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1. 发明授权

US6030620A Skin care compositions containing an organic extract of chick pea 失效
公开(公告)号：US6030620A
公开(公告)日：2000-02-29
申请号：US901052
申请日：1997-07-25
申请人： Sreekumar Pillai , Uma Santhanam , Marieann Carlomusto , Carol Bosko
发明人： Sreekumar Pillai , Uma Santhanam , Marieann Carlomusto , Carol Bosko
IPC分类号： A61K8/00 , A61K8/19 , A61K8/31 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/41 , A61K8/63 , A61K8/66 , A61K8/67 , A61K8/72 , A61K8/96 , A61K8/97 , A61K8/99 , A61Q19/00 , A61Q19/08 , A61K35/78 , A61K7/48
CPC分类号： A61Q19/007 , A61K8/97 , A61Q19/00 , A61Q19/004 , A61Q19/08 , Y10S514/844 , Y10S514/874
摘要： Organic chick pea extracts are phytoestrogens, if present in an amount such as to provide an estrogenic activity equivalent to at least 1 nM of estradiol. Cosmetic compositions containing organic chick pea extracts are useful in improving the appearance of wrinkled, lined, dry, flaky, aged or photodamaged skin and improving skin thickness, elasticity, flexibility and plumpness.

2. 发明授权

US06270780B1 Cosmetic compositions containing resveratrol 失效
标题翻译：包含白藜芦醇的化妆品组合物
公开(公告)号：US06270780B1
公开(公告)日：2001-08-07
申请号：US09098121
申请日：1998-06-16
申请人： Robert George Carson , Krupa Patel , Marieann Carlomusto , Carol Annette Bosko , Sreekumar Pillai , Uma Santhanam , Ronni Lynn Weinkauf , Koichi Iwata , Laura Rose Palanker
发明人： Robert George Carson , Krupa Patel , Marieann Carlomusto , Carol Annette Bosko , Sreekumar Pillai , Uma Santhanam , Ronni Lynn Weinkauf , Koichi Iwata , Laura Rose Palanker
IPC分类号： A61K600
CPC分类号： A61Q19/004 , A61K8/347 , A61Q17/04 , A61Q19/00 , A61Q19/007 , A61Q19/02 , A61Q19/08 , Y10S514/844 , Y10S514/846
摘要： Resveratrol, a component of a variety of common edible plants, including peanuts and red grapes, is a phytoestrogen. Resveratrol inhibits proliferation of skin epidermal cells (keratinocytes) and stimulates their differentiation. Resveratrol was also found to inhibit melanin production by skin cells and to alleviate skin irritation that may be caused by alpha-hydroxy acids. Resveratrol is useful in improving the appearance of wrinkled, lined, dry, flaky, aged or photodamaged skin and improving skin thickness, elasticity, flexibility, radiance, glow and plumpness.
摘要翻译：白藜芦醇是各种常见食用植物的一种成分，包括花生和红葡萄，是植物雌激素。白藜芦醇抑制皮肤表皮细胞（角质形成细胞）的增殖并刺激其分化。还发现白藜芦醇抑制皮肤细胞产生黑色素并减轻由α-羟基酸引起的皮肤刺激。白藜芦醇可用于改善皱纹，衬里，干燥，片状，老化或光损伤皮肤的外观，改善皮肤厚度，弹性，柔韧性，光泽度，发光和丰满度。

3. 发明授权

US06548072B1 Skin care compositions containing an organic extract of chick pea 失效
标题翻译：含有豌豆有机提取物的护肤组合物
公开(公告)号：US06548072B1
公开(公告)日：2003-04-15
申请号：US09398898
申请日：1999-09-20
申请人： Sreekumar Pillai , Uma Santhanam , Marieann Carlomusto , Carol Annette Bosko
发明人： Sreekumar Pillai , Uma Santhanam , Marieann Carlomusto , Carol Annette Bosko
IPC分类号： A61K700
CPC分类号： A61Q19/007 , A61K8/97 , A61Q19/00 , A61Q19/004 , A61Q19/08 , Y10S514/844 , Y10S514/874
摘要： Organic chick pea extracts are phytoestrogens, if present in an amount such as to provide an estrogenic activity equivalent to at least 1 nM of estradiol. Cosmetic compositions containing organic chick pea extracts are useful in improving the appearance of wrinkled, lined, dry, flaky, aged or photodamaged skin and improving skin thickness, elasticity, flexibility and plumpness.
摘要翻译：有机豌豆提取物是植物雌激素，如果存在的量是提供与至少1nM雌二醇相当的雌激素活性。含有有机豌豆提取物的化妆品组合物可用于改善皱纹，衬里，干燥，片状，老化或光损伤皮肤的外观，并改善皮肤厚度，弹性，柔韧性和丰满度。

4. 发明授权

US06395281B1 Cosmetic skin conditioning compositions containing red yeast rice extract 失效
标题翻译：包含红酵母米提取物的化妆品皮肤调理组合物
公开(公告)号：US06395281B1
公开(公告)日：2002-05-28
申请号：US09737072
申请日：2000-12-14
申请人： Thomas Eugene Januario , Uma Santhanam , Sreekumar Pillai , Manisha Narayan Mahajan , John Steven Bajor
发明人： Thomas Eugene Januario , Uma Santhanam , Sreekumar Pillai , Manisha Narayan Mahajan , John Steven Bajor
IPC分类号： A61K3578
CPC分类号： A61Q19/007 , A61K8/671 , A61K8/676 , A61K8/678 , A61K8/97 , A61K8/99 , A61Q19/00 , A61Q19/008 , A61Q19/08
摘要： Cosmetic methods and compositions for conditioning human skin by topical application to the skin of cosmetic compositions containing red yeast rice extract. Cosmetic compositions containing red yeast rice extract in combination with ascorbyl palmitate, or sodium ascorbyl phosphate, or retinol, or retinyl ester are also disclosed.
摘要翻译：用于通过局部施用于含有红酵母米提取物的化妆品组合物的皮肤来调理人皮肤的化妆方法和组合物。还公开了含有红曲霉水稻提取物与抗坏血酸棕榈酸酯或抗坏血酸磷酸钠或视黄醇或视黄酯组合的化妆品组合物。

5. 发明授权

US10195136B2 Collagen and elastin stimulating compositions and uses thereof 有权
公开(公告)号：US10195136B2
公开(公告)日：2019-02-05
申请号：US13216626
申请日：2011-08-24
申请人： Daniel Thorn Leeson , Uma Santhanam , John W. Lyga , Siming W. Chen , Russell Wyborski
发明人： Daniel Thorn Leeson , Uma Santhanam , John W. Lyga , Siming W. Chen , Russell Wyborski
IPC分类号： A61K8/97 , A61K36/19 , A61K36/48 , A61Q19/08
摘要： Methods and compositions for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ a botanical extract of Justicia ventricosa, Archidendron clypearia, Abrus fruticulosus, or combinations thereof and a cosmetically acceptable vehicle.

6. 发明申请

US20140065086A1 Dickkopf-1 Expression Modulating Compositions and Uses Thereof 有权
标题翻译： Dickkopf-1表达调控组合物及其用途
公开(公告)号：US20140065086A1
公开(公告)日：2014-03-06
申请号：US13599631
申请日：2012-08-30
申请人： Uma Santhanam , Qi Hong , Sunghan Yim
发明人： Uma Santhanam , Qi Hong , Sunghan Yim
IPC分类号： A61K8/99 , A61Q7/02 , A61Q19/00 , A61Q19/02 , A61P29/00 , A61P17/02 , A61Q19/08 , A61P25/00 , A61P17/10 , A61K36/06 , A61P17/00
CPC分类号： A61K8/99 , A61K36/06 , A61K36/896 , A61K2236/19 , A61Q7/02 , A61Q19/02 , A61Q19/08 , A61K2300/00
摘要： The present invention relates generally to compositions for topical application to the skin which comprise at least one DICKKOPF-1 expression modulator and the use of such compositions to provide benefits to the skin, including but not limited to lightening or darkening skin; treating hyper or hypopigmented skin; increasing or decreasing skin thickness; reducing or increasing skin hirsuteness; and/or changing skin phenotype from non-palmoplantar to palmoplantar.
摘要翻译：本发明一般涉及用于局部施用于皮肤的组合物，其包含至少一种DICKKOPF-1表达调节剂以及使用这些组合物来为皮肤提供益处，包括但不限于减轻或变暗的皮肤; 治疗皮肤过度或色素沉着; 增加或减少皮肤厚度; 减少或增加皮肤多毛性; 和/或改变皮肤表型从非掌跖到掌跖。

7. 发明申请

US20130052288A1 Collagen and Elastin Stimulating Compositions and Uses Thereof 审中-公开
标题翻译：胶原和弹性蛋白刺激组合物及其用途
公开(公告)号：US20130052288A1
公开(公告)日：2013-02-28
申请号：US13216626
申请日：2011-08-24
申请人： Daniel Thorn Leeson , Uma Santhanam , John W. Lyga , Siming W. Chen , Russell Wyborski
发明人： Daniel Thorn Leeson , Uma Santhanam , John W. Lyga , Siming W. Chen , Russell Wyborski
IPC分类号： A61K8/97 , A61Q19/08 , A61P17/02 , A61Q19/00 , A61K36/48 , A61K36/19
CPC分类号： A61K8/97 , A61K36/19 , A61K36/48 , A61Q19/08 , A61K2300/00
摘要： Methods and compositions for preventing, ameliorating, or reducing dermatological signs of aging are provided which employ a botanical extract of Justicia ventricosa, Archidendron clypearia, Abrus fruticulosus, or combinations thereof and a cosmetically acceptable vehicle.
摘要翻译：提供了用于预防，改善或减少老化皮肤病学症状的方法和组合物，其采用了法蒂西娅（Petricia ventricosa）的植物提取物，西葫芦（Archidendron clypearia）或其组合以及美容上可接受的载体。

8. 发明申请

US20120003168A1 Topical Lightening Composition and Uses Thereof 有权
标题翻译：局部减光成分及用途
公开(公告)号：US20120003168A1
公开(公告)日：2012-01-05
申请号：US12975415
申请日：2010-12-22
申请人： John W. Lyga , Uma Santhanam , William J. Welsh
发明人： John W. Lyga , Uma Santhanam , William J. Welsh
IPC分类号： A61K8/46 , A61Q19/02
CPC分类号： A61K31/74 , A61K8/46 , A61Q19/02
摘要： The disclosure relates to novel topical lightening compositions a skin depigmenting agent and a vehicle. There is provided a topical lightening composition comprising a substituted-4-oxobutanoic acid, ester, or amide tyrosinase inhibitor, and a vehicle. The depigmenting agents of this disclosure can be used as such or as a pharmaceutically acceptable salt including conventional non-toxic salts which include a metal salt or an alkaline earth metal salt, an ammonium salt, or an organic base salt. The depigmenting agents of this disclosure can be incorporated into any cosmetically-, dermatologically-, or cosmeticatically-acceptable vehicle or carrier normally used for topical application. The compositions and methods of the disclosure are effective to lighten skin, hair, lips, and/or nails.
摘要翻译：本公开涉及新颖的局部减光组合物皮肤色素沉着剂和载体。提供了包含取代的-4-氧代丁酸，酯或酰胺酪氨酸酶抑制剂和载体的局部减轻组合物。本公开的脱色剂可以原样使用或作为药学上可接受的盐使用，包括常规无毒盐，包括金属盐或碱土金属盐，铵盐或有机碱盐。本公开的脱色剂可以并入通常用于局部应用的美容，皮肤病学或化妆品可接受的载体或载体中。本公开的组合物和方法有效地减轻皮肤，头发，嘴唇和/或指甲。

9. 发明授权

US6007829A Cosmetic skin care compositions containing succinate compounds 失效
标题翻译：含有琥珀酸酯化合物的化妆品护肤组合物
公开(公告)号：US6007829A
公开(公告)日：1999-12-28
申请号：US213496
申请日：1998-12-17
申请人： Ronni Weinkauf , Uma Santhanam , Laura Rose Palanker , Allan Robert Burger , Anthony Vincent Rawlings
发明人： Ronni Weinkauf , Uma Santhanam , Laura Rose Palanker , Allan Robert Burger , Anthony Vincent Rawlings
IPC分类号： A61K8/00 , A61K20060101 , A61K8/30 , A61K8/362 , A61K8/46 , A61K31/194 , A61P17/00 , A61Q17/04 , A61Q19/00 , A61Q19/08 , A61K7/02
CPC分类号： A61Q19/00 , A61K8/362 , A61Q19/004 , A61Q19/007 , A61Q19/08 , A61Q17/04 , Y10S514/937 , Y10S514/938
摘要： Cosmetic skin care compositions containing succinate compounds and cosmetic method of improving the appearance of wrinkled, lined, dry, flaky, aged or photodamaged skin and improving skin thickness, elasticity, flexibility, radiance, glow and plumpness.
摘要翻译：含有琥珀酸酯化合物的化妆品护肤组合物和改善皱纹，衬里，干燥，片状，老化或光损伤皮肤外观的美容方法，并改善皮肤厚度，弹性，柔韧性，光泽度，发光和丰满度。

10. 发明授权

US5853742A Cosmetic compositions containing lactate dehydrogenase inhibitors 失效
标题翻译：含有乳酸脱氢酶抑制剂的化妆品组合物
公开(公告)号：US5853742A
公开(公告)日：1998-12-29
申请号：US790409
申请日：1997-01-29
申请人： John Brian Bartolone , Christine Marie Penksa , Uma Santhanam , Brian David Lang
发明人： John Brian Bartolone , Christine Marie Penksa , Uma Santhanam , Brian David Lang
IPC分类号： A61K8/30 , A61K8/00 , A61K8/06 , A61K8/36 , A61K8/362 , A61K8/365 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/60 , A61K8/68 , A61K31/185 , A61K31/19 , A61K31/195 , A61K31/197 , A61K31/198 , A61K31/44 , A61K31/47 , A61K31/485 , A61K45/06 , A61P17/00 , A61P43/00 , A61Q3/02 , A61Q5/00 , A61Q5/12 , A61Q19/00 , A61Q19/08 , A61K7/48
CPC分类号： A61Q19/08 , A61K31/19 , A61K31/197 , A61K45/06 , A61K8/365 , A61K8/44 , A61K8/46 , A61K8/494 , A61K8/606 , A61K8/68 , A61Q5/00 , A61K2800/782
摘要： Inhibitors of lactate dehydrogenase stimulate keratinocyte proliferation and collagen synthesis in cutaneous tissues. The inhibitors are used preferably with certain co-active ingredients such as pyruvic acid, acetic acid, acetoacetic acid, .beta.-hydroxybutyric acid, a Krebs cycle pathway metabolite, an aliphatic saturated or an unsaturated fatty acid containing from 8 to 26 carbon atoms, an .omega.-hydroxy acid containing from 22 to 34 carbon atoms, glutamic acid, glutamine, valine, alanine, leucine, and mixtures thereof.
摘要翻译：乳酸脱氢酶抑制剂刺激皮肤组织中的角质形成细胞增殖和胶原合成。抑制剂优选与某些共活性成分例如丙酮酸，乙酸，乙酰乙酸，β-羟基丁酸，克雷伯循环途径代谢物，含有8至26个碳原子的脂族饱和或不饱和脂肪酸，含有22至34个碳原子的ω-羟基酸，谷氨酸，谷氨酰胺，缬氨酸，丙氨酸，亮氨酸及其混合物。

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