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1. 发明授权

US4873172A Process for forming a superhigh contrast negative image 失效
标题翻译：用于形成超高对比度负像的过程
公开(公告)号：US4873172A
公开(公告)日：1989-10-10
申请号：US229796
申请日：1988-08-08
申请人： Shoji Ishiguro , Shigeo Hirano , Tadao Shishido , Akio Miyake
发明人： Shoji Ishiguro , Shigeo Hirano , Tadao Shishido , Akio Miyake
IPC分类号： G03C1/06
CPC分类号： G03C1/061
摘要： A process for forming a superhigh contrast negative image with a stable developer is disclosed, which comprises development processing a silver halide photographic material in the presence of a compound of formula (I) and a compound of formula (II) as defined in the specification.
摘要翻译：公开了一种用稳定显影剂形成超高对比度负像的方法，其包括在本说明书中定义的式（I）化合物和式（II）化合物存在下显影处理卤化银照相材料。

2. 发明授权

US5519024A Quinolonecarboxylic acid derivatives and their use 失效
标题翻译：喹诺酮羧酸衍生物及其用途
公开(公告)号：US5519024A
公开(公告)日：1996-05-21
申请号：US207091
申请日：1994-03-08
申请人： Akio Miyake , Masahira Nakamura , Hideto Fukushi
发明人： Akio Miyake , Masahira Nakamura , Hideto Fukushi
IPC分类号： C07D215/56 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D417/06 , C07D417/14 , C07D471/04 , C07D471/06 , C07D487/04 , C07D513/04 , C07D519/00 , C07D417/04 , A61K31/495
CPC分类号： C07D401/04 , C07D215/56 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D417/06 , C07D417/14 , C07D471/04 , C07D471/06 , C07D487/04 , C07D513/04
摘要： A composition comprises a 1,7-disubstituted-4-oxo-3-quinolinecarboxylic acid or 1,7-disubstituted-4-oxo-3-naphthyridinecarboxylic acid derivative which is useful as a prophylactic and/or therapeutic agent for peripheral arterial obstruction, acute myocardial infarction, an antitumor agent, and as a prophylactic and/or therapeutic agent for osteoporosis.
摘要翻译：组合物包含可用作外周动脉阻塞的预防和/或治疗剂的1,7-二取代-4-氧代-3-喹啉羧酸或1,7-二取代-4-氧代-3-萘啶羧酸衍生物，急性心肌梗死，抗肿瘤剂，以及作为骨质疏松症的预防和/或治疗剂。

3. 发明授权

US5145850A Imidazopyridazines, their production and use 失效
标题翻译：咪达唑德他们的生产和使用
公开(公告)号：US5145850A
公开(公告)日：1992-09-08
申请号：US659704
申请日：1991-02-25
申请人： Akio Miyake , Yasuko Ashida
发明人： Akio Miyake , Yasuko Ashida
IPC分类号： A61K31/50 , A61K31/5025 , A61P11/00 , A61P11/06 , A61P11/08 , A61P29/00 , A61P37/08 , C07D487/04
CPC分类号： C07D487/04
摘要： An imidazo [1,2-b]pyridazine compound of the formula (I): ##STR1## wherein R.sub.1 is a halogen atom or a lower alkyl group optionally having substituent(s), R.sub.2 and R.sub.3 are, independently, a hydrogen atom, a lower alkyl group optionally having substituent(s), a cycloalkyl group or a phenyl group optionally having substituent(s) or R.sub.2 and R.sub.3 together with the adjacent nitrogen atom to which they bond may form a heterolcyclic ring optionally having substituent(s), X is an oxygen atom or S(O).sub.k (k is zero to two), a group --.circle.A-- is a bivalent three to seven membered homocyclic or heterocyclic group optionally having substituent(s), m.sup.1 and m.sup.2 each is an integer of 0 to 4 and n is an integer of 0 or 1; or its salt, which is useful as antiasthmatics.

4. 发明授权

US4864022A 3-Condensed imidazolium-cephem compounds 失效
标题翻译： 3-缩合咪唑 - 头孢烯化合物
公开(公告)号：US4864022A
公开(公告)日：1989-09-05
申请号：US834969
申请日：1986-02-28
申请人： Akio Miyake , Masahiro Kondo , Masahiko Fujino
发明人： Akio Miyake , Masahiro Kondo , Masahiko Fujino
IPC分类号： C07D501/06 , A61K31/545 , A61K31/546 , C07D277/20 , C07D285/08 , C07D463/00 , C07D471/04 , C07D487/04 , C07D498/04 , C07D501/46 , C07D505/00 , C07D519/00
CPC分类号： C07D277/587 , C07D285/08 , C07D463/20 , C07D463/22 , C07D471/04 , C07D487/04 , C07D505/00
摘要： A compound of the formula; ##STR1## wherein R.sup.1 is an amino group which may be protected, R.sup.3 is a hydrogen atom or an optionally substituted hydrocarbon residue; Z is S, S.fwdarw.O, O or CH.sub.2, R.sup.4 is a hydrogen atom, methoxy group or formamido group, R.sup.13 is a hydrogen atom, methyl group, hydroxyl group or halogen atom and A.sym. is an optionally substituted imidazolium-1-yl group forming a condensed ring at the 2,3- or 3,4-position or a pharmaceutically acceptable salt or ester thereof is novel and has excellent antibacterial activity.
摘要翻译：式的化合物; 其中R 1为可被保护的氨基，R 3为氢原子或任选取代的烃残基; Z是S，S-> O，O或CH2，R4是氢原子，甲氧基或甲酰氨基，R13是氢原子，甲基，羟基或卤素原子，A（+）是任选取代的咪唑鎓 - 在2,3-或3,4-位上形成稠合环或其药学上可接受的盐或酯是新的，具有优异的抗菌活性。

5. 发明授权

US5948774A Cephem compounds, their production and use 失效
标题翻译：头孢烯化合物，其生产和使用
公开(公告)号：US5948774A
公开(公告)日：1999-09-07
申请号：US836424
申请日：1997-07-29
申请人： Keiji Kamiyama , Kenji Okonogi , Akio Miyake
发明人： Keiji Kamiyama , Kenji Okonogi , Akio Miyake
IPC分类号： C07D501/00 , C07D501/24 , A61K31/545
CPC分类号： C07D501/00
摘要： Cephem compounds of the formula: ##STR1## wherein R.sup.1 is an optionally protected amino group; R.sup.2 is a fluoro-lower alkyl group; and the ring A may have further substituent(s), or their esters or salts, show broad and excellent antibacterial activities and are useful as antibacterial agents.
摘要翻译： PCT No.PCT / JP96 / 01436 Sec。 371日期1997年7月29日第 102（e）日期1997年7月29日PCT提交1996年5月28日PCT公布。 WO96 / 34851 PCT出版物日期：1996年12月5日化学式：其中R1为任选保护的氨基; R2是氟代低级烷基; 并且环A可以具有其它取代基或其酯或盐，显示出广泛和优异的抗菌活性并且可用作抗菌剂。

6. 发明授权

US5492909A Triazolopyridazine derivatives, their production and use 失效
标题翻译：三唑并哒嗪衍生物，其生产和使用
公开(公告)号：US5492909A
公开(公告)日：1996-02-20
申请号：US225981
申请日：1994-04-12
申请人： Akio Miyake , Masahiro Kajino , Yasuko Ashida
发明人： Akio Miyake , Masahiro Kajino , Yasuko Ashida
IPC分类号： C07D487/04 , A61K31/50 , A61K31/535 , C07D487/14
CPC分类号： C07D487/04
摘要： A compound of the formula: ##STR1## wherein R.sup.1 is a hydrogen atom, a lower alkyl group or a halogen atom; R.sup.2 and R.sup.3 are a hydrogen atom, a lower alkyl group or a 5- to 7-membered cyclic group formed together with the adjacent --C.dbd.C--; X is an oxygen atom, a sulfur atom or a methylene group; Y is an optionally substituted methylene group, a divalent 3- to 7-membered homo- or heterocyclic group; R.sup.6 and R.sup.7 are a hydrogen atom, a lower alkyl group, a cycloalkyl group, an aryl group, or a nitrogen-containing heterocyclic group formed together With the adjacent nitrogen atom; m is an integer of 0 to 4; and n is an integer of 0 to 4, or a salt thereof. Said compound has an excellent anti-PAF activity, antiallergic action, etc., thus is useful as an antiasthmatic agent.
摘要翻译：下式的化合物：其中R 1是氢原子，低级烷基或卤素原子; R2和R3是与相邻的-C = C-一起形成的氢原子，低级烷基或5-至7-元环基; X是氧原子，硫原子或亚甲基; Y是任选取代的亚甲基，二价3-至7-元同 - 或杂环基; R6和R7是与相邻的氮原子一起形成的氢原子，低级烷基，环烷基，芳基或含氮杂环基; m为0〜4的整数。 n为0〜4的整数，或其盐。所述化合物具有优异的抗PAF活性，抗过敏作用等，因此可用作抗哮喘药。

7. 发明授权

US4962100A 3-Condensed imidazolium-cephem compounds 失效
标题翻译： 3-缩合咪唑 - 头孢烯化合物
公开(公告)号：US4962100A
公开(公告)日：1990-10-09
申请号：US331192
申请日：1989-03-28
申请人： Akio Miyake , Masahiro Kondo , Masahiko Fujino
发明人： Akio Miyake , Masahiro Kondo , Masahiko Fujino
IPC分类号： C07D501/06 , A61K31/545 , A61K31/546 , C07D277/20 , C07D285/08 , C07D463/00 , C07D471/04 , C07D487/04 , C07D498/04 , C07D501/46 , C07D505/00 , C07D519/00
CPC分类号： C07D277/587 , C07D285/08 , C07D463/20 , C07D463/22 , C07D471/04 , C07D487/04 , C07D505/00
摘要： A compound of the formula: ##STR1## wherein R.sup.1 is an amino group which may be protected, R.sup.3 is a hydrogen atom or an optionally substituted hydrocarbon residue; Z is S, S.fwdarw.O, O or CH.sub.2, R.sup.4 is a hydrogen atom, methoxy group or formamido group, R.sup.13 is a hydrogen atom, methyl group, hydroxyl group or halogen atom and A.sup..sym. is an optionally substituted imidazolium-1-yl group forming a condensed ring at the 2,3- or 3,4-position or a pharmaceutically acceptable salt or ester thereof is novel and has excellent antibacterial activity.

8. 发明授权

US4725592A 1-Acyloxyalkyl esters of cephalosporin 失效
标题翻译：头孢菌素的1-芳氧基烷基酯
公开(公告)号：US4725592A
公开(公告)日：1988-02-16
申请号：US637138
申请日：1984-08-03
申请人： Akio Miyake , Masayoshi Yamaoka , Mitsuo Numata
发明人： Akio Miyake , Masayoshi Yamaoka , Mitsuo Numata
IPC分类号： A61K31/545 , A61K31/546 , A61P31/04 , C07D501/36 , C07D501/56
CPC分类号： C07D501/36
摘要： A compound of the formula: ##STR1## wherein R.sub.1 stands for n-propyl or isopropyl; and R.sub.2 stands for n-butyl, isobutyl, n-pentyl, n-hexyl or 2-ethylbutyl, or a pharmaceutically acceptable salt thereof, processes for preparing the same and a pharmaceutical composition thereof are provided. The compound can orally be applied as antibiotics having improved bioavailability.
摘要翻译：下式的化合物：其中R 1代表正丙基或异丙基; R2代表正丁基，异丁基，正戊基，正己基或2-乙基丁基，或其药学上可接受的盐，其制备方法及其药物组合物。该化合物可口服施用，具有改善生物利用度的抗生素。

9. 发明授权

US4665065A 3-pyrazolo(1,5-a.alpha.pyridinium cephem compounds 失效
标题翻译： 3-吡唑并（1,5-aα吡啶鎓头孢烯化合物
公开(公告)号：US4665065A
公开(公告)日：1987-05-12
申请号：US739440
申请日：1985-05-30
申请人： Akio Miyake , Masahiro Kondo , Masahiko Fujino
发明人： Akio Miyake , Masahiro Kondo , Masahiko Fujino
IPC分类号： C07D463/00 , C07D501/46 , C07D505/00 , C07D519/00 , A61K31/545
CPC分类号： C07D519/00 , C07D463/16 , C07D463/22 , C07D505/00 , Y02P20/55
摘要： A compound of the formula; ##STR1## wherein R.sup.0 stands for hydrogen atom, nitrogen-containing heterocyclic group, acyl group or amino-protecting group, Z stands for S, S.fwdarw.O, O or CH.sub.2, R.sup.4 stands for hydrogen atom, methoxy group or formamido group, R.sup.13 stands for hydrogen atom, methyl group, hydroxyl group or halogen atom and A stands for an optionally substituted pyrazol-2-yl group forming a fused ring at the 1,5-position or a physiologically or pharmaceutically acceptable salt or ester thereof.This compound is novel and has excellent antibacterial activity.
摘要翻译：式的化合物; 其中R 0表示氢原子，含氮杂环基，酰基或氨基保护基，Z表示S，S-> O，O或CH2，R4表示氢原子，甲氧基或甲酰氨基， R13表示氢原子，甲基，羟基或卤素原子，A表示在1,5-位上形成稠环的任选取代的吡唑-2-基，或其生理或药学上可接受的盐或酯。该化合物新颖，抗菌活性优异。

10. 发明授权

US5482939A Triazolopyridazine compounds, their production and use 失效
标题翻译：三唑并哒嗪化合物，其生产和使用
公开(公告)号：US5482939A
公开(公告)日：1996-01-09
申请号：US306423
申请日：1994-09-16
申请人： Akio Miyake , Yasuhiko Kawano , Yasuko Ashida
发明人： Akio Miyake , Yasuhiko Kawano , Yasuko Ashida
IPC分类号： C07D487/04 , A61K31/50 , A61K31/535 , C07D487/12
CPC分类号： C07D487/04
摘要： Novel compound represented by the formula: ##STR1## wherein R.sup.1 stands for H, an optionally substituted lower alkyl group or a halogen; R.sup.2 and R.sup.3 respectively stands for a hydrogen or an optionally substituted lower alkyl group, or R.sup.2 and R.sup.3 may, taken together with the adjacent --C.dbd.C-- group, form a 5- to 7-membered ring; X stands for O, SO or SO.sub.2 ; Y stands for a group of the formula: ##STR2## (R.sup.4 and R.sup.5 respectively stand for H or an optionally substituted lower alkyl group) or a divalent group derived from an optionally substituted 3- to 7-membered homocyclic or heterocyclic ring; R.sup.6 and R.sup.7 each stands for H, an optionally substituted lower alkyl group, an optionally substituted cycloalkyl group or an optionally substituted aryl group, or R.sup.6 and R.sup.7 may, taken together with the adjacent N, form an optionally substituted N-containing heterocyclic group; m stands for 0 to 4; n stands for 0 to 4, or a salt thereof, which has excellent anti-PAF activities anti-LTC.sub.4 activities and anti-ET-1 activities, and is of value as an antiasthmatic agent, and their production, intermediates and pharmaceutical compositions.
摘要翻译：由下式表示的新化合物：其中R1代表H，任选取代的低级烷基或卤素; R2和R3分别表示氢或任选取代的低级烷基，或者R 2和R 3可以与相邻的C = C-基团一起形成5-至7-元环; X代表O，SO或SO2; Y代表下式的基团：（R 4和R 5分别代表H或任意取代的低级烷基）或衍生自任选取代的3-至7-元级环或杂环的二价基团; R 6和R 7各自代表H，任选取代的低级烷基，任选取代的环烷基或任选取代的芳基，或者R 6和R 7可以与相邻的N一起形成任选取代的含N杂环基; m代表0到4; n代表0至4或其盐，其具有优异的抗PAF活性抗LTC4活性和抗ET-1活性，并且具有价值作为抗哮喘药及其制备，中间体和药物组合物。

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