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1. 发明授权

US07456256B2 BGS 4 失效
公开(公告)号：US07456256B2
公开(公告)日：2008-11-25
申请号：US11726220
申请日：2007-03-21
申请人： Shujian Wu , Stanley R. Krystek, Jr. , Liana M. Lee , John N. Feder , Janet D. Cheng
发明人： Shujian Wu , Stanley R. Krystek, Jr. , Liana M. Lee , John N. Feder , Janet D. Cheng
IPC分类号： C07K14/47 , C12N15/07 , C12N15/64 , C12P21/02
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides novel polynucleotides encoding BGS-2, 3, and 4 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing the polypeptides of the present invention. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-2, 3, and 4 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码BGS-2,3和4多肽的新型多核苷酸，其片段及其同源物。还提供载体，宿主细胞，抗体，以及用于产生本发明多肽的重组和合成方法。本发明还涉及将这些新型BGS-2,3和4多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

2. 发明授权

US07705134B2 Antibodies that bind to BGS-4 失效
标题翻译：与BGS-4结合的抗体
公开(公告)号：US07705134B2
公开(公告)日：2010-04-27
申请号：US12283245
申请日：2008-09-10
申请人： Shujian Wu , Stanley R. Krystek, Jr. , Liana M. Lee , John N. Feder , Janet D. Cheng
发明人： Shujian Wu , Stanley R. Krystek, Jr. , Liana M. Lee , John N. Feder , Janet D. Cheng
IPC分类号： C07K16/18 , C07K14/47 , C12P21/02 , C12N15/63
CPC分类号： C07K14/705 , A61K38/00
摘要： The present invention provides novel polynucleotides encoding BGS-4 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing the polypeptides of the present invention. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-4 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码BGS-4多肽的新型多核苷酸，其片段和同源物。还提供载体，宿主细胞，抗体，以及用于产生本发明多肽的重组和合成方法。本发明还涉及将这些新型BGS-4多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

3. 发明授权

US07309779B2 Antibodies directed to the testis-specific tubulin tyrosine-ligase-like protein, BGS42 有权
标题翻译：针对睾丸特异性微管蛋白酪氨酸连接酶样蛋白BGS42的抗体
公开(公告)号：US07309779B2
公开(公告)日：2007-12-18
申请号：US11445988
申请日：2006-06-02
申请人： John N. Feder , Shujian Wu , Thomas C. Nelson , Liana M. Lee
发明人： John N. Feder , Shujian Wu , Thomas C. Nelson , Liana M. Lee
IPC分类号： C07K16/40 , C12N5/12
CPC分类号： C12N9/93 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K2319/00 , G01N33/57423 , G01N2333/9015 , Y10S435/81
摘要： The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码BGS-42多肽的新型多核苷酸，其片段和同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型BGS-42多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

4. 发明授权

US07273706B2 Method of diagnosing testicular tumors using polynucleotides encoding a novel testis-specific tubulin tyrosine-ligase-like protein, BGS42 有权
标题翻译：使用编码新型睾丸特异性微管蛋白酪氨酸连接酶样蛋白BGS42的多核苷酸诊断睾丸肿瘤的方法
公开(公告)号：US07273706B2
公开(公告)日：2007-09-25
申请号：US11496357
申请日：2006-07-31
申请人： John N. Feder , Shujian Wu , Thomas C. Nelson , Liana M. Lee
发明人： John N. Feder , Shujian Wu , Thomas C. Nelson , Liana M. Lee
IPC分类号： C12Q1/68 , C12N9/00 , C12N15/00 , C12N1/20
CPC分类号： C12N9/93 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K2319/00 , G01N33/57423 , G01N2333/9015 , Y10S435/81
摘要： The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码BGS-42多肽的新型多核苷酸，其片段和同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型BGS-42多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

5. 发明授权

US07741025B2 Method of diagnosing lung cancer using BGS42 有权
标题翻译：使用BGS42诊断肺癌的方法
公开(公告)号：US07741025B2
公开(公告)日：2010-06-22
申请号：US11900344
申请日：2007-09-10
申请人： John N. Feder , Shujian Wu , Thomas C. Nelson , Liana M. Lee
发明人： John N. Feder , Shujian Wu , Thomas C. Nelson , Liana M. Lee
IPC分类号： C12Q1/70 , C12Q1/68
CPC分类号： C12N9/93 , A01K2217/05 , A01K2217/075 , A61K38/00 , C07K2319/00 , G01N33/57423 , G01N2333/9015 , Y10S435/81
摘要： The present invention provides novel polynucleotides encoding BGS-42 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel BGS-42 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码BGS-42多肽的新型多核苷酸，其片段和同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型BGS-42多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

6. 发明授权

US07767418B2 Polynucleotide encoding a novel TRP channel family member, LTRPC3, and splice variants thereof 有权
标题翻译：编码新型TRP通道家族成员的多核苷酸，LTRPC3及其剪接变体
公开(公告)号：US07767418B2
公开(公告)日：2010-08-03
申请号：US12152547
申请日：2008-05-15
申请人： Ning Lee , Jian Chen , John N. Feder , Shujian Wu , Liana M. Lee , Michael A. Blanar
发明人： Ning Lee , Jian Chen , John N. Feder , Shujian Wu , Liana M. Lee , Michael A. Blanar
IPC分类号： C12P21/06 , C12N15/00 , C07K1/00 , C07H21/02
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00
摘要： The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f, respectively. Also provided are vectors, host cells, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码LTRPC3多肽的新型多核苷酸，其片段及其同源物。本发明还提供了分别编码LTRPC3多肽，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f的变体和剪接变体的多核苷酸。还提供载体，宿主细胞，以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型LTRPC3，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

7. 发明授权

US07504481B2 TRP channel family member, LTRPC3 polypeptides 有权
标题翻译： TRP频道家庭成员，LTRPC3e
公开(公告)号：US07504481B2
公开(公告)日：2009-03-17
申请号：US10405793
申请日：2003-03-28
申请人： Ning Lee , Jian Chen , John N. Feder , Shujian Wu , Liana M. Lee , Michael A. Blanar
发明人： Ning Lee , Jian Chen , John N. Feder , Shujian Wu , Liana M. Lee , Michael A. Blanar
IPC分类号： C07K1/00 , C12P21/06 , C12P21/04 , C12N15/00 , A61K39/00
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00
摘要： The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing the novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码LTRPC3多肽的新型多核苷酸，其片段及其同源物。本发明还提供了分别编码LTRPC3多肽，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f的变体和剪接变体的多核苷酸。还提供了用于产生新型LTRPC3，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f多肽的载体，宿主细胞，抗体以及重组和合成方法。本发明还涉及将这些新型LTRPC3，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

8. 发明申请

US20080274505A1 Polynucleotide encoding a novel TRP channel family member, LTRPC3, and splice variants thereof 有权
标题翻译：编码新型TRP通道家族成员的多核苷酸，LTRPC3及其剪接变体
公开(公告)号：US20080274505A1
公开(公告)日：2008-11-06
申请号：US12152547
申请日：2008-05-15
申请人： Ning Lee , Jian Chen , John N. Feder , Shujian Wu , Liana M. Lee , Michael A. Blanar , David Bol , Paul C. Lavesque , Lucy Sun
发明人： Ning Lee , Jian Chen , John N. Feder , Shujian Wu , Liana M. Lee , Michael A. Blanar , David Bol , Paul C. Lavesque , Lucy Sun
IPC分类号： C12N15/12 , C12N15/63 , C12P21/00 , C12N5/10
CPC分类号： C07K14/705 , A61K38/00 , C07K2319/00
摘要： The present invention provides novel polynucleotides encoding LTRPC3 polypeptides, fragments and homologues thereof. The present invention also provides polynucleotides encoding variants and splice variants of LTRPC3 polypeptides, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f, respectively. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying these novel LTRPC3, LTRPC3b, LTRPC3c, LTRPC3d, LTRPC3e, and LTRPC3f polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码LTRPC3多肽的新型多核苷酸，其片段及其同源物。本发明还提供了分别编码LTRPC3多肽，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f的变体和剪接变体的多核苷酸。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将这些新型LTRPC3，LTRPC3b，LTRPC3c，LTRPC3d，LTRPC3e和LTRPC3f多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

9. 发明授权

US07202056B2 Polynucleotides encoding a human cell surface protein with immunoglobulin folds, BGS-19 有权
标题翻译：编码具有免疫球蛋白折叠的人细胞表面蛋白的多核苷酸，BGS-19
公开(公告)号：US07202056B2
公开(公告)日：2007-04-10
申请号：US10403938
申请日：2003-03-28
申请人： Liana M. Lee , John N. Feder , Shujian Wu , Jian Chen
发明人： Liana M. Lee , John N. Feder , Shujian Wu , Jian Chen
IPC分类号： C12P21/06 , C12N15/87 , C12N1/20 , C12N15/74 , C07H21/04
CPC分类号： C07K14/705 , A61K38/00 , C07K14/70503
摘要： The present invention provides novel polynucleotides encoding BGS-19 polypeptides, fragments and homologues thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to diagnostic and therapeutic methods for applying the novel BGS-19 polypeptides to the diagnosis, treatment, and/or prevention of various diseases and/or disorders related to these polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention.
摘要翻译：本发明提供了编码BGS-19多肽的新型多核苷酸，其片段和同源物。还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。本发明还涉及将新型BGS-19多肽应用于诊断，治疗和/或预防与这些多肽相关的各种疾病和/或病症的诊断和治疗方法。本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。

10. 发明授权

US07521044B2 Human histone deacetylase, HDAC9c 有权
标题翻译：人组蛋白脱乙酰酶HDAC9c
公开(公告)号：US07521044B2
公开(公告)日：2009-04-21
申请号：US11497205
申请日：2006-08-01
申请人： Donald G. Jackson , Matthew V. Lorenzi , Liana M. Lee , John N. Feder
发明人： Donald G. Jackson , Matthew V. Lorenzi , Liana M. Lee , John N. Feder
IPC分类号： A61K38/43 , C12N9/00 , C07K14/00
CPC分类号： C12N9/16
摘要： The present invention relates to newly discovered human histone deacetylases (HDACs), also referred to as histone deacetylase-like polypeptides. The polynucleotide sequences and encoded polypeptides of the novel HDACs are encompassed by the invention, as well as vectors comprising these polynucleotides and host cells comprising these vectors. The invention also relates to antibodies that bind to the disclosed HDAC polypeptides, and methods employing these antibodies. Also related are methods of screening for modulators, such as inhibitors or antagonists, or agonists. The invention also relates to diagnostic and therapeutic applications which employ the disclosed HDAC polynucleotides, polypeptides, and antibodies, and HDAC modulators. Such applications can be used with diseases and disorders associated with abnormal cell growth or proliferation, cell differentiation, and cell survival, e.g., neoplastic cell growth, and especially breast and prostate cancers or tumors.
摘要翻译：本发明涉及新发现的人类组蛋白脱乙酰酶（HDAC），也称为组蛋白脱乙酰酶样多肽。本发明涵盖了新型HDAC的多核苷酸序列和编码多肽，以及包含这些多核苷酸的载体和包含这些载体的宿主细胞。本发明还涉及结合所公开的HDAC多肽的抗体以及使用这些抗体的方法。还涉及筛选调节剂的方法，例如抑制剂或拮抗剂或激动剂。本发明还涉及使用所公开的HDAC多核苷酸，多肽和抗体以及HDAC调节剂的诊断和治疗应用。这种应用可以用于与异常细胞生长或增殖，细胞分化和细胞存活相关的疾病和病症，例如肿瘤细胞生长，特别是乳腺癌和前列腺癌或肿瘤。

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