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1. 发明申请

US20070036727A1 Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for "cest" applications 有权
标题翻译：磁共振转移试剂与含有可交换质子的底物之间的加合物用于“cest”应用
公开(公告)号：US20070036727A1
公开(公告)日：2007-02-15
申请号：US10552851
申请日：2004-04-06
申请人： Silvio Aime , Enzo Terreno , Daniela Delli Castelli , Giovanni Giovenzana
发明人： Silvio Aime , Enzo Terreno , Daniela Delli Castelli , Giovanni Giovenzana
IPC分类号： A61K49/10 , C07K14/47 , C08B37/00
CPC分类号： A61K49/085 , A61K49/10 , A61K49/146
摘要： Disclosed are CEST paramagnetic agents comprising a substrate (SH) containing mobile protons bonded to a para-magnetic chelate (SR) containing a metal selected from iron (11) (high-spin configuration), iron (111), cobalt (11), rhodium (11), copper (11), nickel (11), cerium (111), praseodymium (111), neodymium (111), dysprosium (111), erbium (111), terbium (111), holmium (111), thulium (III), ytterbium (III) and europium (111).
摘要翻译：公开了包含含有与包含选自铁（11）（高旋转构型），铁（111），钴（11）），金属（111）等金属的对磁性螯合物（SR）的移动质子的底物（SH）铑（11），铜（11），镍（11），铈（111），镨（111），钕（111），镝（111），铒（111），铽（111） ium（III），镱（III）和铕（111）。

2. 发明授权

US08945512B2 Adducts between magnetic resonance shift reagents and substrates containing exchangeable protons for “cest” applications 有权
标题翻译：磁共振转移试剂和含有可交换质子的底物之间的加合物用于“cest”应用
公开(公告)号：US08945512B2
公开(公告)日：2015-02-03
申请号：US10552851
申请日：2004-04-06
申请人： Silvio Aime , Enzo Terreno , Daniela Delli Castelli , Giovanni Battista Giovenzana
发明人： Silvio Aime , Enzo Terreno , Daniela Delli Castelli , Giovanni Battista Giovenzana
IPC分类号： A61B5/055 , A61B5/00 , C07K1/00 , C08B37/00 , A61K49/08 , A61K49/10 , A61K49/14
CPC分类号： A61K49/085 , A61K49/10 , A61K49/146
摘要： Disclosed are CEST paramagnetic agents comprising a substrate (SH) containing mobile protons bonded to a paramagnetic chelate (SR) containing a metal selected from iron (11) (high-spin configuration), iron (111), cobalt (11), rhodium (11), copper (11), nickel (11), cerium (111), praseodymium (111), neodymium (111), dysprosium (111), erbium (111), terbium (111), holmium (111), thulium (III), ytterbium (III) and europium (111).
摘要翻译：公开了包含与包含选自铁（11）（高自旋构型），铁（111），钴（11），铑（11））的金属的顺磁性螯合物（SR）结合的移动质子的底物（SH）的CEST顺磁性试剂 11），铜（11），镍（11），铈（111），镨（111），钕（111），镝（111），铒（111），铽（111），钬（111） III），镱（III）和铕（111）。

3. 发明申请

US20090234221A1 RESPONSIVE PARAMAGNETIC MRI CONTRAST AGENTS 有权
标题翻译：反应性PARAMAGNETIC MRI对比剂
公开(公告)号：US20090234221A1
公开(公告)日：2009-09-17
申请号：US12418155
申请日：2009-04-03
申请人： Silvio Aime , Daniela Delli Castelli , Franco Fedeli , Enzo Terreno
发明人： Silvio Aime , Daniela Delli Castelli , Franco Fedeli , Enzo Terreno
IPC分类号： A61B5/055 , C07F5/00 , A61K49/10
CPC分类号： A61K49/0002 , A61K49/106
摘要： A method is claimed based on CEST procedure for the in vivo or in vitro determination of physical or chemical parameters which includes the use of a responsive paramagnetic CEST contrast agent.
摘要翻译：基于用于体内或体外测定物理或化学参数的CEST程序要求保护的方法，其包括使用响应性顺磁性CEST造影剂。

4. 发明授权

US08318134B2 Responsive paramagnetic MRI contrast agents 有权
标题翻译：响应顺磁性MRI造影剂
公开(公告)号：US08318134B2
公开(公告)日：2012-11-27
申请号：US12418155
申请日：2009-04-03
申请人： Silvio Aime , Daniela Delli Castelli , Franco Fedeli , Enzo Terreno
发明人： Silvio Aime , Daniela Delli Castelli , Franco Fedeli , Enzo Terreno
IPC分类号： A61K49/00
CPC分类号： A61K49/0002 , A61K49/106
摘要： A method is claimed based on CEST procedure for the in vivo or in vitro determination of physical or chemical parameters which includes the use of a responsive paramagnetic CEST contrast agent.
摘要翻译：基于用于体内或体外测定物理或化学参数的CEST程序要求保护的方法，其包括使用响应性顺磁性CEST造影剂。

5. 发明授权

US08611981B2 MRI-CEST diagnostic technique based on non-punctual analysis 有权
标题翻译：基于非准时分析的MRI-CEST诊断技术
公开(公告)号：US08611981B2
公开(公告)日：2013-12-17
申请号：US13060397
申请日：2009-08-18
申请人： Silvio Aime , Daniela Delli Castelli , Dario Livio Longo , Joseph Stancanello , Enzo Terreno , Fulvio Uggeri
发明人： Silvio Aime , Daniela Delli Castelli , Dario Livio Longo , Joseph Stancanello , Enzo Terreno , Fulvio Uggeri
IPC分类号： A61B5/05 , G01V3/00
CPC分类号： G01R33/5601 , G01R33/5608
摘要： An embodiment in the MRI-CEST field is proposed for analyzing a body-part, which includes a CEST agent providing a magnetization transfer with a bulk substrate of the body-part. A corresponding diagnostic system includes input means for providing an input map including a plurality of input elements each one for a corresponding location of the body-part; each input element is indicative of a spectrum of a magnetic response of the location, which spectrum includes the magnetic response at an agent frequency of resonance of the contrast agent (with the agent frequency that is at an agent offset of frequency from a bulk frequency of resonance of the bulk substance), and at a reference frequency at the opposite of the agent offset from the bulk frequency. The system further includes calculation means for calculating an agent value and a reference value for each one of a set of selected locations; the agent value is calculated according to the magnetic responses of the selected location in a non-punctual agent range of frequencies including the agent frequency, and the reference value is calculated according to the magnetic responses of the selected location in a non-punctual reference range of frequencies including the reference frequency (with the reference range that is symmetric to the agent range with respect to the bulk frequency). Comparison means is then provided for calculating a parametric value for each selected location; the parametric value is calculated according to a comparison between the agent value and the reference value of the selected location.
摘要翻译：提出了MRI-CEST领域中的一个实施例，用于分析身体部位，其包括提供磁化转移的CEST代理与身体部位的体基底。相应的诊断系统包括输入装置，用于提供包括多个输入元件的输入图，每个输入元件各自用于身体部位的对应位置; 每个输入元件指示该位置的磁响应的频谱，该频谱包括在造影剂的谐振的代理频率处的磁响应（代理频率在代理偏移量的频率与主频率散装物质的共振），并且在与体积偏移的试剂相反的参考频率处。该系统还包括用于计算一组选定位置中的每一个的代理值和参考值的计算装置; 根据所选择的位置在包括代理频率的非准时代理频率范围内的磁响应来计算代理值，并且根据所选择的位置在非准时参考范围内的磁响应来计算参考值的频率，其包括参考频率（参考范围与代理范围相对于体频率对称）。然后提供比较装置，用于计算每个选定位置的参数值; 根据代理值与所选位置的参考值之间的比较来计算参数值。

6. 发明申请

US20110152671A1 MRI-CEST DIAGNOSTIC TECHNIQUE BASED ON NON-PUNCTUAL ANALYSIS 有权
标题翻译：基于非泛素化分析的MRI-CEST诊断技术
公开(公告)号：US20110152671A1
公开(公告)日：2011-06-23
申请号：US13060397
申请日：2009-08-18
申请人： Silvio Aime , Daniela Delli Castelli , Dario Livio Longo , Joseph Stancanello , Enzo Terreno , Fulvio Uggeri
发明人： Silvio Aime , Daniela Delli Castelli , Dario Livio Longo , Joseph Stancanello , Enzo Terreno , Fulvio Uggeri
IPC分类号： A61B5/055 , G06F19/00 , G01R33/54
CPC分类号： G01R33/5601 , G01R33/5608
摘要： An embodiment in the MRI-CEST field is proposed for analyzing a body-part, which includes a CEST agent providing a magnetization transfer with a bulk substrate of the body-part. A corresponding diagnostic system includes input means for providing an input map including a plurality of input elements each one for a corresponding location of the body-part; each input element is indicative of a spectrum of a magnetic response of the location, which spectrum includes the magnetic response at an agent frequency of resonance of the contrast agent (with the agent frequency that is at an agent offset of frequency from a bulk frequency of resonance of the bulk substance), and at a reference frequency at the opposite of the agent offset from the bulk frequency. The system further includes calculation means for calculating an agent value and a reference value for each one of a set of selected locations; the agent value is calculated according to the magnetic responses of the selected location in a non-punctual agent range of frequencies including the agent frequency, and the reference value is calculated according to the magnetic responses of the selected location in a non-punctual reference range of frequencies including the reference frequency (with the reference range that is symmetric to the agent range with respect to the bulk frequency). Comparison means is then provided for calculating a parametric value for each selected location; the parametric value is calculated according to a comparison between the agent value and the reference value of the selected location.
摘要翻译：提出了MRI-CEST领域中的一个实施例，用于分析身体部位，其包括提供磁化转移的CEST代理与身体部位的体基底。相应的诊断系统包括输入装置，用于提供包括多个输入元件的输入图，每个输入元件各自用于身体部位的对应位置; 每个输入元件指示该位置的磁响应的频谱，该频谱包括在造影剂的谐振的代理频率处的磁响应（代理频率在代理偏移量的频率与主频率散装物质的共振），并且在与体积偏移的试剂相反的参考频率处。该系统还包括用于计算一组选定位置中的每一个的代理值和参考值的计算装置; 根据所选择的位置在包括代理频率的非准时代理频率范围内的磁响应来计算代理值，并且根据所选择的位置在非准时参考范围内的磁响应来计算参考值的频率，其包括参考频率（参考范围与代理范围相对于体频率对称）。然后提供比较装置，用于计算每个选定位置的参数值; 根据代理值与所选位置的参考值之间的比较来计算参数值。

7. 发明授权

US08636977B2 Integrin targeted synthetic ligands for diagnostic and therapeutic applications 有权
标题翻译：整合素靶向合成配体用于诊断和治疗应用
公开(公告)号：US08636977B2
公开(公告)日：2014-01-28
申请号：US11885353
申请日：2006-03-03
申请人： Luciano Lattuada , Pierfrancesco Morosini , Fulvio Uggeri , Silvio Aime , Enzo Terreno , Daniela Delli Castelli , Carlo Scolastico , Leonardo Manzoni , Daniela Arosio
发明人： Luciano Lattuada , Pierfrancesco Morosini , Fulvio Uggeri , Silvio Aime , Enzo Terreno , Daniela Delli Castelli , Carlo Scolastico , Leonardo Manzoni , Daniela Arosio
IPC分类号： A61K51/08 , A61K38/12 , A61K49/14 , A61K49/18 , A61K51/12 , C07K5/08
CPC分类号： C07K7/64 , C07D401/06 , C07D471/04 , C07K5/06139
摘要： The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel aza-bicycloalkane based cyclic peptides, acting as a targeting moiety towards integrin receptors.
摘要翻译：本发明涉及一类新的诊断或治疗有效的化合物，其包含用作整合素受体的靶向部分的新的基于氮杂 - 双环烷烃的环肽。

8. 发明申请

US20080317668A1 Integrin Targeted Synthetic Ligands for Diagnostic and Therapeutic Applications 有权
标题翻译：用于诊断和治疗应用的整合素靶向合成配体
公开(公告)号：US20080317668A1
公开(公告)日：2008-12-25
申请号：US11885353
申请日：2006-03-03
申请人： Luciano Lattuada , Pierfrancesco Morosini , Fulvio Uggeri , Silvio Aime , Enzo Terreno , Daniela Delli Castelli , Carlo Scolastico , Leonardo Manzoni , Daniela Arosio
发明人： Luciano Lattuada , Pierfrancesco Morosini , Fulvio Uggeri , Silvio Aime , Enzo Terreno , Daniela Delli Castelli , Carlo Scolastico , Leonardo Manzoni , Daniela Arosio
IPC分类号： A61K51/08 , A61K38/12 , C07K7/64 , G06K9/00 , A61K9/127 , A61K49/14
CPC分类号： C07K7/64 , C07D401/06 , C07D471/04 , C07K5/06139
摘要： The present invention relates to a novel class of diagnostically or therapeutically effective compounds comprising novel aza-bicycloalkane based cyclic peptides, acting as a targeting moiety towards integrin receptors.
摘要翻译：本发明涉及一类新的诊断或治疗有效的化合物，其包含用作整合素受体的靶向部分的新的基于氮杂 - 双环烷烃的环肽。

9. 发明申请

US20050191243A1 Responsive paramagnetic mri contrast agents 有权
标题翻译：响应顺磁性mri造影剂
公开(公告)号：US20050191243A1
公开(公告)日：2005-09-01
申请号：US10502701
申请日：2003-01-27
申请人： Silvio Aime , Daniela Delli Castelli , Franco Fedeli , Enzo Terreno
发明人： Silvio Aime , Daniela Delli Castelli , Franco Fedeli , Enzo Terreno
IPC分类号： A61B5/055 , A61K49/00 , A61K49/06 , A61K49/10
CPC分类号： A61K49/0002 , A61K49/106
摘要： A method is claimed based on CEST procedure for the in vivo or in vitro determination of physical or chemical parameters which includes the use of a responsive paramagnetic CEST contrast agent.
摘要翻译：基于用于体内或体外测定物理或化学参数的CEST程序要求保护的方法，其包括使用响应性顺磁性CEST造影剂。

10. 发明授权

US10232060B2 CEST systems exhibiting a concentration independent responsiveness 有权
公开(公告)号：US10232060B2
公开(公告)日：2019-03-19
申请号：US13879083
申请日：2011-11-04
申请人： Silvio Aime , Daniela Delli Castelli , Franco Fedeli , Dario Livio Longo , Enzo Terreno , Fulvio Uggeri
发明人： Silvio Aime , Daniela Delli Castelli , Franco Fedeli , Dario Livio Longo , Enzo Terreno , Fulvio Uggeri
IPC分类号： A61B5/00 , A61B8/00 , A61B10/00 , A61K49/10 , G01R33/56
摘要： The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable stereoisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable stereoisomers in solution useful as concentration independent CEST responsive agents.

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