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    • 4. 发明申请
    • POLYNUCLEOTIDE APTAMER-BASED CROSS -LINKED MATERIALS AND USES THEREOF
    • 基于APTAMER的多晶交联材料及其用途
    • WO2010088276A2
    • 2010-08-05
    • PCT/US2010/022237
    • 2010-01-27
    • SMARTCELLS, INC.ZION, Todd, C.LANCASTER, Thomas, M.
    • ZION, Todd, C.LANCASTER, Thomas, M.
    • A61K48/00
    • C12N15/111A61K47/549C12N2310/16C12N2310/51
    • In one aspect, the disclosure provides cross-linked materials that include multivalent polynucleotide aptamers that bind a target molecule; and conjugates that include two or more separate affinity ligands bound to a conjugate framework, wherein the two or more affinity ligands compete with the target molecule for binding with the aptamers and wherein conjugates are cross-linked within the material as a result of non-covalent interactions between aptamers and affinity ligands on different conjugates. These materials are designed to release amounts of conjugate in response to desired concentrations of the target molecule. Depending on the end application, in various embodiments, the conjugates may also include a drug and/or a detectable label. The drug, detectable label and affinity ligands may be covalently or non-covalently bound to the conjugate framework.
    • 一方面,本公开提供交联材料,其包括结合目标分子的多价多核苷酸适体; 以及包含与缀合物框架结合的两个或更多个分离的亲和配体的缀合物,其中所述两个或更多个亲和配体与靶分子竞争与适配体结合,并且其中结合物由于非共价键而在材料内交联 适体与亲和配体在不同共轭物上的相互作用。 这些材料被设计成响应于目标分子的所需浓度释放结合物的量。 根据最终应用,在各种实施方案中,缀合物还可以包括药物和/或可检测标记。 药物,可检测的标记和亲和配体可以共价或非共价结合到缀合物框架。
    • 7. 发明申请
    • RECOMBINANT LECTINS, BINDING-SITE MODIFIED LECTINS AND USES THEREOF
    • 重组蛋白,结合位点修饰的蛋白及其用途
    • WO2012015691A3
    • 2013-08-08
    • PCT/US2011044989
    • 2011-07-22
    • SMARTCELLS INCLANCASTER THOMAS MBUTTERS ROBERTCHOODNOVSKIY NAOMI RZION TODD C
    • LANCASTER THOMAS MBUTTERS ROBERTCHOODNOVSKIY NAOMI RZION TODD C
    • A61K9/14A61K36/00
    • C07K14/42
    • In one aspect, the disclosure provides cross-linked materials that include multivalent lectins with at least two binding sites for glucose, wherein the lectins include at least one affinity ligand which is capable of competing with glucose for binding with at least one of said binding sites and is covalently linked to a cysteine residue of the lectins; and conjugates that include two or more separate affinity ligands bound to a conjugate framework, wherein the two or more affinity ligands compete with glucose for binding with the lectins at said binding sites and wherein conjugates are cross-linked within the material as a result of non-covalent interactions between lectins and affinity ligands on different conjugates. These materials are designed to release amounts of conjugate in response to desired concentrations of glucose. Depending on the end application, in various embodiments, the conjugates may also include a drug and/or a detectable label.
    • 一方面,本公开提供了交联材料,其包括具有至少两个葡萄糖结合位点的多价凝集素,其中所述凝集素包括至少一种亲和配体,其能够与葡萄糖竞争与至少一个所述结合位点 并与凝集素的半胱氨酸残基共价连接; 以及包含与缀合物框架结合的两个或多个分离的亲和配体的缀合物,其中所述两个或更多个亲和配体与葡萄糖竞争与所述结合位点处的凝集素结合,并且其中缀合物在材料内交联, 在不同共轭物上的凝集素和亲和配体之间的共价相互作用。 这些材料被设计为响应于期望的葡萄糖浓度释放结合物的量。 取决于最终应用,在各种实施方案中,缀合物还可以包括药物和/或可检测标记。
    • 8. 发明申请
    • RECOMBINANT LECTINS, BINDING-SITE MODIFIED LECTINS AND USES THEREOF
    • 重组蛋白,结合位点修饰的蛋白及其用途
    • WO2012015691A2
    • 2012-02-02
    • PCT/US2011/044989
    • 2011-07-22
    • SMARTCELLS, INC.LANCASTER, Thomas, M.BUTTERS, RobertCHOODNOVSKIY, Naomi, R.ZION, Todd, C.
    • LANCASTER, Thomas, M.BUTTERS, RobertCHOODNOVSKIY, Naomi, R.ZION, Todd, C.
    • C07K14/42
    • C07K14/42
    • In one aspect, the disclosure provides cross-linked materials that include multivalent lectins with at least two binding sites for glucose, wherein the lectins include at least one affinity ligand which is capable of competing with glucose for binding with at least one of said binding sites and is covalently linked to a cysteine residue of the lectins; and conjugates that include two or more separate affinity ligands bound to a conjugate framework, wherein the two or more affinity ligands compete with glucose for binding with the lectins at said binding sites and wherein conjugates are cross-linked within the material as a result of non-covalent interactions between lectins and affinity ligands on different conjugates. These materials are designed to release amounts of conjugate in response to desired concentrations of glucose. Depending on the end application, in various embodiments, the conjugates may also include a drug and/or a detectable label.
    • 一方面,本公开提供了交联材料,其包括具有至少两个葡萄糖结合位点的多价凝集素,其中所述凝集素包括至少一种亲和配体,其能够与葡萄糖竞争与至少一个所述结合位点 并与凝集素的半胱氨酸残基共价连接; 以及包含与缀合物框架结合的两个或多个分离的亲和配体的缀合物,其中所述两个或更多个亲和配体与葡萄糖竞争与所述结合位点处的凝集素结合,并且其中缀合物在材料内交联, 在不同共轭物上的凝集素和亲和配体之间的共价相互作用。 这些材料被设计为响应于期望的葡萄糖浓度释放结合物的量。 根据最终应用,在各种实施方案中,缀合物还可以包括药物和/或可检测标记。