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    • 2. 发明授权
    • Amino acid derivatives and anti-inflammatory agents
    • 氨基酸衍生物和抗炎剂
    • US06552061B1
    • 2003-04-22
    • US09285390
    • 1999-04-02
    • Manabu KitazawaKeiji IwasakiEiji Shiojiri
    • Manabu KitazawaKeiji IwasakiEiji Shiojiri
    • C07C22928
    • C07D233/64C07C229/14C07C229/22C07C229/34C07C237/06C07C237/20C07D207/28
    • Provided are an anti-inflammatory agent containing, as an active ingredient, at least one selected from amino acid derivatives represented by formula (I) wherein Ar represents an optionally substituted 2-hydroxyaryl group, n is 0 or 1, R2 represents a hydrogen atom or a side chain of an &agr;-amino acid or &bgr;-amino acid, X represents —O— or —NH—, R1 represents a hydrogen atom or a group that forms, together with R2 and an adjacent atoms, a cyclic structure of pyroglutamic acid, and R3 represents a hydrogen atom, an alkyl group having from 1 to 22 carbon atoms or an alkenyl group having from 2 to 22 carbon atoms, and salts thereof, and toiletries or skin external products containing the same. The anti-inflammatory agent of the invention inhibits expression of an inflammatory protein and activation of a gene transcription control factor that participates therein, and exhibits a good feeling upon use and a safety.
    • 提供含有选自由式(I)表示的氨基酸衍生物中的至少一种作为活性成分的抗炎剂,其中Ar表示任选取代的2-羟基芳基,n为0或1,R 2表示氢原子 或α-氨基酸或β-氨基酸的侧链,X表示-O-或-NH-,R1表示氢原子或与R2和相邻原子一起形成焦谷氨酸的环状结构的基团 酸,R3表示氢原子,具有1至22个碳原子的烷基或具有2至22个碳原子的烯基,以及其盐,以及含有它们的化妆品或皮肤外用产品。 本发明的抗炎剂抑制炎症蛋白的表达和参与其中的基因转录控制因子的活化,并且在使用时表现出良好的感觉和安全性。