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1. 发明授权

US5217986A Anti-allergy agent 失效
标题翻译：抗过敏剂
公开(公告)号：US5217986A
公开(公告)日：1993-06-08
申请号：US858275
申请日：1992-03-26
申请人： Shirley A. Pomponi , Vincent P. Gullo , Ann C. Horan , Mahesh G. Patel , Stephen Coval
发明人： Shirley A. Pomponi , Vincent P. Gullo , Ann C. Horan , Mahesh G. Patel , Stephen Coval
IPC分类号： C07D233/54 , C07D233/64
CPC分类号： C07D233/64
摘要： The compound of the formula ##STR1## is described. This compound is active in an H.sub.3 receptor assay and is an H.sub.3 antagonist. Accordingly, the compound of formula I is useful in the treatment of diseases and conditions such as asthma, rhinitis, airway congestion, inflammation, cardiac arrhythmias, hypertension, hyper and hypo motility and acid secretion of the gastrointestinal tract, hypo and hyper activity of the central nervous system (CNS), migraine, and glaucoma.
摘要翻译：描述了式（IMAGE）I的化合物。该化合物在H3受体测定中是有活性的，并且是H3拮抗剂。因此，式I化合物可用于治疗诸如哮喘，鼻炎，呼吸道充血，炎症，心律失常，高血压，超低运动性和胃肠道酸分泌等疾病和病症，中枢神经系统（CNS），偏头痛和青光眼。

2. 发明授权

US5446207A Anti-dyslipidemic agents 失效
标题翻译：抗血脂异常药
公开(公告)号：US5446207A
公开(公告)日：1995-08-29
申请号：US115947
申请日：1993-09-01
申请人： Shirley A. Pomponi , Vincent P. Gullo , Ann C. Horan , Mahesh G. Patel , Stephen J. Coval
发明人： Shirley A. Pomponi , Vincent P. Gullo , Ann C. Horan , Mahesh G. Patel , Stephen J. Coval
IPC分类号： C07C43/23
CPC分类号： C07C43/23 , C07C2102/28
摘要： Compounds of the formula: ##STR1## wherein a is a single bond and b is a double bond; or a is a double bond and b is a single bond; and enantiomers thereof; or a pharmaceutically acceptable salt thereof are described. These compounds can improve lipoprotein profile of dyslipidemic patients and generate an anti-atherogenic lipoprotein profile of normolipidemic individuals. In addition, inhibition of CETP activity may be useful as antifertility agents.
摘要翻译：下式的化合物：其中a是单键，b是双键; 或a为双键，b为单键; 及其对映异构体; 或其药学上可接受的盐。这些化合物可以改善血脂异常患者的脂蛋白分布，并产生正常脂肪血症个体的抗动脉粥样化脂蛋白。此外，CETP活性的抑制可用作抗生育剂。

3. 发明授权

US07521474B2 Biologically active lasonolide compounds 失效
标题翻译：生物活性季铵化合物
公开(公告)号：US07521474B2
公开(公告)日：2009-04-21
申请号：US11494229
申请日：2006-07-27
申请人： Amy E. Wright , Shirley A. Pomponi , Peter J. McCarthy , Ying Chen , Ross E. Longley
发明人： Amy E. Wright , Shirley A. Pomponi , Peter J. McCarthy , Ying Chen , Ross E. Longley
IPC分类号： A61K31/335 , C07D325/04 , C07D493/12
CPC分类号： C07D493/18
摘要： The subject invention provides novel compositions of biologically active macrolide compounds which can advantageously be used in blocking cellular proliferation, treatment of cancer, treatment of fungal infections and control of spoilage of food, cosmetic and other consumer items.
摘要翻译：本发明提供生物活性大环内酯化合物的新组合物，其可有利地用于阻断细胞增殖，治疗癌症，治疗真菌感染和控制食品，化妆品和其它消费品的腐败。

4. 发明授权

US07115756B2 Biologically active lasonolide compounds 失效
公开(公告)号：US07115756B2
公开(公告)日：2006-10-03
申请号：US10875670
申请日：2004-06-23
申请人： Amy E. Wright , Shirley A. Pomponi , Peter J. McCarthy , Ying Chen , Ross E. Longley
发明人： Amy E. Wright , Shirley A. Pomponi , Peter J. McCarthy , Ying Chen , Ross E. Longley
IPC分类号： C07D325/04 , C07D493/12
CPC分类号： C07D493/18
摘要： The subject invention provides novel compositions of biologically active macrolide compounds which can advantageously be used in blocking cellular proliferation, treatment of cancer, treatment of fungal infections and control of spoilage of food, cosmetic and other consumer items.

5. 发明授权

US06602881B2 Anti-inflammatory uses of manzamines 失效
公开(公告)号：US06602881B2
公开(公告)日：2003-08-05
申请号：US10144888
申请日：2002-05-13
申请人： Alejandro Mayer , Sarath P. Gunasekera , Shirley A. Pomponi , Susan H. Sennett
发明人： Alejandro Mayer , Sarath P. Gunasekera , Shirley A. Pomponi , Susan H. Sennett
IPC分类号： A60K3144
CPC分类号： A61K31/4748 , A61K31/437 , A61K45/06
摘要： The subject invention pertains to compounds which are useful as anti-inflammatory agents and to compositions containing such compounds as active ingredients. The novel uses of the compounds relate to the anti-neurogenic inflammatory properties of the disclosed compounds. Specifically exemplified herein is the use of manzamines A, B, C, D, E, and F, and their salts, analogs, and derivatives.

6. 发明授权

US06384187B1 Antiproliferative activity of microsclerodermins 有权
标题翻译：微生物的抗增殖活性
公开(公告)号：US06384187B1
公开(公告)日：2002-05-07
申请号：US09568692
申请日：2000-05-11
申请人： Amy E. Wright , Shirley A. Pomponi , Ross E. Longley , Richard A. Isbrucker
发明人： Amy E. Wright , Shirley A. Pomponi , Ross E. Longley , Richard A. Isbrucker
IPC分类号： C07K750
CPC分类号： C07K7/56 , A61K38/00
摘要： The subject invention pertains to a series of cyclic peptides known as the microsclerodermins, which possess unusual amino acids, and which have been observed to inhibit the proliferation of tumor cell lines. The subject invention also pertains to methods useful in inhibiting pathological cellular proliferation in animals, including humans and other mammals. In accordance with the teachings of the subject invention, microsclerodermin compounds can be used to inhibit cellular proliferation including that which is responsible for tumors and other cancers. In a specific embodiment, the novel compositions and methods of use of the subject invention can advantageously be useful in the treatment of a patient hosting cancer cells, for example, inhibiting the growth of tumor cells in a mammalian host.
摘要翻译：本发明涉及一系列已知为具有不寻常氨基酸的微小霉菌的环状肽，其已被观察到抑制肿瘤细胞系的增殖。本发明还涉及可用于抑制动物（包括人类和其他哺乳动物）的病理性细胞增殖的方法。根据本发明的教导，可以使用微细胞毒素化合物来抑制细胞增殖，包括负责肿瘤和其它癌症的细胞增殖。在一个具体实施方案中，本发明的新颖组合物和使用方法可以有利地用于治疗宿主癌细胞的患者，例如抑制哺乳动物宿主中肿瘤细胞的生长。

7. 发明授权

US06291501B1 Compounds and methods of use for treatment of neurogenic inflammation 有权
标题翻译：用于治疗神经源性炎症的化合物和方法
公开(公告)号：US06291501B1
公开(公告)日：2001-09-18
申请号：US09253118
申请日：1999-02-19
申请人： Amy E. Wright , Shirley A. Pomponi , Robert S. Jacobs
发明人： Amy E. Wright , Shirley A. Pomponi , Robert S. Jacobs
IPC分类号： C07D40314
CPC分类号： C07D403/14 , A61K31/4178 , A61K31/497 , C07D487/08
摘要： The subject invention pertains to compounds which are useful as antiinflammatory agents and to compositions containing such compounds as active ingredients. The novel uses of the compounds relate to the anti-neurogenic inflammatory properties of the disclosed bis-heterocyclic compounds. Specifically exemplified herein are dragmacidin f, topsentin d, and topsentin e, and their salts, analogs, and derivatives.
摘要翻译：本发明涉及可用作抗炎剂的化合物和含有活性成分的化合物的组合物。所述化合物的新用途涉及所公开的双杂环化合物的抗神经源性炎症性质。具体示例为拖拉霉素f，topentin d和topentin e及其盐，类似物和衍生物。

8. 发明授权

US07179828B2 Biologically active neopeltolide compounds 有权
标题翻译：生物活性新型内酯化合物
公开(公告)号：US07179828B2
公开(公告)日：2007-02-20
申请号：US10874723
申请日：2004-06-22
申请人： Amy E. Wright , Shirley A. Pomponi , Peter J. McCarthy
发明人： Amy E. Wright , Shirley A. Pomponi , Peter J. McCarthy
IPC分类号： A61K31/422 , C07D413/12
CPC分类号： C07D493/08
摘要： The subject invention provides novel compositions of biologically active macrolide compounds which can advantageously be used in blocking cellular proliferation, treatment of cancer, treatment of fungal infections and control of spoilage of food, cosmetic and other consumer items.
摘要翻译：本发明提供生物活性大环内酯化合物的新组合物，其可有利地用于阻断细胞增殖，治疗癌症，治疗真菌感染和控制食品，化妆品和其它消费品的腐败。

9. 发明授权

US06835736B1 Discorhabdin compounds and methods of use 失效
标题翻译： Discorhabdin化合物和使用方法
公开(公告)号：US06835736B1
公开(公告)日：2004-12-28
申请号：US10376118
申请日：2003-02-28
申请人： Sarath P. Gunasekera , Ross E. Longley , Shirley A. Pomponi , Amy E. Wright
发明人： Sarath P. Gunasekera , Ross E. Longley , Shirley A. Pomponi , Amy E. Wright
IPC分类号： A61K3144
CPC分类号： C07D471/10 , A61K31/44
摘要： The subject invention provides novel compositions of biologically active discorhabdin compounds which can advantageously be used for inhibiting pathological cellular proliferation. The compounds of the subject invention have utility for use in the treatment of cancer, including tumors.
摘要翻译：本发明提供了可以有利地用于抑制病理性细胞增殖的生物活性的discorhabdin化合物的新组合物。本发明的化合物可用于治疗包括肿瘤在内的癌症。

10. 发明授权

US06589957B2 Compounds and methods of use for treatment of neurogenic inflammation 失效
公开(公告)号：US06589957B2
公开(公告)日：2003-07-08
申请号：US09944881
申请日：2001-08-31
申请人： Amy E. Wright , Shirley A. Pomponi , Robert S. Jacobs
发明人： Amy E. Wright , Shirley A. Pomponi , Robert S. Jacobs
IPC分类号： C07D47104
CPC分类号： C07D403/14 , A61K31/4178 , A61K31/497 , C07D487/08
摘要： The subject invention pertains to compounds which are useful as anti-inflammatory agents and to compositions containing such compounds as active ingredients. The novel uses of the compounds relate to the anti-neurogenic inflammatory properties of the disclosed bis-heterocyclic compounds. Specifically exemplified herein are dragmacidin f, topsentin d, and topsentin e, and their salts, analogs, and derivatives.

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