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    • 1. 发明授权
    • Antiproliferative activity of microsclerodermins
    • 微生物的抗增殖活性
    • US06384187B1
    • 2002-05-07
    • US09568692
    • 2000-05-11
    • Amy E. WrightShirley A. PomponiRoss E. LongleyRichard A. Isbrucker
    • Amy E. WrightShirley A. PomponiRoss E. LongleyRichard A. Isbrucker
    • C07K750
    • C07K7/56A61K38/00
    • The subject invention pertains to a series of cyclic peptides known as the microsclerodermins, which possess unusual amino acids, and which have been observed to inhibit the proliferation of tumor cell lines. The subject invention also pertains to methods useful in inhibiting pathological cellular proliferation in animals, including humans and other mammals. In accordance with the teachings of the subject invention, microsclerodermin compounds can be used to inhibit cellular proliferation including that which is responsible for tumors and other cancers. In a specific embodiment, the novel compositions and methods of use of the subject invention can advantageously be useful in the treatment of a patient hosting cancer cells, for example, inhibiting the growth of tumor cells in a mammalian host.
    • 本发明涉及一系列已知为具有不寻常氨基酸的微小霉菌的环状肽,其已被观察到抑制肿瘤细胞系的增殖。 本发明还涉及可用于抑制动物(包括人类和其他哺乳动物)的病理性细胞增殖的方法。 根据本发明的教导,可以使用微细胞毒素化合物来抑制细胞增殖,包括负责肿瘤和其它癌症的细胞增殖。 在一个具体实施方案中,本发明的新颖组合物和使用方法可以有利地用于治疗宿主癌细胞的患者,例如抑制哺乳动物宿主中肿瘤细胞的生长。