专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20090216117A1 NOVEL METHOD OF USING TRIACETIN AND AUXILIARY AGENT FOR ULTRASONIC DIAGNOSTIC EXAMINATION 审中-公开
标题翻译：使用TRIACETIN和辅助药物进行超声诊断检查的新方法
公开(公告)号：US20090216117A1
公开(公告)日：2009-08-27
申请号：US11911625
申请日：2006-04-17
申请人： Shozo Koyama , Masaaki Tokuda , Yoshiyuki Hori , Kazumasa Ohsaka
发明人： Shozo Koyama , Masaaki Tokuda , Yoshiyuki Hori , Kazumasa Ohsaka
IPC分类号： A61B8/00 , B65D71/00
CPC分类号： A61K49/221 , A61K31/22
摘要： A drug in the form of a solid preparation soluble or suspendable in water or an aqueous solution characterized by containing at least one biocompatible, gastric motility suppressing component such as triacetin, which is capable of transmitting ultrasonic wave to a target organ via the solution pooled in the body in a noninvasive examination (for example, an ultrasonic examination of an abdominal organ), identifying the area in which the solution exists, or clarifying the boundary of the solution and an organ in contact therewith, is employed as an auxiliary agent in the examination. In addition, triacetin can be extensively used as a gastric motility suppressor.
摘要翻译：可溶于或悬浮于水中的固体制剂形式的药物或水溶液，其特征在于含有至少一种生物相容性胃动力抑制组分如三醋精，其能够通过汇集在溶液中的溶液将超声波传输至靶器官在非侵入性检查中（例如，腹部器官的超声波检查），识别溶液存在的区域或澄清溶液的边界和与其接触的器官的身体被用作辅助剂检查。此外，三醋精可广泛用作胃动力抑制剂。

2. 发明授权

US08440619B2 Utilization of hypertension/hypercardia-preventing effect of D-allose 有权
标题翻译：利用高血压/防高效D-allose的作用
公开(公告)号：US08440619B2
公开(公告)日：2013-05-14
申请号：US12065452
申请日：2006-08-31
申请人： Masaaki Tokuda , Shoji Kimura , Ken Izumori
发明人： Masaaki Tokuda , Shoji Kimura , Ken Izumori
IPC分类号： A61K38/00 , A61K9/12 , A61K31/70 , A61P9/00
CPC分类号： A23K20/163 , A23L33/10 , A61K31/7004
摘要： The object is to provide a novel application of D-allose (e.g., use for prevention of hypertension or hypercardia). Thus, disclosed is a composition for preventing the increase in blood pressure which comprises D-allose as an active ingredient; or a composition containing D-allose and/or a derivative thereof, preferably in an amount of 0.1 to 50% by weight. Preferably, the composition is in a form selected from the group consisting of a food additive, a food material, a beverage/food, a health beverage/food, a pharmaceutical and a feeding stuff which can be used for the prevention and treatment of a cardiovascular system disorder (e.g., hypertension, hypercardia). The increase in blood pressure may be caused by salt-sensitive hypertension. Also disclosed is use of D-allose for preventing the increase in blood pressure (excluding medical practices).
摘要翻译：本发明的目的是提供D-丙氨酸的新应用（例如，用于预防高血压或高血压）。因此，公开了用于防止血压升高的组合物，其包含D-阿洛糖作为活性成分; 或含有D-丙氨酸和/或其衍生物的组合物，优选为0.1〜50重量％。优选地，组合物为选自食品添加剂，食品材料，饮料/食品，保健饮料/食品，药物和饲料的形式，其可用于预防和治疗心血管系统疾病（如高血压，高血压）。血压升高可能是盐敏感性高血压引起的。还公开了使用D-丙氨酸来防止血压升高（不包括医疗实践）。

3. 发明申请

US20090325231A1 THERMOSTABLE L-RIBOSE ISOMERASE AND METHOD FOR PRODUCING SAME AND USE OF SAME 有权
标题翻译：可热裂解的L-赖氨酸异构体及其生产方法及其用途
公开(公告)号：US20090325231A1
公开(公告)日：2009-12-31
申请号：US12515596
申请日：2007-03-26
申请人： Ken Izumori , Kenji Morimoto , Goro Takata , Masaaki Tokuda , Yoshio Tsujisaka , Kei Takeshita , Keiji Tsusaki , Kazuhiro Okuma
发明人： Ken Izumori , Kenji Morimoto , Goro Takata , Masaaki Tokuda , Yoshio Tsujisaka , Kei Takeshita , Keiji Tsusaki , Kazuhiro Okuma
IPC分类号： C12P21/00 , C12N9/90 , C12N1/21 , C12P19/24
CPC分类号： C12N9/90 , C12P19/24 , C12R1/01
摘要： Object: To provide a thermostable L-ribose isomerase.Means for Resolution: The thermostable L-ribose isomerase with MW. 32,000 (by SDS-PAGE), optimal temperature of 45° C., optimal pH of pH 9.0 (glycine-NaOH buffer), and stable physicochemical properties such as temperature stability up to 45° C. during thermal treatment at pH 9.0 for 10 minutes, and with an action to isomerize L-ribose to generate L-ribulose or of inversely to isomerize L-ribulose to generate L-ribose. A conversion method between an aldose and a ketose comprising allowing the thermostable L-ribose isomerase as an enzyme derived from (1) Raoultella ornithinolytica strain MB426 (NITE BP-277) to interact with an aldose selected from L-ribose, D-lyxose, D-tallose, D-mannose, L-allose and L-gulose to isomerize the aldose to generate a ketose selected from the individually corresponding L-ribulose, D-xylulose, D-tagatose, D-fructose, L-psicose and L-sorbose or to interact with a ketose selected from L-ribulose, D-xylulose, D-tagatose, D-fructose, L-psicose and L-sorbose to isomerize the ketose to generate an aldose selected from the individually corresponding L-ribose, D-lyxose, D-tallose, D-mannose, L-allose and L-gulose.
摘要翻译：目的：提供热稳定的L-核糖异构酶。解决方法：具有MW的热稳定的L-核糖异构酶。 32,000（通过SDS-PAGE），最适温度为45℃，pH 9.0的最佳pH（甘氨酸 - NaOH缓冲液），以及稳定的物理化学性质，例如在pH 9.0的热处理期间温度稳定性高达45℃，为10 分钟，并且具有异构化L-核糖以产生L-核酮糖的作用或者与L-核酮糖异构化以产生L-核糖的作用。醛糖和酮糖之间的转化方法，包括使热稳定的L-核糖异构酶作为源自（1）鸟氨酸解脂耶氏杆菌菌株MB426（NITE BP-277）的酶与选自L-核糖，D-赖索糖， D-山梨糖醇，D-甘露糖，L-丙氨酸和L-古洛糖醇以使醛糖异构化以产生选自单独对应的L-核酮糖，D-木酮糖，D-塔格糖，D-果糖，L-灵芝蛋白和L- 山梨糖或与选自L-核酮糖，D-木酮糖，D-塔格糖，D-果糖，L-灵敏糖和L-山梨糖的酮糖相互作用以使酮糖异构化以产生选自相应的L-核糖，D D-果糖，D-甘露糖，D-甘露糖，L-阿洛糖和L-古洛糖。

4. 发明授权

US07501267B2 Gene sequence of L-rhamnose isomerase having new catalytic function and use thereof 有权
标题翻译：具有新催化功能的L-鼠李糖异构酶的基因序列及其应用
公开(公告)号：US07501267B2
公开(公告)日：2009-03-10
申请号：US11714887
申请日：2007-03-07
申请人： Ken Izumori , Goro Takada , Masaaki Tokuda
发明人： Ken Izumori , Goro Takada , Masaaki Tokuda
IPC分类号： C12P21/06 , C07H21/04 , C12N1/21 , C12N9/90
CPC分类号： C12N9/90 , C12P19/02 , C12P19/24 , C12Y503/01014
摘要： In the rare sugar strategy of Izumoring (FIG. 1), it is intended to establish a reaction system of producing rare sugars of many types by acquiring an isomerase which acts on various rare aldoses and, therefore, is most efficient in producing various rare ketoses. A DNA encoding the following protein (a) or (b). The above-mentioned DNA which is L-rhamnose isomerase derived from Pseudomonas stutzerii. A protein comprising the amino acid sequence represented by SEQ ID NO:2. A process for producing a recombinant protein characterized by culturing a host cell containing an expression system that can express the above-mentioned protein in a medium and collecting a recombinant protein having an L-rhamnose isomerase activity from the thus obtained culture. A method of applying FIG. 1 to the production of a rare sugar characterized in that the location of a target rare sugar in the overall picture of monosaccharides is understood and thus the optimum production pathway on which the above protein is allowed to act is designed.
摘要翻译：在采食稀少糖的策略（图1）中，旨在通过获得作用于各种罕见的醛糖的异构酶来建立许多类型的稀有糖的反应体系，因此在生产各种稀有酮糖中是最有效的。编码以下蛋白质（a）或（b）的DNA。上述提供的源自番茄假单胞菌的L-鼠李糖异构酶的DNA。包含SEQ ID NO：2所示的氨基酸序列的蛋白质。一种重组蛋白质的制造方法，其特征在于，在培养基中培养含有能够在培养基中表达上述蛋白质的表达系统的宿主细胞，从所得培养物中收集具有L-鼠李糖异构酶活性的重组蛋白质。一种应用图1的方法。 1涉及生产一种罕见的糖，其特征在于，在单糖的总体图中，目标稀有糖的位置被理解，因此设计了允许上述蛋白质起作用的最佳生产途径。

5. 发明申请

US20060148061A1 Gene sequence of l-rhamnose isomerase having new catalytic function and use thereof 有权
标题翻译：具有新催化功能的L-鼠李糖异构酶的基因序列及其用途
公开(公告)号：US20060148061A1
公开(公告)日：2006-07-06
申请号：US10541822
申请日：2004-01-09
申请人： Ken Izumori , Goro Takada , Masaaki Tokuda
发明人： Ken Izumori , Goro Takada , Masaaki Tokuda
IPC分类号： C07H21/04 , C12P21/06 , C12P19/02 , C12N9/90 , C12N15/74 , C12N1/21
CPC分类号： C12N9/90 , C12P19/02 , C12P19/24 , C12Y503/01014
摘要： In the rare sugar strategy of Izumoring (FIG. 1), it is intended to establish a reaction system of producing rare sugars of many types by acquiring an isomerase which acts on various rare aldoses and, therefore, is most efficient in producing various rare ketoses. A DNA encoding the following protein (a) or (b). The above-mentioned DNA which is L-rhamnose isomerase derived from Pseudomonas stutzerii. A protein comprising the amino acid sequence represented by SEQ ID NO:2. A process for producing a recombinant protein characterized by culturing a host cell containing an expression system that can express the above-mentioned protein in a medium and collecting a recombinant protein having an L-rhamnose isomerase activity from the thus obtained culture. A method of applying FIG. 1 to the production of a rare sugar characterized in that the location of a target rare sugar in the overall picture of monosaccharides is understood and thus the optimum production pathway on which the above protein is allowed to act is designed.
摘要翻译：在采食稀少糖的策略（图1）中，旨在通过获得作用于各种罕见的醛糖的异构酶来建立许多类型的稀有糖的反应体系，因此在生产各种稀有酮糖中是最有效的。编码以下蛋白质（a）或（b）的DNA。上述提供的源自番茄假单胞菌的L-鼠李糖异构酶的DNA。包含SEQ ID NO：2所示的氨基酸序列的蛋白质。一种重组蛋白质的制造方法，其特征在于，在培养基中培养含有能够在培养基中表达上述蛋白质的表达系统的宿主细胞，从所得培养物中收集具有L-鼠李糖异构酶活性的重组蛋白质。一种应用图1的方法。 1涉及生产一种罕见的糖，其特征在于，在单糖的总体图中，目标稀有糖的位置被理解，因此设计了允许上述蛋白质起作用的最佳生产途径。

6. 发明授权

US09668958B2 Noncarious material and anticarious agent containing rare sugar 有权
公开(公告)号：US09668958B2
公开(公告)日：2017-06-06
申请号：US13369780
申请日：2012-02-09
申请人： Tetsuo Iida , Takashi Ichihara , Ken Izumori , Masaaki Tokuda , Takaaki Ogawa
发明人： Tetsuo Iida , Takashi Ichihara , Ken Izumori , Masaaki Tokuda , Takaaki Ogawa
IPC分类号： A61K8/60 , A61Q11/00 , A61K31/047 , A61K31/7004 , C07H3/02
CPC分类号： A61K8/60 , A61K31/047 , A61K31/7004 , A61Q11/00 , C07H3/02
摘要： To provide a composition for preventing periodontal diseases (prophylactic agent of periodontal diseases), the composition having an excellent cariostatic property, being safe and stable for prolonged use and having less effects on flavor. A non-cariogenic material prepared by blending a rare sugar in the D form as selected from the group consisting of D-psicose, D-sorbose and D-tagatose, a rare sugar in the L form as selected from L-fructose, L-psicose and L-tagatose, or allitol as a rare sugar derivative, singly or in combination. A cariostatic agent comprising D-psicose, D-sorbose, D-tagatose, L-fructose, L-psicose and/or L-tagatose. A cariostatic agent in combination with catechins.

7. 发明申请

US20130075075A1 VEHICLE AIR CONDITIONING SYSTEM 有权
标题翻译：车用空调系统
公开(公告)号：US20130075075A1
公开(公告)日：2013-03-28
申请号：US13702954
申请日：2011-05-19
申请人： Masaaki Tokuda , Shinichirou Mizoguchi , Satoshi Ogihara
发明人： Masaaki Tokuda , Shinichirou Mizoguchi , Satoshi Ogihara
IPC分类号： B60H1/00
CPC分类号： B60H1/00007 , B60H1/00278 , B60H1/143 , B60H2001/00307 , B60L1/003 , B60L2240/34 , B60L2240/36 , B60L2240/662 , Y02T10/7291 , Y02T90/16
摘要： A vehicle air conditioning system includes a duct, a refrigerant evaporator, an air conditioning cooling flow passage, a heater core, a heater hot fluid flow passage, a heat exchanger, an electric heater, an electrical component cooling flow passage, a communication flow passage, a fluid temperature sensor and a flow passage selector valve. The duct provides air to a vehicle cabin interior. The cooling flow passage provides cooled refrigerant to the evaporator. The hot fluid flow passage provides hot fluid to the heater core. The heat exchanger exchanges heat between the refrigerant and the hot fluid. The heater warms the hot fluid having undergone heat exchange. The cooling flow passage cools an electrical component. The communication flow passage parallely connects the hot fluid and electrical component flow passages. The valve allows hot fluid to flow into the cooling flow passage when the hot fluid has a high temperature.
摘要翻译：一种车辆空调系统，包括管道，制冷剂蒸发器，空调冷却流路，加热器芯，加热器热流体流路，热交换器，电加热器，电气部件冷却流路，连通流路，流体温度传感器和流路切换阀。管道为车厢内部提供空气。冷却流路将冷却的制冷剂提供给蒸发器。热流体流动通道将热流体提供给加热器芯。热交换器在制冷剂和热流体之间交换热量。加热器加热经过热交换的热流体。冷却流路冷却电气部件。连通流通道并联连接热流体和电气部件流动通道。当热流体具有高温时，阀允许热流体流入冷却流道。

8. 发明授权

US08227232B2 Thermostable L-ribose isomerase and method for producing same and use of same 有权
标题翻译：热稳定性L-核糖异构酶及其制备方法及用途
公开(公告)号：US08227232B2
公开(公告)日：2012-07-24
申请号：US12515596
申请日：2007-03-26
申请人： Ken Izumori , Kenji Morimoto , Goro Takata , Masaaki Tokuda , Yoshio Tsujisaka , Kei Takeshita , Keiji Tsusaki , Kazuhiro Okuma
发明人： Ken Izumori , Kenji Morimoto , Goro Takata , Masaaki Tokuda , Yoshio Tsujisaka , Kei Takeshita , Keiji Tsusaki , Kazuhiro Okuma
IPC分类号： C12N9/90 , C12N1/00 , C12P19/24 , C07H1/00 , C07H1/06
CPC分类号： C12N9/90 , C12P19/24 , C12R1/01
摘要： Object: To provide a thermostable L-ribose isomerase.Means for Resolution: The thermostable L-ribose isomerase with MW. 32,000 (by SDS-PAGE), optimal temperature of 45° C., optimal pH of pH 9.0 (glycine-NaOH buffer), and stable physicochemical properties such as temperature stability up to 45° C. during thermal treatment at pH 9.0 for 10 minutes, and with an action to isomerize L-ribose to generate L-ribulose or of inversely to isomerize L-ribulose to generate L-ribose. A conversion method between an aldose and a ketose comprising allowing the thermostable L-ribose isomerase as an enzyme derived from (1) Raoultella ornithinolytica strain MB426 (NITE BP-277) to interact with an aldose selected from L-ribose, D-lyxose, D-tallose, D-mannose, L-allose and L-gulose to isomerize the aldose to generate a ketose selected from the individually corresponding L-ribulose, D-xylulose, D-tagatose, D-fructose, L-psicose and L-sorbose or to interact with a ketose selected from L-ribulose, D-xylulose, D-tagatose, D-fructose, L-psicose and L-sorbose to isomerize the ketose to generate an aldose selected from the individually corresponding L-ribose, D-lyxose, D-tallose, D-mannose, L-allose and L-gulose.
摘要翻译：目的：提供热稳定的L-核糖异构酶。解决方法：具有MW的热稳定性L-核糖异构酶。 32,000（通过SDS-PAGE），最适温度为45℃，pH 9.0的最佳pH（甘氨酸 - NaOH缓冲液），以及稳定的物理化学性质，例如在pH 9.0的热处理期间温度稳定性高达45℃，为10 分钟，并且具有异构化L-核糖以产生L-核酮糖的作用或者与L-核酮糖异构化以产生L-核糖的作用。醛糖和酮糖之间的转化方法，包括使热稳定的L-核糖异构酶作为源自（1）鸟氨酸解脂耶氏杆菌菌株MB426（NITE BP-277）的酶与选自L-核糖，D-赖索糖， D-山梨糖醇，D-甘露糖，L-丙氨酸和L-古洛糖醇以使醛糖异构化以产生选自单独对应的L-核酮糖，D-木酮糖，D-塔格糖，D-果糖，L-灵芝蛋白和L- 山梨糖或与选自L-核酮糖，D-木酮糖，D-塔格糖，D-果糖，L-灵敏糖和L-山梨糖的酮糖相互作用以使酮糖异构化以产生选自相应的L-核糖，D D-果糖，D-甘露糖，D-甘露糖，L-阿洛糖和L-古洛糖。

9. 发明申请

US20080306011A1 Method of Controlling the Proliferation of Vascular Endothelial Cells and Inhibiting Lumen Formation 审中-公开
标题翻译：控制血管内皮细胞增殖和抑制腔形成的方法
公开(公告)号：US20080306011A1
公开(公告)日：2008-12-11
申请号：US11569635
申请日：2005-05-26
申请人： Masaaki Tokuda , Ikuko Tsukamoto , Ryoji Konishi , Yasuo Kubota , Ken Izumori
发明人： Masaaki Tokuda , Ikuko Tsukamoto , Ryoji Konishi , Yasuo Kubota , Ken Izumori
IPC分类号： A61K31/7004 , C07H3/02 , C07H3/08 , A61P3/10 , C12N5/06
CPC分类号： C07H3/08 , A23L33/10 , A61K31/7004 , C07H3/02
摘要： [PROBLEMS] To find out a specific rare sugar having effects of inhibiting the proliferation of vascular endothelial cells and lumen formation and utilize these effects. To provide this rare sugar as a preventive/remedy for diseases with angiogenesis, a cosmetic or a functional food.[MEANS FOR SOLVING PROBLEMS] A method of controlling the proliferation of vascular endothelial cells characterized by utilizing the vascular endothelial cell proliferation-controlling effect of D-mannose, D-allose, 2-deoxy-D-glucose, 3-deoxy-D-glucose, L-sorbose, 2-deoxy-D-ribose and/or 2-deoxy-L-ribose. A method of inhibiting lumen formation of vascular endothelial cells characterized by utilizing the vascular endothelial cell lumen formation-inhibiting effect of D-allose, D-altrose, D-gulose, D-talose, L-allose, 2-deoxy-D-glucose, 3-deoxy-D-glucose, D-ribose, L-ribose, 2-deoxy-D-ribose and/or 2-deoxy-L-ribose.
摘要翻译： [问题]找出具有抑制血管内皮细胞增殖和管腔形成的作用的特定稀有糖并利用这些效果。提供这种稀有糖作为血管生成疾病，化妆品或功能性食物的预防/补救。【解决问题的手段】控制血管内皮细胞增殖的方法，其特征在于利用D-甘露糖，D-异丙肾上腺素，2-脱氧-D-葡萄糖，3-脱氧-D-葡萄糖的血管内皮细胞增殖抑制作用，葡萄糖，L-山梨糖，2-脱氧-D-核糖和/或2-脱氧-L-核糖。一种抑制血管内皮细胞管腔形成的方法，其特征在于利用D-阿洛糖，D-阿卓糖，D-古洛糖，D-塔洛糖，L-阿洛糖，2-脱氧-D-葡萄糖的血管内皮细胞管腔形成抑制作用，3-脱氧-D-葡萄糖，D-核糖，L-核糖，2-脱氧-D-核糖和/或2-脱氧-L-核糖。

10. 发明申请

US20080299535A1 Preservative Solution for Cells, Tissues and Organs Comprising Rare Sugar and Preservation Method with the Use of the Same 有权
标题翻译：包含稀有糖和保存方法的细胞，组织和器官的防腐剂方案
公开(公告)号：US20080299535A1
公开(公告)日：2008-12-04
申请号：US11569577
申请日：2005-05-26
申请人： Masaaki Tokuda , Masaaki Ueki , Rikiya Taoka , Yoshiyuki Kakehi , Ken Izumori
发明人： Masaaki Tokuda , Masaaki Ueki , Rikiya Taoka , Yoshiyuki Kakehi , Ken Izumori
IPC分类号： A01N1/02 , C12N5/06 , C12N5/04
CPC分类号： A01N1/0221 , A01N1/02
摘要： [Problem] To provide a preservative solution for cells, tissues and organs using a rare sugar and a preservation method using the solution.[Means for Resolution] A preservative solution for cryopreservation of animal or human organs and animal or plant tissues or cells, the solution containing a rare sugar D-allose. A preservative solution for cryopreservation of the human kidney, cells derived from animals or humans, or human or animal sperm and/or ovum and/or fermented ovum in which the cryopreservation is conducted at from −5 to 20° C. A preservative solution for cryopreservation of cells derived from animals or humans, or human or animal sperm and/or ovum and/or fermented ovum in which the cryopreservation is conducted at a temperature at which to start freezing to −196° C. A method for cryopreservation of an animal or human organ and an animal or plant tissue or cell at a low temperature, which comprises (a) refluxing or immersing a preservative solution for cryopreservation containing a rare sugar D-allose and the organ or the tissue or mixing the cell therewith, and (b) cooling the organ, the tissue or the cell to a low temperature of from −5 to 20° C.
摘要翻译： [问题]使用稀有糖和使用该溶液的保存方法为细胞，组织和器官提供防腐剂溶液。 [解决方法]用于冷冻保存动物或人体器官以及动物或植物组织或细胞的防腐剂溶液，所述溶液含有稀有的D-糖原糖。用于人体肾脏的冷冻保存，来自动物或人类的细胞，或人或动物精子和/或卵子和/或发酵的卵子的防腐溶液，其中在-5至20℃下进行冷冻保存。冷冻保存来自动物或人类的细胞，或人类或动物精子和/或卵子和/或发酵的卵子，其中在开始冷冻至-196℃的温度下进行冷冻保存。一种用于动物冷冻保存的方法或人体器官和动物或植物组织或细胞在低温下进行，其包括（a）回流或浸入含有稀有的D-麦芽糖和器官或组织的冷冻保存用防腐溶液或与其混合，和 b）将器官，组织或细胞冷却至-5至20℃的低温。

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