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    • 7. 发明申请
    • USE OF AN OZONE/OXYGEN MIXTURE AS PRIMARY ANTICANCER THERAPY THROUGH INTRAPERITONEAL INSUFFLATION
    • 使用OZY / OXYGEN混合物作为主要治疗方法通过胰岛素消融
    • US20110006261A1
    • 2011-01-13
    • US12742490
    • 2008-11-14
    • Jochen A. WernerAnja-Alexandra DünneEberhard WeiheMichael BetteSiegfried Schulz
    • Jochen A. WernerAnja-Alexandra DünneEberhard WeiheMichael BetteSiegfried Schulz
    • C01B13/00
    • A61K33/00A61K31/00A61K33/40A61K2300/00
    • Head and neck squamous cell carcinomas (HNSCC) represent a group of metastasizing tumors with a high mortality rate in man and animals. Since the biomolecule ozone was found to inhibit growth of various carcinoma cells in vitro we here applied the highly aggressive and lethal VX2 carcinoma HNSCC tumor model of the New Zealand White rabbit to test whether ozone exerts anti-tumorous effects in vivo. Therapeutic insufflation of medical ozone/oxygen (O3/O2) gas mixture into the peritoneum (O3/O2-pneumoperitoneum) at an advanced stage of tumor disease led to a survival rate of 7/14 rabbits. Six of the seven surviving rabbits presented full tumor regression and the absence of local or distant lung metastases. Insufflation of pure oxygen (O2) resulted in a survival rate of 3/13 animals accompanied by full tumor remission in two of the three surviving animals. Of the fourteen sham-treated animals only one had spontaneous tumor remission and survived. No adverse effects or changes in standard blood parameters were observed after repeated intraperitoneal insufflations of the O3/O2 or O2 gas. Animals with O3/O2-induced tumor eradication developed tolerance against re-implantation of the VX2 tumor. This could be reversed by immune suppression with a combination of dexamethasone and cyclosporin A suggesting an anti-tumorous effect of O3/O2-mediated activation of the body's own immunosurveillance. Although the exact mechanisms of action are still unclear the present data point to O3/O2-pneumoperitoneum as a promising new strategy in anticancer therapy.
    • 头颈鳞状细胞癌(HNSCC)代表一组在人和动物死亡率高的转移性肿瘤。 由于发现生物分子臭氧在体外抑制各种癌细胞的生长,因此我们在这里应用了新西兰白兔的高度侵袭性和致死性的VX2癌HNSCC肿瘤模型,以测试臭氧是否在体内发挥抗肿瘤作用。 医疗臭氧/氧气(O3 / O2)气体混合物在肿瘤疾病晚期进入腹膜(O3 / O2-气腹)的治疗性吹入导致7/14兔的存活率。 七只幸存的兔子中的六只发生了完全的肿瘤消退,没有局部或远处的肺转移。 纯氧气(O2)的吹入导致3/13只动物的存活率伴随着三只存活动物中的两只全部肿瘤缓解。 在14只假手术治疗的动物中,只有1只自发性肿瘤缓解并存活。 在O3 / O2或O2气体重复腹膜内吹入后,没有观察到标准血液参数的不良反应或变化。 具有O3 / O2诱导的肿瘤根除的动物对VX2肿瘤的再植入产生耐受性。 这可以通过地塞米松和环孢菌素A的组合的免疫抑制来逆转,表明O3 / O2介导的身体自身免疫监视激活的抗肿瘤作用。 尽管确切的作用机制目前还不清楚目前的数据指向O3 / O2气腹作为抗癌治疗中有希望的新策略。
    • 8. 发明申请
    • Use of an ozone / oxygen mixture as a primary anticancer therapy via intraperitoneal insufflation
    • 使用臭氧/氧气混合物作为主要的抗癌治疗通过腹膜内吹入
    • US20100189807A1
    • 2010-07-29
    • US12320305
    • 2009-01-23
    • Jochen A. WernerAnja-Alexandra DunneRobert MandicEberhard WeiheMichael BetteSiegfried Schulz
    • Jochen A. WernerAnja-Alexandra DunneRobert MandicEberhard WeiheMichael BetteSiegfried Schulz
    • A61K33/00A61P35/00
    • A61K33/00A61K2300/00
    • Head and neck squamous cell carcinomas (HNSCC) represent a group of metastasizing tumors with a high mortality rate in man and animals. Since the biomolecule ozone was found to inhibit growth of various carcinoma cells in vitro we here applied the highly aggressive and lethal VX2 carcinoma HNSCC tumor model of the New Zealand White rabbit to test whether ozone exerts anti-tumorous effects in vivo. Therapeutic insufflation of medical ozone/oxygen (O3/O2) gas mixture into the peritoneum (O3/O2-pneumoperitoneum) at an advanced stage of tumor disease led to a survival rate of 7/14 rabbits. Six of the seven surviving rabbits presented full tumor regression and the absence of local or distant lung metastases. Insufflation of pure oxygen (O2) resulted in a survival rate of 3/13 animals accompanied by full tumor remission in two of the three surviving animals. Of the fourteen sham-treated animals only one had spontaneous tumor remission and survived. No adverse effects or changes in standard blood parameters were observed after repeated intraperitoneal insufflations of the O3/O2 or O2 gas. Animals with O3/O2-induced tumor eradication developed tolerance against re-implantation of the VX2 tumor. This could be reversed by immune suppression with a combination of dexamethasone and cyclosporin A suggesting an anti-tumorous effect of O3/O2-mediated activation of the body's own immunosurveillance. Although the exact mechanisms of action are still unclear the present data point to O3/O2-pneumoperitoneum as a promising new strategy in anticancer therapy.
    • 头颈鳞状细胞癌(HNSCC)代表一组在人和动物死亡率高的转移性肿瘤。 由于发现生物分子臭氧在体外抑制各种癌细胞的生长,因此我们在这里应用了新西兰白兔的高度侵袭性和致死性的VX2癌HNSCC肿瘤模型,以测试臭氧是否在体内发挥抗肿瘤作用。 医疗臭氧/氧气(O3 / O2)气体混合物在肿瘤疾病晚期进入腹膜(O3 / O2-气腹)的治疗性吹入导致7/14兔的存活率。 七只幸存的兔子中的六只发生了完全的肿瘤消退,没有局部或远处的肺转移。 纯氧气(O2)的吹入导致3/13只动物的存活率伴随着三只存活动物中的两只全部肿瘤缓解。 在14只假手术治疗的动物中,只有1只自发性肿瘤缓解并存活。 在O3 / O2或O2气体重复腹膜内吹入后,没有观察到标准血液参数的不良反应或变化。 具有O3 / O2诱导的肿瘤根除的动物对VX2肿瘤的再植入产生耐受性。 这可以通过地塞米松和环孢菌素A的组合的免疫抑制来逆转,表明O3 / O2介导的身体自身免疫监视激活的抗肿瘤作用。 尽管确切的作用机制目前还不清楚目前的数据指向O3 / O2气腹作为抗癌治疗中有希望的新策略。
    • 10. 发明授权
    • Temperature-dependent output control for a heat pump absorber
    • 热泵吸收器的温度依赖输出控制
    • US4364240A
    • 1982-12-21
    • US261807
    • 1981-05-08
    • Siegfried SchulzKarl-Gunter StroppelBernd Meckel
    • Siegfried SchulzKarl-Gunter StroppelBernd Meckel
    • F25B15/04F25B30/04F25B15/00
    • F25B30/04F25B15/04Y02B30/62
    • A parallel-bivalent apparatus functioning as an absorber heat pump and as a boiler for heating a heat carrying medium, includes a condenser, an evaporator, an absorber and an expeller forming the boiler. The heat carrying medium is passed through the absorber. The apparatus further includes a heat exchanger for poor and rich solutions. The heat exchanger receives poor solution from the expeller and applies the poor solution to the absorber through an expansion valve. A bypass conduit circumvents the heat exchanger and is arranged for carrying one of the solutions between the expeller and the absorber. A valve is contained in the bypass conduit for opening the bypass conduit when the flow temperature of the heat carrying medium falls below a predetermined value. Further, heat exchanging surfaces in the absorber are so dimensioned as to effect thereon condensation of flash gas generated by expansion of the poor solution upon passage through the expansion valve.
    • 用作吸收器热泵和用作加热载热介质的锅炉的平行二价装置包括冷凝器,蒸发器,吸收器和形成锅炉的推进器。 载热介质通过吸收器。 该装置还包括用于贫乏和丰富解决方案的热交换器。 热交换器从推进器接收不良溶液,并通过膨胀阀将不良溶液施加到吸收器。 旁通管道绕过热交换器并被布置成用于承载推进器和吸收器之间的一种溶液。 当传热介质的流动温度低于预定值时,旁通管道中容纳有用于打开旁通管道的阀。 此外,吸收器中的热交换表面的尺寸设计成使得在通过膨胀阀时通过膨胀不良溶液而产生的闪蒸气体的冷凝。