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1. 发明申请

US20080020068A1 Use Of Trisubstituted Benzopyranones 审中-公开
标题翻译：三取代苯并吡喃酮的使用
公开(公告)号：US20080020068A1
公开(公告)日：2008-01-24
申请号：US11631393
申请日：2005-06-30
申请人： Stefan Germer , Hermann Hauer , Egon Koch , Karl Schotz
发明人： Stefan Germer , Hermann Hauer , Egon Koch , Karl Schotz
IPC分类号： C07D311/08 , A61K31/352 , A61K36/185
CPC分类号： C07D311/16 , A23L33/105 , A61K31/352 , C07D311/14 , C07D311/18
摘要： The present invention relates to the use of trisubstituted benzopyranones for the treatment or propylaxis of pathological conditions associated with oxidative stress and/or inflammatory reactions as well as to novel trisubstituted benzopyranones and the physiologically acceptable salts thereof. The present invention further relates to plant extracts, medicaments, dietetic food products and pharmaceutical preparations containing these compounds.
摘要翻译：本发明涉及三取代苯并吡喃酮与氧化应激和/或炎症反应相关的病理状况的治疗或丙型肝炎的用途，以及新的三取代苯并吡喃酮及其生理上可接受的盐。本发明还涉及植物提取物，药物，饮食食品和含有这些化合物的药物制剂。

2. 发明申请

US20060251746A1 Method for preparing ginkgo extracts having a low content of 4'-O-methyl pyridoxine and/or biflavones 审中-公开
标题翻译：制备低含量4'-O-甲基吡哆醇和/或双黄酮的银杏提取物的方法
公开(公告)号：US20060251746A1
公开(公告)日：2006-11-09
申请号：US11416924
申请日：2006-05-02
申请人： Clemens Erdelmeier , Hermann Hauer , Egon Koch , Friedrich Lang
发明人： Clemens Erdelmeier , Hermann Hauer , Egon Koch , Friedrich Lang
IPC分类号： A61K36/16
CPC分类号： A61K36/16 , A23L33/11
摘要： The present invention relates to an improved multi-step method for preparing an extract from ginkgo biloba having a reduced content of 4′-O-methyl pyridoxine and/or biflavones, wherein the depletion is carried out by filtration over an adsorber resin and/or an ion exchanger and the substances to be removed are retained on the resin. The invention further relates to an extract from ginkgo biloba having a reduced content of 4′-O-methyl pyridoxine and/or biflavones, which is obtainable by the method according to the present invention, as well as to its use.
摘要翻译：本发明涉及一种用于制备具有降低的4'-O-甲基吡哆醇和/或双黄酮含量的银杏提取物的改进的多步法，其中通过在吸附树脂上过滤和/或离子交换剂和待除去的物质保留在树脂上。本发明还涉及通过本发明的方法获得的具有降低的4'-O-甲基吡哆醛和/或双黄酮含量的银杏提取物及其用途。

3. 发明申请

US20090142428A1 Extracts from the Bark of Corynanthe Species and Use Thereof as Well as Medicaments, Dietetic Food Products and Pharmaceutical Preparations Containing Said Extracts 审中-公开
标题翻译： Corynanthe物种及其用途的皮肤提取物以及含有所述提取物的药物，饮食食品和药物制剂
公开(公告)号：US20090142428A1
公开(公告)日：2009-06-04
申请号：US12084745
申请日：2006-11-07
申请人： Egon Koch , Hermann Hauer
发明人： Egon Koch , Hermann Hauer
IPC分类号： A61K36/00 , A61P29/00 , A61P3/00
CPC分类号： A61K36/74
摘要： The present invention relates to extracts from the bark of corynanthe species, in particular corynanthe pachyceras as well as to their use for the therapy and prophylaxis of diseases of the lower urinary tract, sexual disorders, lipid metabolism disorders, cardiovascular diseases and acute and chronic pain conditions. The present invention further relates to medicaments, dietetic food products and pharmaceutical preparations containing these extracts.
摘要翻译：本发明涉及corynanthe物种的树皮，特别是corynanthe pachyceras的提取物，以及它们用于治疗和预防下尿路疾病，性障碍，脂质代谢紊乱，心血管疾病和急性和慢性疼痛的用途条件。本发明还涉及含有这些提取物的药物，饮食食品和药物制剂。

4. 发明申请

US20060251745A1 Method for preparing a Ginkgo extract having a reduced content of 4'-O-methyl pyridoxine and/or biflavones 审中-公开
标题翻译：制备具有降低的4'-O-甲基吡哆醇和/或双黄酮含量的银杏提取物的方法
公开(公告)号：US20060251745A1
公开(公告)日：2006-11-09
申请号：US11416878
申请日：2006-05-02
申请人： Clemens Erdelmeier , Egon Koch , Karl-Heinz Stumpf , Hermann Hauer , Friedrich Lang
发明人： Clemens Erdelmeier , Egon Koch , Karl-Heinz Stumpf , Hermann Hauer , Friedrich Lang
IPC分类号： A61K36/16
CPC分类号： A61K36/16 , A23L33/105 , A23V2002/00 , A23V2200/322 , A23V2250/2122 , A23V2200/326
摘要： The present invention relates to a method for preparing an extract from Ginkgo biloba having a reduced content of 4′-O-methyl pyridoxine and/or biflavones compared to the original extract. The invention further relates to extracts from Ginkgo biloba having a reduced content of 4′-O-methyl pyridoxine and/or biflavones compared to the original extract, which is obtainable by the method according to the present invention, as well as to their use.
摘要翻译：制备具有降低的4'-O-甲基吡哆醛和/或双黄酮含量的银杏的提取物包括（a）在溶剂中制备银杏提取物溶液; （b）将溶液施加到吸附树脂上并从吸附树脂中洗脱纯化的提取物; 和/或（c）将溶液施加到酸性离子交换剂上并从离子交换剂洗脱纯化的提取物; 并且任选地（d）将提取液浓缩并干燥到干提取物中，其中步骤（b）和（c）可以以相反的顺序进行。与原始提取物相比，制备具有降低的4'-O-甲基吡哆醇和/或双黄酮含量的银杏的提取物包括：（a）在溶剂中制备银杏提取物溶液; （b）将溶液施加到吸附树脂上，并使用溶剂从吸附树脂中洗脱纯化的提取物，其中双黄酮保留在吸附树脂上; 和/或（c）将溶液施加到酸性离子交换剂上，并使用溶剂从离子交换器中洗脱纯化的提取物，其中4'-O-甲基吡哆醛保留在离子交换剂上; 和（d）任选地将提取液浓缩并干燥到干提取物中，其中步骤（b）和（c）可以以相反的顺序进行。与原始提取物相比，具有降低的4'-O-甲基吡哆醛和/或双黄酮含量的银杏提取物的独立权利要求。 - 活动：灵巧。 - 行动机制：没有给出。

5. 发明授权

US08642099B2 Method for preparing ginkgo extracts having a low content of 4′-O-methyl pyridoxine and/or biflavones 有权
标题翻译：制备低含量4'-O-甲基吡哆醇和/或双黄酮的银杏提取物的方法
公开(公告)号：US08642099B2
公开(公告)日：2014-02-04
申请号：US12217803
申请日：2008-07-09
申请人： Clemens Erdelmeier , Hermann Hauer , Egon Koch , Friedrich Lang
发明人： Clemens Erdelmeier , Hermann Hauer , Egon Koch , Friedrich Lang
IPC分类号： A61K35/16
CPC分类号： A61K36/16 , A23L33/11
摘要： The present invention relates to an improved multi-step method for preparing an extract from ginkgo biloba having a reduced content of 4′-O-methyl pyridoxine and/or biflavones, wherein the depletion is carried out by filtration over an adsorber resin and/or an ion exchanger and the substances to be removed are retained on the resin. The invention further relates to an extract from ginkgo biloba having a reduced content of 4′-O-methyl pyridoxine and/or biflavones, which is obtainable by the method according to the present invention, as well as to its use.
摘要翻译：本发明涉及一种用于制备具有降低的4'-O-甲基吡哆醇和/或双黄酮含量的银杏提取物的改进的多步法，其中通过在吸附树脂上过滤和/或离子交换剂和待除去的物质保留在树脂上。本发明还涉及通过本发明的方法获得的具有降低的4'-O-甲基吡哆醛和/或双黄酮含量的银杏提取物及其用途。

6. 发明申请

US20080286391A1 Method for preparing ginkgo extracts having a low content of 4'-O-methyl pyridoxine and/or biflavones 有权
标题翻译：制备低含量4'-O-甲基吡哆醇和/或双黄酮的银杏提取物的方法
公开(公告)号：US20080286391A1
公开(公告)日：2008-11-20
申请号：US12217803
申请日：2008-07-09
申请人： Clemens Erdelmeier , Hermann Hauer , Egon Koch , Friedrich Lang
发明人： Clemens Erdelmeier , Hermann Hauer , Egon Koch , Friedrich Lang
IPC分类号： A61K36/16 , A61P25/00
CPC分类号： A61K36/16 , A23L33/11
摘要： The present invention relates to an improved multi-step method for preparing an extract from ginkgo biloba having a reduced content of 4′-O-methyl pyridoxine and/or biflavones, wherein the depletion is carried out by filtration over an adsorber resin and/or an ion exchanger and the substances to be removed are retained on the resin. The invention further relates to an extract from ginkgo biloba having a reduced content of 4′-O-methyl pyridoxine and/or biflavones, which is obtainable by the method according to the present invention, as well as to its use.
摘要翻译：本发明涉及一种用于制备具有降低的4'-O-甲基吡哆醇和/或双黄酮含量的银杏提取物的改进的多步法，其中通过在吸附树脂上过滤和/或离子交换剂和待除去的物质保留在树脂上。本发明还涉及通过本发明的方法获得的具有降低的4'-O-甲基吡哆醛和/或双黄酮含量的银杏提取物及其用途。

7. 发明申请

US20060263448A1 Use of extracts from roots of pelargonium sidoides and pelargonium reniforme 审中-公开
标题翻译：使用天竺葵根和天竺葵根提取物
公开(公告)号：US20060263448A1
公开(公告)日：2006-11-23
申请号：US10555189
申请日：2005-06-24
申请人： Egon Koch , Hermann Hauer , Karl-Heinz Stumpf
发明人： Egon Koch , Hermann Hauer , Karl-Heinz Stumpf
IPC分类号： A61K36/185
CPC分类号： A61K36/185 , Y02A50/481
摘要： The present invention relates to the use of extracts from roots of Pelargonium sidoides and/or Pelargonium reniforme for the treatment of AIDS and AIDS-associated infections caused by other viruses, bacteria, in particular mycobacteria, fungi and parasites.
摘要翻译：本发明涉及使用来自天竺葵碱和/或雷公藤内酯的根的提取物用于治疗由其它病毒，特别是分枝杆菌，真菌和寄生虫引起的AIDS和AIDS相关感染。

8. 发明授权

US5428038A Benzopyranones, a method for producing them and uses therefor 失效
标题翻译：苯并吡喃酮，其制备方法和用途
公开(公告)号：US5428038A
公开(公告)日：1995-06-27
申请号：US133017
申请日：1993-10-08
申请人： Shyam S. Chatterjee , Michael Noldner , Hermann Hauer , Egon Koch
发明人： Shyam S. Chatterjee , Michael Noldner , Hermann Hauer , Egon Koch
IPC分类号： A61K31/37 , A61K31/4427 , A61K31/443 , A61K31/453 , A61K31/496 , A61P25/00 , A61P25/08 , A61P25/28 , A61P29/00 , A61P37/08 , C07D311/14 , C07D311/16 , C07D311/18 , C07D311/50 , C07D311/78 , C07D311/80 , C07D311/94 , C07D401/12 , C07D405/12 , C07D407/12 , A61K31/495 , A61K31/445 , C07D311/04 , C07D409/00
CPC分类号： C07D405/12 , C07D311/16 , C07D311/80 , C07D311/94 , C07D407/12
摘要： Novel 2H-1-benzopyran-2-ones (coumarin derivatives) of the general formula (I) are provided: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, X and Y are defined as in the specification, and the addition compounds thereof with physiologically compatible acids, intermediates and methods for the preparation thereof. The coumarin compounds possess a neuroprotective and anti-allergic action.
摘要翻译： PCT No.PCT / EP92 / 00739 Sec。 371日期：1993年10月8日 102（e）日期1993年10月8日PCT提交1992年4月2日PCT公布。 WO92 / 18493 PCT出版物日本1 9 9 9年10月29日提供了通式（I）的新颖的2H-1-苯并吡喃-2-酮（香豆素衍生物）：在说明书中定义，其加成化合物与生理上相容的酸，中间体和方法用于制备。香豆素化合物具有神经保护作用和抗过敏作用。

9. 发明授权

US06288109B1 Pyranones, method for the production and use thereof 失效
标题翻译：吡喃酮，其制备方法和用途
公开(公告)号：US06288109B1
公开(公告)日：2001-09-11
申请号：US09554382
申请日：2000-05-12
申请人： Shyam Sunder Chatterjee , Hermann Hauer
发明人： Shyam Sunder Chatterjee , Hermann Hauer
IPC分类号： A61K3135
CPC分类号： C07D407/06 , C07D309/36
摘要： The invention relates to a novel 2H-1-pyran-2-ones of general formula (I), wherein R1 represents an alkyl radical with 2-5 C atoms, a cycloakyl radical with 4-6 C atoms, a cycloalkyl radical with 4-8 C atoms or an alkoxy alkyl radical with a total of 3-5 C atoms and R2 represents a 2-(3, 4-methylene dioxyphenyl) radical or a 2-phenyl ethenyl radical substituted with R3, R4 and R5 in positions 3, 4 and 5, whereby independently from each other R3 and R5 represent methoxy or ethoxy and R4 is a straight chain or branched alkoxy radical with 1-5 C atoms, an alkenyl radical with 3-5 C atoms, a cycloalkoxy radical with 4-6 C atoms, a cycloalkyl radical with 4-8 C atoms or an alkoxy alkoxy radical with a total of 3-5 C atoms. The invention also relates to a method for producing said compunds in addition to novel untermediate products and to a method for the production thereof. The novel pyranone derivatives have an anti-convulsive and/or anti-epileptic efect in addition to a neuroprotective effect or act against neurodegenerate diseases. The invention further relates to medicaments containing these compounds.
摘要翻译：本发明涉及通式（I）的新颖的2H-1-吡喃-2-酮，其中R1表示具有2-5个C原子的烷基，具有4-6个C原子的环烷基，具有4个 -8个C原子或烷氧基烷基，R2表示2-（3,4-亚甲基二氧苯基）基或3-位置R3，R4和R5取代的2-苯基乙烯基，，4和5，其中彼此独立地为R 3和R 5表示甲氧基或乙氧基，R 4为具有1-5个C原子的直链或支链烷氧基，具有3-5个C原子的链烯基， 6个C原子，具有4-8个C原子的环烷基或总共3-5个C原子的烷氧基烷氧基。本发明还涉及一种除了新颖的非中间产物之外生产所述组合物的方法及其生产方法。新型吡喃酮衍生物除了神经保护作用或抗神经变性疾病之外，还具有抗惊厥和/或抗癫痫效果。本发明还涉及含有这些化合物的药物。

10. 发明申请

US20070014880A1 Method for preparing ginkgo extracts having a reduced content of nonpolar plant ingredients and nonpolar impurities due to enviromental influences 审中-公开
标题翻译：由于环境影响，制备非极性植物成分含量和非极性杂质的银杏提取物的方法
公开(公告)号：US20070014880A1
公开(公告)日：2007-01-18
申请号：US11417011
申请日：2006-05-02
申请人： Rainer Oschmann , Frank Waimer , Hermann Hauer , Karl-Heinz Stumpf
发明人： Rainer Oschmann , Frank Waimer , Hermann Hauer , Karl-Heinz Stumpf
IPC分类号： A61K36/16
CPC分类号： A61K36/16 , A23L33/105 , A23V2002/00 , A23V2250/2122
摘要： The present invention relates to a method for preparing an extract from ginkgo biloba having a reduced content of nonpolar plant ingredients and nonpolar impurities due to environmental influences compared to the initial extract, the method being characterized by the following method steps: (a) preparing an aqueous-ketonic or aqueous-alcoholic solution of an initial ginkgo biloba extract and applying the solution to an adsorber resin, (b) eluting the adsorber resin with an aqueous C3-C6 ketone or an aqueous C1-C3 alcohol and (c) optionally concentrating and drying the extract solution thus obtained to the dry extract. The invention further relates to an extract (liquid extract or spissum extract as well as dry extract) from ginkgo biloba having a reduced content of nonpolar plant ingredients and nonpolar impurities due to environmental influences compared to the initial extract, which is obtainable by the method of the present invention.
摘要翻译：本发明涉及与初始提取物相比，由于环境影响而减少非极性植物成分和非极性杂质含量的银杏提取物的方法，该方法的特征在于以下方法步骤：（a）制备初始银杏提取物的水 - 酮或水 - 醇溶液，并将溶液施加到吸附树脂上，（b）用C 3 -C 6水溶液洗脱吸附树脂，或（C）任选地将所得到的提取液浓缩并干燥至干提取物中。本发明还涉及与初始提取物相比，由于与初始提取物相比具有降低的非极性植物成分含量和非极性杂质的来自银杏的提取物（液体提取物或裂解提取物以及干提取物），其可通过以下方法获得：本发明。

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