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1. 发明申请

US20070117771A1 VGLUT-specific dsRNA compounds 审中-公开
标题翻译： VGLUT特异性dsRNA化合物
公开(公告)号：US20070117771A1
公开(公告)日：2007-05-24
申请号：US11518284
申请日：2006-09-11
申请人： Clemens Gillen , Gregor Bahrenberg , Thomas Christoph , Eberhard Weihe , Martin Schaefer , Florian Bender
发明人： Clemens Gillen , Gregor Bahrenberg , Thomas Christoph , Eberhard Weihe , Martin Schaefer , Florian Bender
IPC分类号： A61K48/00 , C07H21/02
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/14 , C12N2799/021
摘要： VGLUT-specific dsRNAs capable of triggering the phenomenon of RNA interference, host cells containing theses dsRNAs, and pharmaceutical compositions containing these dsRNAs, in particular for the treatment of pain and other diseases associated with VGLUT family members.
摘要翻译：能够引发RNA干扰现象的VGLUT特异性dsRNA，含有这些dsRNA的宿主细胞和含有这些dsRNA的药物组合物，尤其用于治疗与VGLUT家族成员相关的疼痛和其他疾病。

2. 发明申请

US20110006261A1 USE OF AN OZONE/OXYGEN MIXTURE AS PRIMARY ANTICANCER THERAPY THROUGH INTRAPERITONEAL INSUFFLATION 审中-公开
标题翻译：使用OZY / OXYGEN混合物作为主要治疗方法通过胰岛素消融
公开(公告)号：US20110006261A1
公开(公告)日：2011-01-13
申请号：US12742490
申请日：2008-11-14
申请人： Jochen A. Werner , Anja-Alexandra Dünne , Eberhard Weihe , Michael Bette , Siegfried Schulz
发明人： Jochen A. Werner , Anja-Alexandra Dünne , Eberhard Weihe , Michael Bette , Siegfried Schulz
IPC分类号： C01B13/00
CPC分类号： A61K33/00 , A61K31/00 , A61K33/40 , A61K2300/00
摘要： Head and neck squamous cell carcinomas (HNSCC) represent a group of metastasizing tumors with a high mortality rate in man and animals. Since the biomolecule ozone was found to inhibit growth of various carcinoma cells in vitro we here applied the highly aggressive and lethal VX2 carcinoma HNSCC tumor model of the New Zealand White rabbit to test whether ozone exerts anti-tumorous effects in vivo. Therapeutic insufflation of medical ozone/oxygen (O3/O2) gas mixture into the peritoneum (O3/O2-pneumoperitoneum) at an advanced stage of tumor disease led to a survival rate of 7/14 rabbits. Six of the seven surviving rabbits presented full tumor regression and the absence of local or distant lung metastases. Insufflation of pure oxygen (O2) resulted in a survival rate of 3/13 animals accompanied by full tumor remission in two of the three surviving animals. Of the fourteen sham-treated animals only one had spontaneous tumor remission and survived. No adverse effects or changes in standard blood parameters were observed after repeated intraperitoneal insufflations of the O3/O2 or O2 gas. Animals with O3/O2-induced tumor eradication developed tolerance against re-implantation of the VX2 tumor. This could be reversed by immune suppression with a combination of dexamethasone and cyclosporin A suggesting an anti-tumorous effect of O3/O2-mediated activation of the body's own immunosurveillance. Although the exact mechanisms of action are still unclear the present data point to O3/O2-pneumoperitoneum as a promising new strategy in anticancer therapy.
摘要翻译：头颈鳞状细胞癌（HNSCC）代表一组在人和动物死亡率高的转移性肿瘤。由于发现生物分子臭氧在体外抑制各种癌细胞的生长，因此我们在这里应用了新西兰白兔的高度侵袭性和致死性的VX2癌HNSCC肿瘤模型，以测试臭氧是否在体内发挥抗肿瘤作用。医疗臭氧/氧气（O3 / O2）气体混合物在肿瘤疾病晚期进入腹膜（O3 / O2-气腹）的治疗性吹入导致7/14兔的存活率。七只幸存的兔子中的六只发生了完全的肿瘤消退，没有局部或远处的肺转移。纯氧气（O2）的吹入导致3/13只动物的存活率伴随着三只存活动物中的两只全部肿瘤缓解。在14只假手术治疗的动物中，只有1只自发性肿瘤缓解并存活。在O3 / O2或O2气体重复腹膜内吹入后，没有观察到标准血液参数的不良反应或变化。具有O3 / O2诱导的肿瘤根除的动物对VX2肿瘤的再植入产生耐受性。这可以通过地塞米松和环孢菌素A的组合的免疫抑制来逆转，表明O3 / O2介导的身体自身免疫监视激活的抗肿瘤作用。尽管确切的作用机制目前还不清楚目前的数据指向O3 / O2气腹作为抗癌治疗中有希望的新策略。

3. 发明申请

US20100189807A1 Use of an ozone / oxygen mixture as a primary anticancer therapy via intraperitoneal insufflation 审中-公开
标题翻译：使用臭氧/氧气混合物作为主要的抗癌治疗通过腹膜内吹入
公开(公告)号：US20100189807A1
公开(公告)日：2010-07-29
申请号：US12320305
申请日：2009-01-23
申请人： Jochen A. Werner , Anja-Alexandra Dunne , Robert Mandic , Eberhard Weihe , Michael Bette , Siegfried Schulz
发明人： Jochen A. Werner , Anja-Alexandra Dunne , Robert Mandic , Eberhard Weihe , Michael Bette , Siegfried Schulz
IPC分类号： A61K33/00 , A61P35/00
CPC分类号： A61K33/00 , A61K2300/00
摘要： Head and neck squamous cell carcinomas (HNSCC) represent a group of metastasizing tumors with a high mortality rate in man and animals. Since the biomolecule ozone was found to inhibit growth of various carcinoma cells in vitro we here applied the highly aggressive and lethal VX2 carcinoma HNSCC tumor model of the New Zealand White rabbit to test whether ozone exerts anti-tumorous effects in vivo. Therapeutic insufflation of medical ozone/oxygen (O3/O2) gas mixture into the peritoneum (O3/O2-pneumoperitoneum) at an advanced stage of tumor disease led to a survival rate of 7/14 rabbits. Six of the seven surviving rabbits presented full tumor regression and the absence of local or distant lung metastases. Insufflation of pure oxygen (O2) resulted in a survival rate of 3/13 animals accompanied by full tumor remission in two of the three surviving animals. Of the fourteen sham-treated animals only one had spontaneous tumor remission and survived. No adverse effects or changes in standard blood parameters were observed after repeated intraperitoneal insufflations of the O3/O2 or O2 gas. Animals with O3/O2-induced tumor eradication developed tolerance against re-implantation of the VX2 tumor. This could be reversed by immune suppression with a combination of dexamethasone and cyclosporin A suggesting an anti-tumorous effect of O3/O2-mediated activation of the body's own immunosurveillance. Although the exact mechanisms of action are still unclear the present data point to O3/O2-pneumoperitoneum as a promising new strategy in anticancer therapy.
摘要翻译：头颈鳞状细胞癌（HNSCC）代表一组在人和动物死亡率高的转移性肿瘤。由于发现生物分子臭氧在体外抑制各种癌细胞的生长，因此我们在这里应用了新西兰白兔的高度侵袭性和致死性的VX2癌HNSCC肿瘤模型，以测试臭氧是否在体内发挥抗肿瘤作用。医疗臭氧/氧气（O3 / O2）气体混合物在肿瘤疾病晚期进入腹膜（O3 / O2-气腹）的治疗性吹入导致7/14兔的存活率。七只幸存的兔子中的六只发生了完全的肿瘤消退，没有局部或远处的肺转移。纯氧气（O2）的吹入导致3/13只动物的存活率伴随着三只存活动物中的两只全部肿瘤缓解。在14只假手术治疗的动物中，只有1只自发性肿瘤缓解并存活。在O3 / O2或O2气体重复腹膜内吹入后，没有观察到标准血液参数的不良反应或变化。具有O3 / O2诱导的肿瘤根除的动物对VX2肿瘤的再植入产生耐受性。这可以通过地塞米松和环孢菌素A的组合的免疫抑制来逆转，表明O3 / O2介导的身体自身免疫监视激活的抗肿瘤作用。尽管确切的作用机制目前还不清楚目前的数据指向O3 / O2气腹作为抗癌治疗中有希望的新策略。

4. 发明申请

US20060154886A1 Regulatory elements in the 5' region of the VR1 gene 审中-公开
标题翻译： VR1基因5'区域的调节元件
公开(公告)号：US20060154886A1
公开(公告)日：2006-07-13
申请号：US11148303
申请日：2005-06-09
申请人： Eberhard Weihe , Annette Bieller , Martin Schaefer
发明人： Eberhard Weihe , Annette Bieller , Martin Schaefer
IPC分类号： A61K48/00 , C07H21/04 , C12N15/87
CPC分类号： C07K14/705 , A61K48/00
摘要： A nucleic acid comprising a sequence section which modulates the expression of the VR1 receptor, a vector containing this nucleic acid and a host cell which is transformed with this vector are disclosed, along with related pharmaceutical formulations. Methods for modulating the expression of the VR1 receptor and the use of the nucleic acid or vector for alleviating, preventing or treating pain and for treating sensibility disorders associated with the VR1 receptor are also provided.
摘要翻译：公开了包含调节VR1受体的表达的序列部分的核酸，含有该核酸的载体和用该载体转化的宿主细胞以及相关的药物制剂。还提供了调节VR1受体表达的方法以及用于减轻，预防或治疗疼痛和用于治疗与VR1受体相关的感觉性障碍的核酸或载体的用途。

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