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1. 发明授权

US07605183B2 Inhibitory or blocking agents of molecular generating and/or inducing functions 失效
标题翻译：分子产生和/或诱导功能的抑制剂或阻断剂
公开(公告)号：US07605183B2
公开(公告)日：2009-10-20
申请号：US11889162
申请日：2007-08-09
申请人： Shozo Koyama , Yoshihiro Yamaguchi
发明人： Shozo Koyama , Yoshihiro Yamaguchi
IPC分类号： A61K31/122 , C07C49/607
CPC分类号： C11D3/0084 , A01N35/06 , A61K8/35 , A61K31/12 , A61K31/122 , A61K31/13 , A61K31/40 , A61K31/445 , A61Q5/02 , A61Q19/00 , C08F2/38
摘要： A method for inhibiting or blocking molecular generating and/or inducing functions of molecules using an inhibitory or blocking agent of the formula: wherein R1-6 are as defined herein.
摘要翻译：使用下式的抑制性或阻断剂抑制或阻断分子产生和/或诱导分子功能的方法：其中R1-6如本文所定义。

2. 发明申请

US20070066654A1 Inhibitory or blocking agents of molecular generating and/or inducing functions 审中-公开
标题翻译：分子产生和/或诱导功能的抑制剂或阻断剂
公开(公告)号：US20070066654A1
公开(公告)日：2007-03-22
申请号：US11513174
申请日：2006-08-31
申请人： Shozo Koyama , Yoshihiro Yamaguchi
发明人： Shozo Koyama , Yoshihiro Yamaguchi
IPC分类号： A61K31/445 , A61K31/40 , A61K31/13 , A61K31/12
CPC分类号： C11D3/0084 , A01N35/06 , A61K8/35 , A61K31/12 , A61K31/122 , A61K31/13 , A61K31/40 , A61K31/445 , A61Q5/02 , A61Q19/00 , C08F2/38
摘要： A method for inhibiting or blocking molecular generating and/or inducing functions of molecules using an inhibitory or blocking agent of the formula: wherein R1-6 are as defined herein.
摘要翻译：使用下式的抑制性或阻断剂抑制或阻断分子产生和/或诱导分子功能的方法：其中R1-6如本文所定义。

3. 发明申请

US20080200558A1 Inhibitory or blocking agents of molecular generating and/or/ inducing functions 失效
标题翻译：分子生成和/或/诱导功能的抑制剂或阻断剂
公开(公告)号：US20080200558A1
公开(公告)日：2008-08-21
申请号：US11889162
申请日：2007-08-09
申请人： Shozo Koyama , Yoshihiro Yamaguchi
发明人： Shozo Koyama , Yoshihiro Yamaguchi
IPC分类号： A61K31/122 , A01N35/06 , A01N1/02 , C07C49/543 , C07H1/00 , C08K3/00 , C08K5/07 , A61P31/00 , A01P3/00 , A01P1/00
CPC分类号： C11D3/0084 , A01N35/06 , A61K8/35 , A61K31/12 , A61K31/122 , A61K31/13 , A61K31/40 , A61K31/445 , A61Q5/02 , A61Q19/00 , C08F2/38
摘要： A method for inhibiting or blocking molecular generating and/or inducing functions of molecules using an inhibitory or blocking agent of the formula: wherein R1-6 are as defined herein.
摘要翻译：使用下式的抑制性或阻断剂抑制或阻断分子产生和/或诱导分子功能的方法：其中R1-6如本文所定义。

4. 发明授权

US06710090B2 Inhibitory or blocking agents of molecular generating and/or inducing functions 失效
标题翻译：分子产生和/或诱导功能的抑制剂或阻断剂
公开(公告)号：US06710090B2
公开(公告)日：2004-03-23
申请号：US10029259
申请日：2001-12-28
申请人： Shozo Koyama , Yoshihiro Yamaguchi
发明人： Shozo Koyama , Yoshihiro Yamaguchi
IPC分类号： A61K31122
CPC分类号： C11D3/0084 , A01N35/06 , A61K8/35 , A61K31/12 , A61K31/122 , A61K31/13 , A61K31/40 , A61K31/445 , A61Q5/02 , A61Q19/00 , C08F2/38
摘要： A method for inhibiting or blocking molecular generating and/or inducing functions of molecules using an inhibitory or blocking agent of the formula: wherein R1-6 and A are as defined herein.
摘要翻译：使用下式的抑制剂或封闭剂抑制或阻断分子产生和/或诱导分子功能的方法：其中R1-6和A如本文所定义。

5. 发明申请

US20070293848A1 Medical Instrument 审中-公开
标题翻译：医疗仪器
公开(公告)号：US20070293848A1
公开(公告)日：2007-12-20
申请号：US11667172
申请日：2005-12-06
申请人： Morinobu Endo , Shozo Koyama , Masao Ichinose
发明人： Morinobu Endo , Shozo Koyama , Masao Ichinose
IPC分类号： A61B17/00
CPC分类号： A61B17/00 , A61B2017/00893
摘要： The present invention provides a medical instrument with use of a composite material, which has antithrombotic characteristics and biocompatibility, has a favorable strength per se and is excellent in handling properties. A part or the whole of a section of the medical instrument, which is brought into contact with blood, is made of or coated with the composite material, which has antithrombotic characteristics and in which carbon nanotubes are blended with matrix resin.
摘要翻译：本发明提供了具有抗血栓特性和生物相容性的复合材料的医疗器械，其本身具有良好的强度，处理性优异。与血液接触的医疗器械的一部分或全部由复合材料制成或涂覆，所述复合材料具有抗血栓特性，并且其中碳纳米管与基质树脂混合。

6. 发明申请

US20090216117A1 NOVEL METHOD OF USING TRIACETIN AND AUXILIARY AGENT FOR ULTRASONIC DIAGNOSTIC EXAMINATION 审中-公开
标题翻译：使用TRIACETIN和辅助药物进行超声诊断检查的新方法
公开(公告)号：US20090216117A1
公开(公告)日：2009-08-27
申请号：US11911625
申请日：2006-04-17
申请人： Shozo Koyama , Masaaki Tokuda , Yoshiyuki Hori , Kazumasa Ohsaka
发明人： Shozo Koyama , Masaaki Tokuda , Yoshiyuki Hori , Kazumasa Ohsaka
IPC分类号： A61B8/00 , B65D71/00
CPC分类号： A61K49/221 , A61K31/22
摘要： A drug in the form of a solid preparation soluble or suspendable in water or an aqueous solution characterized by containing at least one biocompatible, gastric motility suppressing component such as triacetin, which is capable of transmitting ultrasonic wave to a target organ via the solution pooled in the body in a noninvasive examination (for example, an ultrasonic examination of an abdominal organ), identifying the area in which the solution exists, or clarifying the boundary of the solution and an organ in contact therewith, is employed as an auxiliary agent in the examination. In addition, triacetin can be extensively used as a gastric motility suppressor.
摘要翻译：可溶于或悬浮于水中的固体制剂形式的药物或水溶液，其特征在于含有至少一种生物相容性胃动力抑制组分如三醋精，其能够通过汇集在溶液中的溶液将超声波传输至靶器官在非侵入性检查中（例如，腹部器官的超声波检查），识别溶液存在的区域或澄清溶液的边界和与其接触的器官的身体被用作辅助剂检查。此外，三醋精可广泛用作胃动力抑制剂。

7. 发明授权

US07914793B2 Method for producing an antigenic substance and antibody 有权
标题翻译：生产抗原物质和抗体的方法
公开(公告)号：US07914793B2
公开(公告)日：2011-03-29
申请号：US10786369
申请日：2004-02-26
申请人： Shozo Koyama , Satoshi Tanaka
发明人： Shozo Koyama , Satoshi Tanaka
IPC分类号： A61K39/00 , A61K47/06 , G01N33/531
CPC分类号： A61K39/385 , A61K31/122 , A61K2039/6012 , Y02A50/412 , Y10T436/200833
摘要： This invention provides antigen substance inductors which produce highly selective and/or specific vaccine precursor, vaccine, antibody (including idiotype antibody), neutralizing antibody, antitoxin.This invention is to produce and/or manufacture highly selective and/or specific vaccine precursor, vaccine, antibody (including idiotype antibody), neutralizing antibody, antitoxin by quantum thermodynamic and chemical control of molecular functions and morphogenesis, inducing non-functional complex macromolecules which form organism and/or non-organism and which become to be substance with fundamental structure more closed to an induction of the functions, utilizing the fundamental structure of molecule which is indicated in Formula 3-a as a representative molecule. Moreover, by those produced substances, this invention is to produce and/or manufacture antimicrobial agent, antiviral agent, neutralizing antibody, antitoxin, antitumor agent, anti-protozoa agent (malaria, spirochaeta et. al), molecular discriminating agent, antibody as labeled compounds, histocompatible accelerator on tissues or organs, immuno-response accelerator or immuno-response controller, complement chain reaction accelerator.
摘要翻译：本发明提供了产生高选择性和/或特异性疫苗前体，疫苗，抗体（包括独特型抗体），中和抗体，抗毒素的抗原物质电感器。本发明是生产和/或制造高选择性和/或特异性疫苗前体，疫苗，抗体（包括独特型抗体），中和抗体，通过量子热力学的抗毒素和分子功能和形态发生的化学控制，诱导非功能性复合大分子形成生物体和/或非生物体，并且使用式3-a所示的分子的基本结构作为代表性分子，其具有更接近于功能诱导的基本结构的物质。此外，本发明还涉及生产和/或生产抗微生物剂，抗病毒剂，中和抗体，抗毒素，抗肿瘤剂，抗原生动物（疟疾，螺旋虫等），分子鉴别剂，标记抗体化合物，组织或器官上的组织相容促进剂，免疫应答加速剂或免疫应答控制剂，补体链反应促进剂。

8. 发明授权

US4388318A Method of treating endotoxin shock with a pyrimido-pyrimidine derivative 失效
标题翻译：用嘧啶 - 嘧啶衍生物治疗内毒素休克的方法
公开(公告)号：US4388318A
公开(公告)日：1983-06-14
申请号：US306773
申请日：1981-09-29
申请人： Shozo Koyama , John W. Manning, Jr. , William S. Ammons , Hector L. Santiesteban
发明人： Shozo Koyama , John W. Manning, Jr. , William S. Ammons , Hector L. Santiesteban
IPC分类号： C07D487/04 , A61K31/505 , A61P9/02
CPC分类号： A61K31/505 , Y10S514/921
摘要： The method of treating endotoxin shock with 2,2'-[(4,8-bis(diethylamino)-pyrimido[5,4-d]pyrimidine-2,6-diyl)di-(2-methoxyethyl)imino]diethanol or a non-toxic, pharmacologically acceptable acid addition salt thereof.
摘要翻译：用2,2' - [（4,8-双（二乙基氨基） - 嘧啶并[5,4-d]嘧啶-2,6-二基）二 - （2-甲氧基乙基）亚氨基]二乙醇处理内毒素休克的方法其无毒的药学上可接受的酸加成盐。

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