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1. 发明授权

US08987377B2 Poly(amide) polymers for the delivery of oligonucleotides 有权
标题翻译：用于递送寡核苷酸的聚（酰胺）聚合物
公开(公告)号：US08987377B2
公开(公告)日：2015-03-24
申请号：US13885737
申请日：2011-11-16
申请人： Stephanie E. Barrett , Marina Busuek , Steven L. Colletti , Robert M. Garbaccio , Erin N. Guidry , Robert A. Kowtoniuk , Jing Liao , Craig A. Parish , Rubina G. Parmar , Tao Pei , Kevin M. Schlosser , David M. Tellers , Sandra C. Tobias , Quang T. Truong , Jacob H. Waldman , Weimin Wang , J. Michael Williams
发明人： Stephanie E. Barrett , Marina Busuek , Steven L. Colletti , Robert M. Garbaccio , Erin N. Guidry , Robert A. Kowtoniuk , Jing Liao , Craig A. Parish , Rubina G. Parmar , Tao Pei , Kevin M. Schlosser , David M. Tellers , Sandra C. Tobias , Quang T. Truong , Jacob H. Waldman , Weimin Wang , J. Michael Williams
IPC分类号： A61K47/48 , C08G73/02 , C08L79/02
CPC分类号： A61K47/48092 , A61K47/549 , C08G69/10 , C08G73/028 , C08L79/02
摘要： The present invention provides poly(amide) polymers, polyconjugates, compositions and methods for the delivery of oligonucleotides for therapeutic purposes.
摘要翻译：本发明提供用于递送用于治疗目的的寡核苷酸的聚（酰胺）聚合物，多偶联物，组合物和方法。

2. 发明申请

US20130253135A1 POLY(AMIDE) POLYMERS FOR THE DELIVERY OF OLIGONUCLEOTIDES 有权
标题翻译：用于交付寡核苷酸的聚（酰胺）聚合物
公开(公告)号：US20130253135A1
公开(公告)日：2013-09-26
申请号：US13885737
申请日：2011-11-16
申请人： Stephanie E. Barrett , Marina Busuek , Steven L. Colletti , Robert M. Garbaccio , Erin N. Guidry , Robert A. Kowtoniuk , Jing Liao , Craig A. Parish , Rubina G. Parmar , Tao Pei , Kevin M. Schlosser , David M. Tellers , Sandra C. Tobias , Quang T. Truong , Jacob H. Waldman , Weimin Wang , J. Michael Williams
发明人： Stephanie E. Barrett , Marina Busuek , Steven L. Colletti , Robert M. Garbaccio , Erin N. Guidry , Robert A. Kowtoniuk , Jing Liao , Craig A. Parish , Rubina G. Parmar , Tao Pei , Kevin M. Schlosser , David M. Tellers , Sandra C. Tobias , Quang T. Truong , Jacob H. Waldman , Weimin Wang , J. Michael Williams
IPC分类号： A61K47/48
CPC分类号： A61K47/48092 , A61K47/549 , C08G69/10 , C08G73/028 , C08L79/02
摘要： The present invention provides poly(amide) polymers, polyconjugates, compositions and methods for the delivery of oligonucleotides for therapeutic purposes.
摘要翻译：本发明提供用于递送用于治疗目的的寡核苷酸的聚（酰胺）聚合物，多偶联物，组合物和方法。

3. 发明授权

US07678948B2 Synthesis of 3-(5-nitrocyclohex-1-enyl) acrylic acid and esters thereof 失效
标题翻译： 3-（5-硝基环己-1-烯基）丙烯酸及其酯的合成
公开(公告)号：US07678948B2
公开(公告)日：2010-03-16
申请号：US12274075
申请日：2008-11-19
申请人： Tiruvettipuram K. Thiruvengadam , Tao Wang , John S. Chiu , Jing Liao
发明人： Tiruvettipuram K. Thiruvengadam , Tao Wang , John S. Chiu , Jing Liao
IPC分类号： C07C205/01
CPC分类号： C07C251/44 , C07C201/06 , C07C249/08 , C07C2601/16 , C07C205/56 , C07C251/42
摘要： This application discloses provides a process for the introduction of nitro-group functionality into a compound which contains also a site of unsaturation and/or oxygen functionality by direct (one step) oxidation of an oxime functional group mediated by a molybdenum VI/VII peroxo complex, the process comprising: (a) providing a substrate of Formula I containing an oxime functional group; wherein R1 and R2 are selected independently from linear, branched or cyclic alkyl and linear, branched or cyclic alkenyl groups, optionally substituted, with the proviso that at least one of R1 or R2 contains a carbon/carbon double bond; and (b) contacting said substrate of Formula I with a molybdenum oxidation complex, thereby oxidizing said oxime functional group to a nitro functional group to yield the structure of Formula III. Where R1 and R2 are as defined above.
摘要翻译：本申请公开提供了一种通过由钼VI / VII过氧配合物介导的肟官能团的直接（一步）氧化将硝基官能团引入到还含有不饱和位和/或氧官能团位点的化合物的方法该方法包括：（a）提供含有肟官能团的式I的底物; 其中R 1和R 2独立地选自直链，支链或环状的烷基和直链，支链或环状烯基，任选被取代，条件是R 1或R 2中的至少一个含有碳/碳双键; 和（b）使式I的底物与钼氧化络合物接触，从而将所述肟官能团氧化为硝基官能团，得到式III的结构。其中R1和R2如上所定义。

4. 发明申请

US20080009651A1 Synthesis of 3-(5-nitrocyclohex-1-enyl) acrylic acid and esters thereof 失效
标题翻译： 3-（5-硝基环己-1-烯基）丙烯酸及其酯的合成
公开(公告)号：US20080009651A1
公开(公告)日：2008-01-10
申请号：US11824246
申请日：2007-06-29
申请人： Tiruvettipuram Thiruvengadam , Tao Wang , John Chiu , Jing Liao
发明人： Tiruvettipuram Thiruvengadam , Tao Wang , John Chiu , Jing Liao
IPC分类号： C07C61/35 , C07C201/06
CPC分类号： C07C251/44 , C07C201/06 , C07C249/08 , C07C2601/16 , C07C205/56 , C07C251/42
摘要： This application discloses provides a process for the introduction of nitro-group functionality into a compound which contains also a site of unsaturation and/or oxygen functionality by direct (one step) oxidation of an oxime functional group mediated by a molybdenum VI/VII peroxo complex, the process comprising: (a) providing a substrate of Formula I containing an oxime functional group; wherein R1 and R2 are selected independently from linear, branched or cyclic alkyl and linear, branched or cyclic alkenyl groups, optionally substituted, with the proviso that at least one of R1 or R2 contains a carbon/carbon double bond; and (b) contacting said substrate of Formula I with a molybdenum oxidation complex, thereby oxidizing said oxime functional group to a nitro functional group to yield the structure of Formula III. Where R1 and R2 are as defined above.
摘要翻译：本申请公开提供了一种通过由钼VI / VII过氧配合物介导的肟官能团的直接（一步）氧化将硝基官能团引入到还含有不饱和位和/或氧官能团位点的化合物的方法该方法包括：（a）提供含有肟官能团的式I的底物; 其中R 1和R 2独立地选自直链，支链或环状的烷基和直链，支链或环状烯基，任选被取代，条件是至少一个 R 1或R 2 2含有碳/碳双键; 和（b）使式I的底物与钼氧化络合物接触，从而将所述肟官能团氧化为硝基官能团，得到式III的结构。其中R 1和R 2如上定义。

5. 发明申请

US20060173189A1 Synthesis of himbacine analogs 有权
公开(公告)号：US20060173189A1
公开(公告)日：2006-08-03
申请号：US11330935
申请日：2006-01-12
申请人： Tiruvettipuram Thiruvengadam , Tao Wang , Jing Liao , John Chiu , David Tsai , Hong-Chang Lee , Wenxue Wu , Xiaoyong Fu
发明人： Tiruvettipuram Thiruvengadam , Tao Wang , Jing Liao , John Chiu , David Tsai , Hong-Chang Lee , Wenxue Wu , Xiaoyong Fu
IPC分类号： C07D405/02
CPC分类号： C07D405/06
摘要： The present invention relates to an improved process for preparing himbacine analogs. The compounds are useful as thrombin receptor antagonists. The improved process may allow for at least one of easier purification by crystallization, easier scalability, and improved process yield on the desired enantiomer. An example of a step in the synthesis of such a himbacine analog is as follows:

6. 发明申请

US20180111954A1 PROCESS FOR MAKING PHOSPHORAMIDATE PROTECTED NUCLEOSIDE COMPOUNDS 审中-公开
公开(公告)号：US20180111954A1
公开(公告)日：2018-04-26
申请号：US15562973
申请日：2016-03-28
申请人： Steven M. SILVERMAN , Bryon Ladd SIMMONS , Zhuqing LIU , Jing LIAO , Artis KLAPARS , Kevin R. CAMPOS , Ana Ines BELLOMO PERAZA , MERCK SHARP & DOHME CORP.
发明人： Steven M. Silverman , Bryon Ladd Simmons , Zhuqing Liu , Jing Liao , Artis Klapars , Kevin R. Campos , Ana Inés Bellomo Peraza
IPC分类号： C07H1/02 , C07H19/10 , C07H19/20 , C07F9/6558 , C07F9/58 , C07F9/24
CPC分类号： C07H1/02 , C07F9/242 , C07F9/58 , C07F9/65586 , C07H19/10 , C07H19/20
摘要： The present invention is directed to process for making Compounds of Formula (II): (II), and salts thereof, wherein B, X, R2, R3, R4 R7, R8 and R9 are defined herein.

7. 发明授权

US08618314B2 Exo- and diastereo-selective synthesis of himbacine analogs 有权
标题翻译：烟草类似物的外切和非对映选择性合成
公开(公告)号：US08618314B2
公开(公告)日：2013-12-31
申请号：US13563136
申请日：2012-07-31
申请人： George G. Wu , Anantha Sudhakar , Tao Wang , Ji Xie , Frank X. Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram K. Thiruvengadam , Jing Liao , Illia Zavialov , Hoa N. Nguyen , Ngiap Kie Lim
发明人： George G. Wu , Anantha Sudhakar , Tao Wang , Ji Xie , Frank X. Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram K. Thiruvengadam , Jing Liao , Illia Zavialov , Hoa N. Nguyen , Ngiap Kie Lim
IPC分类号： C07D307/92
CPC分类号： C07D263/56 , C07C69/606 , C07C69/732 , C07C201/10 , C07C201/12 , C07C205/44 , C07C205/55 , C07C231/10 , C07C231/12 , C07C235/28 , C07C303/32 , C07C309/08 , C07C2601/16 , C07D277/64 , C07D307/92 , C07D333/56 , C07D405/06 , C07D413/06 , C07D417/06 , C07F7/1804 , C07F9/58 , Y02P20/55 , C07C233/28
摘要： This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following:
摘要翻译：本申请公开了一种制备可用作凝血酶受体拮抗剂的烟肼类似物的新方法。该方法部分基于使用手性硝基中心的碱促进的动态差向异构化。本文教导的化学结构可以举例说明如下：

8. 发明授权

US07605275B2 Exo- and diastereo- selective syntheses of himbacine analogs 有权
标题翻译：烟草类似物的外切和非对映选择性合成
公开(公告)号：US07605275B2
公开(公告)日：2009-10-20
申请号：US11331324
申请日：2006-01-12
申请人： Frank Xing Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , George Wu , Anantha R. Sudhakar , Tao Wang , Ji Xie , Jing Liao , Ilia A. Zavialov , Hoa N. Nguyen , Ngiap Kie Lim , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram K. Thiruvengadam
发明人： Frank Xing Chen , Marc Poirier , Mingsheng Huang , Vijay Sabesan , George Wu , Anantha R. Sudhakar , Tao Wang , Ji Xie , Jing Liao , Ilia A. Zavialov , Hoa N. Nguyen , Ngiap Kie Lim , Daw-long Kwok , Jian Cui , Xiaojing Yang , Tiruvettipuram K. Thiruvengadam
IPC分类号： C07D307/92
CPC分类号： C07D263/56 , C07C69/606 , C07C69/732 , C07C201/10 , C07C201/12 , C07C205/44 , C07C205/55 , C07C231/10 , C07C231/12 , C07C235/28 , C07C303/32 , C07C309/08 , C07C2601/16 , C07D277/64 , C07D307/92 , C07D333/56 , C07D405/06 , C07D413/06 , C07D417/06 , C07F7/1804 , C07F9/58 , Y02P20/55 , C07C233/28
摘要： This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following:
摘要翻译：本申请公开了一种制备可用作凝血酶受体拮抗剂的烟肼类似物的新方法。该方法部分基于使用手性硝基中心的碱促进的动态差向异构化。本文教导的化学结构可以举例说明如下：

9. 发明授权

US07553987B2 Synthesis of 3-(5-nitrocyclohex-1-enyl) acrylic acid and esters thereof 失效
标题翻译： 3-（5-硝基环己-1-烯基）丙烯酸及其酯的合成
公开(公告)号：US07553987B2
公开(公告)日：2009-06-30
申请号：US11824246
申请日：2007-06-29
申请人： Tiruvettipuram K. Thiruvengadam , Tao Wang , John S. Chiu , Jing Liao
发明人： Tiruvettipuram K. Thiruvengadam , Tao Wang , John S. Chiu , Jing Liao
IPC分类号： C07C205/00 , C07C61/08
CPC分类号： C07C251/44 , C07C201/06 , C07C249/08 , C07C2601/16 , C07C205/56 , C07C251/42
摘要： This application discloses provides a process for the introduction of nitro-group functionality into a compound which contains also a site of unsaturation and/or oxygen functionality by direct (one step) oxidation of an oxime functional group mediated by a molybdenum VI/VII peroxo complex, the process comprising: (a) providing a substrate of Formula I containing an oxime functional group; wherein R1 and R2 are selected independently from linear, branched or cyclic alkyl and linear, branched or cyclic alkenyl groups, optionally substituted, with the proviso that at least one of R1 or R2 contains a carbon/carbon double bond; and (b) contacting said substrate of Formula I with a molybdenum oxidation complex, thereby oxidizing said oxime functional group to a nitro functional group to yield the structure of Formula III. Where R1 and R2 are as defined above.
摘要翻译：本申请公开提供了一种通过由钼VI / VII过氧配合物介导的肟官能团的直接（一步）氧化将硝基官能团引入到还含有不饱和位和/或氧官能团位点的化合物的方法该方法包括：（a）提供含有肟官能团的式I的底物; 其中R 1和R 2独立地选自直链，支链或环状的烷基和直链，支链或环状烯基，任选被取代，条件是R 1或R 2中的至少一个含有碳/碳双键; 和（b）使式I的底物与钼氧化络合物接触，从而将所述肟官能团氧化为硝基官能团，得到式III的结构。其中R1和R2如上所定义。

10. 发明授权

US5291391A Fast programmable scan logic controller method and apparatus 失效
标题翻译：快速可编程扫描逻辑控制器的方法和装置
公开(公告)号：US5291391A
公开(公告)日：1994-03-01
申请号：US855187
申请日：1992-03-20
申请人： Ian D. Mead , Jing Liao
发明人： Ian D. Mead , Jing Liao
IPC分类号： G05B19/05 , G05B11/01 , G05B13/02 , G05B21/02
CPC分类号： G05B19/054
摘要： A programmable controller is disclosed for the purpose of controlling devices such as machine tools and other machinery, and which is often mated with a host computer numerical controller. The programmable controller is configured such that certain user-designated "fast-scan" outputs can operate at much higher speeds than non-designated "normal" outputs, thereby greatly increasing the response time and efficiency of the operations that are controlled by those fast-scan outputs. The programmable controller uses a processor which scans through its user-definable program (including the value of all system inputs and outputs) before it attempts to change the value of any of its outputs. The physical input/output (I/O) interfaces are located on I/O racks, each of which also includes an intelligent bus adaptor. The intelligent bus adaptor includes its own processor which periodically communicates with the processor in the programmable controller. The intelligent bus adaptor's processor controls the fast-scan outputs located on that particular I/O rack within very short time intervals, and allows for a response time that is an order of magnitude faster than the response time of normal outputs of the programmable controller.
摘要翻译：公开了可编程控制器，用于控制诸如机床和其他机械的设备，并且其通常与主机数字控制器配合。可编程控制器被配置为使得某些用户指定的“快速扫描”输出可以以比非指定的“正常”输出高得多的速度运行，从而大大增加由那些快速扫描输出控制的操作的响应时间和效率，扫描输出。可编程控制器在尝试更改其任何输出的值之前，使用一个处理器来扫描其用户可定义的程序（包括所有系统输入和输出的值）。物理输入/输出（I / O）接口位于I / O机架上，每个接口还包括智能总线适配器。智能总线适配器包括其自己的处理器，其周期性地与可编程控制器中的处理器进行通信。智能总线适配器的处理器在非常短的时间间隔内控制位于特定I / O机架上的快速扫描输出，并且允许响应时间比可编程控制器的正常输出的响应时间快一个数量级。

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