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1. 发明专利

FR481205A 未知
公开(公告)号：FR481205A
公开(公告)日：1916-11-14
申请号：FR481205D
申请日：1916-03-17
申请人： MARC POIRIER
发明人： POIRIER MARC
IPC分类号： B23K3/02

2. 发明授权

US08374912B2 System and method for managing and optimizing advertising campaigns managed on the internet 有权
标题翻译：用于管理和优化在互联网上管理的广告活动的系统和方法
公开(公告)号：US08374912B2
公开(公告)日：2013-02-12
申请号：US12750352
申请日：2010-03-30
申请人： Sandrine Paroz , Richard Couture , Martin Mailloux , Martin LeSauteur , Marc Poirier , Benoit Allaire
发明人： Sandrine Paroz , Richard Couture , Martin Mailloux , Martin LeSauteur , Marc Poirier , Benoit Allaire
IPC分类号： G06Q30/00
CPC分类号： G06Q90/00 , G06Q30/02 , G06Q30/0256 , G06Q30/0275
摘要： The system of the present invention is used to optimize the returns of advertising campaigns on the internet. The system allows to create portfolios of keywords and to optimize these portfolios. Moreover, the system allows to classify the keywords in the portfolios according to their past data and to agitate the keywords which held a stagnant position over a pre-set period of time.The system support different implementations of the keyword classification in portfolios, different implementations of keyword bids agitation and different implementations of optimization. The various implementations can meet the specific aspects of different industries and/or the distinctive optimization approach of different agencies.The system can leverage the cloud computing whereby shared data, process and information are provided to computers and other devices on-demand. The delivery model involves the provision of dynamically scalable and virtualized resources as a service over the Internet. Some or all of the system components can be executed in the cloud through an on-demand instantiation of the resources required to perform the task.
摘要翻译：本发明的系统用于优化互联网广告活动的回报。该系统允许创建关键字组合并优化这些投资组合。此外，该系统允许根据其过去的数据对投资组合中的关键词进行分类，并且在预设的时间段内搅动保持停滞的关键词。系统支持关键字分类在投资组合中的不同实现，关键字出价激励的不同实现以及优化的不同实现。各种实现可以满足不同行业的特定方面和/或不同机构的独特优化方法。该系统可以利用云计算，从而根据需要将共享数据，过程和信息提供给计算机和其他设备。交付模型涉及通过互联网提供动态可扩展和虚拟化的资源作为服务。部分或全部系统组件可以通过对执行任务所需资源的按需实例化在云中执行。

3. 发明申请

US20120296093A1 EXO- AND DIASTEREO- SELECTIVE SYNTHESIS OF HIMBACINE ANALOGS 有权
标题翻译：乙酰胺类似物的外源和二硫选择性合成
公开(公告)号：US20120296093A1
公开(公告)日：2012-11-22
申请号：US13563136
申请日：2012-07-31
申请人： George Wu , Anantha R. SUDHAKAR , Tao WANG , Ji XIE , Frank Xing CHEN , Marc POIRIER , Mingsheng HUANG , Vijay SABESAN , Daw-long KWOK , Jian CUI , Xiaojing YANG , Tiruvettipuram K. THIRUVENGADAM , Jing LIAO , Ilia A. Zavialov , Hoa N. NGUYEN , Ngiap Kie LIM
发明人： George Wu , Anantha R. SUDHAKAR , Tao WANG , Ji XIE , Frank Xing CHEN , Marc POIRIER , Mingsheng HUANG , Vijay SABESAN , Daw-long KWOK , Jian CUI , Xiaojing YANG , Tiruvettipuram K. THIRUVENGADAM , Jing LIAO , Ilia A. Zavialov , Hoa N. NGUYEN , Ngiap Kie LIM
IPC分类号： C07D405/08 , C07C205/56 , C07D417/08 , C07D307/77 , C07C69/732 , C07F7/18 , C07C205/44 , C07C309/08 , C07C205/55 , C07D277/64 , C07F9/58 , C07C233/09
CPC分类号： C07D263/56 , C07C69/606 , C07C69/732 , C07C201/10 , C07C201/12 , C07C205/44 , C07C205/55 , C07C231/10 , C07C231/12 , C07C235/28 , C07C303/32 , C07C309/08 , C07C2601/16 , C07D277/64 , C07D307/92 , C07D333/56 , C07D405/06 , C07D413/06 , C07D417/06 , C07F7/1804 , C07F9/58 , Y02P20/55 , C07C233/28
摘要： This application discloses a novel process for the preparation of himbacine analogs useful as thrombin receptor antagonists. The process is based in part on the use of a base-promoted dynamic epimerization of a chiral nitro center. The chemistry taught herein can be exemplified by the following:
摘要翻译：本申请公开了一种制备可用作凝血酶受体拮抗剂的烟肼类似物的新方法。该方法部分基于使用手性硝基中心的碱促进的动态差向异构化。本文教导的化学结构可以举例说明如下：

4. 发明申请

US20120084141A1 System and Method to Predict the Performance of Keywords for Advertising Campaigns Managed on the Internet 审中-公开
标题翻译：用于预测互联网上管理的广告活动关键词性能的系统和方法
公开(公告)号：US20120084141A1
公开(公告)日：2012-04-05
申请号：US13316854
申请日：2011-12-12
申请人： Patrick Quinn , Sandrine Paroz , Richard Couture , Marc Poirier
发明人： Patrick Quinn , Sandrine Paroz , Richard Couture , Marc Poirier
IPC分类号： G06Q30/02
CPC分类号： G06Q30/0244
摘要： Historical data from keywords in a pay-per-click internet advertising campaign are used to predict performance of other keywords with the goal of optimizing a keyword portfolio to maximize returns from the advertising campaign. A computing system receives the keyword portfolio for the advertising campaign, and classifies the keywords based on whether or not sufficient historical data exist to generate acceptable predictions about the performance of the keywords in the advertising campaign. Historical data are then used to make performance predictions for keywords having sufficient data. For keywords without sufficient historical data, generic prediction functions are created based on a generic change rate obtained from keywords with sufficient historical data. These generic prediction functions are then used to predict keyword performance in the advertising campaign. Predictions for keywords with and without sufficient historical data are then used to optimize the advertising campaign.
摘要翻译：用于每次点击付费的互联网广告活动中的关键字的历史数据用于预测其他关键字的效果，目的是优化关键字组合，以最大限度地提高广告系列的收益。计算系统接收广告活动的关键词组合，并且基于是否存在足够的历史数据来生成关于广告活动中的关键字的表现的可接受的预测的关键词。然后，历史数据用于对具有足够数据的关键字进行性能预测。对于没有足够历史数据的关键字，基于从具有足够历史数据的关键字获得的通用变化率创建通用预测函数。然后，这些通用预测函数用于预测广告活动中的关键字表现。然后，使用具有和不具有足够历史数据的关键字的预测来优化广告活动。

5. 发明授权

US06820367B2 Drill/injector combination for plug fertilization at lift 有权
标题翻译：钻机/喷射器组合，用于电梯上的塞子受精
公开(公告)号：US06820367B2
公开(公告)日：2004-11-23
申请号：US10245262
申请日：2002-09-16
申请人： Marc Poirier , John Kitchen , Mark Ingram , Ted Bay , Andrew Jackson , Kyle Krushelniski , Philip Leduc , Troy Lucyshyn , Bradley Pauli , Andrew Rauert
发明人： Marc Poirier , John Kitchen , Mark Ingram , Ted Bay , Andrew Jackson , Kyle Krushelniski , Philip Leduc , Troy Lucyshyn , Bradley Pauli , Andrew Rauert
IPC分类号： A01G908
CPC分类号： A01G9/081 , A01C23/027 , A01G29/00
摘要： A drill/injector combination is provided to inject plants that are grown in containers such as blocks at lift with plant growth modulators. The drill/injector combination is comprised of a seedlings holder, a block restraint, a cavity tool apparatus, a metering apparatus, an injection apparatus and optionally, a bore closing apparatus. The combination may be manually operated or may be automated.
摘要翻译：提供钻/喷射器组合以将在植物生长调节剂的电梯上生长的容器如块中的植物注射。钻/喷射器组合由幼苗保持器，块限制器，腔工具装置，计量装置，注射装置和任选的孔闭合装置组成。该组合可以是手动操作的或可以是自动的。

6. 发明申请

US20160009681A1 COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY 有权
标题翻译：化合物抑制富含重复激素激酶活性
公开(公告)号：US20160009681A1
公开(公告)日：2016-01-14
申请号：US14772525
申请日：2014-02-27
申请人： Michael MILLER , Kallol BASU , Duane MONG , Jack SCOTT , Hong LIU , Xing DAI , Andrew STAMFORD , Marc POIRIER , Paul TEMPEST , MERCK SHARP & DOHME CORP.
发明人： Michael Miller , Kallol Basu , Duane DeMong , Jack Scott , Hong Liu , Xing Dai , Andrew Stamford , Marc Poirier , Paul Tempest
IPC分类号： C07D401/04 , C07D498/08 , C07D401/14 , C07D495/08 , C07D498/04 , C07D487/04 , C07D413/14 , C07D405/14 , C07D417/14
CPC分类号： C07D401/04 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D491/08 , C07D495/08 , C07D498/04 , C07D498/08
摘要： The present invention is directed to indazole compounds which are potent inhibitors of LRRK2 kinase and useful in the treatment or prevention of diseases in which the LRRK2 kinase is involved, such as Parkinson's Disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which LRRK2 kinase is involved.
摘要翻译：本发明涉及作为LRRK2激酶的有效抑制剂的吲唑化合物，可用于治疗或预防其中涉及LRRK2激酶的疾病，例如帕金森病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及LRRK2激酶的疾病中的用途。

7. 发明授权

US08680294B2 Enantio- and stereo specific synthesis of β-amino-α-hydroxy amides 有权
标题翻译：氨基-α-羟基酰胺的对映体和立体特异性合成
公开(公告)号：US08680294B2
公开(公告)日：2014-03-25
申请号：US13387619
申请日：2010-07-27
申请人： John Traverse , William M. Leong , Steven P. Miller , Jennifer Albaneze-Walker , Thomas J. Hunter , Lijun Wang , Hongbiao Liao , Ashok Arasappan , Scott T. Trzaska , Randi M. Smith , Azzeddine Lekhal , Stephane L. Bogen , Jianshe Kong , Frank Bennett , F. George Njoroge , Marc Poirier , Shen-Chun Kuo , Yonggang Chen , Kenneth S. Matthews , Patrice Demonchaux , Amadeo Ferreira
发明人： John Traverse , William M. Leong , Steven P. Miller , Jennifer Albaneze-Walker , Thomas J. Hunter , Lijun Wang , Hongbiao Liao , Ashok Arasappan , Scott T. Trzaska , Randi M. Smith , Azzeddine Lekhal , Stephane L. Bogen , Jianshe Kong , Frank Bennett , F. George Njoroge , Marc Poirier , Shen-Chun Kuo , Yonggang Chen , Kenneth S. Matthews , Patrice Demonchaux , Amadeo Ferreira
IPC分类号： C07D207/06
CPC分类号： C07D209/52 , C07C51/353 , C07C67/04 , C07C237/04 , C07C315/02 , C07C315/04 , C07C317/28 , C07C319/14 , C07C319/20 , C07C2601/02 , C07C2601/14 , C07K5/0202 , C07K5/06034 , C07C323/53 , C07C317/44 , C07C57/03 , C07C69/533
摘要： Processes useful for the preparation of a Compound of Formula I: Formula (I). Intermediates useful for the preparation of the compound of Formula I, and processes useful for preparing said intermediates are disclosed.
摘要翻译：用于制备式I化合物的方法：式（I）。公开了可用于制备式I化合物的中间体和用于制备所述中间体的方法。

8. 发明申请

US20140058116A1 PROCESS FOR PREPARING INHIBITORS OF THE HEPATITIS C VIRUS 审中-公开
标题翻译：制备丙型肝炎病毒的抑制剂的方法
公开(公告)号：US20140058116A1
公开(公告)日：2014-02-27
申请号：US14114251
申请日：2012-05-02
申请人： Ji Xie , George Wu , Joseph Lamberson , Marc Poirier , Frank Chen
发明人： Ji Xie , George Wu , Joseph Lamberson , Marc Poirier , Frank Chen
IPC分类号： C07D209/52
CPC分类号： A61K9/00 , A61K38/005 , A61K38/06 , C07D209/52 , C07K1/36
摘要： The present invention relates to synthetic processes useful in the preparation of compounds of Formula (I) that are useful as inhibitors of the hepatitis C virus (HCV) NS3 protease and have application in the treatment of conditions caused by HCV. In particular, the present invention relates to novel oxidation processes useful for preparing compounds of Formula (I) and related compounds, including pharmaceutically acceptable salts, hydrates and solvates thereof, and including stereoisomers thereof.
摘要翻译：本发明涉及用于制备式（I）化合物的合成方法，其可用作丙型肝炎病毒（HCV）NS3蛋白酶的抑制剂，并且可用于治疗由HCV引起的病症。特别地，本发明涉及可用于制备式（I）化合物和相关化合物的新型氧化方法，包括其药学上可接受的盐，水合物和溶剂合物，并包括它们的立体异构体。

9. 发明申请

US20070149459A1 Oxidation process for the preparation of N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3-{N-[(tert-butylamino)carbonyl]-3-methyl-L-valyl}-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide and related compounds 失效
标题翻译：制备N- [3-氨基-1-（环丁基甲基）-2,3-二氧代丙基] -3- {N - [（叔丁基氨基）羰基] -3-甲基-L-缬氨酰基} -6的氧化方法，6-二甲基-3-氮杂双环[3.1.0]己烷-2-甲酰胺及相关化合物
公开(公告)号：US20070149459A1
公开(公告)日：2007-06-28
申请号：US11598528
申请日：2006-11-13
申请人： George Wu , Ji Xie , Paitoon Rashatasakhon , Frank Chen , Marc Poirier , Victoria Sprague
发明人： George Wu , Ji Xie , Paitoon Rashatasakhon , Frank Chen , Marc Poirier , Victoria Sprague
IPC分类号： A61K38/05 , C07K5/08
CPC分类号： C07D209/52 , A61K38/00 , C07K5/0202
摘要： The present application relates to a process for preparing a compound of formula I: wherein R1 is alkyl; R2 is alkyl; and R3 is optionally substituted cycloalklylalkyl which comprises oxidizing a compound of the formula wherein R1, R2 and R3 are defined above to yield a compound of formula I.
摘要翻译：本申请涉及制备式I化合物的方法：其中R 1是烷基; R 2是烷基; 和R 3是任选取代的环烷基烷基，其包括将下式化合物其中R 1，R 2和R 3， SUP>如上定义，得到式I化合物。

10. 发明授权

US06495689B2 Synthesis of intermediates useful in preparing tricyclic compounds 有权
标题翻译：可用于制备三环化合物的中间体的合成
公开(公告)号：US06495689B2
公开(公告)日：2002-12-17
申请号：US09886845
申请日：2001-06-21
申请人： Charles F. Bernard , Michael Casey , Frank Xing Chen , Denise C. Grogan , Marc Poirier , Robert P. Williams , Yee-Shing Wong , George G. Wu
发明人： Charles F. Bernard , Michael Casey , Frank Xing Chen , Denise C. Grogan , Marc Poirier , Robert P. Williams , Yee-Shing Wong , George G. Wu
IPC分类号： C07D22116
CPC分类号： C07D221/16
摘要： Disclosed is a process for preparing a compound having the formula: wherein R, R1, R2, R3, and R4 are independently selected from the group consisting of H, Br, Cl, F, alkyl, or alkoxy.
摘要翻译：公开了一种制备具有下式的化合物的方法：其中R，R 1，R 2，R 3和R 4独立地选自H，Br，Cl，F，烷基或烷氧基。

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