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1. 发明申请

US20100247664A1 METHOD OF PREVENTING OR TREATING METABOLIC SYNDROME 审中-公开
标题翻译：预防或治疗代谢综合征的方法
公开(公告)号：US20100247664A1
公开(公告)日：2010-09-30
申请号：US12446371
申请日：2007-10-18
申请人： Stephanie K. Lynch , Wallace Yokoyama , Maciej Turowski , Jerry R. Conklin
发明人： Stephanie K. Lynch , Wallace Yokoyama , Maciej Turowski , Jerry R. Conklin
IPC分类号： A61K31/717 , A61K9/14 , C08B11/02
CPC分类号： A61K31/717
摘要： Water-insoluble cellulose derivatives such as ethyl cellulose can be used to treat or prevent metabolic syndrome and/or one of the abnormalities of metabolic syndrome.
摘要翻译：水不溶性纤维素衍生物如乙基纤维素可用于治疗或预防代谢综合征和/或代谢综合征异常之一。

2. 发明申请

US20110071107A1 USES OF WATER-SOLUBLE CELLULOSE DERIVATIVES FOR PREVENTING OR TREATING METABOLIC SYNDROME 审中-公开
标题翻译：用于预防或治疗代谢综合征的水溶性纤维素衍生物的使用
公开(公告)号：US20110071107A1
公开(公告)日：2011-03-24
申请号：US12446366
申请日：2007-10-18
申请人： Stephanie K Lynch , Maciej Turowski , Wallace Yokoyama , Yun-Jeong Hong , Jerry R. Conklin , Shao-Ching Hung , Scott A. Young
发明人： Stephanie K Lynch , Maciej Turowski , Wallace Yokoyama , Yun-Jeong Hong , Jerry R. Conklin , Shao-Ching Hung , Scott A. Young
IPC分类号： A61K31/717 , A61P3/00 , A61P9/12 , A61P29/00
CPC分类号： A61K31/717
摘要： Water-soluble cellulose derivatives are useful in methods of preventing or treating metabolic syndrome or a symptom or condition associated with the metabolic syndrome in an individual, and in particular for preventing or treating one or more of the symptoms a) hypertension, b) proinflammatory or inflammation state and c) prothrombotic state.
摘要翻译：水溶性纤维素衍生物可用于预防或治疗代谢综合征或与个体代谢综合征有关的症状或病症的方法，特别是用于预防或治疗一种或多种症状a）高血压，b）促炎症或炎症状态和c）血栓前状态。

3. 发明申请

US20090093442A1 USES OF WATER-SOLUBLE CELLULOSE DERIVATIVES FOR PREVENTING OR TREATING METABOLIC SYNDROME 审中-公开
标题翻译：用于预防或治疗代谢综合征的水溶性纤维素衍生物的使用
公开(公告)号：US20090093442A1
公开(公告)日：2009-04-09
申请号：US11874671
申请日：2007-10-18
申请人： Stephanie K. Lynch , Maciej Turowski , Wallace Yokoyama , Yun-Jeong Hong , Jerry R. Conklin , Shao-Ching Hung , Scott A. Young
发明人： Stephanie K. Lynch , Maciej Turowski , Wallace Yokoyama , Yun-Jeong Hong , Jerry R. Conklin , Shao-Ching Hung , Scott A. Young
IPC分类号： A61K31/717 , A61P9/12 , A61P9/00 , A61P29/00
CPC分类号： A61K31/717
摘要： Water-soluble cellulose derivatives are useful in methods of preventing or treating metabolic syndrome or a symptom or condition associated with the metabolic syndrome in an individual, and in particular for preventing or treating one or more of the symptoms a) hypertension, b) proinflammatory or inflammation state and c) prothrombotic state.
摘要翻译：水溶性纤维素衍生物可用于预防或治疗代谢综合征或与个体代谢综合征有关的症状或病症的方法，特别是用于预防或治疗一种或多种症状a）高血压，b）促炎症或炎症状态和c）血栓前状态。

4. 发明申请

US20090093441A1 PREVENTING OR REDUCING OXIDATIVE STRESS OR OXIDATIVE CELL INJURY 审中-公开
标题翻译：预防或减少氧化应激或氧化性细胞损伤
公开(公告)号：US20090093441A1
公开(公告)日：2009-04-09
申请号：US11874663
申请日：2007-10-18
申请人： Stephanie K. Lynch , Maciej Turowski , Wallace Yokoyama
发明人： Stephanie K. Lynch , Maciej Turowski , Wallace Yokoyama
IPC分类号： A61K31/717 , A61P3/00
CPC分类号： A61K31/717
摘要： A water-insoluble cellulose derivative, such as ethyl cellulose is useful for preventing or reducing oxidative stress or oxidative cell injury in tissues of an animal and in particular for influencing the level Stearoyl-CoA Desaturase-1 (SCD1) gene expression or ATP synthase mitochondrial F1 complex assembly factor 1 (ATPAF1) gene expression in non-adipose tissues of the animal.
摘要翻译：水不溶性纤维素衍生物如乙基纤维素可用于预防或减少动物组织中的氧化应激或氧化性细胞损伤，特别是用于影响硬脂酰辅酶A去饱和酶-1（SCD1）基因表达或ATP合成酶线粒体的水平 F1复合装配因子1（ATPAF1）基因在动物非脂肪组织中的表达。

5. 发明申请

US20080176819A1 METHOD OF PREVENTING OR TREATING METABOLIC SYNDROME 审中-公开
标题翻译：预防或治疗代谢综合征的方法
公开(公告)号：US20080176819A1
公开(公告)日：2008-07-24
申请号：US11874674
申请日：2007-10-18
申请人： Stephanie K. Lynch , Maciej Turowski , Wallace Yokoyama , Jerry R. Conklin
发明人： Stephanie K. Lynch , Maciej Turowski , Wallace Yokoyama , Jerry R. Conklin
IPC分类号： A61K31/717 , A61P3/10 , A61P9/00
CPC分类号： A61K31/717
摘要： Water-insoluble cellulose derivatives such as ethyl cellulose can be used to treat or prevent metabolic syndrome and/or one of the abnormalities of metabolic syndrome.
摘要翻译：水不溶性纤维素衍生物如乙基纤维素可用于治疗或预防代谢综合征和/或代谢综合征异常之一。

6. 发明申请

US20070123490A1 Preventing or reducing oxidative stress or oxidative cell injury 审中-公开
标题翻译：预防或减少氧化应激或氧化细胞损伤
公开(公告)号：US20070123490A1
公开(公告)日：2007-05-31
申请号：US11289914
申请日：2005-11-30
申请人： Wallace Yokoyama , Maciej Turowski , Qiming Shao , Stephanie Lynch
发明人： Wallace Yokoyama , Maciej Turowski , Qiming Shao , Stephanie Lynch
IPC分类号： A61K31/717
CPC分类号： A61K31/717
摘要： A water-soluble cellulose derivative is useful for preventing or reducing oxidative stress or oxidative cell injury in tissues of an animal and in particular for regulating Stearoyl-CoA Desaturase-1 gene expression and/or ATPF1 gene expression in non-adipose tissues of the animal.
摘要翻译：水溶性纤维素衍生物可用于预防或减少动物组织中的氧化应激或氧化细胞损伤，特别是用于在动物的非脂肪组织中调节硬脂酰辅酶A脱氢酶-1基因表达和/或ATPF1基因表达。

7. 发明申请

US20060057231A1 Pterostilbene as a new agonist for the peroxisome proliferator-activated receptor alpha isoform 审中-公开
标题翻译：作为过氧化物酶体增殖物激活受体α亚型的新型激动剂
公开(公告)号：US20060057231A1
公开(公告)日：2006-03-16
申请号：US11207038
申请日：2005-08-18
申请人： Agnes Rimando , Dennis Feller , Wallace Yokoyama
发明人： Agnes Rimando , Dennis Feller , Wallace Yokoyama
IPC分类号： A61K36/45 , A61K36/87 , A61K31/704
CPC分类号： A61K31/704 , A23L33/105 , A23V2002/00 , A61K31/352 , A61K36/45 , A61K36/87 , A23V2200/3262 , A23V2250/21
摘要： Resveratrol, a stilbenoid antioxidant found in grapes, wine, peanuts and other berries, has been reported to have hypolipidemic properties. We investigated whether resveratrol and its three analogs (pterostilbene, piceatannol and resveratrol trimethyl ether) would activate the peroxisome proliferator-activated receptor alpha (PPARα) isoform. This nuclear receptor is proposed to mediate the activity of lipid-lowering drugs such as the fibrates. The four stilbenes were evaluated along with ciprofibrate (positive control) at 1, 10, 100, 300 μM concentrations, for the activation of endogenous PPARα in H4IIEC3 cells. Cells were transfected with a peroxisome proliferator response element-AB (rat fatty acyl CoA β-oxidase response element)—luciferase gene reporter construct. Of the four analogs, pterostilbene demonstrated the highest induction of PPARα showing 7- and 9-14 fold increases in luciferase activity at 100 and 300 μM, respectively, relative to control. The maximal luciferase activity responses to pterostilbene at 100 μM are similar to those obtained with the hypolipidemic drug, ciprofibrate. These results suggest that pterostilbene acts as a PPARα agonist, like that of the fibrate class, and may be a more effective hypolipidemic agent than resveratrol.
摘要翻译：据报道，白藜芦醇是葡萄，葡萄酒，花生和其他浆果中发现的芪类抗氧化剂，具有降血脂特性。我们调查了白藜芦醇及其三种类似物（ter il ene，白藜芦醇和白藜芦醇三甲基醚）是否会激活过氧化物酶体增殖物激活受体α（PPARα）同种型。提议这种核受体介导降脂药物如贝特类药物的活性。在1,10,100,300μM浓度下，四环己烷与环丙哌酸（阳性对照）一起进行评估，以激活H4IIEC3细胞中的内源性PPARα。用过氧化物酶体增殖物反应元件-AB（大鼠脂肪酰辅酶A氧化酶应答元件） - 荧光素酶基因报道构建体转染细胞。在四种类似物中，萜烯二烯显示PPARα的诱导最高，显示相对于对照，分别为100和300μM的荧光素酶活性增加7和9-14倍。对100μM的p芪烯的最大荧光素酶活性的反应与用降血脂药物环丙哌酸得到的相似。这些结果表明，ter il ene ene ene。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。。

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