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1. 发明申请

WO2012050822A1 USES OF MACROPHAGE MANNOSE RECEPTOR TO SCREEN COMPOUNDS AND USES OF THESE COMPOUNDS 审中-公开
标题翻译：使用MACHOPHAT MANNOSE受体筛选化合物和这些化合物的用途
公开(公告)号：WO2012050822A1
公开(公告)日：2012-04-19
申请号：PCT/US2011/053390
申请日：2011-09-27
申请人： SMARTCELLS, INC. , MURIKIPUDI, Sylaja , LANCASTER, Thomas, M. , ZION, Todd, C.
发明人： MURIKIPUDI, Sylaja , LANCASTER, Thomas, M. , ZION, Todd, C.
IPC分类号： A61K38/14 , C07K17/00 , C07K1/00 , C07K14/00 , A01N25/00
CPC分类号： G01N33/5308 , A61K47/61 , C07K14/705 , G01N33/566 , G01N2333/62
摘要： Methods and associated compositions of matter (e.g., kits, cell lines, etc.) for screening compounds that bind to macrophase mannose receptor (MMR). Compounds identified by these methods and drug conjugates that includes these compounds are also encompassed as are their uses in the manufacture of medicaments.
摘要翻译：用于筛选与巨噬细胞甘露糖受体（MMR）结合的化合物的物质（例如试剂盒，细胞系等）的相关组合物。通过这些方法鉴定的化合物和包括这些化合物的药物偶联物也包括在制备药物中的用途。

2. 发明申请

WO2012015692A2 RECOMBINANTLY EXPRESSED INSULIN POLYPEPTIDES AND USES THEREOF 审中-公开
标题翻译：重组表达的胰岛素多肽及其用途
公开(公告)号：WO2012015692A2
公开(公告)日：2012-02-02
申请号：PCT/US2011/045008
申请日：2011-07-22
申请人： SMARTCELLS, INC. , LANCASTER, Thomas, M. , MURIKIPUDI, Sylaja , LALEAU, Rassol , ZION, Todd, C.
发明人： LANCASTER, Thomas, M. , MURIKIPUDI, Sylaja , LALEAU, Rassol , ZION, Todd, C.
IPC分类号： C07K14/62
CPC分类号： C07K14/62 , A61K38/28
摘要： The present disclosure provides recombinantly expressed insulin polypeptides that comprise an N-linked glycan motif. The N-linked glycan motif is not present in wild-type insulins and enables the recombinant expression of glycosylated insulin polypeptides (e.g., in yeast cells). Based on results obtained with synthetic glycosylated insulin conjugates we predict that when these recombinant glycosylated insulin polypeptides are administered to a mammal, at least one pharmacokinetic or pharmacodynamic property of the glycosylated insulin polypeptide will be sensitive to serum concentrations of glucose (or an exogenous saccharide such as alpha-methyl mannose). Exemplary insulin polypeptides, polynucleotides encoding these insulin polypeptides, glycosylated insulin polypeptides, pharmaceutical formulations and sustained release formulations are provided in addition to methods of use and preparation.
摘要翻译：本公开提供了包含N-连接的聚糖基序的重组表达的胰岛素多肽。 N-连接的聚糖基序不存在于野生型胰岛素中并且能够重组表达糖基化胰岛素多肽（例如在酵母细胞中）。基于用合成糖基化胰岛素缀合物获得的结果，我们预测当将这些重组糖基化胰岛素多肽施用于哺乳动物时，糖基化胰岛素多肽的至少一种药代动力学或药效学性质将对血清葡萄糖浓度（或外源糖类作为α-甲基甘露糖）。除了使用和制备方法外，还提供了示例性的胰岛素多肽，编码这些胰岛素多肽的多核苷酸，糖基化的胰岛素多肽，药物制剂和缓释制剂。

3. 发明公开

EP2627347A1 USES OF MACROPHAGE MANNOSE RECEPTOR TO SCREEN COMPOUNDS AND USES OF THESE COMPOUNDS 审中-公开
标题翻译：使用巨噬细胞甘露糖受体筛选化合物及这些化合物的用途
公开(公告)号：EP2627347A1
公开(公告)日：2013-08-21
申请号：EP11833005.9
申请日：2011-09-27
申请人： Smartcells, Inc.
发明人： MURIKIPUDI, Sylaja , LANCASTER, Thomas, M. , ZION, Todd, C.
IPC分类号： A61K38/14 , C07K17/00 , C07K1/00 , C07K14/00 , A01N25/00
CPC分类号： G01N33/5308 , A61K47/61 , C07K14/705 , G01N33/566 , G01N2333/62
摘要： Methods and associated compositions of matter (e.g., kits, cell lines, etc.) for screening compounds that bind to macrophase mannose receptor (MMR). Compounds identified by these methods and drug conjugates that includes these compounds are also encompassed as are their uses in the manufacture of medicaments.

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