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1. 发明授权

US08883495B2 Human T-cell population 有权
标题翻译：人类T细胞群体
公开(公告)号：US08883495B2
公开(公告)日：2014-11-11
申请号：US12282977
申请日：2007-03-15
申请人： Shuji Nakamura , Ryuichi Motoda , Masayoshi Kibata , Kunzo Orita , Fumiyuki Yamasaki
发明人： Shuji Nakamura , Ryuichi Motoda , Masayoshi Kibata , Kunzo Orita , Fumiyuki Yamasaki
IPC分类号： C12N5/00 , A61K35/14 , C12N5/0783 , A61K35/12
CPC分类号： C12N5/0636 , A61K35/17 , A61K2035/122 , A61K2300/00
摘要： The present invention has objects to provide a novel human T-cell population having both cytotoxic and immunosuppressive activities, and to a method for preparing the same. The above objects are attained by providing a human T-cell population which is obtainable by coculturing mononuclear cells, collected from human blood, with stroma cells and which has the following features: (1) being positive for CD3, CD25, CD28 and T-cell antigen receptor αβ; (2) essentially consisting of three groups of a CD4 positive and CD8 positive (CD4+CD8+) T-cell group, a CD4 positive and CD8 dimly positive (CD4+CD8dim) T-cell group, and a CD4 negative and CD8 positive (CD4−CD8+) T-cell group; (3) exerting a cytotoxic activity against the cocultured stroma cells; and (4) exerting an immunosuppressive activity against activated T cells.
摘要翻译：本发明的目的是提供具有细胞毒性和免疫抑制活性两者的新型人T细胞群及其制备方法。上述目的是通过提供通过共培养从人血液收集的单核细胞与基质细胞获得的人类T细胞群而获得的，并且具有以下特征：（1）对于CD3，CD25，CD28和T- 细胞抗原受体α＆bgr; （2）基本上由CD4阳性和CD8阳性（CD4 + CD8 +）T细胞组，CD4阳性和CD8阳性（CD4 + CD8dim）T细胞组和CD4阴性和CD8阳性（CD4 + CD4-CD8 +）T细胞组; （3）对共培养的基质细胞发挥细胞毒活性; 和（4）对活化的T细胞施加免疫抑制活性。

2. 发明申请

US20090297490A1 NOVEL HUMAN T-CELL POPULATION 有权
标题翻译：新人类T细胞人口
公开(公告)号：US20090297490A1
公开(公告)日：2009-12-03
申请号：US12282977
申请日：2007-03-15
申请人： Shuji Nakamura , Ryuichi Motoda , Masayoshi Kibata , Kunzo Orita , Fumiyuki Yamasaki
发明人： Shuji Nakamura , Ryuichi Motoda , Masayoshi Kibata , Kunzo Orita , Fumiyuki Yamasaki
IPC分类号： A61K35/12 , C12N5/08
CPC分类号： C12N5/0636 , A61K35/17 , A61K2035/122 , A61K2300/00
摘要： The present invention has objects to provide a novel human T-cell population having both cytotoxic and immunosuppressive activities, and to a method for preparing the same. The above objects are attained by providing a human T-cell population which is obtainable by coculturing mononuclear cells, collected from human blood, with stroma cells and which has the following features: (1) being positive for CD3, CD25, CD28 and T-cell antigen receptor αβ; (2) essentially consisting of three groups of a CD4 positive and CD8 positive (CD4+CD8−) T-cell group, a CD4 positive and CD8 dimly positive (CD4+CD8dim) T-cell group, and a CD4 negative and CD8 positive (CD4−CD8+) T-cell group; (3) exerting a cytotoxic activity against the cocultured stroma cells; and (4) exerting an immunosuppressive activity against activated T cells.
摘要翻译：本发明的目的是提供具有细胞毒性和免疫抑制活性两者的新型人T细胞群及其制备方法。上述目的是通过提供通过共培养从人血液收集的单核细胞与基质细胞获得的人类T细胞群而获得的，并且具有以下特征：（1）对于CD3，CD25，CD28和T- 细胞抗原受体（2）基本上由CD4阳性和CD8阳性（CD4 + CD8-）T细胞组，CD4阳性和CD8阳性（CD4 + CD8dim）T细胞组和CD4阴性和CD8阳性三组组成（CD4-CD8 +）T细胞组; （3）对共培养的基质细胞发挥细胞毒活性; 和（4）对活化的T细胞施加免疫抑制活性。

3. 发明授权

US07015308B1 Hedgehog protein 失效
公开(公告)号：US07015308B1
公开(公告)日：2006-03-21
申请号：US09063778
申请日：1998-04-22
申请人： Toshio Ariyasu , Shuji Nakamura , Kunzo Orita
发明人： Toshio Ariyasu , Shuji Nakamura , Kunzo Orita
IPC分类号： C07K14/475
CPC分类号： C07K14/47 , A61K38/00 , C07K16/18
摘要： Disclosed are a novel hedgehog protein, i.e., a Desert hedgehog protein of human origin including mature and precursor forms, a DNA encoding the protein, a monoclonal antibody recognizing the protein, a process for producing the protein, and a method for detecting the protein. The hedgehog protein is useful in establishment of hybridomas which produce antibodies recognizing the protein, and the monoclonal antibody is useful in detection and purification of the protein. The hedgehog protein, DNA, and monoclonal antibody of this invention have efficacy in elucidation of hereditary morphological abnormalities in humans to establish their treatments and diagnoses.

4. 发明授权

US07098026B1 Human desert hedgehog protein 失效
标题翻译：人类沙漠刺猬蛋白
公开(公告)号：US07098026B1
公开(公告)日：2006-08-29
申请号：US09617545
申请日：2000-07-14
申请人： Toshio Ariyasu , Shuji Nakamura , Kunzo Orita
发明人： Toshio Ariyasu , Shuji Nakamura , Kunzo Orita
IPC分类号： C12N5/00
CPC分类号： C07K14/47 , A61K38/00 , C07K16/18
摘要： Disclosed are a novel hedgehog protein, i.e., a Desert hedgehog protein of human origin including mature and precursor forms, a DNA encoding the protein, a monoclonal antibody recognizing the protein, a process for producing the protein, and a method for detecting the protein. The hedgehog protein is useful in establishment of hybridomas which produce antibodies recognizing the protein, and the monoclonal antibody is useful in detection and purification of the protein. The hedgehog protein, DNA, and monoclonal antibody of this invention have efficacy in elucidation of hereditary morphological abnormalities in humans to establish their treatments and diagnoses.
摘要翻译：公开了一种新颖的刺猬蛋白，即人源的沙漠刺猬蛋白，包括成熟和前体形式，编码蛋白质的DNA，识别蛋白质的单克隆抗体，产生蛋白质的方法和检测蛋白质的方法。刺猬蛋白可用于产生识别蛋白质的抗体的杂交瘤的建立，并且单克隆抗体可用于蛋白质的检测和纯化。本发明的刺猬蛋白，DNA和单克隆抗体具有阐明人类遗传性形态学异常以确定其治疗和诊断的功效。

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