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1. 发明授权

US07119098B2 Heteroarylakanoic acids as intergrin receptor antagonists 失效
标题翻译：杂芳基烷酸作为整合蛋白受体拮抗剂
公开(公告)号：US07119098B2
公开(公告)日：2006-10-10
申请号：US10311385
申请日：2001-06-15
申请人： Srinivasan Raj Nagarajan , Ish Kumar Khanna , Michael B. Tollefson , Scott B. Mohler , Barbara B. Chen , Mark Russell , Balekudru Devadas , Thomas D. Penning , Lori A. Schretzman , Dale P. Spangler , Mark L. Boys , Nizal S. Chandrakumar , Hwang-Fun Lu
发明人： Srinivasan Raj Nagarajan , Ish Kumar Khanna , Michael B. Tollefson , Scott B. Mohler , Barbara B. Chen , Mark Russell , Balekudru Devadas , Thomas D. Penning , Lori A. Schretzman , Dale P. Spangler , Mark L. Boys , Nizal S. Chandrakumar , Hwang-Fun Lu
IPC分类号： C07D403/12 , C07D403/14 , C07D401/12 , A61K31/443 , A61K31/4375
CPC分类号： C07D213/74 , C07D231/38 , C07D233/88 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention relates to a class of compounds represented by formula (I) or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of Formula (I), and methods of selectively antagonizing the ανβ3 and/or the ανβ5 integrin without significantly antagonizing the IIb/IIIa integrin.
摘要翻译：本发明涉及一类由式（I）表示的化合物或其药学上可接受的盐，包含式（I）化合物的药物组合物，和选择性拮抗化合物3和/或在不显着拮抗IIb / IIIa整联蛋白的情况下，所述的5'-整联蛋白。

2. 发明授权

US06933304B2 Heteroarylalkanoic acids as integrin receptor antagonists 失效
标题翻译：杂芳基链烷酸作为整联蛋白受体拮抗剂
公开(公告)号：US06933304B2
公开(公告)日：2005-08-23
申请号：US09881913
申请日：2001-06-15
申请人： Srinivasan Raj Nagarajan , Ish Kumar Khanna , Michael B. Tollefson , Scott B. Mohler , Barbara Chen , Mark Russell , Balekudru Devadas , Thomas D. Penning , Lori A. Schretzman , Dale P. Spangler , Mark Laurence Boys , Nizal Samuel Chandrakumar , Hung-Fun Lu
发明人： Srinivasan Raj Nagarajan , Ish Kumar Khanna , Michael B. Tollefson , Scott B. Mohler , Barbara Chen , Mark Russell , Balekudru Devadas , Thomas D. Penning , Lori A. Schretzman , Dale P. Spangler , Mark Laurence Boys , Nizal Samuel Chandrakumar , Hung-Fun Lu
IPC分类号： A61K31/4245 , A61K31/4375 , A61K31/4439 , A61K31/444 , A61K31/4545 , A61K31/4709 , A61K31/496 , A61K31/5383 , A61P3/14 , A61P9/00 , A61P9/08 , A61P9/10 , A61P19/02 , A61P19/10 , A61P21/00 , A61P27/02 , A61P35/00 , A61P43/00 , C07D213/74 , C07D231/38 , C07D233/60 , C07D233/88 , C07D405/12 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/12 , C07D471/04 , C07D498/04
CPC分类号： C07D213/74 , C07D231/38 , C07D233/88 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively antagonizing the αVβ3 and/or the αVβ5 integrin without significantly antagonizing the IIb/IIIa or αVβ6 integrin.
摘要翻译：本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物和选择性拮抗α-β3 和/或α5AT55整联蛋白，而不显着拮抗IIb / IIIa或α5β6 / SUB>整合素。

3. 发明授权

US06720315B2 Dihydrostilbene alkanoic acid derivatives 失效
标题翻译：二氢芪链烷酸衍生物
公开(公告)号：US06720315B2
公开(公告)日：2004-04-13
申请号：US09882137
申请日：2001-06-15
申请人： Thomas Rogers , Michael Clare , Hwang-Fun Lu , Mark Russell , James W. Malecha , Ish Kumar Khanna , Thomas Penning , Srinivasan Raj Nagarajan , Heather Stenmark
发明人： Thomas Rogers , Michael Clare , Hwang-Fun Lu , Mark Russell , James W. Malecha , Ish Kumar Khanna , Thomas Penning , Srinivasan Raj Nagarajan , Heather Stenmark
IPC分类号： A61K3133
CPC分类号： C07D213/74 , C07D239/14 , C07D401/12
摘要： The present invention relates to a class of compounds represented by the Formula 1. or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula 1, and methods of selectively inhibiting or antagonizing the &agr;V&bgr;3 and/or the &agr;V&bgr;5 integrin.
摘要翻译：本发明涉及一类由式1表示的化合物或其药学上可接受的盐，包含式1化合物的药物组合物和选择性抑制或拮抗αVβ3和/或αVbeta5整联蛋白的方法。

4. 发明授权

US06833366B1 Dihydrostilbene alkanoic acid derivatives 失效
标题翻译：二氢芪链烷酸衍生物
公开(公告)号：US06833366B1
公开(公告)日：2004-12-21
申请号：US10657932
申请日：2003-09-09
申请人： Thomas Rogers , Michael Clare , Hwang-Fun Lu , Mark Russell , James W. Malecha , Ish Kumar Khanna , Thomas Penning , Srinivasan Raj Nagarajan
发明人： Thomas Rogers , Michael Clare , Hwang-Fun Lu , Mark Russell , James W. Malecha , Ish Kumar Khanna , Thomas Penning , Srinivasan Raj Nagarajan
IPC分类号： A61K3133
CPC分类号： C07D213/74 , C07D239/14 , C07D401/12
摘要： The present invention relates to a class of compounds represented by the Formula 1. or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula 1, and methods of selectively inhibiting or antagonizing the &agr;v&bgr;3 and/or the &agr;v&bgr;5 integrin.
摘要翻译：本发明涉及一类由式1表示的化合物或其药学上可接受的盐，包含式1的化合物的药物组合物，以及选择性抑制或拮抗阿尔法博三唑和/或阿尔法肽5整联蛋白的方法。

5. 发明授权

US07115596B2 Thiazole compounds as integrin receptor antagonists derivatives 失效
标题翻译：噻唑化合物作为整合素受体拮抗剂衍生物
公开(公告)号：US07115596B2
公开(公告)日：2006-10-03
申请号：US10741056
申请日：2003-12-19
申请人： John A. Wendt , Heather Stenmark , Hongwei Wu , Yaping Wang , Barbara B. Chen , Thomas D. Penning , Victoria L. Downs , Mark L. Boys , Mark Russell , Dale P. Spangler
发明人： John A. Wendt , Heather Stenmark , Hongwei Wu , Yaping Wang , Barbara B. Chen , Thomas D. Penning , Victoria L. Downs , Mark L. Boys , Mark Russell , Dale P. Spangler
IPC分类号： A61K31/55 , A61K31/5025 , A61K31/44 , A61K31/425 , A61K31/36 , C07D401/00 , C07D417/00 , C07D413/00 , C07D471/02 , C07D207/00 , C07D317/46
CPC分类号： C07D417/14 , C07D471/04
摘要： The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αvβ3 and/or the αvβ5 integrin without significantly inhibiting the αvβ6 integrin.
摘要翻译：本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物和选择性抑制或拮抗α > 3和/或α5β5整联蛋白，而不显着抑制α3β6 整合素。

6. 发明授权

US06921767B2 Cycloalkyl alkanoic acids as integrin receptor antagonists derivatives 失效
标题翻译：环烷基链烷酸作为整联蛋白受体拮抗剂衍生物
公开(公告)号：US06921767B2
公开(公告)日：2005-07-26
申请号：US10326299
申请日：2002-12-20
申请人： Nagarajan R. Srinivasan , Ish Kumar Khanna , Michael Clare , Alan Gasiecki , Thomas Rogers , Barbara Chen , Mark Russell , Hwang-Fun Lu , Yu Yi , Renee M. Huff , Bipinchandra N. Desai , Balekudru Devadas , Mihir D. Parikh , Thomas Penning
发明人： Nagarajan R. Srinivasan , Ish Kumar Khanna , Michael Clare , Alan Gasiecki , Thomas Rogers , Barbara Chen , Mark Russell , Hwang-Fun Lu , Yu Yi , Renee M. Huff , Bipinchandra N. Desai , Balekudru Devadas , Mihir D. Parikh , Thomas Penning
IPC分类号： C07D213/74 , C07D231/38 , C07D233/88 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D498/04 , C07D239/14 , A61K31/505 , A61P9/10 , A61P19/10
CPC分类号： C07D213/74 , C07D231/38 , C07D233/88 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αvβ3 and/or αvβ5 integrin.
摘要翻译：本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物和选择性抑制或拮抗α > 3和/或α

7. 发明授权

US06949578B2 Cycloalkyl alkanoic acids as integrin receptor antagonists 失效
标题翻译：环烷基链烷酸作为整联蛋白受体拮抗剂
公开(公告)号：US06949578B2
公开(公告)日：2005-09-27
申请号：US10891361
申请日：2004-07-14
申请人： Ish Kumar Khanna , Michael Clare , Alan F. Gasiecki , Thomas Rogers , Barbara Chen , Mark Russell , Hwang-Fun Lu
发明人： Ish Kumar Khanna , Michael Clare , Alan F. Gasiecki , Thomas Rogers , Barbara Chen , Mark Russell , Hwang-Fun Lu
IPC分类号： A61K31/4168 , A61K31/4375 , A61K31/44 , A61K31/4402 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/5383 , A61P3/14 , A61P9/00 , A61P9/10 , A61P19/02 , A61P19/10 , A61P21/00 , A61P27/02 , A61P35/00 , A61P35/04 , C07D213/74 , C07D231/38 , C07D233/88 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D498/04 , A61K31/415 , A61K31/4172 , C07D233/38
CPC分类号： C07D213/74 , C07D231/38 , C07D233/88 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αvβ3 and/or αvβ5 integrin.
摘要翻译：本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物和选择性抑制或拮抗α > 3和/或α

8. 发明授权

US06900232B2 Cycloalkyl alkanoic acids as integrin receptor antagonists 失效
标题翻译：环烷基链烷酸作为整联蛋白受体拮抗剂
公开(公告)号：US06900232B2
公开(公告)日：2005-05-31
申请号：US09882186
申请日：2001-06-15
申请人： Ish Kumar Khanna , Michael Clare , Alan F. Gasiecki , Thomas Rogers , Barbara Chen , Mark Russell , Hwang-Fun Lu
发明人： Ish Kumar Khanna , Michael Clare , Alan F. Gasiecki , Thomas Rogers , Barbara Chen , Mark Russell , Hwang-Fun Lu
IPC分类号： A61K31/4168 , A61K31/4375 , A61K31/44 , A61K31/4402 , A61K31/443 , A61K31/4439 , A61K31/444 , A61K31/5383 , A61P3/14 , A61P9/00 , A61P9/10 , A61P19/02 , A61P19/10 , A61P21/00 , A61P27/02 , A61P35/00 , A61P35/04 , C07D213/74 , C07D231/38 , C07D233/88 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D498/04 , C07D213/72
CPC分类号： C07D213/74 , C07D231/38 , C07D233/88 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The present invention relates to a class of compounds represented by the Formula I Wherein A1 is a pyridinyl of the formula optionally substituted by one or more Rk selected from the group consisting of hydroxy, alkyl, alkoxy, alkoxyalkyl, thioalkyl, haloalkyl, cyano, amino alkylamino, halogen, acylamino, sulfonamide and —COR; and R is hydroxy, alkoxy, alkyl or amino; and pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αvβ3 and/or αvβ5 integrin.
摘要翻译：本发明涉及由式I表示的一类化合物，其中A 1是下式的吡啶基，其任选被一个或多个选自下组的R 0选自羟基，烷基，烷氧基，烷氧基烷基，硫代烷基，卤代烷基，氰基，氨基烷基氨基，卤素，酰氨基，磺酰胺和-COR; 且R为羟基，烷氧基，烷基或氨基; 和其药学上可接受的盐，包含式I化合物的药物组合物，以及选择性抑制或拮抗α3β3和/或α / 5> 5＆lt; 5＆gt;整联蛋白。

9. 发明申请

US20050043344A1 Heteroarylalkanoic acids as integrin receptor antagonists derivatives 审中-公开
标题翻译：杂芳基链烷酸作为整联蛋白受体拮抗剂衍生物
公开(公告)号：US20050043344A1
公开(公告)日：2005-02-24
申请号：US10743354
申请日：2003-12-22
申请人： Mark Boys , Lori Schretzman , Michael Tollefson , Nizal Chandrakumar , Ish Khanna , Maria Nguyen , Victoria Downs , Scott Mohler , Glen Gesicki , Thomas Penning , Barbara Chen , Yaping Wang , Albert Khilevich , Bipinchandra Desai , Yi Yu , John Wendt , Heather Stenmark , Hongwei Wu , Renee Huff , Srinivasan Nagarajan , Balekudru Devadas , Hwang-Fun Lu , Mark Russell , Dale Spangler , Mihir Parikh
发明人： Mark Boys , Lori Schretzman , Michael Tollefson , Nizal Chandrakumar , Ish Khanna , Maria Nguyen , Victoria Downs , Scott Mohler , Glen Gesicki , Thomas Penning , Barbara Chen , Yaping Wang , Albert Khilevich , Bipinchandra Desai , Yi Yu , John Wendt , Heather Stenmark , Hongwei Wu , Renee Huff , Srinivasan Nagarajan , Balekudru Devadas , Hwang-Fun Lu , Mark Russell , Dale Spangler , Mihir Parikh
IPC分类号： A61K31/4245 , A61K31/4745 , A61P19/02 , A61P19/10 , A61P27/00 , A61P35/00 , A61P35/04 , A61P43/00
CPC分类号： A61K31/4245 , A61K31/4745
摘要： The present invention relates to pharmaceutical compositions comprising compounds of the Formula I, or a pharmaceutically acceptable salt thereof, and methods of selectively inhibiting or antagonizing the αVβ3 and/or the αVβ5 integrin without significantly inhibiting the αVβ6 integrin.
摘要翻译：本发明涉及包含式I化合物或其药学上可接受的盐的药物组合物，以及选择性抑制或拮抗αVβ3和/或αVβ5整联蛋白而不显着抑制αVβ6整联蛋白的方法。

10. 发明申请

US20120193152A1 CUTTING TOOL INSERTS 审中-公开
标题翻译：切割工具插件
公开(公告)号：US20120193152A1
公开(公告)日：2012-08-02
申请号：US13500167
申请日：2010-09-15
申请人： Mark Russell , Andy Ollerenshaw
发明人： Mark Russell , Andy Ollerenshaw
IPC分类号： E21B10/36
CPC分类号： E21B10/56 , E21B10/567 , E21B10/5673 , E21B10/627 , E21B10/633 , E21B29/002
摘要： An insert (10) for a cutting tool (100) for use down a well bore comprises a body of a hard material (tungsten carbide) suitable for cutting steel. The body is shaped for formation in a mould that comprises a die (70) and first (74) and second (78) punches and arranged so that the first punch can eject the body after formation from an opening of the die closed during formation by said second punch. The insert has first (12) and second (14) ends whose faces are defined, at least in part, by corresponding faces of the first and second punch. Between them is a longitudinal axis (24) of the insert. The area of the first end is less than the area of the second end. The body has flanks (16) that form ridges (18) extending between the first and second ends. The ridges form cutting edges of the insert. They are separated by V-shaped troughs (20) of said flanks. The ridges taper and spiral about the axis.
摘要翻译：用于井下使用的用于切削工具（100）的刀片（10）包括适于切割钢的硬质材料（碳化钨）的主体。本体被成形为在模具中形成，该模具包括模具（70）和第一（74）和第二（78）冲头，并且布置成使得第一冲头可以在形成期间从模具的开口在形成期间封闭的主体第二拳插入件具有至少部分地由第一和第二冲头的对应面限定其面的第一（12）和第二（14）端。它们之间是插入件的纵向轴线（24）。第一端的面积小于第二端的面积。主体具有形成在第一和第二端之间延伸的脊（18）的侧面（16）。脊形成插入物的切割边缘。它们由所述侧面的V形槽（20）分开。脊部围绕轴线逐渐变细并旋转。

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