专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100330154A1 AMPHOTERIC LIPOSOMES COMPRISING NEUTRAL LIPIDS 审中-公开
标题翻译：包含中性脂肪的大肠杆菌
公开(公告)号：US20100330154A1
公开(公告)日：2010-12-30
申请号：US12682703
申请日：2008-10-12
申请人： Steffen Panzner , Silke Lutz , Evgenios Siepi , Claudia Muller , Ute Vinzens
发明人： Steffen Panzner , Silke Lutz , Evgenios Siepi , Claudia Muller , Ute Vinzens
IPC分类号： A61K9/127 , A61K31/7105 , A61K31/713 , A61K38/02 , C12N5/07 , A61K31/711 , A61P29/00 , A61P37/02 , A61P35/00 , A61P3/00
CPC分类号： A61K9/1272
摘要： An amphoteric liposome comprising neutral lipids wherein said neutral lipids are selected from the group comprising cholesterol or mixtures of cholesterol and at least one neutral or zwitterionic lipid and wherein K (neutral) of said mixtures is 0.3 or less. Said amphoteric liposome may encapsulate an active agent, such as nucleic acid therapeutics. Also disclosed are pharmaceutical compositions comprising said amphoteric liposomes as a carrier for the delivery or targeted delivery of active agents or ingredients.
摘要翻译：一种包含中性脂质的两性脂质体，其中所述中性脂质选自胆固醇或胆固醇和至少一种中性或两性离子脂质的混合物，其中所述混合物的K（中性）为0.3以下。所述两性脂质体可以包封活性剂，例如核酸治疗剂。还公开了包含所述两性脂质体作为用于递送或靶向递送活性剂或成分的载体的药物组合物。

2. 发明申请

US20080089932A1 Amphoteric liposomes, a method of formulating an amphoteric liposome and a method of loading an amphoteric liposome 审中-公开
公开(公告)号：US20080089932A1
公开(公告)日：2008-04-17
申请号：US11974350
申请日：2007-10-12
申请人： Steffen Panzner , Silke Lutz , Evgenios Siepi , Claudia Muller
发明人： Steffen Panzner , Silke Lutz , Evgenios Siepi , Claudia Muller
IPC分类号： A61K9/127 , A61K31/711
CPC分类号： A61K9/127 , A61K9/1272 , A61K31/713 , Y02P20/582
摘要： An amphoteric liposome composed of a mixture of lipids, said mixture comprising a cationic amphiphile, an anionic amphiphile and optionally one or more neutral amphiphiles, at least one of said cationic and anionic amphiphiles being chargeable and the respective amounts of said cationic and anionic amphiphiles being selected such there is a stoichiometric excess of positively charged cationic amphiphile at a first lower pH, a stoichiometric excess of negatively charged anionic amphiphile at a second higher pH and said mixture has an isoelectric point intermediate said first and second pHs; characterised in that said positively charged cationic and negatively charged anionic amphiphiles are adapted to form a lipid salt with one another at said isoelectric point. Also disclosed are methods of predicting the fusogenicity of an amphoteric liposome at a given pH, formulating an amphoteric liposome and loading an amphoteric liposome with a cargo moiety.

3. 发明申请

US20080306153A1 Lipids and lipid assemblies comprising transfection enhancer elements 有权
标题翻译：包含转染增强子元件的脂质和脂质组件
公开(公告)号：US20080306153A1
公开(公告)日：2008-12-11
申请号：US12004154
申请日：2007-12-19
申请人： Steffen Panzner , Evgenios Siepi , Silke Lutz , Christian Reinsch , Claudia Muller
发明人： Steffen Panzner , Evgenios Siepi , Silke Lutz , Christian Reinsch , Claudia Muller
IPC分类号： A61K31/20 , C07C53/122 , C07C231/00
CPC分类号： A61K9/1272 , A61K9/127 , A61K31/7052 , A61K47/542 , A61K47/544 , A61K47/545 , A61K47/554 , A61K47/6911 , A61K48/0008 , A61K48/0025 , A61K48/0033 , A61K48/0041 , C07C229/24 , C12N15/88 , Y02P20/582
摘要： Lipid assemblies, such as liposomes, comprising transfection enhancer elements (TEE's), which are complexed with the lipid assemblies by means of ionic interactions, or lipids incorporating such TEE's are disclosed for enhancing the fusogenicity of the lipid assemblies. The TEE's have the formula: hydrophobic moiety-pH sensitive hydrophilic moiety (II) The pH sensitive hydrophilic moiety of each TEE is a weak acid having a pka of between 2 and 6 or a zwitterionic structure comprising a combination of acidic groups with weak bases having a pKa of between 3 and 8. Lipids incorporating one or more such TEEs have the formula (I): Lipid moiety-[Hydrophobic moiety-pH sensitive hydrophilic moiety] (I)
摘要翻译：公开了脂质体组合物，例如脂质体，其包含通过离子相互作用与脂质组合物复合的转染增强子元件（TEE）或掺入这种TEE的脂质，用于增强脂质组件的融合性。 TEE具有以下公式：<？in-line-formula description =“In-line Formulas”end =“lead”？>疏水部分 - pH敏感亲水部分（II）<？in-line-formula description =“In- 线型“end =”tail“？>每个TEE的pH敏感的亲水部分是pka为2至6的弱酸或包含具有pKa在3和3之间的弱碱基的酸性基团的组合的两性离子结构包含一个或多个这样的TEE的脂质具有式（I）：<？在线公式描述=“在线公式”end =“lead”？>脂质部分 - [疏水部分 - pH敏感亲水部分] （I）<？in-line-formula description =“In-line Formulas”end =“tail”？>

4. 发明授权

US09283186B2 Amphoteric liposomes, a method of formulating an amphoteric liposome and a method of loading an amphoteric liposome 有权
标题翻译：两性脂质体，配制两性脂质体的方法和加载两性脂质体的方法
公开(公告)号：US09283186B2
公开(公告)日：2016-03-15
申请号：US13350137
申请日：2012-01-13
申请人： Steffen Panzner , Silke Lutz , Evgenios Siepi , Claudia Müller
发明人： Steffen Panzner , Silke Lutz , Evgenios Siepi , Claudia Müller
IPC分类号： C07D265/30 , A61K9/127
CPC分类号： A61K9/127 , A61K9/1272 , A61K31/713 , Y02P20/582
摘要： An amphoteric liposome composed of a mixture of lipids, said mixture comprising a cationic amphiphile, an anionic amphiphile and optionally one or more neutral amphiphiles, at least one of said cationic and anionic amphiphiles being chargeable and the respective amounts of said cationic and anionic amphiphiles being selected such there is a stoichiometric excess of positively charged cationic amphiphile at a first lower pH, a stoichiometric excess of negatively charged anionic amphiphile at a second higher pH and said mixture has an isoelectric point intermediate said first and second pHs; characterised in that said positively charged cationic and negatively charged anionic amphiphiles are adapted to form a lipid salt with one another at said isoelectric point. Also disclosed are methods of predicting the fusogenicity of an amphoteric liposome at a given pH, formulating an amphoteric liposome and loading an amphoteric liposome with a cargo moiety.
摘要翻译：由脂质混合物组成的两性脂质体，所述混合物包含阳离子两亲物，阴离子两亲物和任选的一个或多个中性两亲物，所述阳离子和阴离子两亲物中的至少一个是可带电的，并且相应量的所述阳离子和阴离子两亲物为选择这样，在第二较低pH下，在第一较低pH下具有化学计量过量的带正电荷的阳离子两亲物，在第二较高pH下具有化学计量过量的带负电荷的阴离子两亲物，并且所述混合物具有介于所述第一和第二pH之间的等电点; 其特征在于所述带正电荷的阳离子和带负电荷的阴离子两亲物适于在所述等电点处彼此形成脂质盐。还公开了在给定pH下预测两性脂质体的融合性的方法，配制两性脂质体并加载具有货物部分的两性脂质体。

5. 发明授权

US08193246B2 Lipids and lipid assemblies comprising transfection enhancer elements 有权
标题翻译：包含转染增强子元件的脂质和脂质组件
公开(公告)号：US08193246B2
公开(公告)日：2012-06-05
申请号：US12004154
申请日：2007-12-19
申请人： Steffen Panzner , Evgenios Siepi , Silke Lutz , Christian Reinsch , Claudia Müller
发明人： Steffen Panzner , Evgenios Siepi , Silke Lutz , Christian Reinsch , Claudia Müller
IPC分类号： A61K31/20 , C07C53/122 , C07C231/00
CPC分类号： A61K9/1272 , A61K9/127 , A61K31/7052 , A61K47/542 , A61K47/544 , A61K47/545 , A61K47/554 , A61K47/6911 , A61K48/0008 , A61K48/0025 , A61K48/0033 , A61K48/0041 , C07C229/24 , C12N15/88 , Y02P20/582
摘要： Lipid assemblies, such as liposomes, comprising transfection enhancer elements (TEE's), which are complexed with the lipid assemblies by means of ionic interactions, or lipids incorporating such TEE's are disclosed for enhancing the fusogenicity of the lipid assemblies. The TEE's have the formula: hydrophobic moiety-pH sensitive hydrophilic moiety (II) The pH sensitive hydrophilic moiety of each TEE is a weak acid having a pka of between 2 and 6 or a zwitterionic structure comprising a combination of acidic groups with weak bases having a pKa of between 3 and 8. Lipids incorporating one or more such TEEs have the formula (I): Lipid moiety-[Hydrophobic moiety-pH sensitive hydrophilic moiety] (I).
摘要翻译：公开了脂质体组合物，例如脂质体，其包含通过离子相互作用与脂质组合物复合的转染增强子元件（TEE）或掺入这种TEE的脂质，用于增强脂质组件的融合性。 TEE具有以下配方：疏水部分 - pH敏感的亲水部分（II）每个TEE的pH敏感的亲水部分是pka为2至6的弱酸或包含具有弱碱基的酸性基团的组合的两性离子结构，含有一个或多个这样的TEE的脂质具有式（I）：脂质部分 - [疏水部分 - pH敏感的亲水部分]（I）。

6. 发明申请

US20120135065A1 Amphoteric Liposomes, A Method Of Formulating An Amphoteric Liposome And A Method Of Loading An Amphoteric Liposome 有权
标题翻译：两性脂质体，制备两性脂质体的方法和加载两性脂质体的方法
公开(公告)号：US20120135065A1
公开(公告)日：2012-05-31
申请号：US13350137
申请日：2012-01-13
申请人： Steffen Panzner , Silke Lutz , Evgenios Siepi , Claudia Müller
发明人： Steffen Panzner , Silke Lutz , Evgenios Siepi , Claudia Müller
IPC分类号： A61K9/127 , A61K47/44 , A61K31/7088 , C07J43/00
CPC分类号： A61K9/127 , A61K9/1272 , A61K31/713 , Y02P20/582
摘要： An amphoteric liposome composed of a mixture of lipids, said mixture comprising a cationic amphiphile, an anionic amphiphile and optionally one or more neutral amphiphiles, at least one of said cationic and anionic amphiphiles being chargeable and the respective amounts of said cationic and anionic amphiphiles being selected such there is a stoichiometric excess of positively charged cationic amphiphile at a first lower pH, a stoichiometric excess of negatively charged anionic amphiphile at a second higher pH and said mixture has an isoelectric point intermediate said first and second pHs; characterised in that said positively charged cationic and negatively charged anionic amphiphiles are adapted to form a lipid salt with one another at said isoelectric point. Also disclosed are methods of predicting the fusogenicity of an amphoteric liposome at a given pH, formulating an amphoteric liposome and loading an amphoteric liposome with a cargo moiety.
摘要翻译：由脂质混合物组成的两性脂质体，所述混合物包含阳离子两亲物，阴离子两亲物和任选的一个或多个中性两亲物，所述阳离子和阴离子两亲物中的至少一个是可带电的，并且相应量的所述阳离子和阴离子两亲物为选择这样，在第二较低pH下，在第一较低pH下具有化学计量过量的带正电荷的阳离子两亲物，在第二较高pH下具有化学计量过量的带负电荷的阴离子两亲物，并且所述混合物具有介于所述第一和第二pH之间的等电点; 其特征在于所述带正电荷的阳离子和带负电荷的阴离子两亲物适于在所述等电点处彼此形成脂质盐。还公开了在给定pH下预测两性脂质体的融合性的方法，配制两性脂质体并加载具有货物部分的两性脂质体。

7. 发明申请

US20070053918A1 Injectable depots consisting of liposomal aggregates for the delivery of active substances 审中-公开
标题翻译：由用于递送活性物质的脂质体聚集体组成的可注射贮库
公开(公告)号：US20070053918A1
公开(公告)日：2007-03-08
申请号：US10556703
申请日：2004-05-10
申请人： Steffen Panzner , Silke Lutz
发明人： Steffen Panzner , Silke Lutz
IPC分类号： A61K38/28 , A61K31/727 , A61K39/00 , A61K9/127
CPC分类号： A61K9/0024 , A61K9/1272
摘要： The invention relates to formulations of liposomes and polymers for the production of an injectable depot of active substances, which has sustained release and effect in a mammal organism.
摘要翻译：本发明涉及用于生产活性物质的可注射贮库的脂质体和聚合物的制剂，其在哺乳动物生物体中具有持续的释放和作用。

8. 发明申请

US20110076322A1 Amphoteric liposomes 有权
标题翻译：两性脂质体
公开(公告)号：US20110076322A1
公开(公告)日：2011-03-31
申请号：US12807707
申请日：2010-09-09
申请人： Steffen Panzner , Yvonne Kerwitz , Una Rauchhaus , Silke Lutz , Gerold Endert
发明人： Steffen Panzner , Yvonne Kerwitz , Una Rauchhaus , Silke Lutz , Gerold Endert
IPC分类号： A61K9/127 , A61K47/44 , A61P29/00 , A61K31/713 , A61P25/28 , A61P37/06 , A61P19/02 , A61P11/06
CPC分类号： A61K9/1271 , A61K9/0019 , A61K9/127 , A61K9/1272 , A61K31/713 , A61K48/00 , C12N15/1138 , C12N15/88 , C12N2310/11 , C12N2320/32
摘要： A serum-stable mixture of lipids capable of encapsulating an active agent to form a liposome, said mixture comprising phosphatidylcholine and phosphatidylethanolamine in a ratio in the range of about 0.5 to about 8. The mixture may also include pH sensitive anionic and cationic amphiphiles, such that the mixture is amphoteric, being negatively charged or neutral at pH 7.4 and positively charged at pH 4. Amphoteric liposomes comprising such a mixture may be used for encapsulating nucleic acid therapeutics, such as oligonucleotides and DNA plasmids. The drug/lipid ratio may be adjusted to target the liposomes to particular organs or other sites in the body.
摘要翻译：能够包封活性剂形成脂质体的脂质的血清稳定混合物，所述混合物包含比例在约0.5至约8范围内的磷脂酰胆碱和磷脂酰乙醇胺。该混合物还可包括pH敏感的阴离子和阳离子两亲物，混合物是两性的，在pH7.4下带负电荷或中性，并在pH4下带正电。包含这种混合物的两性脂质体可用于包封核酸治疗剂，例如寡核苷酸和DNA质粒。可以调节药物/脂质比以将脂质体靶向体内特定器官或其他部位。

9. 发明授权

US09066867B2 Amphoteric liposomes 有权
标题翻译：两性脂质体
公开(公告)号：US09066867B2
公开(公告)日：2015-06-30
申请号：US12807707
申请日：2010-09-09
申请人： Steffen Panzner , Yvonne Kerwitz , Una Rauchhaus , Silke Lutz , Gerold Endert
发明人： Steffen Panzner , Yvonne Kerwitz , Una Rauchhaus , Silke Lutz , Gerold Endert
IPC分类号： A61K48/00 , A61K9/127 , A61K9/00 , C12N15/88
CPC分类号： A61K9/1271 , A61K9/0019 , A61K9/127 , A61K9/1272 , A61K31/713 , A61K48/00 , C12N15/1138 , C12N15/88 , C12N2310/11 , C12N2320/32
摘要： A serum-stable mixture of lipids capable of encapsulating an active agent to form a liposome, said mixture comprising phosphatidylcholine and phosphatidylethanolamine in a ratio in the range of about 0.5 to about 8. The mixture may also include pH sensitive anionic and cationic amphiphiles, such that the mixture is amphoteric, being negatively charged or neutral at pH 7.4 and positively charged at pH 4. Amphoteric liposomes comprising such a mixture may be used for encapsulating nucleic acid therapeutics, such as oligonucleotides and DNA plasmids. The drug/lipid ratio may be adjusted to target the liposomes to particular organs or other sites in the body.
摘要翻译：能够包封活性剂形成脂质体的脂质的血清稳定混合物，所述混合物包含比例在约0.5至约8范围内的磷脂酰胆碱和磷脂酰乙醇胺。该混合物还可包括pH敏感的阴离子和阳离子两亲物，混合物是两性的，在pH7.4下带负电荷或中性，并在pH4下带正电。包含这种混合物的两性脂质体可用于包封核酸治疗剂，例如寡核苷酸和DNA质粒。可以调节药物/脂质比以将脂质体靶向体内特定器官或其他部位。

10. 发明申请

US20060286161A1 Injectable liposomal depots for delivering active ingredients 审中-公开
标题翻译：用于递送活性成分的可注射脂质体贮库
公开(公告)号：US20060286161A1
公开(公告)日：2006-12-21
申请号：US10556123
申请日：2004-05-08
申请人： Steffen Panzner , Silke Lutz
发明人： Steffen Panzner , Silke Lutz
IPC分类号： A61K48/00 , A61K31/573 , A61K9/127
CPC分类号： A61K9/0024 , A61K9/127 , A61K9/1271 , A61K9/1272
摘要： The invention relates to liposomal formulations for the production of an injectable depot of peptide, protein and oligonucleotide active substances for sustained release and effect in a mammal body.
摘要翻译：本发明涉及用于生产用于持续释放和在哺乳动物体内起作用的肽，蛋白质和寡核苷酸活性物质的可注射贮库的脂质体制剂。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式