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1. 发明授权

US5038839A Filling apparatus 失效
标题翻译：灌装机
公开(公告)号：US5038839A
公开(公告)日：1991-08-13
申请号：US380599
申请日：1989-07-17
申请人： Shuji Morimoto , Haruhiko Yoshida , Masakazu Oi , Jotaro Kishimoto , Seiji Ohtani
发明人： Shuji Morimoto , Haruhiko Yoshida , Masakazu Oi , Jotaro Kishimoto , Seiji Ohtani
IPC分类号： G01G13/29 , G01G15/00
CPC分类号： G01G15/006 , G01G13/2943
摘要： A filling machine provided with a filling amount weighing apparatus which is used in a step of preparing medical supplies and so on, and continuously fills automatically powder, liquid or the like of a very small amount into a container such as vial, ampul or the like so as to weigh the filling amount, on the employment of an electronic balance to effect a weighing operation of high speed and precision so as to improve the filling amount accuracy through the reduction in dispersion in the filling amount.
摘要翻译：一种填充机，设置有用于制备医疗用品等的步骤中的填充量计量装置，并且将少量的粉末，液体等自动连续填充到小瓶，安瓿等容器中以便对使用电子天平进行称量，以进行高速精确的称重操作，从而通过减少填充量的分散来提高填充量的精度。

2. 发明授权

US5865799A Prefilled syringe 失效
标题翻译：预充注射器
公开(公告)号：US5865799A
公开(公告)日：1999-02-02
申请号：US899053
申请日：1997-07-23
申请人： Nobuo Tanaka , Jotaro Kishimoto , Kotaro Wakamatsu , Takayuki Hagihara , Seiji Ohtani
发明人： Nobuo Tanaka , Jotaro Kishimoto , Kotaro Wakamatsu , Takayuki Hagihara , Seiji Ohtani
IPC分类号： A61M5/28 , A61M5/31 , A61M5/315 , A61M37/00
CPC分类号： A61M5/31596 , A61M5/284 , A61M5/315 , A61M5/31511 , A61M2005/3132 , A61M5/31505 , A61M5/31513
摘要： A prefilled syringe capable of separate storage of different substances before use. It includes a tubular body having an injection needle at one end and a plunger at the other end, and a partition axially slidable in the tubular body. The partition includes a front part and a rear part independent of each other, and as a whole divides the interior space of the tubular body into a front compartment and a rear compartment in a sealing manner for storing mutually different substances. A bypass is disposed generally between the front and rear compartments to introduce the substance in the rear compartment into the front compartment when the partition is slid under pressure provided by the plunger to be adjacent to the bypass to thereby mix the substances immediately prior to injection.
摘要翻译：一种预充式注射器，可在使用前分离储存不同物质。它包括管状体，其一端具有注射针，另一端具有柱塞，以及在管状体中可轴向滑动的分隔件。分隔件包括彼此独立的前部和后部，并且整体上以密封方式将管状体的内部空间分隔成前隔室和后隔间以存储彼此不同的物质。旁路通常设置在前隔室和后隔室之间，以便当隔板在由柱塞提供的压力下滑动以邻近旁路时将后部隔室中的物质引入前隔室，从而在注射之前立即混合物质。

3. 发明授权

US5817056A Prefilled syringe 失效
标题翻译：预充注射器
公开(公告)号：US5817056A
公开(公告)日：1998-10-06
申请号：US711936
申请日：1996-09-11
申请人： Nobuo Tanaka , Jotaro Kishimoto , Kotaro Wakamatsu , Takayuki Hagihara , Seiji Ohtani
发明人： Nobuo Tanaka , Jotaro Kishimoto , Kotaro Wakamatsu , Takayuki Hagihara , Seiji Ohtani
IPC分类号： A61M5/28 , A61M5/31 , A61M5/315 , A61M37/00
CPC分类号： A61M5/31596 , A61M5/284 , A61M5/315 , A61M5/31511 , A61M2005/3132 , A61M5/31505 , A61M5/31513
摘要： A prefilled syringe capable of separate storage of different substances before use. It includes a tubular body having an injection needle at one end and a plunger at the other end, and a partition slidable axially in the tubular body. The partition includes a front part and a rear part independent of each other, and as a whole dividing the interior space of the tubular body into a front compartment and a rear compartment in a sealing manner for storing mutually different substances. A bypass is disposed generally between the front and rear compartments to introduce the substance in the rear compartment into the front compartment when the partition is slid under pressure provided by the plunger to be adjacent to the bypass to thereby mix the substances immediately prior to injection.
摘要翻译：一种预充式注射器，可在使用前分离储存不同物质。它包括一个管状体，其一端具有注射针，在另一端具有一个柱塞，以及在该管状体中可轴向滑动的分隔件。分隔件包括彼此独立的前部和后部，并且整体上以密封方式将管状体的内部空间分隔成前隔室和后隔间以存储彼此不同的物质。旁路通常设置在前隔室和后隔室之间，以便当隔板在由柱塞提供的压力下滑动以邻近旁路时将后部隔室中的物质引入前隔室，从而在注射之前立即混合物质。

4. 发明授权

US5605542A Prefilled syringe 失效
标题翻译：预充注射器
公开(公告)号：US5605542A
公开(公告)日：1997-02-25
申请号：US557517
申请日：1995-11-14
申请人： Nobuo Tanaka , Jotaro Kishimoto , Kotaro Wakamatsu , Takayuki Hagihara , Seiji Ohtani
发明人： Nobuo Tanaka , Jotaro Kishimoto , Kotaro Wakamatsu , Takayuki Hagihara , Seiji Ohtani
IPC分类号： A61M5/28 , A61M5/31 , A61M5/315 , A61M37/00
CPC分类号： A61M5/31596 , A61M5/284 , A61M5/315 , A61M5/31511 , A61M2005/3132 , A61M5/31505 , A61M5/31513
摘要： A prefilled syringe is capable of separate storage of different substances before use. It includes a tubular body having an injection needle at one end and a plunger at the other end, and a partition axially slidable in the tubular body. The partition includes a front part and a rear part independent of each other, and as a whole divides the interior space of the tubular body into a front compartment and a rear compartment in a sealing manner for storing mutually different substances. A bypass is disposed generally between the front and rear compartments to introduce the substance in the rear compartment into the front compartment when the partition is slid under pressure provided by the plunger to be adjacent to the bypass to thereby mix the substances immediately prior to injection.
摘要翻译：预充式注射器在使用前能够分离储存不同的物质。它包括管状体，其一端具有注射针，另一端具有柱塞，以及在管状体中可轴向滑动的分隔件。分隔件包括彼此独立的前部和后部，并且整体上以密封方式将管状体的内部空间分隔成前隔室和后隔间以存储彼此不同的物质。旁路通常设置在前隔室和后隔室之间，以便当隔板在由柱塞提供的压力下滑动以邻近旁路时将后部隔室中的物质引入前隔室，从而在注射之前立即混合物质。

5. 发明授权

US4895274A Auger feeder 失效
标题翻译：螺旋进料器
公开(公告)号：US4895274A
公开(公告)日：1990-01-23
申请号：US204524
申请日：1988-06-09
申请人： Shuji Morimoto , Hiyoshi Doi , Seiji Ohtani
发明人： Shuji Morimoto , Hiyoshi Doi , Seiji Ohtani
IPC分类号： B65B1/12
CPC分类号： B65B1/12
摘要： An auger feeder suitable for use in subdividing and feeding of powdery particles such as precious medicines in a trace amount, because the component parts of the auger feeder can be easily disassembled for sterilization treatment before use. In addition, it can be prevented owing to the electric detection system in the auger feeder of the present invention that foreign particles resulting from the contact or the friction between the components are mixed with the powdery particles.

6. 发明授权

US5891087A Mixing syringe 失效
标题翻译：混合注射器
公开(公告)号：US5891087A
公开(公告)日：1999-04-06
申请号：US818679
申请日：1997-03-14
申请人： Seiji Ohtani , Nobuo Tanaka , Katsuyuki Yokokawa , Teruo Matsuda
发明人： Seiji Ohtani , Nobuo Tanaka , Katsuyuki Yokokawa , Teruo Matsuda
IPC分类号： A61M5/28 , A61M5/31 , A61M5/315 , A61M37/00
CPC分类号： A61M5/284 , A61M5/31511 , A61M2005/3101 , A61M2005/3121 , A61M2005/3132 , A61M5/31501 , A61M5/31505
摘要： Behind a slidable end sealing member 3c, there is provided a liquid-absorbing element M which has a liquid-holding function so as to absorb and hold a liquid L flowing out from the end sealing member 3c when the end sealing member passes over a bypass portion 6. As this liquid-absorbent element M, such as a disk-like element D and a cylindrical element R, are typically impregnated with a water-holding and liquid-absorbing accelerator to enhance a leak preventing effect and with an antimicrobial active agent to enhance hygiene.
摘要翻译：在可滑动端部密封构件3c的后面，设置有液体吸收元件M，其具有液体保持功能，以便当端部密封构件通过旁路时吸收并保持从端部密封构件3c流出的液体L. 作为这样的液体吸收元件M，例如圆盘状元件D和圆柱形元件R，通常浸渍有吸水和吸液促进剂，以增强防漏效果，并具有抗微生物活性剂加强卫生。

7. 发明授权

US5851451A Production of microspheres 失效
标题翻译：生产微球
公开(公告)号：US5851451A
公开(公告)日：1998-12-22
申请号：US766611
申请日：1996-12-13
申请人： Nobuyuki Takechi , Seiji Ohtani , Akihiro Nagai
发明人： Nobuyuki Takechi , Seiji Ohtani , Akihiro Nagai
IPC分类号： A61K9/16 , A61K9/50 , A61K9/52
CPC分类号： A61K9/1647 , A61K9/1694 , Y10S514/937 , Y10S514/938
摘要： Disclosed is a method of producing microspheres which comprises subjecting a w/o/w emulsion or o/w emulsion to an in-water drying method under the following conditions: 1) the amount of microspheres per m.sup.3 of an external aqueous phase is about 0.1 to about 500 kg, 2) the square root of the area (unit: m.sup.2) of the liquid surface in contact with the gas phase is about 0.2 to about 4.5 per the cube root of the volume (unit: m.sup.3) of an external aqueous phase, 3) the w/o/w emulsion or o/w emulsion is replaced at the replacement frequency of about 0.01 to about 10 times/minutes, 4) a gas is blown to the w/o/w emulsion or o/w emulsion at the gas transfer rate near the liquid surface of about 0.1 to about 300 m/second, and 5) the gas is replaced at the replacement frequency of not less than about 0.5 times/minutes; and the method of the present invention increases the rate of solvent removal from microspheres in in-water drying, reduces the amount of solvent in microspheres in a short time.
摘要翻译：公开了一种制备微球体的方法，其包括在以下条件下使w / o / w乳液或o / w乳液进行水中干燥方法：1）每m3外部水相的微球体的量为约0.1至约500kg，2）与气相接触的液面的面积（单位：m2）的平方根相对于外部水相的体积的立方根（单位：m3）为约0.2〜约4.5 ，3）w / o / w乳液或o / w乳液以约0.01至约10次/分钟的替换频率替换，4）将气体吹入w / o / w乳液或o / w乳液在液体表面附近的气体传输速率为约0.1至约300m /秒，以及5）以不小于约0.5次/分钟的替换频率更换气体; 并且本发明的方法增加了水中干燥中微球溶剂去除速率，在短时间内减少了微球中的溶剂量。

8. 发明授权

US5078542A Apparatus to prevent the entrance of aquatic species into the intake watercourse 失效
标题翻译：防止水生物种进入进水道的装置
公开(公告)号：US5078542A
公开(公告)日：1992-01-07
申请号：US658902
申请日：1991-02-23
申请人： Tohru Yoshikawa , Syohei Shimodaira , Mamoru Abe , Hidehiko Maehata , Hiroaki Arai , Hiroyuki Daiku , Masanori Tsukahara , Seiji Ohtani
发明人： Tohru Yoshikawa , Syohei Shimodaira , Mamoru Abe , Hidehiko Maehata , Hiroaki Arai , Hiroyuki Daiku , Masanori Tsukahara , Seiji Ohtani
IPC分类号： E02B1/00 , E02B9/04
CPC分类号： E02B1/006 , Y02E10/22
摘要： The present invention provides an apparatus to prevent the entrance of aquatic species into the intake watercourse having a U-shaped cross section with a narrow bottom and a wide surface, in which oppositely facing electrodes are installed vertically along the side walls on both sides of the intake watercourse, and the distance between the upper ends of the electrodes is made greater than the distance between the lower ends of the electrodes, and a voltage is impressed between the both electrodes. Since the electric barrier intensity is smallest at the surface of water and becomes greater as it goes toward the bottom of water, the river fish moving around the bottom of water make a U-turn when they reach the strong electric barrier, or alternatively, after reaching the strong electric barrier, they move upward to where the electric barrier is weaker and then make a U-turn, thereby the entrance of aquatic species into the intake watercourse can be prevented.
摘要翻译：本发明提供了一种防止水生物质进入具有窄底部和宽表面的U形横截面的进水道的装置，其中相对的电极沿着沿着侧壁的两侧的侧壁垂直地安装进气道和电极上端之间的距离大于电极下端之间的距离，并且在两个电极之间施加电压。由于水面表面的电阻势强度最小，随着水底部的电阻势强度越来越大，当水流到达强电隔离区时，沿着水底移动的河流变为U型，达到强大的电气屏障，向上移动到电屏障较弱的地方，然后进行U型转弯，从而可以防止水生物种进入进水道。

9. 发明授权

US6036976A Sustained release microspheres and preparation thereof 有权
标题翻译：缓释微球及其制备方法
公开(公告)号：US6036976A
公开(公告)日：2000-03-14
申请号：US154164
申请日：1998-09-16
申请人： Nobuyuki Takechi , Seiji Ohtani , Akihiro Nagai
发明人： Nobuyuki Takechi , Seiji Ohtani , Akihiro Nagai
IPC分类号： A61K9/16 , A61K9/42
CPC分类号： A61K9/1647 , A61K9/1694 , Y10S514/937 , Y10S514/938
摘要： Disclosed is a method of producing microspheres which comprises subjecting a w/o/w emulsion or o/w emulsion to an in-water drying method under the following conditions:1) the amount of microspheres per m.sup.3 of an external aqueous phase is about 0.1 to about 500 kg,2) the square root of the area (unit: m.sup.2) of the liquid surface in contact with the gas phase is about 0.2 to about 4.5 per the cube root of the volume (unit: m.sup.3) of an external aqueous phase,3) the w/o/w emulsion or o/w emulsion is replaced at the replacement frequency of about 0.01 to about 10 times/minutes,4) a gas is blown to the w/o/w emulsion or o/w emulsion at the gas transfer rate near the liquid surface of about 0.1 to about 300 m/second, and5) the gas is replaced at the replacement frequency of not less than about 0.5 times/minutes;and the method of the present invention increases the rate of solvent removal from microspheres in in-water drying, reduces the amount of solvent in microspheres in a short time.
摘要翻译：公开了一种制备微球体的方法，其包括在以下条件下使w / o / w乳液或o / w乳液进行水中干燥方法：1）每m3外部水相的微球体的量为约0.1至约500kg，2）与气相接触的液面的面积（单位：m2）的平方根相对于外部水相的体积的立方根（单位：m3）为约0.2〜约4.5 ，3）w / o / w乳液或o / w乳液以约0.01至约10次/分钟的替换频率替换，4）将气体吹入w / o / w乳液或o / w乳液在液体表面附近的气体传输速率为约0.1至约300m /秒，以及5）以不小于约0.5次/分钟的替换频率更换气体; 并且本发明的方法增加了水中干燥中微球溶剂去除速率，在短时间内减少了微球中的溶剂量。

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