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1. 发明授权

US07892247B2 Devices and methods for interconnecting vessels 有权
标题翻译：用于互连血管的装置和方法
公开(公告)号：US07892247B2
公开(公告)日：2011-02-22
申请号：US10264741
申请日：2002-10-03
申请人： Stanley R. Conston , Ronald K. Yamamoto , Jodi J. Akin , Gitanjali V. Barry
发明人： Stanley R. Conston , Ronald K. Yamamoto , Jodi J. Akin , Gitanjali V. Barry
IPC分类号： A61B17/08
CPC分类号： A61F2/064 , A61B17/11 , A61B50/362 , A61B2050/364
摘要： The present invention provides implantable devices and associated methods for interconnecting human vessels in a side-to-side or an end-to-side arrangement rapidly, safely and in a minimally invasive manner. The devices comprise a vessel connector and a intravascular support mechanism for establishing fluid communication between two vessels. Certain embodiments further include a sealing member for further sealing the openings in the vessels created for inserting the subject devices.
摘要翻译：本发明提供可植入装置和相关联的方法，用于将人血管以一对一侧或端对侧的排列方式快速，安全地并以微创方式相互连接。所述装置包括血管连接器和用于在两个血管之间建立流体连通的血管内支撑机构。某些实施例还包括用于进一步密封用于插入主体装置的容器中的开口的密封构件。

2. 发明授权

US08425473B2 Subretinal access device 失效
标题翻译：视网膜下进入装置
公开(公告)号：US08425473B2
公开(公告)日：2013-04-23
申请号：US12359157
申请日：2009-01-23
申请人： Friedrich Ho , Stanley R. Conston , Ronald K. Yamamoto
发明人： Friedrich Ho , Stanley R. Conston , Ronald K. Yamamoto
IPC分类号： A61M25/00 , A61M31/00 , A61M1/00 , A61M5/32 , A61M35/00
CPC分类号： A61F9/007 , A61B1/313 , A61B3/102 , A61B3/12 , A61B5/0066 , A61B17/3421 , A61B2017/306 , A61F9/0017 , A61F9/008 , A61F2009/00863 , A61F2009/00874
摘要： The invention provides surgical devices that provide access to the sub-retinal space using delicate traction to hold the sensory retina to create and maintain a patent sub-retinal space of sufficient size to introduce and perform treatments on the eye. Such treatments may include the introduction of illumination or imaging agents or tools, surgical tools, the infusion of pharmaceutical or biological agents, and the placement of grafts, transplants or implants and the closure of the site through the delivery of a sealant.
摘要翻译：本发明提供了外科装置，其使用微妙的牵引力提供对次视网膜空间的接近以保持感觉视网膜以产生和维持足够尺寸的专利视网膜空间以引入和执行对眼睛的治疗。这样的治疗可以包括引入照明或成像剂或工具，手术工具，药物或生物制剂的输注，以及移植物，移植物或植入物的放置以及通过递送密封剂来封闭部位。

3. 发明申请

US20100191176A1 SUBRETINAL ACCESS DEVICE 失效
标题翻译： SUBRETINAL访问设备
公开(公告)号：US20100191176A1
公开(公告)日：2010-07-29
申请号：US12359157
申请日：2009-01-23
申请人： Friedrich Ho , Stanley R. Conston , Ronald K. Yamamoto
发明人： Friedrich Ho , Stanley R. Conston , Ronald K. Yamamoto
IPC分类号： A61F9/008 , A61B17/32 , A61F9/007 , A61B1/00
CPC分类号： A61F9/007 , A61B1/313 , A61B3/102 , A61B3/12 , A61B5/0066 , A61B17/3421 , A61B2017/306 , A61F9/0017 , A61F9/008 , A61F2009/00863 , A61F2009/00874
摘要： The invention provides surgical devices that provide access to the sub-retinal space using delicate traction to hold the sensory retina to create and maintain a patent sub-retinal space of sufficient size to introduce and perform treatments on the eye. Such treatments may include the introduction of illumination or imaging agents or tools, surgical tools, the infusion of pharmaceutical or biological agents, and the placement of grafts, transplants or implants and the closure of the site through the delivery of a sealant.
摘要翻译：本发明提供了外科装置，其使用微妙的牵引力提供对次视网膜空间的接近以保持感觉视网膜以产生和维持足够尺寸的专利视网膜空间以引入和执行对眼睛的治疗。这样的治疗可以包括引入照明或成像剂或工具，手术工具，药物或生物制剂的输注，以及移植物，移植物或植入物的放置以及通过递送密封剂来封闭部位。

4. 发明授权

US08123729B2 Treatment of ocular disease 失效
标题翻译：眼病的治疗
公开(公告)号：US08123729B2
公开(公告)日：2012-02-28
申请号：US12587375
申请日：2009-10-05
申请人： Ronald K. Yamamoto , Stanley R. Conston , Michael F. Nash , Paul S. Koch
发明人： Ronald K. Yamamoto , Stanley R. Conston , Michael F. Nash , Paul S. Koch
IPC分类号： A61M35/00
CPC分类号： A61B8/10 , A61B8/0841 , A61F9/00781
摘要： The invention relates to a novel apparatus for the treatment of ocular disease, particularly glaucoma. The apparatus consists of a locating device to locate Schlemm's Canal within the anterior portion of the eye and a surgical tool to access the canal for treatment. The apparatus allows for guided, minimally invasive surgical access to Schlemm's Canal to enable surgical procedures to be performed on the canal and trabecular meshwork to reduce intraocular pressure. The apparatus may also deliver devices or substances to Schlemm's Canal in the treatment of glaucoma.
摘要翻译：本发明涉及用于治疗眼部疾病，特别是青光眼的新型装置。该装置包括一个定位装置，用于在眼前部位置定位Schlemm's运河，另外还有一个外科手术工具可以进入运河进行治疗。该装置允许引导，微创手术进入施莱姆运河，使得能够在运河和小梁网上进行外科手术以降低眼内压。该装置还可以将器械或物质运送到施莱姆运河治疗青光眼。

5. 发明申请

US20120022424A1 DEVICE FOR PLACING CIRCUMFERENTIAL IMPLANT IN SCHLEMM'S CANAL 审中-公开
标题翻译：用于在SCHLEMM's CANAL中放置循环植入物的装置
公开(公告)号：US20120022424A1
公开(公告)日：2012-01-26
申请号：US13115543
申请日：2011-05-25
申请人： Ronald K. YAMAMOTO , Stanley R. Conston
发明人： Ronald K. YAMAMOTO , Stanley R. Conston
IPC分类号： A61F9/007
CPC分类号： A61F9/00781 , A61B2090/306 , A61B2090/3945
摘要： A device is provided to enable placing an implant within the full circumference of Schlemm's canal of an eye. The device comprises a flexible elongated solid element with a proximal end and a distal tip that transmits light such as one or more strands of a fiber optic. The device is characterized by selected mechanical characteristics to allow advancement within Schlemm's canal. The fiber optic element transmits light from a proximal connector to the distal tip to provide a lighted tip that may be viewed transclerally when the device is advanced along Schlemm's canal.
摘要翻译：提供了一种装置，以使植入物能够放置在眼睛的施莱姆运河的整个圆周内。该装置包括具有近端的柔性细长实体元件和透射诸如光纤的一束或多股的光的远端。该装置的特征在于选择的机械特性，以允许在施莱姆运河内前进。光纤元件将光从近端连接器透射到远侧末端，以提供当器件沿着施莱姆氏管前进时可以经视观察的点亮尖端。

6. 发明申请

US20100191177A1 DEVICE FOR ASPIRATING FLUIDS 审中-公开
标题翻译：吸入流体装置
公开(公告)号：US20100191177A1
公开(公告)日：2010-07-29
申请号：US12359169
申请日：2009-01-23
申请人： Tom S. Chang , Friedrich Ho , Stanley R. Conston , Ronald K. Yamamoto
发明人： Tom S. Chang , Friedrich Ho , Stanley R. Conston , Ronald K. Yamamoto
IPC分类号： A61F9/00
CPC分类号： A61F9/00736 , A61F9/00727 , A61M1/0084 , A61M2210/0612
摘要： Surgical devices are provided for aspiration of the subretinal fluid (SRF) of the eye in a retinal detachment that allows re-apposition of the sensory retina to the underlying RPE. The device is connected to a vacuum source, introduced into the posterior chamber through a sclerostomy port and placed against the detached retinal tissue. The device pulls on and captures the surface of the sensory retina, causing a micro needle to pierce through the tissue. As the sensory retina is captured and held in place by the vacuum, a protected pocket is created and the tissue is prevented from folding onto itself and occluding the micro needle tip.
摘要翻译：提供手术装置用于在视网膜脱离中吸引眼睛的视网膜下液体（SRF），其允许感觉视网膜重新附着到下面的RPE。该装置连接到真空源，通过硬皮造口进入后腔，并抵靠分离的视网膜组织放置。该装置拉动并捕获感觉视网膜的表面，导致微针刺穿组织。当感官视网膜通过真空捕获并保持在适当位置时，产生受保护的口袋，并且防止组织折叠到自身上并封闭微针尖端。

7. 发明授权

US08491549B2 Ophthalmic microsurgical system 有权
标题翻译：眼科显微外科系统
公开(公告)号：US08491549B2
公开(公告)日：2013-07-23
申请号：US10496254
申请日：2002-11-21
申请人： Stanley R. Conston , Ronald K. Yamamoto
发明人： Stanley R. Conston , Ronald K. Yamamoto
IPC分类号： A61M35/00 , A61M5/00
CPC分类号： A61B17/32002 , A61B17/3421 , A61B2017/00867 , A61B2017/305 , A61B2017/320044 , A61B2090/306 , A61F9/00763 , A61F9/00781 , A61F9/0133
摘要： An ophthalmic microsurgical system is described for treatment of eye diseases, such as glaucoma, using minimally invasive surgical techniques. The microsurgical system includes a thin walled outer sheath microcannula 1 slidably disposed about an inner member 4, which extends slightly beyond the distal end of the microcannula 1. The inner member 4 may be straight or curved and may optionally include a surgical instrument and/or a sensor or signaling beacon. The microsurgical system is used in a surgical procedure for opening Schlemm's Canal to provide drainage of aqueous fluid in order to relieve excess intraocular pressure that results from glaucoma and other diseases of the eye.
摘要翻译：描述了一种眼科显微外科系统，用于使用微创手术技术治疗诸如青光眼的眼部疾病。显微外科系统包括可滑动地设置在内部构件4周围的薄壁外护套微型插管1，其稍微延伸超出微型插管1的远端。内部构件4可以是直的或弯曲的，并且可以可选地包括外科器械和/或传感器或信号灯。显微手术系统用于开放施莱姆运河的外科手术，以提供含水液体的排水，以缓解由青光眼和其他眼睛疾病引起的过多的眼内压。

8. 发明申请

US20090028953A1 METHOD OF TREATMENT USING MICROPARTICULATE BIOMATERIAL COMPOSITION 审中-公开
标题翻译：使用微生物生物组合物治疗的方法
公开(公告)号：US20090028953A1
公开(公告)日：2009-01-29
申请号：US12211001
申请日：2008-09-15
申请人： Ronald K. Yamamoto , Stanley R. Conston
发明人： Ronald K. Yamamoto , Stanley R. Conston
IPC分类号： A61K9/14 , A61K31/728 , A61P27/06
CPC分类号： A61K31/728
摘要： Compositions of microspheres formed of stabilized hyaluronic acid are disclosed. The unique biological properties of hyaluronic acid provide for very inert properties when exposed to tissues. Microsphere formulations of hyaluronic acid have medical utility due to the resultant properties of flowability, physical stability, and degradability. High concentration formulations of the microspheres have utility when injected to form a localized mass within tissues by providing physical stability and anti-fibrotic biological activity, especially suitable for certain surgical reconstructions. Low concentration formulation of the microspheres of the appropriate size range have utility when injected into the blood system to delivery diagnostic and therapeutic compounds.
摘要翻译：公开了由稳定化的透明质酸形成的微球的组合物。当暴露于组织时，透明质酸的独特生物学特性提供非常惰性的特性。透明质酸的微球制剂由于所得到的流动性，物理稳定性和降解性的特性而具有医疗效用。通过提供物理稳定性和抗纤维化生物活性，特别适用于某些外科重建，微注射剂的高浓度制剂在注射时可用于在组织内形成局部质量。适当尺寸范围的微球的低浓度制剂在注射到血液系统中以递送诊断和治疗化合物时具有效用。

9. 发明授权

US06458140B2 Devices and methods for interconnecting vessels 失效
标题翻译：用于互连血管的装置和方法
公开(公告)号：US06458140B2
公开(公告)日：2002-10-01
申请号：US09771007
申请日：2001-01-26
申请人： Jodi Akin , Amr Salahieh , Michael Mack , Hani Shennib , Jackson Demond , Ronald K. Yamamoto , Stanley R. Conston
发明人： Jodi Akin , Amr Salahieh , Michael Mack , Hani Shennib , Jackson Demond , Ronald K. Yamamoto , Stanley R. Conston
IPC分类号： A61B1704
CPC分类号： A61F2/064 , A61B17/11 , A61B2017/00867 , A61B2017/1107 , A61B2017/1135 , A61B2017/1139
摘要： The present invention provides implantable devices and associated methods forinterconnecting human vessels in a side-to-side or an end-to-side arrangement rapidly, safely and in a minimally invasive manner. The devices comprises at least a first segment, a second component, and a flow opening between the at least one segment and the second component when operatively used. The first segment is flexible and has physical and mechanical properties which allow it to be easily inserted into a vessel, to conformably seal with the inside wall of the vessel and to be resistant to dislodging from the vessel. The second component may comprise a second segment having the same or a similar configuration as the first segment or may be a tubular member which extends from the first segment. The first and second segments are flexible for easy insertion into an incision made within the side of each vessel. Upon release from a constricted state, each flexible segment subsequently conforms to the interior walls of a vessel to provide a sealing contact along the contact surface of the segment inserted within. The tubular member is configured to be inserted into a transected end of a vessel. The flow opening provides fluid interconnectivity between the vessels connected by the implanted devices. The devices are configured so as to: (1) not impede flow inside a vessel; (2) prevent leakage from the incisions within the vessels; and (3) apposition the vessels toward each other allowing the vessels to heal together so that flow in one vessel may flow to the other.
摘要翻译：本发明提供可植入装置和用于以快速，安全和微创的方式将人血管以一对侧或端对侧的排列方式相互连接的方法。当操作使用时，这些装置至少包括第一部分，第二部分和至少一个部分和第二部件之间的流动开口。第一段是柔性的并且具有物理和机械性质，其允许其容易地插入容器中，以与容器的内壁一致地密封并且抵抗从容器移出的阻力。第二部件可以包括具有与第一部分相同或相似的构造的第二部分，或者可以是从第一部分延伸的管状部件。第一和第二段是柔性的，以便于插入到在每个容器的侧面内形成的切口中。当从收缩状态释放时，每个柔性段随后与容器的内壁一致，以沿着插入其中的段的接触表面提供密封接触。管状构件被构造成插入到容器的横截面中。流动开口在由注入装置连接的容器之间提供流体互连。这些装置被配置为：（1）不妨碍容器内的流动; （2）防止血管内的切口渗漏; 和（3）将血管相互放置，使血管相互愈合，使一个血管中的流动流向另一个血管。

10. 发明授权

US06207180B1 Intravesical drug delivery 失效
标题翻译：膀胱内给药
公开(公告)号：US06207180B1
公开(公告)日：2001-03-27
申请号：US09525609
申请日：2000-03-14
申请人： Thomas B. Ottoboni , Ronald K. Yamamoto , Stanley R. Conston
发明人： Thomas B. Ottoboni , Ronald K. Yamamoto , Stanley R. Conston
IPC分类号： A61F202
CPC分类号： A61K9/0034 , A61K9/1647 , A61K9/70 , A61K47/10 , A61K47/12 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/44
摘要： Bioerodible, sustained release preparations are provided for placement into the bladder through the urethra which provide sustained release of drugs. Configurations are provided which are insertable through a catheter, such as a coiled filament, patch or a flowable gel. The device is bioeroded during or after the sustained release of the drug such that there is no blockage of the urinary tract while the device is in place within the bladder.
摘要翻译：生物可降解的持续释放制剂被提供用于通过尿道放置到膀胱中，其提供药物的持续释放。提供可通过导管插入的配置，例如卷绕长丝，贴片或可流动的凝胶。该装置在药物持续释放期间或之后进行生物编码，使得在装置在膀胱内就位时不会阻塞尿道。

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