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1. 发明申请

US20120207769A1 Inhibitors of IAP 有权
标题翻译： IAP抑制剂
公开(公告)号：US20120207769A1
公开(公告)日：2012-08-16
申请号：US13456274
申请日：2012-04-26
申请人： Mark G. PALERMO , Sushil Kumar SHARMA , Christopher STRAUB , Run-Ming WANG , Leigh ZAWEL , Yanlin ZHANG , Zhuoliang CHEN , Yaping WANG , Fan YANG , Wojciech WRONA , Gang LIU , Mark G. CHAREST , Feng HE
发明人： Mark G. PALERMO , Sushil Kumar SHARMA , Christopher STRAUB , Run-Ming WANG , Leigh ZAWEL , Yanlin ZHANG , Zhuoliang CHEN , Yaping WANG , Fan YANG , Wojciech WRONA , Gang LIU , Mark G. CHAREST , Feng HE
IPC分类号： A61K31/40 , A61K31/663 , A61K31/55 , A61K31/53 , A61K31/519 , A61K31/497 , A61K31/506 , A61K31/437 , A61K31/444 , A61K31/4439 , A61K31/4245 , A61K31/427 , A61K31/422 , A61K31/41 , A61K31/4178 , A61K31/4025 , A61P35/00 , A61P5/26 , A61K39/395
CPC分类号： C07D207/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
摘要： Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I).
摘要翻译：抑制Smac蛋白与式（I）的凋亡蛋白抑制剂（IAP）结合的新型化合物。

2. 发明申请

US20110281875A1 Inhibitors of IAP 有权
标题翻译： IAP抑制剂
公开(公告)号：US20110281875A1
公开(公告)日：2011-11-17
申请号：US13178946
申请日：2011-07-08
申请人： Mark G. PALERMO , Sushil Kumar SHARMA , Christopher STRAUB , Run-Ming WANG , Leigh ZAWEL , Yanlin ZHANG , Zhuoliang CHEN , Yaping WANG , Fan YANG , Wojciech WRONA , Gang LIU , Mark G. CHAREST , Feng HE
发明人： Mark G. PALERMO , Sushil Kumar SHARMA , Christopher STRAUB , Run-Ming WANG , Leigh ZAWEL , Yanlin ZHANG , Zhuoliang CHEN , Yaping WANG , Fan YANG , Wojciech WRONA , Gang LIU , Mark G. CHAREST , Feng HE
IPC分类号： A61K31/53 , A61K31/444 , C07D401/04 , A61K31/4245 , A61K31/427 , A61K31/422 , A61K31/41 , A61K31/4178 , A61K31/4155 , A61K31/4025 , A61K31/40 , C07D401/14 , A61K31/4439 , C07D413/04 , C07D417/04 , C07D403/04 , C07D207/16 , A61K31/506
CPC分类号： C07D207/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
摘要： Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I).
摘要翻译：抑制Smac蛋白与式（I）的凋亡蛋白抑制剂（IAP）结合的新型化合物。

3. 发明授权

US07989441B2 Organic compounds 失效
标题翻译：有机化合物
公开(公告)号：US07989441B2
公开(公告)日：2011-08-02
申请号：US11916887
申请日：2006-06-06
申请人： Zhuoliang Chen , Mark G. Palermo , Sushil K. Sharma , Troy Smith , Christopher S. Straub , Run-Ming D. Wang , Yaping Wang , Leigh Zawel
发明人： Zhuoliang Chen , Mark G. Palermo , Sushil K. Sharma , Troy Smith , Christopher S. Straub , Run-Ming D. Wang , Yaping Wang , Leigh Zawel
IPC分类号： A61K31/44 , C07D223/12 , C07D211/76
CPC分类号： C07K5/0808 , C07D213/56 , C07D223/10 , C07D223/16 , C07D471/04 , C07D487/04 , C07D487/06 , C07D513/04 , C07K5/06026 , C07K5/06191 , C07K5/0806 , C07K5/0827 , C07K5/1008
摘要： The present disclosure relates to XIAP inhibitor compounds of the formula I.
摘要翻译：本公开涉及式I的XIAP抑制剂化合物。

4. 发明申请

US20090069294A1 Organic Compounds 失效
标题翻译：有机化合物
公开(公告)号：US20090069294A1
公开(公告)日：2009-03-12
申请号：US11916887
申请日：2006-06-06
申请人： Zhuoliang Chen , Mark G. Palermo , Sushil K. Sharma , Troy Smith , Christopher S. Straub , Run-Ming D. Wang , Yaping Wang , Leigh Zawel
发明人： Zhuoliang Chen , Mark G. Palermo , Sushil K. Sharma , Troy Smith , Christopher S. Straub , Run-Ming D. Wang , Yaping Wang , Leigh Zawel
IPC分类号： A61K31/55 , C07D243/02 , A61K31/551 , A61K31/407 , A61K31/435 , C07D221/04 , C07D487/04 , A61P35/00 , C07D495/04 , A61K31/4365 , A61K31/4412 , C07D211/76 , C07D223/14
CPC分类号： C07K5/0808 , C07D213/56 , C07D223/10 , C07D223/16 , C07D471/04 , C07D487/04 , C07D487/06 , C07D513/04 , C07K5/06026 , C07K5/06191 , C07K5/0806 , C07K5/0827 , C07K5/1008
摘要： The present disclosure relates to XIAP inhibitor compounds of the formula I.
摘要翻译：本公开涉及式I的XIAP抑制剂化合物。

5. 发明申请

US20080242658A1 Inhibitors of Iap 审中-公开
标题翻译：抑制剂
公开(公告)号：US20080242658A1
公开(公告)日：2008-10-02
申请号：US10594413
申请日：2005-04-06
申请人： Mark G Palermo , Sushil Kumar Sharma , Christopher Straub , Run-Ming Wang , Leigh Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
发明人： Mark G Palermo , Sushil Kumar Sharma , Christopher Straub , Run-Ming Wang , Leigh Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
IPC分类号： A61K31/407 , C07D471/04 , C07D207/08 , C07D487/04 , C07D207/32 , A61P35/00 , A61K31/4439 , A61K31/422 , A61K31/41 , A61K31/506 , C07D401/04 , C07D403/12 , A61K31/437 , A61K31/55 , A61K31/40
CPC分类号： C07D207/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
摘要： Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I
摘要翻译：抑制Smac蛋白与抑制凋亡蛋白抑制剂（IAP）的新型化合物

6. 发明授权

US07419975B2 Organic compounds 有权
标题翻译：有机化合物
公开(公告)号：US07419975B2
公开(公告)日：2008-09-02
申请号：US11099941
申请日：2005-04-06
申请人： Mark Gabriel Palermo , Sushil Kumar Sharma , Christopher Straub , Run-Ming Wang , Leigh Scott Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
发明人： Mark Gabriel Palermo , Sushil Kumar Sharma , Christopher Straub , Run-Ming Wang , Leigh Scott Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
IPC分类号： A61K31/407 , A61K31/437 , A61K31/55 , C07D487/04 , C07D471/04
CPC分类号： C07D207/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
摘要： Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I
摘要翻译：抑制Smac蛋白与抑制凋亡蛋白抑制剂（IAP）的新型化合物

7. 发明授权

US07230156B2 Method for preparing a sterile transgenic carp 失效
标题翻译：制备无菌转基因鲤鱼的方法
公开(公告)号：US07230156B2
公开(公告)日：2007-06-12
申请号：US11094286
申请日：2005-03-31
申请人： Wei Hu , Zuoyan Zhu , Yaping Wang , Shuangfei Li
发明人： Wei Hu , Zuoyan Zhu , Yaping Wang , Shuangfei Li
IPC分类号： A01K67/027 , C12N15/00
CPC分类号： C07K14/461 , A01K67/0275 , A01K2217/05 , A01K2227/40 , A01K2267/02
摘要： The present application disclosed a method for preparing a sterile transgenic fish, comprising constructing antisense RNA expression vector of salmon-type gonadotropin-releasing hormone, introducing the recombinant DNA fragment into carp oosperm by microinjection, and screening the sterile transgenic fish by Polymerase Chain Reaction and radioimmunoassay, wherein the expression vector comprising a promoter of carp beta actin (β-actin) gene, a complementary DNA fragment of antisense salmon-type gonadotropin-releasing hormone (sGnRH) gene from carp with 323 bp as a target gene comprising sGnRH decapeptide, the coding region of gonadotropin-releasing hormone associated peptide and 3′ non-coding sequence, and 3′ flanking sequence of grass carp growth hormone gene as a stop sequence. The method of the present invention is easy and convenient for operation which provides a basis for providing a technical platform of general applicability for solving the hereditary and ecological safety problems of transgenic fishes.
摘要翻译：本申请公开了一种制备无菌转基因鱼的方法，包括构建鲑鱼型促性腺激素释放激素的反义RNA表达载体，通过显微注射将重组DNA片段引入鲤鱼胚乳，并通过聚合酶链式反应筛选无菌转基因鱼，放射免疫测定法，其中包含鲤鱼β肌动蛋白（β-肌动蛋白）基因启动子的表达载体，具有323bp作为靶基因的来自鲤鱼的反义鲑鱼型促性腺激素释放激素（sGnRH）基因的互补DNA片段，其包含sGnRH十肽，促性腺激素释放激素相关肽和3'非编码序列的编码区和草鱼生长激素基因的3'侧翼序列作为停止序列。本发明的方法操作简单方便，为提供解决转基因鱼遗传和生态安全问题的通用技术平台提供依据。

8. 发明申请

US20050070564A1 Oripavine derivatives and their uses as medicines 有权
标题翻译：奥曲连衍生物及其作为药物的用途
公开(公告)号：US20050070564A1
公开(公告)日：2005-03-31
申请号：US10489656
申请日：2002-09-13
申请人： Bohua Zhong , Zehui Gong , Yaping Wang , Yongshao Liu
发明人： Bohua Zhong , Zehui Gong , Yaping Wang , Yongshao Liu
IPC分类号： B42F1/00 , C07D489/12 , A61K31/485
CPC分类号： C07D489/12
摘要： The present invention relates to oripavine derivatives of formula (I), wherein R1 is hydrogen or methyl, R2 is methyl, cyclopropyl methyl, cyclobutyl methyl or allyl, R3 is thiophenyl ethyl or cycloalkyl methyl where the cycloalkyl has 3 to 6 carbon atoms, or nontoxic pharmaceutically acceptable salts thereof. These compounds can be used for the preparation of analgesics or abstinence agents of opium habit-forming drugs.
摘要翻译：本发明涉及式（I）的oripavine衍生物，其中R 1是氢或甲基，R 2是甲基，环丙基甲基，环丁基甲基或烯丙基，R 3是噻吩基乙基或环烷基甲基，其中环烷基具有3至6个碳原子，或其无毒的药学上可接受的盐。这些化合物可用于制备鸦片习性形成药物的止痛剂或禁欲剂。

9. 发明申请

US20050004200A1 Pyrazole compounds as integrin receptor antagonists derivatives 审中-公开
标题翻译：吡唑类化合物作为整合素受体拮抗剂衍生物
公开(公告)号：US20050004200A1
公开(公告)日：2005-01-06
申请号：US10741860
申请日：2003-12-19
申请人： Thomas Penning , Albert Khilevich , Barbara Chen , Preete Gandhi , Yaping Wang , Victoria Downs , Mark Boys , Mark Russell , Dale Spangler , Renee Huff
发明人： Thomas Penning , Albert Khilevich , Barbara Chen , Preete Gandhi , Yaping Wang , Victoria Downs , Mark Boys , Mark Russell , Dale Spangler , Renee Huff
IPC分类号： A61K31/415 , A61K31/416 , C07D401/14 , C07D405/14 , C07D471/04 , C07
CPC分类号： C07D401/14 , C07D405/14 , C07D417/14 , C07D471/04
摘要： The present invention relates to a class of compounds represented by the Formula I or a pharmaceutically acceptable salt thereof, pharmaceutical compositions comprising compounds of the Formula I, and methods of selectively inhibiting or antagonizing the αVβ3 and/or the αVβ5 integrin without significantly inhibiting the αVβ6 integrin.
摘要翻译：本发明涉及一类由式I表示的化合物或其药学上可接受的盐，包含式I化合物的药物组合物以及选择性抑制或拮抗αVbeta3和/或αVβ5整联蛋白而不显着抑制αVβ6的方法整合素

10. 发明申请

US20150099737A1 PYRROLOPYRIMIDINE COMPOUNDS AS INHIBITORS OF CDK4/6 审中-公开
标题翻译：作为CDK4 / 6的抑制剂的吡咯烷酮化合物
公开(公告)号：US20150099737A1
公开(公告)日：2015-04-09
申请号：US14568410
申请日：2014-12-12
申请人： Christopher Thomas BRAIN , Young Shin CHO , John William GIRALDES , Bharat LAGU , Julian Roy LEVELL , Michael Joseph LUZZIO , Lawrence Blas PEREZ , Yaping WANG , Fan YANG
发明人： Christopher Thomas BRAIN , Young Shin CHO , John William GIRALDES , Bharat LAGU , Julian Roy LEVELL , Michael Joseph LUZZIO , Lawrence Blas PEREZ , Yaping WANG , Fan YANG
IPC分类号： C07D487/04 , C07D487/08 , C07D498/10 , C07D498/08 , C07D487/10 , C07D471/08 , C07D471/10
CPC分类号： C07D487/04 , C07D471/08 , C07D471/10 , C07D487/08 , C07D487/10 , C07D498/08 , C07D498/10 , C07D498/20 , C07D519/00
摘要： The invention is directed to novel pyrrolopyrimidine compounds of formula (1) wherein R1, R2y, R4, R8-R11, A and L are defined herein and to salts, including pharmaceutically acceptable salts thereof. The compounds of the present invention are CDK4/6 inhibitors and could be useful in the treatment of diseases and disorders mediated by CDK4/6, such as cancer, including mantle cell lymphoma, liposarcoma, non small cell lung cancer, melanoma, squamous cell esophageal cancer and breast cancer. The invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting CDK4/6 activity and to the treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
摘要翻译：本发明涉及式（1）的新颖的吡咯并嘧啶化合物，其中R 1，R 2y，R 4，R 8 -R 11，A和L在本文中定义，并且包括其药学上可接受的盐。本发明的化合物是CDK4 / 6抑制剂，可用于治疗由CDK4 / 6介导的疾病和病症，如癌症，包括外套细胞淋巴瘤，脂肪肉瘤，非小细胞肺癌，黑素瘤，鳞状细胞食管癌癌症和乳腺癌。本发明还涉及包含本发明化合物的药物组合物。本发明还涉及抑制CDK4 / 6活性的方法以及使用本发明化合物或包含本发明化合物的药物组合物治疗与之相关的病症。

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