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1. 发明申请

US20100330154A1 AMPHOTERIC LIPOSOMES COMPRISING NEUTRAL LIPIDS 审中-公开
标题翻译：包含中性脂肪的大肠杆菌
公开(公告)号：US20100330154A1
公开(公告)日：2010-12-30
申请号：US12682703
申请日：2008-10-12
申请人： Steffen Panzner , Silke Lutz , Evgenios Siepi , Claudia Muller , Ute Vinzens
发明人： Steffen Panzner , Silke Lutz , Evgenios Siepi , Claudia Muller , Ute Vinzens
IPC分类号： A61K9/127 , A61K31/7105 , A61K31/713 , A61K38/02 , C12N5/07 , A61K31/711 , A61P29/00 , A61P37/02 , A61P35/00 , A61P3/00
CPC分类号： A61K9/1272
摘要： An amphoteric liposome comprising neutral lipids wherein said neutral lipids are selected from the group comprising cholesterol or mixtures of cholesterol and at least one neutral or zwitterionic lipid and wherein K (neutral) of said mixtures is 0.3 or less. Said amphoteric liposome may encapsulate an active agent, such as nucleic acid therapeutics. Also disclosed are pharmaceutical compositions comprising said amphoteric liposomes as a carrier for the delivery or targeted delivery of active agents or ingredients.
摘要翻译：一种包含中性脂质的两性脂质体，其中所述中性脂质选自胆固醇或胆固醇和至少一种中性或两性离子脂质的混合物，其中所述混合物的K（中性）为0.3以下。所述两性脂质体可以包封活性剂，例如核酸治疗剂。还公开了包含所述两性脂质体作为用于递送或靶向递送活性剂或成分的载体的药物组合物。

2. 发明申请

US20080306153A1 Lipids and lipid assemblies comprising transfection enhancer elements 有权
标题翻译：包含转染增强子元件的脂质和脂质组件
公开(公告)号：US20080306153A1
公开(公告)日：2008-12-11
申请号：US12004154
申请日：2007-12-19
申请人： Steffen Panzner , Evgenios Siepi , Silke Lutz , Christian Reinsch , Claudia Muller
发明人： Steffen Panzner , Evgenios Siepi , Silke Lutz , Christian Reinsch , Claudia Muller
IPC分类号： A61K31/20 , C07C53/122 , C07C231/00
CPC分类号： A61K9/1272 , A61K9/127 , A61K31/7052 , A61K47/542 , A61K47/544 , A61K47/545 , A61K47/554 , A61K47/6911 , A61K48/0008 , A61K48/0025 , A61K48/0033 , A61K48/0041 , C07C229/24 , C12N15/88 , Y02P20/582
摘要： Lipid assemblies, such as liposomes, comprising transfection enhancer elements (TEE's), which are complexed with the lipid assemblies by means of ionic interactions, or lipids incorporating such TEE's are disclosed for enhancing the fusogenicity of the lipid assemblies. The TEE's have the formula: hydrophobic moiety-pH sensitive hydrophilic moiety (II) The pH sensitive hydrophilic moiety of each TEE is a weak acid having a pka of between 2 and 6 or a zwitterionic structure comprising a combination of acidic groups with weak bases having a pKa of between 3 and 8. Lipids incorporating one or more such TEEs have the formula (I): Lipid moiety-[Hydrophobic moiety-pH sensitive hydrophilic moiety] (I)
摘要翻译：公开了脂质体组合物，例如脂质体，其包含通过离子相互作用与脂质组合物复合的转染增强子元件（TEE）或掺入这种TEE的脂质，用于增强脂质组件的融合性。 TEE具有以下公式：<？in-line-formula description =“In-line Formulas”end =“lead”？>疏水部分 - pH敏感亲水部分（II）<？in-line-formula description =“In- 线型“end =”tail“？>每个TEE的pH敏感的亲水部分是pka为2至6的弱酸或包含具有pKa在3和3之间的弱碱基的酸性基团的组合的两性离子结构包含一个或多个这样的TEE的脂质具有式（I）：<？在线公式描述=“在线公式”end =“lead”？>脂质部分 - [疏水部分 - pH敏感亲水部分] （I）<？in-line-formula description =“In-line Formulas”end =“tail”？>

3. 发明授权

US5750761A Cyanation of double bond systems 失效
标题翻译：双键系统的氰化
公开(公告)号：US5750761A
公开(公告)日：1998-05-12
申请号：US608455
申请日：1996-02-28
申请人： Rainer Hamprecht , Claudia Muller
发明人： Rainer Hamprecht , Claudia Muller
IPC分类号： C07D239/88 , C07B43/08 , C07C253/00 , C07C253/08 , C07C255/32 , C07C255/34 , C07C255/41 , C07C317/44 , C07D213/74 , C07D215/12 , C07D231/36 , C07D231/52 , C07D277/20 , C07D277/42 , C07D333/60 , C07D405/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D491/052 , C07D498/04 , C09B23/01 , C09B23/10 , C09B23/14 , C09B57/00 , C09B57/02 , D06P1/16 , D06P3/26 , C07C255/03
CPC分类号： C07C315/04 , C07B43/08 , C07C253/00 , C07C253/08 , C09B23/0091 , C09B23/102 , C09B23/143 , C09B57/00 , C09B57/02
摘要： A process for the preparation of compounds of the formula ##STR1## wherein the substituents X, Y and Z have the meaning given in the description, by reaction of compounds of the formula ##STR2## with a cyanide and an oxidizing agent other than Br.sub.2 in the presence of halides which offers industrial hygiene advantages and renders possible large-scale industrial access to dyestuff syntheses has been found.
摘要翻译：制备式“IMAGE”化合物的方法，其中取代基X，Y和Z具有本说明书中给出的含义，通过式（ⅩⅧ）化合物与氰化物和除Br2之外的氧化剂的反应已经发现存在提供工业卫生优点并使大规模工业进入染料合成的卤化物。

4. 发明申请

US20080089932A1 Amphoteric liposomes, a method of formulating an amphoteric liposome and a method of loading an amphoteric liposome 审中-公开
公开(公告)号：US20080089932A1
公开(公告)日：2008-04-17
申请号：US11974350
申请日：2007-10-12
申请人： Steffen Panzner , Silke Lutz , Evgenios Siepi , Claudia Muller
发明人： Steffen Panzner , Silke Lutz , Evgenios Siepi , Claudia Muller
IPC分类号： A61K9/127 , A61K31/711
CPC分类号： A61K9/127 , A61K9/1272 , A61K31/713 , Y02P20/582
摘要： An amphoteric liposome composed of a mixture of lipids, said mixture comprising a cationic amphiphile, an anionic amphiphile and optionally one or more neutral amphiphiles, at least one of said cationic and anionic amphiphiles being chargeable and the respective amounts of said cationic and anionic amphiphiles being selected such there is a stoichiometric excess of positively charged cationic amphiphile at a first lower pH, a stoichiometric excess of negatively charged anionic amphiphile at a second higher pH and said mixture has an isoelectric point intermediate said first and second pHs; characterised in that said positively charged cationic and negatively charged anionic amphiphiles are adapted to form a lipid salt with one another at said isoelectric point. Also disclosed are methods of predicting the fusogenicity of an amphoteric liposome at a given pH, formulating an amphoteric liposome and loading an amphoteric liposome with a cargo moiety.

5. 发明申请

US20070154953A1 Identification of antigen epitopes 审中-公开
标题翻译：抗原表位的鉴定
公开(公告)号：US20070154953A1
公开(公告)日：2007-07-05
申请号：US10547533
申请日：2004-03-03
申请人： Herwig Brunner , Gunter Tover , Thomas Schiestel , Claudia Muller , Thomas Flad
发明人： Herwig Brunner , Gunter Tover , Thomas Schiestel , Claudia Muller , Thomas Flad
IPC分类号： G01N33/567 , G01N33/555 , G01N33/53
CPC分类号： G01N33/543 , G01N33/6893
摘要： The present invention relates to methods for identifying and/or detecting T-cell epitopes of a protein antigen, to methods for preparing peptide vaccines against a protein antigen, to methods for controlling the quality of receptor/ligand complexes and/or their components, to methods for preparing nanoparticles having at least one immobilized receptor unit or an immobilized receptor, to methods for preparing nanoparticles having immobilized receptor/ligand complexes, in particular peptide-presenting MHC molecules, to methods for enriching and/or isolating specific CD4+-T- or CD8+-T-lymphocytes from peripheral blood mononuclear cells, to methods for priming a CD8+-T-lymphocyte reaction in vitro, to nanoparticles having an immobilized receptor unit, in particular an immobilized chain of an MHC molecule, to nanoparticles having an immobilized receptor, in particular an immobilized MHC molecule, to nanoparticles having an immobilized receptor/ligand complex, in particular a peptide-presenting MHC molecule, to a peptide vaccine, to a kit for identifying and/or detecting T-cell epitopes of a protein antigen, and to the use of the nanoparticles for identifying and/or detecting T-cell epitopes, for preparing peptide vaccines, for enriching and/or isolating specific T-lymphocytes and for priming a CD8+-T-lymphocyte reaction in vitro.
摘要翻译：本发明涉及用于鉴定和/或检测蛋白质抗原的T细胞表位的方法，用于制备针对蛋白质抗原的肽疫苗的方法，以及用于控制受体/配体复合物和/或其组分的质量的方法，用于制备具有至少一个固定化受体单元或固定化受体的纳米颗粒的方法，制备具有固定化受体/配体复合物，特别是肽呈递MHC分子的纳米颗粒的方法，用于富集和/或分离特异性CD4 + 来自外周血单核细胞的 -T-或CD8 + T淋巴细胞，以及用于在体外引发CD8 + T淋巴细胞反应的方法，具有固定化受体单元，特别是MHC分子的固定化链的纳米颗粒具有固定化受体特别是固定的MHC分子的纳米颗粒具有固定的受体/配体复合物的纳米颗粒，特别是提供肽的MHC分子，用于肽疫苗，用于鉴定和/或检测蛋白质抗原的T细胞表位的试剂盒，以及使用纳米颗粒鉴定和/或检测T细胞表位用于制备肽疫苗，用于富集和/或分离特异性T淋巴细胞和用于在体外引发CD8 + T淋巴细胞反应。

6. 发明申请

US20120021042A1 Efficient Method For Loading Amphoteric Liposomes With Nucleic Acid Active Substances 审中-公开
标题翻译：用核酸活性物质加载两性脂质体的有效方法
公开(公告)号：US20120021042A1
公开(公告)日：2012-01-26
申请号：US12225030
申请日：2007-03-16
申请人： Steffen Panzner , Gerold Endert , Una Rauchhaus , Natalie Herzog , Claudia Muller
发明人： Steffen Panzner , Gerold Endert , Una Rauchhaus , Natalie Herzog , Claudia Muller
IPC分类号： A61K9/127 , A61K31/713 , A61K38/02 , A61K48/00 , C12N5/00
CPC分类号： A61K9/1277 , A61K9/127 , A61K31/7088 , C12N15/88
摘要： A method for preparing amphoteric liposomes loaded with polyanionic active agent as cargo, characterised by admixing an aqueous solution of said polyanionic active agent and an alcoholic solution of one or more amphiphiles and buffering said admixture to an acidic pH, said one or more amphiphiles being susceptible of forming amphoteric liposomes at said acidic pH, thereby to form such amphoteric liposomes in suspension encapsulating said active agent under conditions such that said liposomes form aggregates, and thereafter treating said suspension to dissociate said aggregates. Also disclosed are nucleic acid loaded amphoteric liposomes produced in accordance with the method, wherein said nucleic acids are oligonucleotides and said liposomes are multilamellar.
摘要翻译：一种制备负载聚阴离子活性剂作为货物的两性脂质体的方法，其特征在于将所述聚阴离子活性剂的水溶液与一种或多种两亲物的醇溶液混合并将所述混合物缓冲至酸性pH，所述一种或多种两亲物易感在所述酸性pH下形成两性脂质体，从而在使所述脂质体形成聚集体的条件下形成包封所述活性剂的悬浮液的这种两性脂质体，然后处理所述悬浮液以离解所述聚集体。还公开了根据该方法生产的核酸负载的两性脂质体，其中所述核酸是寡核苷酸，所述脂质体是多层的。

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