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    • 3. 发明授权
    • Aza-bridged-ring compound
    • 氮杂桥环化合物
    • US08367696B2
    • 2013-02-05
    • US12524758
    • 2008-02-08
    • Shinya NagashimaToru KontaniHiroshi NagataYuji MatsushimaHisao HamaguchiTadatsura Koshika
    • Shinya NagashimaToru KontaniHiroshi NagataYuji MatsushimaHisao HamaguchiTadatsura Koshika
    • A61K31/439C07D221/00C07D221/02
    • C07D453/02C07D471/18
    • [PROBLEMS] Provided is a compound which has an antagonistic action on a muscarinic M3 receptor and is useful as an active ingredient of a prophylactic and/or therapeutic agent for an inflammatory disease such as a chronic obstructive pulmonary disease (COPD), asthma and the like.[MEANS For SOLVING PROBLEMS] The present inventors have made studies on a compound having an antagonistic action on the binding of a muscarinic M3 receptor, and they have found that an aza-bridged-ring compound or a salt thereof has an antagonistic action on the binding of a muscarinic M3 receptor, thereby completing the present invention. The aza-bridged-ring compound of the present invention has an antagonistic action on the binding of a muscarinic M3 receptor, and can be used as a prophylactic and/or therapeutic agent for an inflammatory disease such as a chronic obstructive pulmonary disease (COPD), asthma and the like.
    • [问题]提供对毒蕈碱M3受体具有拮抗作用并可用作炎性疾病如慢性阻塞性肺疾病(COPD),哮喘的预防和/或治疗剂的活性成分的化合物 喜欢。 解决问题的手段本发明人研究了对毒蕈碱性M3受体的结合具有拮抗作用的化合物,并且已经发现氮杂桥环化合物或其盐对其具有拮抗作用 结合毒蕈碱M3受体,从而完成本发明。 本发明的氮杂桥环化合物对毒蕈碱性M3受体的结合具有拮抗作用,可用作炎性疾病如慢性阻塞性肺疾病(COPD)的预防和/或治疗剂, ,哮喘等。
    • 8. 发明授权
    • Single-lens reflex camera
    • 单镜头反光相机
    • US07748914B2
    • 2010-07-06
    • US11712310
    • 2007-02-27
    • Hiroshi Nagata
    • Hiroshi Nagata
    • G03B13/02G03B19/12
    • G03B19/12
    • A single-lens reflex camera has a first image pickup device as a main image pickup device, a second image pickup device for live-view observation, a reflection mirror which switches an optical path between an optical path directed toward the first image pickup device and an optical path directed toward the second image pickup device, and a control section. When the shooting operation is instructed with the second image pickup device driven and a live-view displayed, the control section starts driving the reflection mirror to retract the reflection mirror from the optical path, and stops the second image pickup device and starts driving the first image pickup device while the reflection mirror is driven in a retracting direction.
    • 单镜反光相机具有作为主要图像拾取装置的第一图像拾取装置,用于实时观察的第二图像拾取装置,用于切换朝向第一图像拾取装置的光路之间的光路的反射镜和 指向第二图像拾取装置的光路,以及控制部。 当第二图像拾取装置被驱动和实时显示指示拍摄操作时,控制部分开始驱动反射镜以使反射镜从光路缩回,并停止第二图像拾取装置并开始驱动第一 当反射镜沿回缩方向被驱动时,图像拾取装置。