。在一些实施例中，该系统可完全植入患者体内，例如在血管内，血管外或壁内位置。

8. 发明申请

US20090030262A1 BAROREFLEX ACTIVATION FOR SEDATION AND SLEEP 有权
标题翻译： BAROREFLEX激活用于治疗和睡眠
公开(公告)号：US20090030262A1
公开(公告)日：2009-01-29
申请号：US12245636
申请日：2008-10-03
申请人： Robert S. Kieval , Martin Rossing
发明人： Robert S. Kieval , Martin Rossing
IPC分类号： A61M21/00 , A61M19/00
CPC分类号： A61N1/08 , A61N1/0556 , A61N1/36071 , A61N1/36114
摘要： Systems and methods provide baroreflex activation to treat or reduce pain and/or to cause or enhance sedation or sleep. Methods involve activating the baroreflex system to provide pain reduction, sedation, improved sleep or some combination thereof. Systems include at least one baroreflex activation device, at least one sensor for sensing physiological activity of the patient, and a processor coupled with the baroreflex activation device(s) and the sensor(s) for processing sensed data received from the sensor and for activating the baroreflex activation device. In some embodiments, the system is fully implantable within a patient, such as in an intravascular, extravascular or intramural location.
摘要翻译：系统和方法提供压力反射激活以治疗或减少疼痛和/或引起或增强镇静或睡眠。方法包括激活压力反射系统以提供疼痛减轻，镇静，改善的睡眠或其某些组合。系统包括至少一个压力反射激活装置，用于感测患者的生理活动的至少一个传感器，以及与压力反射激活装置和传感器耦合的处理器，用于处理从传感器接收的感测数据并激活压力反射激活装置。在一些实施例中，该系统可完全植入患者体内，例如在血管内，血管外或壁内位置。

9. 发明申请

US20080215111A1 Devices and Methods for Cardiovascular Reflex Control 审中-公开
标题翻译：心血管反射控制装置与方法
公开(公告)号：US20080215111A1
公开(公告)日：2008-09-04
申请号：US11933218
申请日：2007-10-31
申请人： Robert S. Kieval , Martin Rossing
发明人： Robert S. Kieval , Martin Rossing
IPC分类号： A61N1/05 , A61N1/08
CPC分类号： A61N1/36114 , A61N1/08 , A61N1/36117
摘要： Devices, systems and methods are described which control blood pressure, nervous system activity, and neurohormonal activity by activating baroreceptors. By selectively and controllably activating baroreceptors, the present invention reduces excessive blood pressure, sympathetic nervous system activity and neurohormonal activity, thereby minimizing their deleterious effects on the heart, vasculature and other organs and tissues. A baroreceptor activation device is positioned near a low-pressure baroreceptor, preferably in the venous system, heart, or pulmonary vasculature.
摘要翻译：描述了通过激活压力感受器来控制血压，神经系统活性和神经激素活性的装置，系统和方法。本发明通过选择性地和可控制地激活压力感受器，降低过度的血压，交感神经系统活性和神经激素活性，从而使其对心脏，脉管系统和其他器官和组织的有害作用最小化。压力感受器激活装置位于低压压力感受器附近，优选位于静脉系统，心脏或肺脉管系统中。

10. 发明申请

US20080082137A1 ELECTRODE ARRAY STRUCTURES AND METHODS OF USE FOR CARDIOVASCULAR REFLEX CONTROL 有权
标题翻译：电极阵列结构和用于心脏反射控制的方法
公开(公告)号：US20080082137A1
公开(公告)日：2008-04-03
申请号：US11862508
申请日：2007-09-27
申请人： Robert S. Kieval , Martin Rossing
发明人： Robert S. Kieval , Martin Rossing
IPC分类号： A61N1/08
CPC分类号： A61N1/0551 , A61N1/0556 , A61N1/0558 , A61N1/36114 , A61N1/36117
摘要： A tissue stimulation device includes an electrode array having at least four independently switchable electrodes. In one embodiment, the electrode array comprises a flexible base to which the electrodes are fixed that flexes to encompass at least a portion of an artery or other elongate biological structure. The electrodes are electrically coupled to and energized by a signal generator coupled to a control system. In one embodiment, the array of electrodes are configured such that a suitable signal pattern for stimulation pulses between or among a set of the switchable electrodes may be determined without having to reposition the electrode assembly by using a series of signal patterns activating different combinations of switchable electrodes in response to sub-stimulation test signals to determine a signal pattern that provides suitable patient response. In another embodiment, the array of electrodes includes an array of selectively activatable multi-polar electrodes.
摘要翻译：组织刺激装置包括具有至少四个可独立切换的电极的电极阵列。在一个实施例中，电极阵列包括柔性基座，电极被固定到柔性基座上，该电极弯曲以包围动脉或其他细长生物结构的至少一部分。电极电耦合到耦合到控制系统的信号发生器并由其激励。在一个实施例中，电极阵列被配置为使得可以确定用于在一组可切换电极之间或之间进行刺激脉冲的合适信号图案，而不必通过使用一系列信号图案来激活电极组件，所述信号图案激活不同的可切换组合电极响应亚刺激测试信号以确定提供合适的患者反应的信号图案。在另一个实施例中，电极阵列包括可选择性激活的多极电极的阵列。

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