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    • 8. 发明授权
    • MRI-CEST diagnostic technique based on non-punctual analysis
    • 基于非准时分析的MRI-CEST诊断技术
    • US08611981B2
    • 2013-12-17
    • US13060397
    • 2009-08-18
    • Silvio AimeDaniela Delli CastelliDario Livio LongoJoseph StancanelloEnzo TerrenoFulvio Uggeri
    • Silvio AimeDaniela Delli CastelliDario Livio LongoJoseph StancanelloEnzo TerrenoFulvio Uggeri
    • A61B5/05G01V3/00
    • G01R33/5601G01R33/5608
    • An embodiment in the MRI-CEST field is proposed for analyzing a body-part, which includes a CEST agent providing a magnetization transfer with a bulk substrate of the body-part. A corresponding diagnostic system includes input means for providing an input map including a plurality of input elements each one for a corresponding location of the body-part; each input element is indicative of a spectrum of a magnetic response of the location, which spectrum includes the magnetic response at an agent frequency of resonance of the contrast agent (with the agent frequency that is at an agent offset of frequency from a bulk frequency of resonance of the bulk substance), and at a reference frequency at the opposite of the agent offset from the bulk frequency. The system further includes calculation means for calculating an agent value and a reference value for each one of a set of selected locations; the agent value is calculated according to the magnetic responses of the selected location in a non-punctual agent range of frequencies including the agent frequency, and the reference value is calculated according to the magnetic responses of the selected location in a non-punctual reference range of frequencies including the reference frequency (with the reference range that is symmetric to the agent range with respect to the bulk frequency). Comparison means is then provided for calculating a parametric value for each selected location; the parametric value is calculated according to a comparison between the agent value and the reference value of the selected location.
    • 提出了MRI-CEST领域中的一个实施例,用于分析身体部位,其包括提供磁化转移的CEST代理与身体部位的体基底。 相应的诊断系统包括输入装置,用于提供包括多个输入元件的输入图,每个输入元件各自用于身体部位的对应位置; 每个输入元件指示该位置的磁响应的频谱,该频谱包括在造影剂的谐振的代理频率处的磁响应(代理频率在代理偏移量的频率与主频率 散装物质的共振),并且在与体积偏移的试剂相反的参考频率处。 该系统还包括用于计算一组选定位置中的每一个的代理值和参考值的计算装置; 根据所选择的位置在包括代理频率的非准时代理频率范围内的磁响应来计算代理值,并且根据所选择的位置在非准时参考范围内的磁响应来计算参考值 的频率,其包括参考频率(参考范围与代理范围相对于体频率对称)。 然后提供比较装置,用于计算每个选定位置的参数值; 根据代理值与所选位置的参考值之间的比较来计算参数值。
    • 9. 发明申请
    • MRI-CEST DIAGNOSTIC TECHNIQUE BASED ON NON-PUNCTUAL ANALYSIS
    • 基于非泛素化分析的MRI-CEST诊断技术
    • US20110152671A1
    • 2011-06-23
    • US13060397
    • 2009-08-18
    • Silvio AimeDaniela Delli CastelliDario Livio LongoJoseph StancanelloEnzo TerrenoFulvio Uggeri
    • Silvio AimeDaniela Delli CastelliDario Livio LongoJoseph StancanelloEnzo TerrenoFulvio Uggeri
    • A61B5/055G06F19/00G01R33/54
    • G01R33/5601G01R33/5608
    • An embodiment in the MRI-CEST field is proposed for analyzing a body-part, which includes a CEST agent providing a magnetization transfer with a bulk substrate of the body-part. A corresponding diagnostic system includes input means for providing an input map including a plurality of input elements each one for a corresponding location of the body-part; each input element is indicative of a spectrum of a magnetic response of the location, which spectrum includes the magnetic response at an agent frequency of resonance of the contrast agent (with the agent frequency that is at an agent offset of frequency from a bulk frequency of resonance of the bulk substance), and at a reference frequency at the opposite of the agent offset from the bulk frequency. The system further includes calculation means for calculating an agent value and a reference value for each one of a set of selected locations; the agent value is calculated according to the magnetic responses of the selected location in a non-punctual agent range of frequencies including the agent frequency, and the reference value is calculated according to the magnetic responses of the selected location in a non-punctual reference range of frequencies including the reference frequency (with the reference range that is symmetric to the agent range with respect to the bulk frequency). Comparison means is then provided for calculating a parametric value for each selected location; the parametric value is calculated according to a comparison between the agent value and the reference value of the selected location.
    • 提出了MRI-CEST领域中的一个实施例,用于分析身体部位,其包括提供磁化转移的CEST代理与身体部位的体基底。 相应的诊断系统包括输入装置,用于提供包括多个输入元件的输入图,每个输入元件各自用于身体部位的对应位置; 每个输入元件指示该位置的磁响应的频谱,该频谱包括在造影剂的谐振的代理频率处的磁响应(代理频率在代理偏移量的频率与主频率 散装物质的共振),并且在与体积偏移的试剂相反的参考频率处。 该系统还包括用于计算一组选定位置中的每一个的代理值和参考值的计算装置; 根据所选择的位置在包括代理频率的非准时代理频率范围内的磁响应来计算代理值,并且根据所选择的位置在非准时参考范围内的磁响应来计算参考值 的频率,其包括参考频率(参考范围与代理范围相对于体频率对称)。 然后提供比较装置,用于计算每个选定位置的参数值; 根据代理值与所选位置的参考值之间的比较来计算参数值。