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1. 发明授权

US06801041B2 Sensor having electrode for determining the rate of flow of a fluid 有权
标题翻译：传感器具有用于确定流体流速的电极
公开(公告)号：US06801041B2
公开(公告)日：2004-10-05
申请号：US10145837
申请日：2002-05-14
申请人： Shridhara Alva Karinka , Isabella Moser , Gerhard Jobst , Uwe Tietjen , Panagiota S. Petrou , Uwe Herberth , Gerald Urban
发明人： Shridhara Alva Karinka , Isabella Moser , Gerhard Jobst , Uwe Tietjen , Panagiota S. Petrou , Uwe Herberth , Gerald Urban
IPC分类号： G01N2702
CPC分类号： G01F1/64 , C12Q1/006
摘要： Sensors that are capable measuring the rate of flow of a fluid that passes over the electrodes of the sensor. In these sensors, an electrode, designated the flow rate-determining electrode, is used in conjunction with the conventional electrodes, e.g., the working electrode, the reference electrode, and the counter electrode, to determine the rate of flow of the fluid. In one aspect, this invention provides a sensor for measuring the concentration of an analyte in a sample of fluid when the sample flows continuously over the electrodes of the sensor, especially when the rate of flow of the sample is relatively low. In another aspect, this invention provides a method for measuring the concentration of an analyte in a sample of fluid, wherein the rate of flow of the sample varies during the period of time that the sensor is in place. In a preferred embodiment, the sensor employs four electrodes, namely, a working electrode, a reference electrode, a counter electrode, and a flow rate-determining electrode. Alternatively, a single electrode that performs both the function of the reference electrode and the function of the counter electrode can replace the reference electrode and the counter electrode. In addition, a dummy electrode or a blank electrode can be used to compensate for interference from electrochemically active species. The reagent(s) specific to the analyte of interest is required to be deposited on the working electrode.
摘要翻译：能够测量通过传感器电极的流体流速的传感器。在这些传感器中，与常规电极（例如工作电极，参比电极和对电极）结合使用称为流速确定电极的电极，以确定流体的流速。一方面，本发明提供一种传感器，用于当样品连续地流过传感器的电极时，特别是当样品的流速相对较低时，用于测量流体样品中分析物的浓度。在另一方面，本发明提供了一种用于测量流体样品中分析物浓度的方法，其中样品的流速在传感器就位的时间段内变化。在优选实施例中，传感器使用四个电极，即工作电极，参考电极，对电极和流速确定电极。或者，执行参考电极的功能和对电极的功能的单个电极可以替代参考电极和对电极。此外，可以使用虚拟电极或空白电极来补偿来自电化学活性物质的干扰。需要将特定于目标分析物的试剂沉积在工作电极上。

2. 发明授权

US07455874B2 Method for the fabrication of a biosensor comprising an enzyme electrode arrangement 失效
标题翻译：用于制造包括酶电极装置的生物传感器的方法
公开(公告)号：US07455874B2
公开(公告)日：2008-11-25
申请号：US10987671
申请日：2004-11-12
申请人： Isabella Moser , Gerald A. Urban , Anastasia Zacharopoulou , Panagiota S. Petrou
发明人： Isabella Moser , Gerald A. Urban , Anastasia Zacharopoulou , Panagiota S. Petrou
IPC分类号： G01N3/00 , G01N27/327 , H01B13/00 , B32B3/26
CPC分类号： C12Q1/001 , C12Q1/002
摘要： The present invention relates to an enzyme electrode arrangement comprising a substrate with a surface roughness in the range of 20 nm to 10 microns, a metal electrode, an ultrathin semipermeable membrane with a thickness in the range of 10-100 nm and at least one enzyme membrane, a method for the fabrication of such arrangement and a biosensor arrangement comprising such electrode arrangement.
摘要翻译：本发明涉及一种酶电极装置，其包括表面粗糙度在20nm至10微米范围内的基底，金属电极，厚度在10-100nm范围内的超薄半透膜和至少一种酶膜，用于制造这种布置的方法和包括这种电极布置的生物传感器布置。

3. 发明申请

US20050205422A1 Enzyme electrode arrangement, a method for the fabrication of such arrangement and a biosensor arrangement comprising such electrode arrangement 失效
标题翻译：酶电极布置，制造这种布置的方法和包括这种电极布置的生物传感器布置
公开(公告)号：US20050205422A1
公开(公告)日：2005-09-22
申请号：US10987671
申请日：2004-11-12
申请人： Isabella Moser , Gerald Urban , Anastasia Zacharopoulou , Panagiota Petrou
发明人： Isabella Moser , Gerald Urban , Anastasia Zacharopoulou , Panagiota Petrou
IPC分类号： C12Q1/00 , G01N27/26
CPC分类号： C12Q1/001 , C12Q1/002
摘要： The present invention relates to an enzyme electrode arrangement comprising a substrate with a surface roughness in the range of 20 nm to 10 microns, a metal electrode, an ultrathin semipermeable membrane with a thickness in the range of 10-100 nm and at least one enzyme membrane, a method for the fabrication of such arrangement and a biosensor arrangement comprising such electrode arrangement.
摘要翻译：本发明涉及一种酶电极装置，其包括表面粗糙度在20nm至10微米范围内的基底，金属电极，厚度在10-100nm范围内的超薄半透膜和至少一种酶膜，用于制造这种布置的方法和包括这种电极布置的生物传感器布置。

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