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    • 10. 发明申请
    • METHOD FOR ANALYZING ACTIVATED POLYETHYLENE GLYCOL COMPOUNDS
    • 分析活性聚乙烯甘油化合物的方法
    • US20120125852A1
    • 2012-05-24
    • US13280790
    • 2011-10-25
    • Ross A. WallingfordMaciej Turowski
    • Ross A. WallingfordMaciej Turowski
    • B01D15/08
    • G01N30/88A61K47/60G01N2030/8813G01N2030/8854Y10T436/200833Y10T436/2575
    • A chemical analysis method for the determination of RO(CH2CH2O)nH, RO(C2H4O)nA, and AO(C2H4O)nA in a mixture thereof, wherein R is an alkyl group, A is a functional group for coupling with a surface or a biologically active material or another thing of use and n is an integer greater than 10. The method includes the derivatizing the A groups of the mixture with a derivatizing agent to form a derivatized mixture comprising RO(CH2CH2O)nH, RO(C2H4O)nAD, and DAO(C2H4O)nAD, wherein AD is the derivatized A group. The second step is chromatographing a sample of the derivatized mixture by liquid chromatography under critical conditions to determine the relative amounts of RO(CH2CH2O)nH, RO(C2H4O)nAD, and DAO(C2H4O)nAD in the derivatized mixture.
    • 用于在其混合物中测定RO(CH 2 CH 2 O)n H,RO(C 2 H 4 O)n A和AO(C 2 H 4 O)n A)的化学分析方法,其中R是烷基,A是与表面偶联的官能团 生物活性物质或另一种使用的物质,n是大于10的整数。该方法包括用衍生剂衍生化A组混合物以形成衍生化的混合物,其包含RO(CH 2 CH 2 O)nH,RO(C 2 H 4 O)n AD, 和DAO(C2H4O)nAD,其中AD是衍生的A基团。 第二步是在临界条件下通过液相色谱法对衍生化混合物的样品进行色谱分析,以确定衍生化混合物中RO(CH2CH2O)nH,RO(C2H4O)nAD和DAO(C2H4O)nAD的相对量。